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Effect of Moderate Oxygen Preconditioning on Pulmonary Function and Electrophysiological Properties of Hippocampal Neurons in Rats with Lung Cancer

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Chinese Journal of Biomedical Engineering 2024年第2期33卷 69-75页

作者： ZENG Fan-pei ZHANG jing-min LAI Ru-jing Longyan First Affiliated Hospital of Fujian Medical University The Affiliated Hospital of Chengde Medical University

Objective: To observe the effect of moderate oxygen preconditioning on pulmonary function and electrophysiological properties of hippocampal neurons in rats with lung cancer. Methods: By establishing a lung cancer surgery model in rats, the experimental animals were randomly divided into model group, surgery group, oxygen treatment group A, oxygen treatment group B, and oxygen treatment group C. Lung cancer group was not treated, lung cancer surgery group underwent surgery to remove lung tissue, oxygen treatment group A received oxygen pre-treatment at a concentration of 1-3 L/min, oxygen treatment group B received oxygen pre-treatment at a concentration of 4-5 L/min, and oxygen treatment group C received oxygen pre-treatment at a concentration of 6-8 L/min. After operation, Morris water maze behavior was observed, lung function indicators were measured by lung function test,and the amplitude and frequency of micro-excitatory postsynaptic current of hippocampal neurons in rats were detected by electrophysiological membrane ***: Lung cancer surgery would have an effect on the spatial memory in lung cancer rats, and the spatial memory ability of oxygen-treated group A, group B and group C was improved compared with that of the surgery group. FEV 0.3(forced expiratory capacity at0.3 s) and FVC(forced vital capacity) in the oxygen-treated group B were significantly higher than those in the model group, in which the improvement of FEV 0.3 and FVC reached(3.32±0.42) m L and(3.79±0.82) m L, respectively. The FEV 0.3/FVC ratio of87.04 ±1.44 in oxygen-treated group B was higher than that of the model group and surgery group. The post-synaptic current frequency(3.73±0.27) Hz and post-synaptic current(13.74 ±0.26) p A of oxygen-treated group B were also significantly increased compared to other groups(Pmin, can exert protective effects on lung and hippocampal neurons in a rat m

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A Chinese Multi-Specialty Delphi Consensus to Optimize RAASi Usage and Hyperkalaemia Management in Patients with Chronic Kidney Disease and Heart Failure

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Chinese Medical Sciences Journal 2024年第2期39卷 79-90页

作者： ming-Hui Zhao Wei Chen Hong Cheng Bi-Cheng Liu Zhi-Guo Mao Zhuang Tian Gang Xu jing-min Zhou Renal Division Peking University First HospitalBeijing 100034China Department of Nephrology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080China Department of Nephrology Capital Medical UniversityBeijing 100029China Department of Nephrology Southeast University Zhongda HospitalNanjing 210009China Department of Nephrology Shanghai Changzheng HospitalShanghai 200003China Department of Cardiology Peking Union Medical College HospitalBeijing 100730China Renal Division Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China

Objective Variations are present in common clinical practices regarding best practice in managing hyperkalaemia(HK),there is therefore a need to establish a multi-specialty approach to optimal renin angiotension-aldosterone system inhibitors(RAASi)usage and HK management in patients with chronic kidney disease(CKD)&heart failure(HF).This study aimed to establish a multi-speciality approach to the optimal use of RAASi and the management of HK in patients with CKD and *** A steering expert group of cardiology and nephrology experts across China were convened to discuss challenges to HK management through a nominal group *** group then created a list of 41 statements for a consensus questionnaire,which was distributed for a further survey in extended panel group of cardiologists and nephrologists across *** was assessed using a modified Delphi technique,with agreement defined as"strong"(≥75%and<90%)and"very strong"(≥90%).The steering group,data collection,and analysis were aided by an independent *** A total of 150 responses from 21 provinces across China were recruited in the *** were comprised of an even split(n=75,50%)between cardiologists and *** 41 statements achieved the 75%consensus agreement threshold,of which 27 statements attained very strong consensus(≥90%agreement)and 14 attained strong consensus(agreement between 75%and 90%).Conclusion Based on the agreement levels from respondents,the steering group agreed a set of recommendations intended to improve patient outcomes in the use of RAASi therapy and HK management in China.

