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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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When Electronically Inert Polymers Meet Conjugated Polymers:Emerging Opportunities in Organic Photovoltaics

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Chinese Journal of Polymer Science 2022年第8期40卷 861-869,I0006页

作者： jing-jing Wang Long Ye School of Materials Science&Engineering Tianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300350China State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun130033China

Insulating polymers(commodity plastics in particular)are a major category of polymeric materials widely used in our daily life,but they exhibit abysmal electrical ***,conjugated polymers are gaining tremendous interest due to their excellent electrical properties and versatile applications in organic *** this perspective,we provide a concise account of the added value in organic solar cells,as brought by the combined use of conjugated and insulating *** challenging tasks and prospective directions are given to the potential benefits of employing insulating polymer additives,which spans from common commodity plastics to high-temperature resistant resins and thermoplastic ***,the inert polymers can improve many important properties such as mechanical and thermal robustness but not sacrifice optoelectronic performance.

关键词： Organic solar cells Insulating polymers Photovoltaic polymers Miscibility Morphology

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The Bott-Chern and Aeppli Cohomologies of Complex Structures on S^(3)×S^(3)

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Acta Mathematica Sinica,English Series 2021年第4期37卷 581-587页

作者： jing jing WANG School of Mathematical Sciences Fudan UniversityShanghai 200433P.R.China

We calculate the dimensions of Bott–Chern and Aeppli cohomologies associated to a complex structure on S^(3)×S^(3).We express them in terms mainly of Hogde numbers.

关键词： Complex structure S^(3)×S^(3) Bott–Chern cohomology Aeppli cohomology

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A new study of neutrino energy loss of nuclides ^(53-60)Cr by electron capture in magnetars

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Research in Astronomy and Astrophysics 2013年第8期13卷 945-951页

作者： jing-jing Liu College of Sciences and Technology Qiongzhou University

Following the theory of relativity, in the presence of an ultrastrong magnetic field （UMF） and utilizing a nuclear shell model, we carry out an estimation of the neutrino energy loss （NEL） rates of nuclides ^53-60Cr, which occur by electron capture in magnetars. The results show that the NEL rates greatly increase when a UMF is present, and can even exceed nine orders of magnitude at relatively lower density and temperature （e.g. ρ7 = 5.86, Ye = 0.47, T9 = 7.33） in the range from 1013 G to 1018 G. However, the increase in rates was no more than six orders of magnitude at relatively higher density and temperature （e.g.ρ7 = 4.86 × 10^8, Ye = 0.39, T9 = 14.35）.

关键词： physical data and processes: neutrinos nuclear reactions - stars: super- novae - stars: evolution

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Neutrino energy spectrum and electron capture of Nuclides^(56))Fe,^(56)Co,^(56)Ni,^(56)Mn,^(56)Cr and^(56)V in stellar interiors

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Research in Astronomy and Astrophysics 2014年第8期14卷 971-978页

作者： jing-jing Liu College of Science and Technology Qiongzhou University

Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum （NES） and the electron capture （EC） of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in presupemova surroundings. The results show that the EC rates are affected greatly at different densities and temperatures. The rates increase greatly and even exceed six orders of magnitude at lower temperature. On the other hand, the NES is very sensitive to stellar temperature and electron energy. The higher the temperature and the lower the electron energy, the larger the influence on NES is. For example, the maxima of NES in the ground state are 9.02, 160, 80, 24.01, 0.44, 1.42 me c^2 for ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V respectively at ρ7 = 10.7, Ye = 0.45 and T9 = 15. Furthermore, the influence on NES due to EC for different nuclei has some otherness because of different Qo-values. For example, the spectrum of ^56Co shows a double bump structure.

关键词： physical data and processes neutrinos, nuclear reactions -- stars super- novae -- stars evolution

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Strong screening effects on resonant nuclear reaction ^(23)Mg(p,γ) ^(24)Al in the surface of magnetars

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Research in Astronomy and Astrophysics 2016年第5期16卷 117-124页

作者： jing-jing Liu College of Electronic and Communication Engineering Hainan Tropical Ocean University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University

Based on the theory of relativistic superstrong magnetic fields （SMFs）, by using the method of Thomas-Fermi-Dirac approximations, we investigate the problem of strong electron screening （SES） in SMFs and the influence of SES on the nuclear reaction of 23Mg （p, Y）24A1. Our calculations show that the nuclear reaction will be markedly effected by the SES in SMFs in the surface of magnetars. Our calculated screening rates can increase two orders of magnitude due to SES in SMFs.

关键词： physical data and processes: nuclear reactions nucleosynthesis abundances -- stars: neutron-- stars: magnetic fields

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The Neutrino Energy Loss by Electron Capture of Nuclides ^(52,53,54,55,56)Fe in Core-Collapse Supernova

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Chinese Physics Letters 2012年第12期29卷 61-64页

作者： LIU jing-jing College of Sciences and Technology Qiongzhou UniversitySanya 572022

Using the shell-model Monte Carlo method and random phase approximation theory,we carry out an estimation on neutrino energy loss(NEL)of ^(52,53,54,55,56)*** find the NEL rates increase greatly at some typical stellar conditions,and even exceed eight orders of *** the other hand,in order to compare our results ofλ_(SMMC)^(LJ)(which are calculated by using the SMMC method)with those ofλ_(FFN)^(LJ)(which are calculated by using the Fuller-Fowler-Newman(FFN)method),the error factor C,betweenλ_(SMMC)^(LJ) andλ_(FFN)^(LJ),is discussed and shows that at higher density and temperature,the fit is fairly good for the two results(λ_(SMMC)^(LJ) andλ_(FFN)^(LJ)),and the maximum error is~6.20%.However,the maximum error is~95.50%(e.g.53Fe)at lower density and temperature.

关键词： temperature. 56Fe method

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IMPROVED OXYGEN PERMEABILITY AND MECHANICAL STRENGTH OF SILICONE HYDROGELS WITH INTERPENETRATING NETWORK STRUCTURE

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Chinese Journal of Polymer Science 2010年第6期28卷 849-857页

作者： jing-jing Wang Xin-song Li Biomaterials and Drug Delivery Laboratories School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

The interpenetrating polymer network(IPN) silicone hydrogels with improved oxygen permeability and mechanical strength were prepared by UV-initiated polymerization of monomers including methacryloxypropyl tris(trimethylsiloxy)silane(TRIS),2-hydroxyethylmethacrylate(HEMA) and N-vinyl pyrrolidone(NVP) in the presence of free radical photoinitiator and cationic *** polymerization mechanism was investigated by the formation of gel *** structure of IPN hydrogels was characterized by Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry(DSC) and transmission electron microscopy(TEM).The results showed that the IPN hydrogels exhibited a heterogeneous *** mechanical properties,surface wettability and oxygen permeability were examined by using a tensile tester,a contact angle goniometer and an oxygen transmission tester,*** equilibrium water content of the hydrogels was measured by the gravimetric *** results revealed that the IPN hydrogels possessed hydrophilic surface and high water *** exhibited improved oxygen permeability and mechanical strength because of the incorporation of TRIS.

关键词： Interpenetrating polymer network Silicone hydrogel Photopolymerization Oxygen permeability Mechanical strength

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The neutrino energy loss by electron capture of nuclides ^(55)Co and ^(56)Ni in explosive stellar environments

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Research in Astronomy and Astrophysics 2013年第1期13卷 99-103页

作者： jing-jing Liu College of Science and Technology Qiongzhou University

Using the Shell-Model Monte Carlo method and the Random Phase Approximation theory, we carry out an estimation of neutrino energy loss （NEL） for 55Co and 56Ni by electron capture. We find that the NEL rates increase greatly at some typical stellar conditions, and can even exceed five orders of magnitude （e.g. T9 = 38.5, Ye = 0.42 for 56Ni）. On the other hand, the error factor C shows that the fit is fairly good for two results at higher density and lower temperature, and the max- imum error is - 1.2%. However, the maximum error is ,- 55.60% （e.g. T9 = 18.5, Ye = 0.45） at lower density and higher temperature.

关键词： physical data and processes: neutrinos nuclear reactions -- stars: super-novae -- stars: evolution

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Multi-year monitoring of paddy rice planting area in Northeast China using MODIS time series data

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第10期14卷 934-946页

作者： jing-jing SHI jing-feng HUANG Feng ZHANG Institute of Agricultural Remote Sensing and Information Application Zhejiang University Key Laboratory of Agricultural Remote Sensing and Information System of Zhejiang Province Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health Zhejiang University

e The objective of this study was to investigate the tempo-spatial distribution of paddy rice in Northeast China using moderate resolution imaging spectroradiometer （MODIS） data. We developed an algorithm for detection and estimation of the transplanting and flooding periods of paddy rice with a combination of enhanced vegetation index （EVI） and land surface water index with a central wavelength at 2130 nm （LSW12130）. In two intensive sites in Northeast China, fine resolution satellite imagery was used to validate the performance of the algorithm at pixel and 3x3 pixel window levels, respectively. The commission and omission errors in both of the intensive sites were approximately less than 20%. Based on the algorithm, annual distribution of paddy rice in Northeast China from 2001 to 2009 was mapped and analyzed. The results demonstrated that the MODIS-derived area was highly correlated with published agricultural statistical data with a coefficient of determination （R^2） value of 0.847. It also revealed a sharp decline in 2003, especially in the Sanjiang Plain located in the northeast of Heilongjiang Province, due to the oversupply and price decline of rice in 2002. These results suggest that the approaches are available for accurate and reliable monitoring of rice cultivated areas and variation on a large scale.

关键词： Paddy rice Moderate resolution imaging spectroradiometer(MODIS) Northeast China Enhanced vegetation index Land surface water index

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