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Identifying Neighborhood Effects on Geohazard Adaptation in Mountainous Rural Areas of China:A Spatial Econometric Model

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International Journal of Disaster Risk Science 2023年第6期14卷 919-931页

作者： Li Peng jing tan College of Geography and Resources Sichuan Normal UniversityChengdu 610101China School of Public Policy and Administration Chongqing UniversityChongqing 400044China Center for Public Economics&Public Policy Chongqing UniversityChongqing 400044China

In mountainous rural settlements facing the threat of geohazards,local adaptation is a self-organizing process influenced by individual and group *** a wide range of local populations to embrace geohazard adaptation strategies emerges as a potent means of mitigating disaster *** purpose of this study was to investigate whether neighbors influence individuals'adaptation decisions,as well as to unravel the mechanisms through which neighborhood effects exert their *** employed a spatial Durbin model and a series of robustness checks to confirm the *** dataset used in this research came from a face-to-face survey involving 516 respondents residing in 32 rural settlements highly susceptible to *** empirical results reveal that neighborhood effects are an important determinant of adaptation to *** is,a farmer's adaptation decision is influenced by the adaptation choices of his/her ***,when neighbors adopt adaptation strategies,the focal individuals may also want to adapt,both because they learn from their neighbors'choices(social learning)and because they tend to abide by the majority's choice(social norms).Incorporating neighborhood effects into geohazard adaptation studies offers a new perspective for promoting disaster risk reduction decision making.

关键词： Disaster risk reduction Geohazard adaptation Neighborhood effects Rural China Spatial Durbin model(SDM)

Active Sites for Adsorption and Reaction of Molecules on Rutile TiO2(110) and Anatase TiO2(001) Surfaces

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Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： Shi-jing tan Bing Wang Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 China

The reactivity of specific sites on rutile TiO2(110)−(1×1) surface and anatase TiO2(001)−(1×4) surface has been comparably studied by means of high resolution scanning tunneling microscopy. At the rutile TiO2(110)−(1×1) surface, we find the defects of oxygen vacancy provide distinct reactivity for O2 and CO2 adsorption, while the terminal fivefold-coordinated Ti sites dominate the photocatalytic reactivity for H2O and CH3OH dissociation. At the anatase TiO2(001)−(1×4) surface, the sixfold-coordinated terminal Ti sites at the oxidized surface seem to be inert in both O2 and H2O reactions, but the Ti-rich defects which introduce the Ti3+ state into the reduced surface are found to provide high reactivity for the reactions of O2 and H2O. By comparing the reactions on both rutile and anatase surfaces under similar experimental conditions, we find the reactivity of anatase TiO2(001) is actually lower than rutile TiO2(110), which challenges the conventional knowledge that the anatase (001) is the most reactive TiO2 surface. Our findings could provide atomic level insights into the mechanisms of TiO2 based catalytic and photocatalytic chemical reactions.

关键词： TiO2 Rutile Anatase Photocatalysis Scanning tunneling microscopy

Assemblies of covalent organic framework microcrystals:multiple-dimensional manipulation for enhanced applications

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Science China Chemistry 2018年第2期61卷 143-152页

作者： Fuyu Yuan jing tan Jia Guo State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan University

Covalent organic frameworks (COFs) are well known as the next generation of shape-persistent zeolite analogues, which have brought new impetus to the development of porous organic materials as well as two-dimensional polymers. Since the advent of COFs in 2005, many striking findings have definitely proven their great potentials expanding applications across energy,environment and healthcare fields. With thorough exploration over a decade, research interest has been drawn on the scientific challenges on chemistry, while making full play of COF values has remained far from satisfactory yet. Thus opening an avenue to modulating COF assemblies on the multi-scale is no longer just an option, but a necessity for matching the application requirements with enhanced performances. In this mini-review, we summarize the recent progress on design of nanoscale COFs with varying forms. Detailed description is concentrated on the synthetic strategies of COF assemblies such as spheres, fibers,tubes, coatings and films, thereby shedding light on the flexible manipulation over dimensions, compositions and ***, the advanced applications of nanoscale COFs have been discussed here with comparison of their bulky counterparts.