关键词： Sardiorenal syndrome chronic kidney failure heart failure hyperkalemia multidisciplinary communication RAASi

“中国式现代化”政治话语的四重资源及其传播调用

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编辑之友 2024年第6期 14-22页

作者：于淑婧荆学民中国传媒大学政治传播研究所北京100024 中国传媒大学政府与公共事务学院北京100024

“中国式现代化”政治话语涵盖四重资源:官方话语、学术话语、民间话语和外部话语。官方话语构成了“中国式现代化”政治话语的轴心资源,既是中国向国内和世界发出的政治宣言,也为中国形成和建构现代化的政治话语提供了体现当代中国最... 详细信息

“中国式现代化”政治话语涵盖四重资源:官方话语、学术话语、民间话语和外部话语。官方话语构成了“中国式现代化”政治话语的轴心资源,既是中国向国内和世界发出的政治宣言,也为中国形成和建构现代化的政治话语提供了体现当代中国最大公约数的政治共识。其他三方面话语构成了“中国式现代化”政治话语的外围资源:学术话语为“中国式现代化”政治话语在知识层面提供了学理支撑、审慎立场和规范思考;民间话语为“中国式现代化”政治话语获得舆论传播、舆论认同提供了大众化修辞、个体化表达和故事型叙事;外部话语作为对照,为中国催生兼具独立性和普遍性的现代化话语体系提供了自主动力、认知参照和求同路径。“中国式现代化”话语的政治传播,按照“轴心吸纳—外围合力”进行资源调用,突破了官方、学术、民间以及外部话语的圈层壁垒,实现了话语建构的主体间性,在场域融合中提高了“中国式现代化”政治话语的传播效能。

关键词： “中国式现代化” 政治话语政治传播

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建设学术共同体,推动中国翻译研究

上海翻译（中英文） 2024年第4期 5-6页

作者：傅敬民上海大学上海200444

由外语教学与研究出版社特别策划,并由许钧、王克非、任文担任总主编的“‘翻译中国’研究丛书”,旨在“凝聚‘翻译中国’学术共同体,建立一个全面而系统的‘翻译中国’研究体系,推动相关实践和学思不断开疆拓土,纵深发展”(许钧等,202... 详细信息

由外语教学与研究出版社特别策划,并由许钧、王克非、任文担任总主编的“‘翻译中国’研究丛书”,旨在“凝聚‘翻译中国’学术共同体,建立一个全面而系统的‘翻译中国’研究体系,推动相关实践和学思不断开疆拓土,纵深发展”(许钧等,2024:iv)。

关键词：许钧学术共同体中国翻译研究外语教学与研究出版社开疆拓土研究丛书王克非翻译

光声光谱技术应用于痕量气体浓度测量的研究进展

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光谱学与光谱分析 2024年第1期44卷 1-14页

作者：郑洪全戴景民哈尔滨工业大学仪器科学与工程学院黑龙江哈尔滨150001

光声光谱技术作为实现痕量气体浓度高效率、高精度测量的重要气体传感技术,因其响应速度快、灵敏度高、选择性好等优点被广泛应用到大气环境检测、电力系统故障诊断、医疗健康诊断等领域当中。首先介绍了光声光谱技术痕量气体浓度测量... 详细信息

