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Effects of two silicone resin coatings on performance of FeSiAl magnetic powder cores

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Journal of Iron and Steel Research International 2024年第5期31卷 1279-1288页

作者： Jia-qi Liu Zheng-qu Zhu Pu Wang Yi-fan Li jing pang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Qingdao Yunlu Advanced Materials Technology Co. Ltd.Qingdao266232ShandongChina

Two silicon resins with excellent thermal stability,JH1123 and JH7102,are used as the insulated agents and binders for the gas-atomized FeSiAl powder,and corresponding magnetic powder cores(MPCs)are *** insulation capability and application prospects of the two silicon resins are evaluated by comparing the magnetic properties of the coated powder and *** scanning electron microscopy,energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy results show that uniform insulation layers are both formed on the powder ***1123 has stronger binding ability,and the JH1123-coated powder exhibits severe agglomeration,with d50(average particle size)approximately twice that of the JH7102-coated *** as-prepared MPCs exhibit outstanding soft magnetic ***,the permeability of FeSiAl@JH1123 is up to 74.0,which is 35.5%higher than that of FeSiAl@JH7102 because JH1123 can further improve the density of the *** for FeSiAl@JH7102,it has better direct current bias and lower core loss of 716.9 mW cm^(−3) at 20 mT and 1000 kHz due to its lower coercivity and greater anti-magnetic saturation ability.A comprehensive comparison shows that FeSiAl@JH1123 is suitable for medium and high frequency applications,while FeSiAl@JH7102 is more suitable for high frequency *** indicates that the use of JH1123 and JH7102 silicon resins for binding and insulated coating not only simplifies the preparation process of MPCs,but also enables the controlled production of MPCs for different applications.

关键词： FeSiAl Insulated coating Magnetic powder core Permeability Core loss

Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing b-1-6-Linked Poly-N-Acetylglucosamine(PNAG)

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Engineering 2024年第7期38卷 69-76页

作者： Xi Lu Guoqing Li jing pang Xinyi Yang Colette Cywes-Bentley Xuefu You Gerald B.Pier Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

The b-1-6-linked poly-N-acetylglucosamine(PNAG)polymer is a conserved surface polysaccharide produced by many bacteria,fungi,and protozoan(and even filarial)*** wide-ranging expression makes PNAG an attractive target for vaccine development,as it potentially encompasses a broad range of *** progress has been made in discovering important properties of the biology of PNAG expression in recent *** molecular characterization and regulation of operons for the production of PNAG biosynthetic proteins and enzymes have been studied in many *** addition,the physiological function of PNAG has been further ***-based vaccines and PNAG-targeting antibodies have shown great efficacy in preclinical ***,clinical tests for both vaccines and antibodies have been carried out in humans and economically important animals,and the results are *** it is not destined to be a smooth road,we are optimistic about new vaccines and immunotherapeutics targeting PNAG becoming validated and eventually licensed for clinical use against multiple infectious agents.

关键词： Poly-N-acetylglucosamine Conjugate vaccine Monoclonal antibody

PENG ZU Study on Healthy Aging in China(PENG ZU Cohort):Design and Goals

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China CDC weekly 2024年第34期6卷 876-882页

作者： Ju Cui jing pang Liqun Zhang Juan Li Xiaolan Wu Xinyi Zhu Wei Ma Senlin Luo Huafang Gao Zhao Wang Jianping Cai Tiemei Zhang The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijing Hospital/National Center of Gerontology of National Health CommissionBeijingChina Beijing Institute of Geriatrics Beijing HospitalBeijingChina Institute of Geriatric Medicine Chinese Academy of Medical ScienceBeijing HospitalBeijingChina Center on Aging Psychology CAS Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of SciencesBeijingChina Institute of Healthy Ageing China Research Center on AgeingBeijingChina Institute of Statistics and Big Data Renmin University of ChinaBeijingChina Beijing Institute of Technology BeijingChina National Human Genetic Resources Center National Research Institute for Family PlanningBeijingChina Department of Pharmacology School of Pharmaceutical SciencesTsinghua UniversityBeijingChina

