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Morphological and Sulfur-Isotopic Characteristics of Pyrites in the Deep Sediments from Xisha Trough,South China Sea

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Journal of Ocean University of China 2024年第1期23卷 138-148页

作者： CHANG jingyi LIU Yujia LU Hailong LU jing’an SU Xin ye Jianliang XIE Wenwei College of Engineering Peking UniversityBeijing 100871China Beijing International Center for Gas Hydrate School of Earth and Planetary SciencesPeking UniversityBeijing 100871China School of Marine Science Nanjing University of Information Science and TechnologyNanjing 210044China MLR Key Laboratory of Marine Mineral Resources Guangzhou Marine Geological SurveyMinistry of Land and ResourcesGuangzhou 510075China School of Ocean Sciences China University of GeosciencesBeijing 100083China

Pyrite is one of the common authigenic minerals in marine *** studies have shown that the morphological and isotopic characteristics of pyrite are closely related to the geochemical environment where it is *** better understand the for-mation mechanism of authigenic pyrite,we analyzed the isotopic composition,morphology,and distribution of pyrite in the sediment at 500m below the seafloor from Xisha Trough,South China *** morphologies were observed by scanning electron micros-copy and Raman spectrography.X-Ray computed tomography was applied to measure the particle size of *** size of pyrite crystals in the matrix sediment mainly ranged between 25 and 65µm(***.40µm),although crystals were larger(***.50μm)in the *** pyrites had a fine-grained truncated octahedral shape with occasionally well-developed growth steps,which implies the low growth rate and weak anaerobic oxidation of methane-sulfate reduction when pyrite was ***δ^(34)S values of pyrites ranged from+20.8‰Vienna-defined Canyon Diablo Troilite(V-CDT)to+33.2‰V-CDT and from+44.8‰V-CDT to+48.9‰,which suggest two growth *** the first stage,with the continuous low methane flux,the pyrite possibly formed in an environment with good access to *** the second stage,the pyrites mainly developed in sediment fractures and appeared in veins,probably due to the limited availability of *** less exposure of pyrite to the environment in the second stage was probably caused by sediment accumulation or *** this study,an episodic pyritization process was identified,and the paleoenvironment was reconstructed for the sediment investigated.

关键词： pyrite sulfur isotope AOM methane flux Xisha Trough South China Sea

Expanding the horizons of targeted protein degradation:A non-small molecule perspective

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2402-2427页

作者： Xiaowei Huang fengbo Wu jing ye Lian Wang Xiaoyun Wang Xiang Li Gu He Department of Pharmacy and Department of Dermatology&Venerology West China HospitalSichuan UniversityChengdu 610041China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Dermatology Clinical Institute of Inflammation and ImmunologyFrontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but have the potential to unlock functionalities beyond ***-small-molecule-based approaches play an irreplaceable role in this field.A wide variety of agents spanning a broad chemical spectrum,including peptides,nucleic acids,antibodies,and even vaccines,which not only prove instrumental in overcoming the constraints of conventional small molecule entities but also provided rapidly renewing *** we summarize the burgeoning non-small molecule technological platforms inspired by PROTACs,including three major trajectories,to provide insights for the design strategies based on novel paradigms.

关键词： Targeted protein degradation Proteolysis targeting chimera Endocytosis Autophagy Proximity-inducing modality Post-translational modification

Mechanical responses of underground carriageway structures due to construction of metro tunnels beneath the existing structure:A case study

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Deep Underground Science and Engineering 2024年第2期3卷 231-246页

作者： Xin Han Fei ye Xingbo Han Chao Ren jing Song Ruliang Zhao School of Highway Chang'an UniversityXi'anChina Shandong Province Transportation Planning and Design Institute JinanChina China Water Resources Beifang Investigation Design and Research Co.Ltd.TianjinChina

To understand the mechanical response pattern of the existing structure and ground due to the construction of metro tunnels underneath,the finite difference method is adopted to study the torsional deformation and stress variation of the existing structure and the effect of underground carriageway structures on the surface *** curves of the maximum differential subsidence,torsion angle,and distortion of the cross-section of the existing structure show two peaks in succession during traversing of two metro tunnels beneath *** torsion angle of the existing structure changes when the two tunnels traverse beneath it in opposite *** first traversing of the shield tunnel mainly induces the magnitude variation in torsional deformation of the existing structure,but the second traversing of the subsurface tunnel may cause a dynamic change in the magnitude and form of torsional deformation in the existing *** shielding effect can reduce the surface subsidence caused by metro tunnel excavation to a certain extent,and the development trend of subsidence becomes slower as the excavation continues.