光声光谱技术作为实现痕量气体浓度高效率、高精度测量的重要气体传感技术,因其响应速度快、灵敏度高、选择性好等优点被广泛应用到大气环境检测、电力系统故障诊断、医疗健康诊断等领域当中。首先介绍了光声光谱技术痕量气体浓度测量的基本原理,对应用光声效应实现痕量气体浓度测量的机理进行了简要的描述,同时,介绍了基于光声光谱技术的典型痕量气体浓度测量装置的结构。其次,从光声信号强度的理论分析出发,引出国内外学者在光声光谱痕量气体浓度测量领域的研究热点,为了实现基于光声光谱技术的痕量气体浓度测量装置更强的抗干扰能力、更紧凑的结构、更低的检测下限、更高的检测灵敏度,国内外学者的研究重点可以总结为以下三点:(1)辐射光源的选取和设计,以实现更佳辐射光源的输出波长、更宽的调谐范围、更高的辐射光源输出功率。(2)更优秀的光声池设计,以实现更高效的声能量积聚、更紧凑的结构和更强的抗干扰能力。(3)声敏探测器的设计,以实现更高的声音灵敏度、更高的信噪比。详细介绍了基于光声光谱痕量气体浓度测量装置的三个核心元件:辐射光源,主要介绍了相干光源和非相干光源的应用研究进展;光声池,主要介绍了光声池的设计原则以及非共振式和共振式光声池的应用研究进展;微音器,主要介绍了电容式微音器、压电式微音器的应用研究进展,并对近期研究热点石英增强光声光谱技术进行简要的介绍。在介绍目前辐射光源、光声池、微音器应用研究进展的同时,分析了各元件的优势和需要解决的问题。最后,总结了光声光谱技术应用于痕量气体浓度测量领域装置存在的信噪比不高、结构复杂、检测灵敏度和检测下限易受混合气体之间的交叉干扰等问题,并且对未来测量装置中的三个核心元件:辐射光源、光声池、微音器的发展趋势进行了展望。

关键词：光声光谱痕量气体检测辐射光源光声池微音器

Effect of cetuximab plus FOLFOX4 regimen on clinical outcomes in advanced gastric carcinoma patients receiving evidence-based care

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World Journal of Clinical Cases 2024年第18期12卷 3360-3367页

作者： Hui Ying Ren-Jun Huang Xiao-min jing Yan Li Qun-Qiu Tong Department of General Surgery Yongkang First People's HospitalYongkang 321300Zhejiang ProvinceChina Department of Oncology Yongkang First People's HospitalYongkang 321300Zhejiang ProvinceChina

BACKGROUND Although chemotherapy is effective for treating advanced gastric carcinoma(aGC),it may lead to an adverse *** a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC *** To determine the efficacy and safety of cetuximab(CET)combined with the FOLFOX4 regimen(infusional fluorouracil,folinic acid,and oxaliplatin)as firstline therapy for patients with aGC,who received evidence-based care(EBC).METHODS A total of 117 aGC patients who received EBC from March 2019 to March 2022 were *** these,60 in the research group(RG)received CET+FOLFOX4 as first-line therapy,whereas 57 in the control group(CG)received *** efficacy[clinical response rate(RR)and disease control rate(DCR)],safety(liver and kidney dysfunction,leukopenia,thrombocytopenia,rash,and diarrhea),serum tumor marker expression[STMs;carbohydrate antigen(CA)19-9,CA72-4,and carcinoembryonic antigen(CEA)],inflammatory indicators[interleukin(IL)-2 and IL-10],and quality of life(QOL)of the two groups were *** A markedly higher RR and DCR were observed in the RG compared with the CG,with an equivalent safety profile between the two *** exhibited notably reduced CA19-9,CA72-4,CEA,and IL-2 levels following treatment,which were lower than the pre-treatment levels and those in the ***-treatment IL-10 was statistically increased in RG,higher than the pre-treatment level and the ***,a significantly improved QOL was evident in the *** The CET+FOLFOX4 regimen is highly effective as first-line treatment for aGC patients receiving *** facilitates the suppression of STMs,ameliorates the serum inflammatory microenvironment,and enhances QOL,without increased adverse drug effects.

