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Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： yuan-jing Jiang Lu Wu Xiao Yang Yu Pu Bing-Jie Ning Na Peng Xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

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Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di Zhang Jin-Feng Wang Wan-Lin Lu jing-yuan Wang Shi-Feng Liang Ran Liu jing-Xin Jiang Hong-Tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

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Robustness of s-wave pairing symmetry in iron-based superconductors and its implications for fundamentals of magnetically driven high-temperature superconductivity

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Frontiers of physics 2016年第5期11卷 79-89页

作者： Jiangping Hu jing yuan Institute of Physics Chinese Academy of Sciences Beijing 100190 China Department of Physics Purdue University West Lafayette IN 47907 USA Collaborative Innovation Center of Quantum Matter Beijing 100871 China

Based on the assumption that the superconducting state belongs to a single irreducible representation of lattice symmetry, we propose that the pairing symmetry in all measured iron-based superconductors is generally consistent with the A1g s-wave. Robust s-wave pairing throughout the different families of iron-based superconductors at different doping regions signals two fundamental principles behind high-To superconducting mechanisms：（i） the correspondence principle： the short-range magnetic-exchange interactions and the Fermi surfaces act collaboratively to achieve high-Tc superconductivity and determine pairing symmetries; （ii） the magnetic-selection pairing rule： supercon- ductivity is only induced by the magnetic-exchange couplings from the super-exchange mechanism through cation-anion-cation chemical bonding. These principles explain why unconventional high- Tc superconductivity appears to be such a rare but robust phenomena, with its strict requirements regarding the electronic environment. The results will help us to identify new electronic structures that can support high-Tc superconductivity.

关键词： iron-based superconductors cuprates unconventional superconductivity high-temperature superconductors

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Linear and Nonlinear Spectra in Photosynthetic Light Harvesting Complexes: Benchmark Tests of Modified Redfield Method

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Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： yuan-yuan jing Kai Song Shu-ming Bai Qiang Shi Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100190China

We employ the numerically exact hierarchical equations of motion (HEOM) method to perform benchmark tests for the popular modified Redfield method in calculating linear and nonlinear spectroscopic signals of molecular aggregates in photosynthetic light harvesting complexes. It is currently well known that the perturbative and Markovian approximations involved in the modified Redfield equation may give inappropriate description of the excitation energy transfer processes in the intermediate coupling regime. An interesting topic is thus to test the validity of the modified Redfield method in calculating various types of spectroscopic signals. By using model dimers with different sets of parameters and a model of the Fenna-Matthews-Olson complex, we calculate and compare the absorption, emission, and 2D spectra using the modified Redfield and HEOM methods. It is found that results from the modified Redfield method agree well with the HEOM ones in a wide range of parameter regimes. The comparison also helps to understand the quantum beating signals in the 2D spectra of the photosynthetic light harvesting complexes.

关键词： Linear spectra Nonlinear spectra Light harvesting complexes Modified Redfield method

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Comprehensive review of targeted therapy for colorectal cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2155-2184页

作者： yuan-Hong Xie Ying-Xuan Chen jing-yuan Fang Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseaseState Key Laboratory for Oncogenes and Related GenesKey Laboratory of Gastroenterology&HepatologyMinistry of HealthRenji HospitalSchool of MedicineShanghai Jiao Tong University145 Middle Shandong Road200001 ShanghaiChina

Colorectal cancer(CRC)is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in *** and chemotherapy have long been the first choices for cancer ***,the prognosis of CRC has never been satisfying,especially for patients with metastatic *** therapy is a new optional approach that has successfully prolonged overall survival for CRC *** successes with the anti-EGFR(epidermal growth factor receptor)agent cetuximab and the anti-angiogenesis agent bevacizumab,new agents blocking different critical pathways as well as immune checkpoints are emerging at an unprecedented *** worldwide are currently updating the recommended targeted drugs on the basis of the increasing number of high-quality clinical *** review provides an overview of existing CRC-targeted agents and their underlying mechanisms,as well as a discussion of their limitations and future trends.

关键词： Surgery drugs chemotherapy

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Late-Time Evolution of the Phantom Scalar Perturbation in the Background of a Spherically Symmetric Static Black Hole

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Chinese Physics Letters 2010年第6期27卷 9-12页

作者： PAN Qi-yuan jing Ji-Liang Institute of Physics and Department of Physics Hunan Normal University Changsha 410081

The late-time evolution of the phantom scalar perturbation is investigated in the spacetime of a four-dimensionai spherically symmetric static black hole. It is revealed that the asymptotic tail of the phantom scalar field is dominated by the growth behavior t-（l＋3/2）eμt, which depends on the multipole moment l and the field moss but is independent of the mass M and charge Q of the black hole. This growth behavior is in strong contrast to the decaying tall of the usual massive scalar perturbation and shows that the external phantom scalar perturbation is unstable in the spherically symmetric static black hole spacetime.

关键词： PHANTOMS (Radiology) SCALAR field theory PERTURBATION (Quantum dynamics) COSMIC background radiation SYMMETRY (Physics) SUPERMASSIVE black holes

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Influence of the microbiota on epigenetics in colorectal cancer

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National Science Review 2019年第6期6卷 1138-1148页

作者： Danfeng Sun Yingxuan Chen jing-yuan Fang Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related GenesShanghai Institute of Digestive DiseaseRenji Hospital School of Medicine Shanghai Jiao Tong University

Colorectal cancer is one of the most common malignancies and is the second leading cause of cancer death worldwide. Generally, there are three categories of colorectal cancer development mechanism—genetic,epigenetic and aberrant immunological signaling pathways—all of which may be initiated by an imbalanced gut microbiota. Epigenetic modifications enable host cells to change gene expression without modifying the gene sequence. The microbiota can interact with the host genome dynamically through the interface presented by epigenetic modifications. In particular, bacterially derived short-chain fatty acids have been identified as one clear link in the interaction of the microbiota with host epigenetic pathways. This review discusses recent findings relating to the cross talk between the microbiota and epigenetic modifications in colorectal cancer.