Life expectancy is increasing,leading to the continuous aging of the population in *** the health status of the older population is crucial to achieving healthy *** primary objective of the PENG ZU Study on Healthy Aging in China(PENG ZU Cohort)is to understand the natural progression of health status among the aging Chinese ***,the PENG ZU cohort aims to identify and validate multidimensional aging markers,uncover the underlying mechanisms of systemic aging and functional decline,and develop novel strategies and measures to delay functional decline and adverse health outcomes,while maintaining overall good *** PENG ZU cohort consists of 26,000 individuals aged 25 to 89 years from seven major geographical regions in *** data and biospecimens are collected according to standardized procedures at baseline and follow-up *** recruitment for the PENG ZU cohort was completed in October *** extensive analysis of multidimensional health-related data and bioresources collected from the cohort is anticipated to develop methods for evaluating functional status and elucidating multilevel,cross-scale interactions and regulatory mechanisms of healthy *** findings from this study will enhance the understanding of health changes due to aging,facilitate efficient and effective interventions to maintain functional ability,and reduce the incidence and severity of age-related diseases,thereby further promoting healthy aging.

关键词： aging thereby maintain

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3449-3466页

作者： Xixi Guo Xiaosa Zhao Xi Lu Liping Zhao Qingxuan Zeng Fenbei Chen Zhimeng Zhang Mengyi Xu Shijiao Feng Tianyun Fan Wei Wei Xin Zhang jing pang xuefu You Danqing Song Yanxiang Wang Jiandong Jiang Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College100050 BeijingChina School of Information Science and Technology Northeast Normal UniversityChangchun 130117China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272029 ShandongChina Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei230601AnhuiChina

Helicobacter pylori(***)is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis,and its high prevalence and resistance make it difficult to tackle.A graph neural network-based deep learning model,employing different training sets of 13,638 molecules for pre-training and fine-tuning,was aided in predicting and exploring novel molecules against ***.A positively predicted novel berberine derivative 8 with 3,13-disubstituted alkene exhibited a potency against all tested drug-susceptible and resistant *** strains with minimum inhibitory concentrations(MICs)of 0.25-0.5μg/*** studies demonstrated an ideal gastric retention of 8,with the stomach concentration significantly higher than its MIC at 24 h post *** administration of 8 and omeprazole(OPZ)showed a comparable gastric bacterial reduction(2.2-log reduction)to the triple-therapy,namely OPZ+amoxicillin(AMX)+clarithromycin(CLA)without obvious disturbance on the intestinal flora.A combination of OPZ,AMX,CLA,and 8 could further decrease the bacteria load(2.8-log reduction).More importantly,the mono-therapy of 8 exhibited comparable eradication to both triple-therapy(OPZ+AMX+CLA)and quadrupletherapy(OPZ+AMX+CLA+bismuth citrate)*** and BamD,playing a major role in outer membrane protein(OMP)transport and assembling,were identified and verified as the direct targets of 8 by employing the chemoproteomics technique.n summary,by targeting the relatively conserved OMPs transport and assembling system,8 has the potential to be developed as a novel *** candidate,especially for the eradication of drug-resistant strains.

关键词： berberine stomach retention

鲍曼不动杆菌铁离子摄取机制与基于抑制铁摄取的抗菌策略

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药学学报 2024年第5期59卷 1113-1125页

作者：张芷萌游雪甫庞晶中国医学科学院、北京协和医学院医药生物技术研究所抗感染北京市重点实验室北京100050

细菌耐药一直是抗感染药物研究领域亟待攻克的难题。鲍曼不动杆菌作为引起院内感染的重要病原菌,严重威胁患者的生命健康。近年来,多重耐药、泛耐药,甚至全耐药鲍曼不动杆菌的检出率不断升高,因此开发新的治疗鲍曼不动杆菌感染的策略迫... 详细信息

细菌耐药一直是抗感染药物研究领域亟待攻克的难题。鲍曼不动杆菌作为引起院内感染的重要病原菌,严重威胁患者的生命健康。近年来,多重耐药、泛耐药,甚至全耐药鲍曼不动杆菌的检出率不断升高,因此开发新的治疗鲍曼不动杆菌感染的策略迫在眉睫。铁是鲍曼不动杆菌生存必需的基本元素,也是参与感染进程的重要物质。细菌为了应对宿主铁饥饿现象,发展了一系列铁摄取手段,如分泌铁载体螯合铁、摄取血红素、利用Feo系统转运亚铁等。开发相应的抗菌策略以抑制鲍曼不动杆菌的铁摄取,是应对鲍曼不动杆菌感染的有效手段。本文将从鲍曼不动杆菌铁摄取机制以及基于此机制发展的抗菌策略两个方面进行综述。