关键词： metro tunnel numerical simulation structural deformation surface subsidence underground carriageway structure

Biophotoelectrochemistry for the treatment of emerging contaminants

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Science China Technological Sciences 2024年第10期67卷 3051-3066页

作者： HU jing CHEN Man GU WenZhi DENG WenEr HONG MingQiu HU AnDong ye Jie ZHOU ShunGui Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry University

Emerging contaminants(ECs) of significant concern are widely distributed throughout the environment due to various industrial practices and human activities. Given the alarming ecological threats and potential risks that ECs pose to human health and aquatic life, even at trace concentrations, it is imperative to develop innovative technologies to effectively address these challenges. The biophotoelectrochemistry(BPEC) system, which integrates microbial cells with photosensitizers for solar-tochemical conversion, holds great potential as an efficient strategy for the removal of ECs. In this review, we provide new insights into the BPEC system for the ECs treatment by systematically summarizing the classification, sources, and environmental occurrence of ECs. Additionally, we explore the research progress and degradation mechanisms in ECs removal with ***, the current challenges and future perspectives for the applications of the BPEC system in the ECs treatment are *** review aims to promote the development of BPEC technology for ECs treatment, offering a promising prospect for environmental remediation, circular economy, and clean-energy production.

关键词： emerging contaminants biophotoelectrochemistry photocatalysis biodegradation

APFA:Ameliorated Pathfinder Algorithm for Engineering Applications

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Journal of Bionic Engineering 2024年第3期21卷 1592-1616页

作者： Keyu Zhong fen Xiao Xieping Gao Key Laboratory of Computing and Stochastic Mathematics of Ministry of Education Hunan Normal UniversityChangsha410081China School of Mathematics and Statistics Hunan Normal UniversityChangsha410081China School of Computer Science Xiangtan UniversityXiangtan411105China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha410081China

Pathfinder algorithm(PFA)is a swarm intelligent optimization algorithm inspired by the collective activity behavior of swarm animals,imitating the leader in the population to guide followers in finding the best food *** algorithm has the characteristics of a simple structure and high ***,PFA faces challenges such as insufficient population diversity and susceptibility to local optima due to its inability to effectively balance the exploration and exploitation *** paper proposes an Ameliorated Pathfinder Algorithm called APFA to solve complex engineering optimization ***,a guidance mechanism based on multiple elite individuals is presented to enhance the global search capability of the ***,to improve the exploration efficiency of the algorithm,the Logistic chaos mapping is introduced to help the algorithm find more high-quality potential solutions while avoiding the worst ***,a comprehensive following strategy is designed to avoid the algorithm falling into local optima and further improve the convergence *** three strategies achieve an effective balance between exploration and exploitation overall,thus improving the optimization performance of the *** performance evaluation,APFA is validated by the CEC2022 benchmark test set and five engineering optimization problems,and compared with the state-of-the-art metaheuristic *** numerical experimental results demonstrated the superiority of APFA.

关键词： Pathfinder algorithm Swarm intelligent Metaheuristic Engineering problems

MOF-Derived Iron-Cobalt Phosphide Nanoframe as Bifunctional Electrocatalysts for Overall Water Splitting

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Energy & Environmental Materials 2024年第6期7卷 312-320页

作者： Yanqi Yuan Kun Wang Boan Zhong Dongkun Yu Fei ye jing Liu Joydeep Dutta Peng Zhang School of Materials Science and Engineering Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Functional NanoMaterials Group Department of Applied PhysicsSchool of Engineering SciencesKTH Royal Institute of TechnologyHannes Alfv´ens v¨ag 1211419StockholmSweden Shanghai Key Laboratory of Hydrogen Science Shanghai 200240China

Transition metal phosphides(TMPs)have emerged as an alternative to precious metals as efficient and low-cost catalysts for water *** doping and morphology control are effective approaches to further improve the performance of ***,Fe-doped CoP nanoframes(Fe-CoP NFs)with specific open cage configuration were designed and *** unique nano-framework structured Fe-CoP material shows overpotentials of only 255 and 122 mV at 10 mA cm^(−2)for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER),respectively,overwhelming most transition metal *** overall water splitting,the cell voltage is 1.65 V for Fe-CoP NFs at a current density of 10 mA cm^(−2),much superior to what is observed for the classical nanocubic ***-CoP NFs show no activity degradation up to 100 h which contrasts sharply with the rapidly decaying performance of noble metal catalyst *** superior electrocatalytic performance of Fe-CoP NFs due to abundant accessible active sites,reduced kinetic energy barrier,and preferable*O-containing intermediate adsorption is demonstrated through experimental observations and theoretical *** findings could provide a potential method for the preparation of multifunctional material with hollow structures and offer more hopeful prospects for obtaining efficient earth-abundant catalysts for water splitting.