关键词： colorectal cancer gut microbiota epigenetics short-chain fatty acids

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Facile aqueous synthesis and thermal insulating properties of low-density glass/TiO_2 core/shell composite hollow spheres

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Particuology 2012年第4期10卷 475-479页

作者： jing yuan Zhenguo An Bing Li jingjie Zhang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

TiO2 shells assembled on hollow glass microspheres （HGM） with tunable morphologies were suc- cessfully prepared through a controllable chemical precipitation method with urea as the precipitator. Thus, glass/TiO2 core/shell composite hollow spheres with low particle density （0.40 g/cm3） were fabri- cated. The phase structures, morphologies, particle sizes, shell thicknesses, and chemical compositions of the composite microspheres were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and energy dispersive X-ray spectroscopy （EDS）. The morphology of the TiO2 shell can be tailored by properly monitoring the reaction system component and parameters. The probable growth mecha- nism and fabrication process of the core/shell products involving the nucleation and oriented growth of TiO2 nanocrystals on hollow glass microspheres was proposed. A low infrared radiation study revealed that the radiation properties of the products are greatly influenced by the unique product shell structures. A thermal conductivity study showed that the TiO2/HGM possess low thermal conductivity that is similar to that of the pristine HGMs. This work provides an additional strategy to prepare low-density thermal insulating particles with tailored morphologies and properties.

关键词： Hollow glass microspheresTiO2Core/shellEmissivityThermal conductivity

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Economic Policy Uncertainty:Cross-Country Linkages and Spillover Effects on Economic Development in Some Belt and Road Countries

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Journal of Systems Science & Complexity 2023年第3期36卷 1169-1188页

作者： yuan jing DONG Yajing ZHAI Weijie CAI Zongwu School of Statistics Shandong Technology and Business UniversityYantai 264005China School of Statistics and Data Science Nankai UniversityTianjin 300071China Department of Economics University of KansasLawrenceKS 66045USA

With the increase of economic environment uncertainty,it is of great importance to study the linkage and spillover effects of economic policy uncertainty among ***,this article selects eight countries along the Belt and Road as the core countries(China,Korea,Croatia,India,Russia,Greece,Pakistan,and Singapore)and four countries(Germany,France,Japan,and UK)as the peripheral countries,and then copula technique and mixed-frequency global vector autoregressive model are employed to analyze the correlation and the spillover effect of the economic policy uncertainty(EPU)for the twelve selected countries,*** proposed empirical findings show clearly that the EPU correlation among the eight core Belt and Road countries is stronger and the spillover effect of the core countries to the peripheral countries is statistically *** a result,for harmonious and win-win development,the Belt and Road countries should pay a close attention to the EPU,because the stability of the EPU promotes greatly the economy development.

关键词： Belt and road initiative copula functions economic policy uncertainty global VAR spillover effects

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Effect of trace HA on microstructure, mechanical properties and corrosion behavior of Mg-2Zn-0.5Sr alloy

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Journal of Materials Science & Technology 2018年第2期34卷 299-310页

作者： Jian-Xing Li yuan Zhang jing-yuan Li Jian-Xin Xie School of Materials Science and Engineering University of Science and Technology Beijing Institute for Advanced Materials and Technology University of Science and Technology Beijing

Effect of the addition of trace HA particles into Mg-2Zn-0.5Sr on microstructure, mechanical properties, and bio-corrosion behavior was investigated in comparison with pure Mg. Microstructures of the Mg-2Zn-0.5Sr-xHA composites （x= 0, 0.1 and 0.3 wt%） were characterized by optical microscopy （OM）, scanning electron microscopy （SEM） equipped with energy dispersion spectroscopy （EDS） and X-ray diffraction （XRD）. Results of tensile tests at room temperature show that yield strength （YS） of Mg- 2Zn-0.5Sr/HA composites increases significantly, but the ultimate tensile strength （UTS） and elongation decrease with the addition of HA particles from 0 up to 0.3 wt%. Bio-corrosion behavior was investigated by immersion tests and electrochemical tests. Electrochemical tests show that corrosion potential （Ecorr） of Mg-2Zn-0.5Sr/HA composites significantly shifts toward nobler direction from -1724 to -1660 mVscE and the corrosion current density decreases from 479.8 to 280.8 ***^-2 with the addition of HA particles. Immersion tests show that average corrosion rate of ***/HA composites decreases from 11.7 to 9.1 mm/year with the addition of HA particles from 0 wt% up to 0.3 wt%. Both microstructure and mechanical properties can be attributed to grain refinement and mechanical bonding of HA particles with second phases and α-Mg matrix. Bio-corrosion behavior can be attributed to grain refinement and the formation of a stable and dense CaHPO4 protective film due to the adsorption of Ca^2＋ on HA particles. Our analysis shows that the Mg-2Zn-0.5Sr/0.3HA with good strength and corrosion resistance can be a good material candidate for biomedical applications.

关键词： Magnesium alloys Bio-composites Hydroxyapatite Microstructure Mechanical property Bio-corrosion behavior

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