关键词：宿主铁饥饿铁摄取鲍曼不动杆菌细菌耐药抗菌策略

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“千万工程”变迁的逻辑及启示

农业经济问题 2024年第4期 95-103页

作者：王成军庞婧李雷浙江农林大学浙江省乡村振兴研究院杭州311300 浙江农林大学经济管理学院杭州311300

2003年,习近平同志立足于浙江的实际情况,创造性地谋划并持久推进“千村示范、万村整治”工程。本文梳理了“千村示范、万村整治”工程实施以来浙江省农村人居环境整治的变迁阶段,基于理论逻辑和实践逻辑的分析框架,厘清农村人居环境整... 详细信息

2003年,习近平同志立足于浙江的实际情况,创造性地谋划并持久推进“千村示范、万村整治”工程。本文梳理了“千村示范、万村整治”工程实施以来浙江省农村人居环境整治的变迁阶段,基于理论逻辑和实践逻辑的分析框架,厘清农村人居环境整治的嬗变规律,形成如下研究结论:第一,浙江省农村人居环境整治经历了政府主导、政府引导农户参与、农户主动参与三个阶段。第二,社会共识是农村人居环境整治的社会基础,且通过影响环境整治的制度性交易成本,改善政府与农户的效用水平,形成农村人居环境整治变迁参与主体的内在驱动力。第三,“千村示范、万村整治”持续深化,逐步从外在的环境治理,升级到内在的乡村经营,形成了迈向“千村引领、万村振兴、全域共富、城乡和美”的长效机制。本文的研究结论对加快城乡融合发展、积极推动美丽中国建设,以及全面推进乡村振兴具有一定启示作用。

关键词： “千村示范、万村整治”工程农村人居环境制度变迁

精细化护理管理在剖宫产孕产妇围手术期的研究进展

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实用妇科内分泌电子杂志 2024年第7期11卷 44-46页

作者：庞静长春市中医药大学吉林长春130118

随着我国社会公共服务体系的建设,人们对护理质量的要求也越来越高,而剖宫产孕产妇作为一个家庭的重中之重,其围手术期的护理质量更成为人们关注的焦点。在剖宫产孕产妇围手术期应用精细化护理的模式,能够让护理人员更加注重细节,突破... 详细信息

随着我国社会公共服务体系的建设,人们对护理质量的要求也越来越高,而剖宫产孕产妇作为一个家庭的重中之重,其围手术期的护理质量更成为人们关注的焦点。在剖宫产孕产妇围手术期应用精细化护理的模式,能够让护理人员更加注重细节,突破护理质量瓶颈,提升患者的满意度。本文对精细化护理管理模式在剖宫产孕产妇围手术期的应用进行综述,分析精细化护理管理在孕产妇围手术期中的应用并总结精细化护理在孕产妇围手术期的研究进展,为临床工作提供依据。

关键词：精细化护理孕产妇护理围手术期

Finemet型非晶合金的复杂晶化动力学行为

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材料导报 2024年第3期38卷 161-167页

作者：王璞朱争取董延楠杨东庞靖张家泉北京科技大学冶金与生态工程学院北京100083 青岛云路先进材料技术股份有限公司山东青岛266232

Finemet型铁基多元合金是目前应用极广泛的纳米晶软磁材料之一。深入认识其形成过程的晶化动力学特性,对更好地调控制备工艺以获得稳定且软磁性能更优的目标纳米晶具有重要意义。为此,通过差示扫描量热仪(Differential scanning calorim... 详细信息