关键词： covalent organic frameworks controllable synthesis porous materials nanoscale

Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy

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Chinese Journal of Cancer 2013年第7期32卷 376-379页

作者： jing tan Qiang Yu Cancer Therapeutics and Stratified Oncology Genome Institute of SingaporeA*STAR(Agency for ScienceTechnology and Research)BiopolisSingapore 138672Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Cancer and Stem Cell Biology DUKE-NUS Graduate Medical School of SingaporeSingapore 169857Singapore

Deregulation of the phosphatidylinositide 3-kinase(PI3K) and mammalian target of rapamycin(mTOR) signaling pathway occurs frequently in a wide range of human cancers and is a major driving force in ***,small molecules targeting this pathway are under active development as anticancer *** small-molecule inhibitors of the PI3K-mTOR pathway have shown promising clinical efficacy against human cancers,the emergence of drug resistance may limit their success in the *** date,several resistance mechanisms,including both PI3K-dependent and-independent mechanisms,have been ***,we summarize the current understanding of resistance mechanisms to PI3K-mTOR inhibitors and discuss potential strategies for overcoming resistance for potential clinical application.

关键词：分子机制肿瘤耐药靶向治疗信号通路磷脂酰肌醇放松管制 mTOR 雷帕霉素

Multi-sources information fusion algorithm in airborne detection systems

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Journal of Systems Engineering and Electronics 2007年第1期18卷 171-176页

作者： Yang Yan jing Zhanrong Gao tan Wang Huilong Coll. of Electronic Information Engineering Northwestern Polytechnical Univ. Xi'an 710072 P. R. China

To aim at the multimode character of the data from the airplane detecting system, the paper combines Dempster- Shafer evidence theory and subjective Bayesian algorithm and makes to propose a mixed structure multimode data fusion algorithm. The algorithm adopts a prorated algorithm relate to the incertitude evaluation to convert the probability evaluation into the precognition probability in an identity frame, and ensures the adaptability of different data from different source to the mixed system. To guarantee real time fusion, a combination of time domain fusion and space domain fusion is established, this not only assure the fusion of data chain in different time of the same sensor, but also the data fusion from different sensors distributed in different platforms and the data fusion among different modes. The feasibility and practicability are approved through computer simulation.

关键词： Information fusion Dempster-Shafer evidence theory Subjective Bayesian algorithm Airplane detecting system

Conjugated microporous polymers with distinctive π-electronic properties exhibiting enhanced optical applications

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Chinese Chemical Letters 2016年第8期27卷 1405-1411,1470页

作者： jing tan Wu-Ji Chen Jia Guo State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Lab of Advanced MaterialsFudan University

The short review discusses a family of amorphous porous organic polymers,conjugated microporous polymer（CMP）,which is distinctive in fusion of a large π-electronic conjugation within the topological network *** kind of polymers has shown the synthetic variety,the advanced capability and the wide applicability in contrast to the reported ***,the significant progress of CMP applications has been summarized to showcase their capability in constructing photo-functional systems.

关键词： Conjugated polymers Porous materials Light harvesting Photocatalysis Optoelectronics Chemosensor Phototherapy

Molecular cloning, characterization and expression analysis of a catalase gene in Paphia textile

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Acta Oceanologica Sinica 2016年第8期35卷 65-73页

作者： WU Xiangwei LI Jiakai tan jing LIU Xiande Fujian Provincial Key Laboratory of Marine Fishery Resources and Eco-environment Fisheries College Jimei University Animal Science and Technology College Yunnan Agricultural University