关键词： electrocatalysis hollow structure iron-doped cobalt phosphide MOF overall water splitting

An Efficient Multi-objective Approach Based on Golden Jackal Search for Dynamic Economic Emission Dispatch

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Journal of Bionic Engineering 2024年第3期21卷 1541-1566页

Dynamic Economic Emission Dispatch(DEED)aims to optimize control over fuel cost and pollution emission,two conflicting objectives,by scheduling the output power of various units at specific *** many methods well-performed on the DEED problem,most of them fail to achieve expected results in practice due to a lack of effective trade-off mechanisms between the convergence and diversity of non-dominated optimal dispatching *** address this issue,a new multi-objective solver called Multi-Objective Golden Jackal Optimization(MOGJO)algorithm is proposed to cope with the DEED *** proposed algorithm first stores non-dominated optimal solutions found so far into an ***,it chooses the best dispatching solution from the archive as the leader through a selection mechanism designed based on elite selection strategy and Euclidean distance index *** mechanism can guide the algorithm to search for better dispatching solutions in the direction of reducing fuel costs and pollutant ***,the basic golden jackal optimization algorithm has the drawback of insufficient search,which hinders its ability to effectively discover more Pareto *** this end,a non-linear control parameter based on the cosine function is introduced to enhance global exploration of the dispatching space,thus improving the efficiency of finding the optimal dispatching *** proposed MOGJO is evaluated on the latest CEC benchmark test functions,and its superiority over the state-of-the-art multi-objective optimizers is highlighted by performance ***,empirical results on 5-unit,10-unit,IEEE 30-bus,and 30-unit systems show that the MOGJO can provide competitive compromise scheduling solutions compared to published DEED ***,in the analysis of the Pareto dominance relationship and the Euclidean distance index,the optimal dispatching solutions provided by MOGJO are the closest to the ideal solutions for minimizing fuel costs

关键词： Dynamic economic emission dispatch Multi-objective optimization Golden jackal Euclidean distance index

Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking

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Chinese Chemical Letters 2024年第6期35卷 353-357页

作者： Jinyan Zhang fen Liu Qian Jin Xueyi Li Qiong Zhan Mu Chen Sisi Wang Zhenlong Wu Wencai ye Lei Wang State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative Drugs and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)*** 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage *** structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical *** pathways for compounds 1-5 were proposed on the basis of the coexisting *** by the biogenetic pathways,the biomimetic synthesis of compound 1 was also ***,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关键词： Phloroglucinol-triterpenoid adduct Myrtaceae Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity

Observation of therapeutic effect of lamp irradiation combined with purple gromwell oil gauze on alleviating intestinal colic in patients

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1749-1755页

作者： Bi-Zhi Cen Yin-Song Chen Li-Ping Li jing-Wen Wu Yan-fen Xie Department of Tumor Center Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina

BACKGROUND Intestinal colic is a common complication in patients who have undergone radical surgery for colorectal *** Chinese medicine has advantages,including safety and stability,for the treatment of intestinal *** irra-diation for abdominal ironing has been applied in the treatment of many gas-trointestinal *** gromwell oil has the effects of clearing heat,cooling blood,reducing swelling,and relieving *** The general effective rate in the observation group was 95.00%,which was significantly higher than that in the control group(86.67%,P0.05).After 1,2,3,and 4 d of treatment,the duration of symptoms in both groups were decreased,and the duration in the observation group was significantly lower than that in the control group(96.54±9.57 vs 110.45±11.23,87.26±12.07 vs 104.44±11.68,80.45±16.21 vs 99.44±14.95,73.18±15.58 vs 92.17±14.20;P0.05).CONCLUSION The use of lamp irradiation combined with purple gromwell oil gauze in patients with intestinal colic after radical surgery for colorectal cancer can reduce symptom duration,alleviate intestinal colic,and improve treatment efficacy,and this approach is *** is worth promoting the use of this treatment in clinical practice.

关键词： Lamp irradiation Purple gromwell oil gauze Intestinal colic Radical surgery for colorectal cancer Therapeutic effect