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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Weike Deng sheng Long Jiliang jing Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Educationand Synergetic Innovation Center for Quantum Effects and Applications Hunan Normal University Center for Gravitation and Cosmology College of Physical Science and Technology Yangzhou University

We extend our research on the energy flux and waveform characteristics of gravitational waves generated by merging nonspinning binary black holes through self-consistent effective one-body theory to include binary systems with slowly spinning black ***, we decompose the equation for the null tetrad component of the gravitationally perturbed Weyl tensor ψB4into radial and angular parts, leveraging the second-order approximation of the rotation parameter a. Subsequently, we derive an analytical solution for the radial equation and observe that our results are contingent upon the parameters a2, a3, and a, which represent the second-and third-order correction parameters, respectively. Ultimately, we calculate the energy flux, the radiation-reaction force and the waveform for the “plus” and “cross” modes of the gravitational waves generated by merging slowly spinning binary black holes.

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Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

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Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： jing-jing Yang Ying-Xin Liu Yan-Fang Wang Bi-Ying Ge Ying Wang Qing-Shan Wang sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong sheng-Ming Yin Jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

Improving mathematical model of burden distribution and correcting chute angle to cope with fluctuation of stock line

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Journal of Iron and Steel Research(International) 2024年第2期31卷 342-356页

作者： Jian-sheng Chen Wen-guo Liu Hao Guo Wang Ding Qing-guo Xue jing-song Wang Hai-bin Zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China MCC Capital Engineering&Research Incorporation Limited Beijing100176China Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Accurate evaluations of the burden distribution are of critical importance to stabilize the operation of blast *** mathematical model and discrete element method(DEM)are two attractive methods for predicting burden *** on DEM,the initial velocities of the pellet,sinter,and coke were calculated,and the velocity attenuations of the above three particles between the burden and the chute were *** initial velocity and velocity attenuation were applied to a mathematical model for improving the ***,based on the improved model,a scheme for rectifying the chute angles was proposed to address the fluctuation of the stock line and maintain a stable burden *** validity of the scheme was confirmed via a stable burden distribution under different stock *** mathematical model has been successfully applied to evaluate the online burden distribution and cope with the fluctuation of the stock line.

关键词： Burden distribution Mathematical model Discrete element method Velocity attenuation Stock line fluctuation

Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 55-64页

作者： Xu-Yun Wang Wen-jing Xu Bo-Nan Li Tian-Song Sun Wen sheng Department of Andrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Dermatology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha410021China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Andrology Laboratory Hunan University of Chinese MedicineChangsha410208China School of Rehabilitation Medicine and Health Care Hunan University of MedicineHuaihua418000China School of Traditional Chinese Medicine Hunan University of MedicineHuaihua418000China

Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying ***:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and *** expression was analyzed using monodansylcadaverine *** and Western blot analyses were used to evaluate protein expressions related to autophagy,pyroptosis,and the mTOR *** damage was examined using the lactate dehydrogenase ***,cathepsin B and NLRP3 were detected by ***:Icariin plus curcumol led to a decrease in PC3 cell proliferation and an enhancement of *** levels of LC3-Ⅱ/LC3-Ⅰand beclin-1 were increased,while the levels of p62 and mTOR were decreased after treatment with icariin plus *** changes were reversed upon overexpression of ***,3-methyladenine resulted in a decrease in inflammatory cytokines,pyroptosis-related protein levels,and lactate dehydrogenase concentration,compared to the icariin plus curcumol *** cathepsin B reversed the regulatory effects of icariin plus ***:Icariin plus curcumol demonstrates great potential as a therapeutic agent for castration-resistant prostate cancer by enhancing autophagy via the mTOR pathway and promoting pyroptosis mediated by cathepsin *** findings provide valuable insights into the molecular mechanisms underlying the therapeutic potential of icariin and curcumol for prostate cancer treatment.