Catalase is an important antioxidant protein that can protect organisms against various forms of oxidative damage by eliminating hydrogen peroxide. In this study, the catalase c DNA of Paphia textile（Pt CAT） was cloned using RTPCR and rapid amplification of c DNA ends（RACE）. Pt CAT is 1 921 bp long and consists of a 5′-UTR of 50 bp, a 3′-UTR of 349 bp, and an ORF of 1 542 bp that encodes 513 amino acids with a molecular weight of 58.4 k D and an estimated isoelectric point of 8.2. Sequence alignment indicated that Pt CAT contained a highly conserved catalytic signature motif（^（61）FNRERIPERVVHAKGAG^（77））, a proximal heme-ligand signature sequence（^（352）RLFSYSDP^（359））, and three catalytic amino acid residues（H^（72）, N^（145）, and Y^（356））. Pt CAT also contains two putative N-glycosylation sites（^（34）NKT^（36） and ^（437）NFT^（439）） and a peroxisome-targeting signal（^（511）AQL^（513））. Furthermore, Pt CAT shares 53%–88% identity and 29%–89% similarity with other catalase amino acid sequences. Pt CAT m RNA was present in all tested organs, including the heart, digestive gland, adductor muscle, gonad, gill, and mantle, but its expression was highest in the digestive gland. High-temperature-induced stress produced two expression patterns of Pt CAT m RNA： first, an initial up-regulation followed by a down-regulation in the heart, digestive gland, and gonad and, second, consistent down-regulation in all other organs. These results demonstrate that Pt CAT is a typical member of the catalase family and might be involved in the responses to harmful environmental factors.

关键词： Paphia textile catalase(CAT) cloning sequence analysis expression analysis high temperature stress

Incidence,predictors and prognosis of acute kidney injury in acute ST-segment elevation myocardial infarction patients undergoing emergent coronary angiography/primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2023年第2期20卷 139-149页

作者： jing tan Ying-Hua ZHANG Jin SI Ke-Ling XIAO Qi HUA jing LI Department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Acute kidney injury(AKI) after coronary angiography(CAG) and primary percutaneous coronary intervention(PPCI) is frequently observed, and often interpreted as contrast induced-AKI. This study aimed to investigate the incidence, predictors and outcomes of AKI in acute ST-segment elevation myocardial infarction(STEMI) patients undergoing emergent CAG/PPCI using the control group of STEMI patients who were not exposed to contrast agents within the first 72 *** We performed a retrospective analysis of 1670 STEMI patients. Of them, 673 patients underwent emergent CAG/PPCI, and 997 patients treated with thrombolysis or no reperfusion therapy who were not exposed to contrast material during the first 72 h. AKI was defined as an increase of serum creatinine ≥ 44.2 mmol/L or ≥ 25% from baseline within 72 h. Patents were then followed up for the occurrence of all-cause mortality for 40 months(interquartile range: 24–55 months).RESULTS After propensity score matching, 505 pairs of patients were matched. Overall, the incidence of AKI was 27.4%, and AKI rates were not significantly different in patients with and without emergent CAG/PPCI procedure(27.5% vs. 27.3%, P = 0.944). Multivariate logistic regression analysis identified that the independent predictors of AKI were female, elevated interleukin-6 level,decreased lymphocyte count, left ventricular ejection fraction < 50% and use of diuretics in patients with emergent CAG/PPCI. Patients with AKI than those without AKI experienced higher incidence of acute heart failure with Killip class Ⅲ(9.4% vs. 3.3%, P =0.005;15.2% vs. 6.8%, P = 0.003, respectively) and mortality(5.8% vs. 1.4%, P = 0.014;12.3% vs. 4.6%, P = 0.002, respectively) in patients with and without emergent CAG/PPCI. Multivariate Cox regression analysis confirmed that AKI was independently associated with long-term mortality rate at 40 months follow-up in patients with and without emergent CAG/PPCI(HR = 1.867, 95% CI:1.086–3.210, P = 0.024;HR = 1.7

关键词： patients coronary infarction

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2024年第4期21卷 421-430页

作者： jing tan Jin SI Ke-Ling XIAO Ying-Hua ZHANG Qi HUA jing LI Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMI) are *** We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(< 170 mg/L) and those with the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% CI: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% CI: 0.651–0.754, P< 0.001;sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction