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Relationship between dietary fiber intake and chronic diarrhea in adults

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World Journal of Clinical Cases 2024年第19期12卷 3692-3700页

作者： Lin Wang Yan Li Yu-jing Zhang Li-hua Peng Department of gastroenterology and Hepatology The First Medical CenterChinese People's Liberation Army General HospitalBeijing 100853China Department of gastroenterology and Hepatology Chinese People's Liberation Army Medical SchoolBeijing 100853China

BACKgROUND Dietary fiber is essential for human health and can help reduce the symptoms of ***,the relationship between dietary fiber and diarrhea is,poorly *** To evaluate the relationship between dietary fiber and chronic *** This retrospective study was conducted using data from the United States National Health and Nutrition Examination Survey,conducted between 2005 and *** over the age of 20 were *** measure dietary fiber consumption,two 24-hour meal recall interviews were *** independent relationship between the total amount of dietary fiber and chronic diarrhea was evaluated with multiple logistic regression and interaction *** Data from 12829 participants were *** without chronic diarrhea consumed more dietary fiber than participants with chronic diarrhea(29.7 vs 28.5,P=0.004).Additionally,in participants with chronic diarrhea,a correlation between sex and dietary fiber intake was present:Women who consume more than 25 g of dietary fiber daily can reduce the occurrence of chronic *** Dietary fiber can reduce the occurrence of chronic diarrhea.

关键词： Fiber Chronic diarrhea National Health and Nutrition Examination Survey Sex Prebiotics

Targeting gPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun Zhang Meng-Xia Zhang Xiao-Xiang Meng jing Zhu Jia-Jun Wang Yi-Fan He Ye-hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:g-protein coupled receptors(gPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how gPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of gPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of gPR65 was evaluated in both human and mouse fibrotic ***,gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of gPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of gPR65’s action in liver ***,the therapeutic potential of gPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched gPR65 was upregulated in both human and mouse fibrotic ***,knockout of gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that gpr65 silencing and gPR65 antagonist inhibited,while gPR65 overexpression and application of gPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TgF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,gPR65 overexpression,the acidic pH and gPR65 exogenous agonist induced up-regulation of

关键词： gPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

基于水波进化和动态莱维飞行的爬行动物搜索算法

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控制与决策 2024年第1期39卷 59-68页

作者：付华许桐邵靖宇辽宁工程技术大学电气与控制学院辽宁葫芦岛125105 百度在线网络技术有限公司北京100080

针对爬行动物搜索算法存在收敛速度慢、寻优精度低和易陷入局部极值等缺陷,提出一种基于水波进化和动态莱维飞行的爬行动物搜索算法.采用Halton序列初始化种群,生成均匀分布的个体,减少个体搜索盲区和重叠概率以提升种群多样性;引入水... 详细信息

针对爬行动物搜索算法存在收敛速度慢、寻优精度低和易陷入局部极值等缺陷,提出一种基于水波进化和动态莱维飞行的爬行动物搜索算法.采用Halton序列初始化种群,生成均匀分布的个体,减少个体搜索盲区和重叠概率以提升种群多样性;引入水波动态进化因子和自适应权重,协调算法全局搜索与局部开发之间的转换,提高算法收敛速度和寻优精度;结合一种动态莱维飞行变异策略,提升算法局部抗停滞能力.通过对14个基准测试函数的寻优对比分析、Wilcoxon秩和检验以及寻优时间对比结果可知,改进算法具有更好的收敛性能、寻优性能和鲁棒性.最后,通过工程应用中焊接梁设计的优化对比结果,进一步验证了改进算法处理实际工程问题的优越性.

关键词：爬行动物搜索算法 Halton序列水波动态进化因子动态莱维飞行焊接梁设计

Identification of NR3C2 as a functional diagnostic and prognostic biomarker and potential therapeutic target in non‐small cell lung cancer

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Cancer Innovation 2024年第4期3卷 67-86页

作者： Yuan‐yuan Sun Hai‐cheng gao Peng guo Na Sun Chan Peng Zhi‐hua Cheng jing gu Jin‐yi Liu Fei Han Department of Clinical Pharmacy Jilin University School of Pharmaceutical SciencesChangchunChina Institute of Toxicology College of Preventive MedicineArmy Medical UniversityChongqingChina Department of Hepatobiliary Surgery Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina College of Pharmaceutical Sciences Southwest UniversityChongqingChina Vascular Surgery Department General Surgery CenterFirst Hospital of Jilin UniversityChangchunChina Department of Toxicology School of Public HealthChongqing Medical UniversityChongqingChina Laboratory of Reproductive Biology Chongqing Medical UniversityChongqingChina

Background:Non‐small cell lung cancer(NSCLC),including the lung squamous cell carcinoma(LUSC)and lung adenocarcinoma(LUAD)subtypes,is a malignant tumor type with a poor 5‐year survival *** identification of new powerful diagnostic biomarkers,prognostic biomarkers,and potential therapeutic targets in NSCLC is urgently ***:The UCSC Xena,UALCAN,and gEO databases were used to screen and analyze differentially expressed genes,regulatory modes,and genetic/epigenetic alterations in *** UCSC Xena database,gEO database,tissue microarray,and immunohistochemistry staining analyses were used to evaluate the diagnostic and prognostic ***‐of‐function assays were performed to examine the *** ESTIMATE,TIMER,Linked Omics,STRINg,and DAVID algorithms were used to analyze potential molecular ***:NR3C2 was identified as a potentially important molecule in ***3C2 is expressed at low levels in NSCLC,LUAD,and LUSC tissues,which is significantly related to the clinical indexes of these *** operating characteristic curve analysis suggests that the altered NR3C2 expression patterns have diagnostic value in NSCLC,LUAD,and especially LUSC *** NR3C2 expression levels can help predict poor prognosis in NSCLC and LUAD patients but not in LUSC *** results have been confirmed both with database analysis and real‐world clinical samples on a tissue *** number variation contributes to low NR3C2 expression levels in NSCLC and LUAD,while promoter DNA methylation is involved in its downregulation in *** NR3C2 promoter methylation sites have high sensitivity and specificity for LUSC diagnosis with clinical application ***3C2 may be a key participant in NSCLC development and progression and is closely associated with the tumor microenvironment and immune cell ***3C2 co‐expressed genes are involved in many cancer‐related signaling pathways,further supporting a potentially si

关键词： diagnosis and prognosis expression regulation function immune cell infiltration non‐small cell lung cancer NR3C2 therapeutic target tumor microenvironment

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun gao Zhi-Wei Mo Jia-guo Zhou Zhi-Jun Ou jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATg5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATg5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATg5 miRNA endothelial nitric oxide synthase

数字化何以赋能财政政策提质增效——以地方财政支出效率为主线的分析

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江海学刊 2024年第3期 94-101,255页

作者：刘骅崔婧南京审计大学金融学院

财政政策提质增效是实现经济高质量发展的根本保证,而在经济形势趋紧的背景下,改进地方财政支出效率是积极财政政策提质增效的关键举措。基于省级面板数据的实证分析结果表明,数字化显著提升了地方财政支出效率,并且这种促进作用主要源... 详细信息

财政政策提质增效是实现经济高质量发展的根本保证,而在经济形势趋紧的背景下,改进地方财政支出效率是积极财政政策提质增效的关键举措。基于省级面板数据的实证分析结果表明,数字化显著提升了地方财政支出效率,并且这种促进作用主要源于透明度效应、协同效应和飞轮效应,具体表现为推进财政透明、约束金融分权和提高政府治理能力三条路径。因此,必须推动财政资金公开透明,协同金融助力新基建,持续建设数字政府,全面提升地方财政支出效率,从而充分发挥数字化对财政政策提质增效的赋能功效。

关键词：数字化财政政策地方财政支出效率

Efficient micrometer-scale thick-film perovskite solar cells with superior stability

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Rare Metals 2024年第4期43卷 1647-1657页

作者： Jian-Fei Hu gang Chen Shun-Zhang Yu Yue-Xin Lin Kai-Yu Wang Zong-Wei Li guo-Dong Zhang Teng-Fei Pan Ya-jing Li Ming-Jie Li Ying-Dong Xia Yi-Fan Lv Yong-hua Chen Key Laboratory of Flexible Electronics(KLoFE)and Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong999077China Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhen518057China Optics Valley Laboratory Hubei430074China

It is essential to enhance the thickness of the absorber layer for perovskite solar cells(PSCs)to improve device performance and reduce industry ***,thick perovskite films(>1μm)are difficult to be fabricated by employing traditional solvents,such as N,N-dimethylformamide(DMF),dimethyl sulfoxide(DMSO).Besides,it is a challenge to fabricate thick-film perovskite owing to the deteriorated surface morphology and serious defect ***,a simple method was reported to deposit uniform pinhole-free perovskite films with a thickness of more than 2μm utilizing the methylamine acetate(MAAc)ionic liquid as the *** with methylammonium chloride(MACl)as an additive,thick-film perovskite with~2μm in grain size and few grain boundaries(gBs)was prepared,which dramatically improved the perovskite crystal quality and enhanced carrier transport *** final PSCs exhibited a power conversion efficiency(PCE)of 20.16%.The device showed improved stability with 95%of its initial efficiency in a nitrogen environment over 5000 *** work provides an alternative strategy to produce extremely efficient and stable thick-film *** can be believed that this device has great potential in the application of large areas and laminated PSCs.

关键词： Perovskite solar cells Thick-film Stability Ionic liquid

Research progress on the mechanism of exercise fatigue and the role of probiotics in counteracting it

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Food and Health 2024年第3期6卷 33-41页

作者： Zi-Xia Chen jing Yang Jia-Jia Song hua-Yi Suo College of Food Science Southwest UniversityChongqing400715China Chongqing Engineering Research Center for Processing&Storage of Distinct Agricultural Products Chongqing Technology and Business UniversityChongqing 400067China

Exercise fatigue is a physiological phenomenon where the body cannot maintain a specific level after being stimulated by excessive *** five main theories include“energy depletion”,“accumulation of metabolites”,“homeostasis disorder of the internal environment”,“free radicals”,and“central nervous system protection inhibition”.The imbalance of intestinal flora caused by vigorous exercise can further lead to ***,maintaining healthy intestinal flora is crucial for athlete health and *** studies have demonstrated that probiotics can regulate intestinal flora and alleviate exercise fatigue;however,there are no systematic reviews on the anti-fatigue effects of *** on the mechanisms of exercise-induced fatigue,this article summarizes the effects and mechanisms by which probiotics combat exercise fatigue,aiming to provide research ideas for the development of probiotics that prevent exercise fatigue.

关键词： probiotics gut microbiota exercise fatigue mechanism

中国式农业现代化发展水平测度及区域差异分析——以吉林省为例

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中国农业资源与区划 2024年第7期45卷 156-169页

作者：华坚李菁河海大学商学院

[目的]中国式农业现代化发展立足我国国情农情，因地制宜。吉林省作为规划率先基本实现农业现代化的排头兵，有必要对吉林省中国式农业现代化发展水平进行科学测度，并分析吉林省县域中国式农业现代化发展水平及区域差异。[方法]文章基... 详细信息

[目的]中国式农业现代化发展立足我国国情农情，因地制宜。吉林省作为规划率先基本实现农业现代化的排头兵，有必要对吉林省中国式农业现代化发展水平进行科学测度，并分析吉林省县域中国式农业现代化发展水平及区域差异。[方法]文章基于对吉林省中国式农业现代化发展的逻辑机理分析，构建县域层面农业供给保障现代化、农业科技创新现代化、农业产业体系现代化、农业绿色发展现代化等4个维度的中国式农业现代化发展水平评价体系；结合省内水土资源分异特点，运用泰尔指数和障碍度模型探究其区域差异及演进趋势。[结果]（1） 2011—2020年吉林省中国式农业现代化发展水平整体经历“稳定（2011—2014年）—下降（2015—2017年）—提高（2018—2020年）”演进过程。（2）吉林省中国式农业现代化发展水平区域间差距显著，总体表现为由东向西梯度递增态势。（3）泰尔指数整体呈波动上升趋势，2011—2015年区域内差异是吉林省中国式农业现代化发展水平总体差异的主要来源，2016—2020年区域间差异的贡献度最大。（4）影响吉林省中国式农业现代化发展的障碍因子主要来自农业供给保障现代化和农业产业体系现代化两个方面。[结论]吉林省各地应因地制宜发展优势产业、全面布局弥合区域差异、统筹发展突破主要障碍。

关键词：中国式农业现代化时空格局区域差异障碍度吉林省