关键词： Icariin Curcumol Autophagy mTOR Cathepsin B Pyroptosis Prostate cancer

Clinical significance of preoperative nutritional status in elderly gastric cancer patients undergoing radical gastrectomy:A singlecenter retrospective study

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2211-2220页

作者： Xi-Ning Zhao jing Lu Hong-Yong He sheng-Jin Ge Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nursing Zhongshan HospitalFudan UniversityShanghai 200032China Department of General Surgery/Emergency Surgery Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND The population of elderly patients with gastric cancer is increasing,which is a major public health issue in *** is one of the greatest risk factors for adverse clinical outcomes in elderly patients with gastric *** To investigate the preoperative nutritional status and its association with delayed discharge of elderly gastric cancer patients following radical *** A total of 783 patients aged 65 years and older harboring gastric adenocarcinoma and following radical gastrectomy were retrospectively analyzed from the prospectively collected database of Zhongshan Hospital of Fudan University between January 2018 and May *** The overall rate of malnutrition was 31.8%.The incidence of postoperative complications was significantly higher in the malnourished group compared to the well-nourished group(P<0.001).Nutritional characteristics in the malnourished group,including body mass index,prognostic nutritional index(PNI),albumin,prealbumin,and hemoglobin,were all significantly lower than those in the well-nourished *** percentage of patients who received postoperative total nutrient admixture was lower in the malnourished group compared to the wellnourished group(22.1%vs 33.5%,P=0.001).Age≥70 years(HR=1.216,95%CI:1.048-1.411),PNI<44.5(HR=1.792,95%CI:1.058-3.032),operation time≥160 minutes(HR=1.431,95%CI:1.237-1.656),and postoperative complications grade III or higher(HR=2.191,95%CI:1.604-2.991)were all recognized as independent risk factors associated with delayed *** Malnutrition is relatively common in elderly patients undergoing *** PNI is an independent risk factor associated with delay *** strategies are needed to improve the clinical outcome of these patients.

关键词： Gastric cancer Preoperative nutritional status Malnutrition Elderly Radical gastrectomy

In-line Plasma-induced Graft-copolymerization of Pentaerythritol Triacrylate onto Polypropylene

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Chinese Journal of Polymer Science 2018年第8期36卷 979-983页

作者： Gui-Qiu Ma Guan-Kai Sun Zhe Ma jing-Qing Li jing sheng Department of Polymer Material Science and Engineering Institute of Advanced Polymer MaterialsSchool of Material Science and EngineeringTianjin Key Laboratory of Composite and Functional MaterialsTianjin University

Pentaerythritol triacrylate （PETA） was successfully grafted onto the plasma-treated isotactic polypropylene （iPP） via the in situ melt processing. The X-ray photoelectron spectroscopy （XPS） results showed that the hydroxyl and carbonyl groups, and peroxides could be generated via plasma treatment. The content of free radical in plasma-treated iPP （PiPP） was measured by 2,2-diphenyl-1- picrylhydrazyl （DPPH）. It was found that the resulting peroxides induced the grafting copolymerization of PETA onto iPP, and the grafted PETA promoted the formation of β-crystal in PiPP, which was evidenced by Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC） and wide-angle X-ray diffraction （WAXD） measurements, respectively.

关键词： Plasma treatment Melt processing Graft copolymerization Pentaerythritol triacrylate

Clustering properties of partly charged superfine particles in a light medium

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Chinese Chemical Letters 2007年第11期18卷 1419-1422页

作者： jing sheng Li Juan Wang Qin Shen School of Chemistry and Chemical Engineering Jiangsu University 301 Xue Fu Road Zhenjiang 212013 China

This paper investigated average cluster sizes （ACS） and cluster size distributions （CSD） at different shear rates by Brownian dynamics in non-, bi-, and uni-polar systems with partly charged superfine particles, The investigation indicates that clusters in non- polar systems are the weakest and easiest to be damaged by increasing shear stresses; charged particles play important and different roles： in bi-polar system, it intends to strengthen clusters to some extent provided that the sign-like ions homogeneously arranged; in uni-polar system charged particles cracked the clusters into smaller ones, but the small clusters are strong to stand with larger shear stress. The relationship between ACS and shear rates follows power law with exponents in a range 0.18-0.28, these values are in a good agreement with experiment range but at the lower limit compared with other systems of non-metallic cluster particles.

关键词： Partly charged particles Average cluster sizes Cluster size distributions

Chemical-physical aspects of formation and evolution of phase structure in multi-polymers: Intensity fluctuation, phase structure and its fractal characteristics in blends of isotactic polypropylene with poly(cis-1,4-butadiene) rubber

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Science China Chemistry 2012年第5期55卷 854-864页

作者： MA GuiQiu YANG YuPing HUANG DingHai sheng jing School of Materials Science and Engineering Tianjin University Tianjin 300072 China Tianjin Key Laboratory of Composite and Functional Materials Tianjin 300072 China

This paper studies the formation and evolution of phase structure of isotactic polypropylene/poly(cis-1,4-butadiene) (iPP/PcBR) blends during molten and mixing in a visual mixer by on-line analysis of the small angle light back scattering. The density fluctuation of iPP/PcBR blends during molten and mixing is discussed using the integral-intensity Js, of the scattering intensity of the blends. The "invariant" Q, which shows fluctuation of the system, is calculated by data of the small angle light back scattering, and the variation of Q with the blending time, temperature and shear rate during molten and mixing in iPP/PcBR blends is discussed. The structure parameters which characterize dimensions of phase in the blends, as the correlation distance ac, and the average chord lengths of two-phase, as li PP and lP cBR, are calculated by data of scattering intensity. The average diameters dp of dispersed phases are calculated from SEM images. The variation of ac, dp, li PP and lP cBR with the blending time and compositions in the blends during molten and mixing is discussed. The scale law is analyzed to find multi-scale characteristics in this system. The generalized fractal dimension Dp is calculated and the relation of Dp with generalized entropy function is discussed to determine that Dp is state function and the physical significance of Dp is the same as that of the generalized entropy function.

关键词：聚合物共混物等规聚丙烯物相结构强度波动分形特征丁二烯物理化学演化

Effects of post-heading high temperature on some quality traits of malt barley

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Journal of Integrative Agriculture 2020年第11期19卷 2674-2679页

作者： NI sheng-jing ZHAO Hui-fang ZHANG Guo-ping Department of Agronomy College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310029P.R.China

Global change is bringing barley with more frequency of suffering from high ***,little has been known about the influence of high temperature on malt quality *** this study,we investigated the impact of 1-wk heat stress(32°C/26°C,day/night,12 h/12 h)initiating from the 7th(HT7)and 14th(HT14)days after heading on some grain and malt quality traits of two barley *** comparison with normal temperature(24°C/18°C,day/night,12 h/12 h),heat stress significantly reduced kernel weight,seed setting rate and grains per spike:HT7 having a larger effect than ***,total protein andβ-glucan contents,andβ-amylase and limit dextrinase activities were significantly increased under high temperature,with HT7-treated plants showing larger ***,the different changes of four protein fractions under heat stress were found in the two barley cultivars,indicating the possibility of breaking positive association between protein content and enzyme activity.

关键词： barley β-glucan β-amylase heat stress limited dextrinase protein

考虑方案间过渡影响的Kagscv-DBSCAN单点交通控制时段划分方法

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科学技术与工程 2024年第4期24卷 1699-1706页

作者：姚辰达王景升杨政陶葛帅杰中国人民公安大学交通管理学院北京100038 中国人民公安大学侦查学院北京100038

为提高单点交通控制时段划分准确性,首先提出一种基于KD-tree加速搜索并利用GridsearchCV进行超参数寻优的kagscv-DBSCAN算法用来求解基于检测器自然数据的时段划分初步方案,并加入了对方案间过渡的考虑对初步方案进行修正。最后,以车... 详细信息

为提高单点交通控制时段划分准确性,首先提出一种基于KD-tree加速搜索并利用GridsearchCV进行超参数寻优的kagscv-DBSCAN算法用来求解基于检测器自然数据的时段划分初步方案,并加入了对方案间过渡的考虑对初步方案进行修正。最后,以车总延误、交叉口通行能力和运算速度为评价指标进行实际案例分析并与传统方法进行了对比。结果表明:所提方法对比K-means、PAW、FCM和RSAGA-FCM在车总延误方面分别降低8.69%、6.61%、3.68%和1.04%,通行能力提升效率分别为5.67%、5.07%、3.48%、1.69%,并在运算速度上具备明显优势。

关键词：交通运输系统工程信号控制时段划分聚类算法方案过渡