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肝癌合并门静脉癌栓患者的癌栓碘化油沉积与预后关系

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中华肿瘤防治杂志 2024年第11期31卷 693-699页

作者：岳衍晓刘吉兵李辉宁尚昆马翔宇原晓红王睛山东省肿瘤防治研究院(山东省肿瘤医院)介入科山东第一医科大学(山东省医学科学院)山东济南250117 济宁市第一人民医院介入放射科山东济宁272011 山东第一医科大学第三附属医院骨科山东济南250031 济宁市第一人民医院门诊部山东济宁272011

目的探讨原发性肝癌合并门静脉癌栓的患者经TACE联合靶向药物治疗后,门静脉癌栓的碘化油沉积情况与患者生存期、生活质量及临床并发症关系。方法选取山东省肿瘤医院2015-05-01-2019-04-03及山东省济宁市第一人民医院2018-01-01-2019-12... 详细信息

目的探讨原发性肝癌合并门静脉癌栓的患者经TACE联合靶向药物治疗后,门静脉癌栓的碘化油沉积情况与患者生存期、生活质量及临床并发症关系。方法选取山东省肿瘤医院2015-05-01-2019-04-03及山东省济宁市第一人民医院2018-01-01-2019-12-02收治的原发性肝癌合并门静脉癌栓的患者74例纳入研究,根据门静脉癌栓碘化油的沉积情况分为碘化油沉积良好组(A组,39例)和沉积差或无沉积组(B组,35例)。比较2组无进展生存期(PFS)、总生存期(OS)以及临床并发症发生率。结果A组中位OS为29(21.1~36.9)个月,B组中位OS为9(5.8~12.2)个月,2组OS各时点死亡率差异有统计学意义,χ^(2)=26.308,P<0.001;A组中位PFS为19(15.4~22.6)个月,B组中位PFS为6(2.6~9.4)个月,χ^(2)=19.766,P<0.001。A组并发症发生率为74.4%,B组并发症发生率为68.6%,χ^(2)=0.304,P=0.615。2组癌栓Ⅰ型患者OS各时点死亡率差异有统计学意义,χ^(2)=4.174,P=0.041;2组癌栓Ⅱ型患者PFS各时点死亡率差异有统计学意义,χ^(2)=4.119,P=0.042;2组癌栓Ⅱ型患者各时点OS死亡率差异有统计学意义,χ^(2)=3.902,P=0.048;2组癌栓Ⅲ+Ⅳ型患者各时点PFS死亡率差异有统计学意义,χ^(2)=24.784,P<0.001;2组癌栓Ⅲ+Ⅳ型患者各时点OS死亡率差异有统计学意义,χ^(2)=24.013,P<0.001。结论癌栓碘化油沉积是影响患者预后的重要因素,沉积良好的患者预后良好。癌栓碘化油沉积情况与患者并发症发生率无明显关联。癌栓分型会对癌栓碘化油沉积良好和沉积差者的PFS、OS产生影响。

关键词：原发性肝癌门静脉癌栓肝动脉化疗栓塞术碘化油沉积靶向药物

Genetic analysis of biomass and photosynthetic parameters in wheat grown in different light intensities

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Journal of Integrative Plant Biology 2014年第6期56卷 594-604页

作者： Hongwei Li Gui Wang Qi Zheng Bin Li Ruilian jing Zhensheng Li State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology the Chinese Academy of Sciences Institute of Crop Sciences the Chinese Academy of Agricultural Sciences

Growth light intensities largely determine photo-synthesis, biomass, and grain yield of cereal crops. To explore the genetic basis of light responses of biomass and photosynthetic parameters in wheat （Triticum aestivum L.）, a quantitative trait locus （QTL） analysis was carried out in a doubled haploid （DH） population grown in low light （ll）, medium light （ML）, and high light （HL）, respectively. The results showed that the wheat seedlings grown in HL produced more biomass with lower total chlorophyll content （Chl）, carotenoid content, and maximum photochemical efficiency of photosystem II （Fv/Fm） while the wheat seed-lings grown in ll produced less biomass with higher Chl compared with those grown in ML. In total, 48 QTLs were identified to be associated with the investigated parameters in relation to growth light intensities. These QTLs were mapped to 15 chromosomes which individually explained 6.3%-36.0% of the phenotypic variance, of which chromo-somes 3A, 1D, and 6B were specifically involved in ll response, 5D and 7A specifically involved in ML response, and 4B specifically involved in HL response. Several light-responsive QTLs were co-located with QTLs for photosyn-thetic parameters, biomass, and grain weight under various conditions which may provide new hints to uncover the genetic control of photosynthesis, biomass, and grain weight.

关键词： Biomass carotenoids chlorophyll Fv/Fm quantitative trait locus Triticum aestivum L.

Calycosin-7-O-β-D-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways

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Acta Pharmaceutica Sinica B 2015年第5期5卷 454-460页

作者： jing Jian Lijuan Sun Xun Cheng Xiaofang Hu Jichao Liang Yong Chen Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources Hubei University

The iso fl avone calycosin-7-O-β-D-glucopyranoside(CG) is a principal constituent of Astragalus membranaceus(AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this study was to investigate the osteogenic effects of CG and its underlying mechanism in ST2 cells. The results show that exposure of cells to CG in osteogenic differentiation medium increases ALP activity, osteocalcin(Ocal) m RNA expression and the osteoblastic mineralization process. Mechanistically, CG treatment increased the expression of bone morphogenetic protein 2(BMP-2), p-Smad 1/5/8, β-catenin and Runx2, all of which are regulators of the BMP- or wingless-type MMTV integration site family(WNT)/β-catenin-signaling pathways. Moreover, the osteogenic effects of CG were inhibited by Noggin and DKK-1 which are classical inhibitors of the BMP and WNT/β-catenin-signaling pathways, respectively. Taken together, the results indicate that CG promotes the osteoblastic differentiation of ST2 cells through regulating the BMP/WNT signaling pathways. On this basis, CG may be a useful lead compound for improving the treatment of bone-decreasing diseases and enhancing bone regeneration.

关键词： BMP signaling pathway WNT/β-catenin signaling pathway Osteoblastic differentiation Calycosin-7-O-β-d-glucopyranoside ST2 cells

Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)

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Journal of Integrative Agriculture 2021年第3期20卷 646-663页

作者： jing WAN HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING Long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU Wan-xue WANG Wen-kai QIAN Wan-qiang Simon MCKIRDY WAN Fang-hao Harry Butler Institute Murdoch UniversityPerthWA 6150Australia Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109P.R.China Hubei Engineering Research Center for Pest Forewarning and Management Yangtze UniversityJingzhou 434025P.R.China Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193P.R.China

The fall armyworm(FAW),Spodoptera frugiperda(***),is native to the *** has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in *** is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous *** inherently superior biological characteristics of FAW contribute to its *** pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and *** gaps remain to be filled to:(1)understand the invasive mechanisms of ***;(2)understand how to prevent its further spread and(3)provide better management *** review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management.

关键词： invasive alien species fall armyworm Spodoptera frugiperda biological invasions prevention management biosecurity

云南不同蚕区僵蚕致病菌株的分离鉴定及致病力差异研究

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西南农业学报 2024年第7期37卷 1628-1634页

作者：江秀均李玲利柴建萍李克花倪婧白兴荣云南省农业科学院蚕桑蜜蜂研究所云南蒙自661100

[目的]了解云南省不同蚕区家蚕僵蚕病原的多样性及不同来源白僵菌菌株对家蚕的致病力差异。[方法]从云南省9个县(市)收集僵蚕样品,分离纯化获得病原菌,通过观察菌株的形态特征、产孢结构,并结合菌株核糖体rDNA-ITS序列的系统发育分析,... 详细信息

[目的]了解云南省不同蚕区家蚕僵蚕病原的多样性及不同来源白僵菌菌株对家蚕的致病力差异。[方法]从云南省9个县(市)收集僵蚕样品,分离纯化获得病原菌,通过观察菌株的形态特征、产孢结构,并结合菌株核糖体rDNA-ITS序列的系统发育分析,确认病原种类。同时测定分析不同地理来源以及不同孢子浓度的球孢白僵菌菌株对家蚕致病力的影响。[结果]形态学和ITS序列分析发现,云南蚕区僵病病原菌属于白僵菌属(Beauveria)、虫草菌属(Cordyceps)和绿僵菌属(Metarhizium),其中以球孢白僵菌(Beauveria bassiana)和莱氏绿僵菌(Metarhizium rileyi)为主要病原,分别占57.58%和30.30%。不同地理来源的球孢白僵菌株对家蚕幼虫的致病力存在一定差异,供试菌株侵染后,家蚕的僵蚕率在72.5%~95.0%,半致死时间(LT50)在5.093~7.133 d,其中ll1-1菌株的僵蚕率最高(95.0%),半致死时间最短(5.093 d),致病力最强;CB1-2菌株的僵蚕率较低(75.0%),半致死时间最长(7.133 d),致病力最弱。随着接种浓度的增加,病原的致病力变强,家蚕的僵蚕率也升高。[结论]云南省蚕区家蚕僵病病原种类呈多样性,球孢白僵菌和莱氏绿僵菌为主要病原菌,不同来源的白僵菌株对家蚕的致病力存在差异,本研究结果可为家蚕僵病的防治和僵蚕的生产提供参考依据。

关键词：家蚕僵病分离鉴定 rDNA-ITS序列分析致病力

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Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury

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Neural Regeneration Research 2020年第8期15卷 1526-1531页

作者： Lian Liu Xiao-Yuan Sha Yi-Ning Wu Meng-Ting Chen jing-Xiang Zhong Department of Ophthalmology Affiliated First Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology Guangdong Women and Children HospitalGuangzhouGuangdong ProvinceChina

The accumulation of excessive reactive oxygen species can exacerbate any injury of retinal tissue because free radicals can trigger lipid peroxidation,protein damage and DNA *** oxidative stress is associated with the common pathological process of many eye diseases,such as glaucoma,diabetic retinopathy and ischemic optic *** studies have demonstrated that Lycium barbarum polysaccharides(LBP)protects against oxidative injury in numerous cells and *** the model of hypoxia we used cultured retinal ganglion cells and induced hypoxia by incubating with 200μM cobalt chloride(CoCl2)for 24 *** investigate the protective effect of LBP and its mechanism of action against oxidative stress injury,the retinal tissue was pretreated with 0.5 mg/mL LBP for 24 *** results of flow cytometric analysis showed LBP could effectively reduce the CoCl2-induced retinal ganglion cell apoptosis,inhibited the generation of reactive oxygen species and the reduction of mitochondrial membrane *** findings suggested that LBP could protect retinal ganglion cells from CoCl2-induced apoptosis by reducing mitochondrial membrane potential and reactive oxygen species.

关键词： caspase cell apoptosis cobalt chloride Lycium barbarum polysaccharides mitochondrial membrane potential oxidative stress injury reactive oxygen species retinal ganglion cells

Ni_(1-x)Pt_(x) (x=00.08) Films as the Photocathode of Dye-Sensitized Solar Cells with High Effi ciency

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Nano Research 2009年第6期2卷 484-492页

作者： Shengjie Peng Jifu Shi Juan Pei Yanliang Liang Fangyi Cheng jing Liang Jun Chen Institute of New Energy Material Chemistry Key Laboratory of Energy Material Chemistryand Engineering Research Center of High-Energy Storage and ConversionMinistry of EducationNankai UniversityTianjin 300071China

Films of Ni_(1-x)Pt_(x)(x=0,0.02,0.04,0.06,and 0.08)have been prepared on fluorine-doped tin oxide-coated(FTO)glass substrates by a chemical plating method and used as the photocathode for dye-sensitized solar cells(DSCs).The Ni_(0.94)Pt_(0.06 )film consisted of nanoparticles with a size of 46 nm and a Pt loading of 5.13μg/cm^(2).The Ni_(0.94)Pt_(0.06) photocathode exhibited high catalytic performance toward triiodide reduction,high light refl ectance,and low charge-transfer *** DSC assembled with the Ni_(0.94)Pt_(0.06) photocathode gave a short-circuit photocurrent density(Jsc)of 16.79 mA/cm^(2),an open-circuit photovoltage(Voc)of 736 mV,and a fi ll factor(FF)of 66.4%,corresponding to an overall conversion effi ciency of 8.21%under standard AM 1.5 irradiation(100 mW/cm^(2)),which is higher than that for the DSC with a pure Pt photocathode obtained by conventional thermal ***,the DSC based on the Ni0.94Pt0.06 photocathode showed good *** results indicate that Ni0.94Pt0.06 fi lms are promising low-cost and high-performance photocathodes for use in DSCs.

关键词： Ni_(1–x)Pt_(x)fi lms chemical plating nanoparticles photocathode dye-sensitized solar cells

A new guaianolide from the roots of Pterocypsela elata

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Chinese Chemical Letters 2013年第1期24卷 55-56页

作者： Yi-Xiao Bai jing Tan Fu-Lin Yan Ming-Ming Ding Xiang Wang Pharmacy College Xinxiang Medical University Third Clinical College of Xinxiang Medical University

In order to find more biologically active substances, we have carefully investigated the chemical constituents of Pterocypsela elata. One new guaianolide, （4S）-ll-methoxycarbonyl-guaiane- l（10）,5（6）,7（11）,8（9）-tetraen-6,12-olide was isolated from the EtOAc extracts of the roots of P. elata. Its structure was elucidated by various spectroscopic methods and confirmed by X-ray crystallographic analysis.

关键词： CompositaePterocypsela elataSesquiterpene lactonesGuaianolide

基于分层回归的本科护生时间管理倾向与自主学习能力关系研究

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中国高等医学教育 2024年第1期 46-48页

作者：魏云张静李洁郑继盛赵晓敏滨州医学院护理学院山东烟台264003

目的:了解本科护生时间管理倾向和自主学习能力现状及关系,为教育方案的制定提供理论依据。方法:选取某医学院411名本科护生为研究对象,采用一般资料问卷、时间管理倾向量表和自主学习能力量表进行在线调查。结果:本科护生时间管理倾向... 详细信息

目的:了解本科护生时间管理倾向和自主学习能力现状及关系,为教育方案的制定提供理论依据。方法:选取某医学院411名本科护生为研究对象,采用一般资料问卷、时间管理倾向量表和自主学习能力量表进行在线调查。结果:本科护生时间管理倾向总分为(157.11±16.99)分,自主学习能力总分为(89.26±9.21)分;分层回归分析显示,时间管理倾向可以解释护生自主学习能力变异的28.1%(ΔF=80.582,P<0.001)。结论:本科护生的时间管理倾向和自主学习能力居中等水平,护理教育者可重点通过提升护生的时间监控观,加强师生交流频率,来提高其自主学习能力。

关键词：护理本科生自主学习能力时间管理倾向多层回归