Finemet型铁基多元合金是目前应用极广泛的纳米晶软磁材料之一。深入认识其形成过程的晶化动力学特性,对更好地调控制备工艺以获得稳定且软磁性能更优的目标纳米晶具有重要意义。为此,通过差示扫描量热仪(Differential scanning calorimeter,DSC)在不同升温速率的条件下研究了Fe_(74)Si_(14.5)B_(7.5)Nb-(3)Cu_(1)(原子分数,%)非晶的非等温晶化行为,首先利用Kissinger-Akahira-Sinose(KAS)、Flyn-Wall-Ozawa(FWO)、Starik和Boswell这几种典型的等转化率法求得Fe_(74)Si_(14.5)B_(7.5)Nb-(3)Cu_(1)合金的晶化过程激活能Eα,之后采用补偿效应法得出指前因子A,从而实现了反应模型f(α)的数值重建和Avrami指数n(α)的求解。结果表明,Fe_(74)Si_(14.5)B_(7.5)Nb-(3)Cu_(1)非晶合金的晶化仅较接近维度扩散的反应机理模型,但不完全符合现有任何理论模型,是一个涉及多个反应模型的复杂反应。晶体形核速率在晶化初期(α0.5),晶体在已有晶粒的基础上继续长大(n(α)<1.5),整个晶化过程为形核速率持续降低的三维生长。Fe_(74)Si_(14.5)B_(7.5)Nb-(3)Cu_(1)非晶合金的晶化是一个由三维扩散主导的多个晶化机制共同控制、多个反应模型协同参与的复杂过程。

关键词： Finemet型合金晶化行为等转化率法反应模型形核速率晶化机制

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小儿耳廓畸形无创矫正治疗效果研究

中华整形外科杂志 2024年第8期40卷 870-877页

作者：卓姗姗任海棠庞静王敏天津市天津医院耳鼻咽喉头颈外科天津300211

目的探讨小儿耳廓畸形无创矫正治疗效果及影响因素。方法回顾性分析2019年1月1日至2023年6月30日天津市天津医院耳鼻咽喉头颈外科门诊收治的使用国产外耳矫形器治疗的先天性耳廓畸形患儿资料。治疗前常规备皮,先安装矫形器底座并按压贴... 详细信息

目的探讨小儿耳廓畸形无创矫正治疗效果及影响因素。方法回顾性分析2019年1月1日至2023年6月30日天津市天津医院耳鼻咽喉头颈外科门诊收治的使用国产外耳矫形器治疗的先天性耳廓畸形患儿资料。治疗前常规备皮,先安装矫形器底座并按压贴合耳周皮肤,之后根据耳廓畸形类型安装耳钩及耳盖,胶布固定。矫正治疗期间全天佩戴矫形器,矫正满意后观察1个月无明显反弹,则治疗结束。治疗期间密切观察并发症情况。治疗结束后评价治疗效果,分为显效、有效、无效,计算显效率(显效耳数/总耳数×100%)和有效率[(显效耳数+有效耳数)/总耳数×100%],同时记录显效患儿的治愈时间,并按照不同耳廓畸形类型及矫正初始年龄(6周龄)分组,进行相关指标的比较。使用SPSS 23.0软件进行统计学分析,计量资料用±s表示,多组间比较采用单因素方差分析,组间两两比较采用LSD法,计数资料用频数(%或者比值)表示,多组间比较采用χ2检验,组间两两比较采用调整α值的Fisher检验。结果共纳入31例患儿(55只耳),男13例(23耳),女18例(32只耳),出生后4至127 d;垂耳13只,环缩耳6只,杯状耳6只,猿耳4只,招风耳5只,耳轮畸形18只,耳甲腔横突畸形2只,Ⅱ度小耳畸形1只。治疗过程中5只耳出现皮损,5只耳出现轻度过敏反应,2只耳出现严重过敏反应,通过摘除矫正器晾晒后间断涂抹红霉素软膏后明显好转并继续治疗。经无创矫正治疗后患儿耳廓畸形均有不同程度改善,总体显效率为70.91%(39/55),总体有效率为90.91%(50/55),其中,垂耳、环缩耳、杯状耳、猿耳、招风耳、耳轮畸形、耳甲腔横突及Ⅱ度小耳畸形的显效率分别为13/13、4/6、4/6、4/4、4/5、8/18、2/2、0/1。39只显效耳的治愈时间为(36.08±14.77)d。不同耳廓畸形类型的治愈时间不同(P6周龄组(9例,15只耳)的显效率分别为90.5%(19/21)、13/18和7/15,差异有统计学意义(P6周龄组(P0.05)。结论小儿耳廓畸形无创矫正治疗效果显著。耳廓畸形类型是影响治疗效果及治愈时间的关键因素,垂耳、猿耳、招风耳和耳甲腔横突畸形的治疗效果好,其中,垂耳治愈时间较短,招风耳治愈时间较长,而环缩耳、杯状耳、耳轮畸形和Ⅱ度小耳畸形的治疗效果较差。初始矫正年龄越早,效果越好。

关键词：耳廓耳廓畸形无创矫正治疗效果治愈时间