关键词： Cetuximab FOLFOX4 regimen Evidence-based care Advanced gastric carcinoma Efficacy and safety

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返乡青年治村的实践逻辑与空间再生产

中国青年研究 2024年第8期 50-59页

作者：闵兢黄慧淮阴工学院人文学院清华大学社会科学学院

本文以质性访谈材料为基础,以“空间—实践”的双向建构为分析框架,探讨了兼具强责任认知与治理能力的返乡青年治理乡村的实践逻辑及其具体实践对乡村空间的再生产结果。研究发现,返乡青年作为城市与乡村双重空间的实践者,既有先赋性“... 详细信息

本文以质性访谈材料为基础,以“空间—实践”的双向建构为分析框架,探讨了兼具强责任认知与治理能力的返乡青年治理乡村的实践逻辑及其具体实践对乡村空间的再生产结果。研究发现,返乡青年作为城市与乡村双重空间的实践者,既有先赋性“乡土基因”赋予其对于乡土文化的高度自觉,也受到现代性城市对其个体文明的开化,从而在实践中表现出对乡土文明的亲和与对现代性追寻的双重面向。在乡村振兴战略的指引下,返乡青年以“反思性实践者”的身份,积极回应传统性与现代性之间的张力,将行政权力及资源要素人格化地导入乡村治理实践中,对传统乡村的生计空间、生态空间与生活空间开展了全景式的现代性重构,成为乡村治理中的“乡村新权威”,为建设宜居宜业的和美乡村提供了主体性动能。

关键词：返乡青年乡村治理实践空间再生产

Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： Yan Li Li-Na Jiang Bo-Kang Zhao Mei-Ling Li Yi-Yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye jing-min Zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor ***,the mechanism of metastasis remains poorly *** To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version *** machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC *** was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC *** analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in *** data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model

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基于近红外光谱法的精米品种判别优化研究

光谱学与光谱分析 2024年第7期44卷 1988-1992页

作者：杨森王振民宋文龙邢键戴景民东北林业大学计算机与控制工程学院黑龙江哈尔滨150040 哈尔滨工业大学仪器科学与工程学院黑龙江哈尔滨150001

由于地理标志性大米巨大的市场价值,导致掺假行为时有发生。因此,为保证地理标志性大米品牌效益和消费者权益,实现准确的精米品种判别具有重要意义。近红外光谱法是精米品种判别的常用方法,通过提取不同品种近红外光谱中的差异性特征实... 详细信息

由于地理标志性大米巨大的市场价值,导致掺假行为时有发生。因此,为保证地理标志性大米品牌效益和消费者权益,实现准确的精米品种判别具有重要意义。近红外光谱法是精米品种判别的常用方法,通过提取不同品种近红外光谱中的差异性特征实现品种分类。然而,现有研究中存在特征波长选取性能不足和针对指定品种判别准确度不足的问题,限制了基于近红外光谱法的精米品种判别准确度的提升。针对上述问题,面向东北地区五常、响水、越光、银水四种大米,从特征波长选取和品种判别策略两个方面,研究基于近红外光谱法的精米品种判别优化。首先,为提高特征波长选取性能,将排列熵和自适应滑动窗口分割相结合,提出了基于自适应滑动排列熵的精米光谱特征波长选取方法,并开展与传统特征波长选取算法的对比实验。其次,为提高面向不同指定品种的判别准确度,提出基于判别目标的精米品种判别策略,通过研究光谱预处理算法与分类建模算法匹配优化,建立“指定品种-选定模型-选定算法的”的判别流程。实验结果表明,采用所提出的自适应滑动排列熵算法进行特征波长选取,相比于传统算法精米品种判别误差至少可降低50%;采用所提出的基于判别目标的精米品种判别策略,相比于传统的基于固定模型的判别策略的判别准确度至少可提高2.5%。

关键词：精米近红外光谱特征波长选取品种判别策略