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干细胞抗卵巢颗粒细胞衰老的作用机制及进展

中国组织工程研究 2025年第25期29卷 5414-5421页

作者：林美玉赵玺龙高景赵晶阮光萍解放军联勤保障部队第九二〇医院基础医学实验室云南省昆明市650032 干细胞与免疫细胞生物医药技术国家地方联合工程研究中心云南省昆明市650032 云南省细胞治疗技术转化医学重点实验室云南省昆明市650032

背景:干细胞疗法作为一种新兴的治疗手段,有望改善卵巢环境,延缓卵巢颗粒细胞的衰老,为高龄妊娠女性带来新的希望。目的:综述干细胞抗卵巢颗粒细胞衰老的机制及研究进展。方法:检索中国知网和PubMed数据库中关于干细胞抗卵巢颗粒细胞衰... 详细信息

背景:干细胞疗法作为一种新兴的治疗手段,有望改善卵巢环境,延缓卵巢颗粒细胞的衰老,为高龄妊娠女性带来新的希望。目的:综述干细胞抗卵巢颗粒细胞衰老的机制及研究进展。方法:检索中国知网和PubMed数据库中关于干细胞抗卵巢颗粒细胞衰老的文献,以“干细胞,卵巢颗粒细胞,衰老”为中文检索词,以“stem cells,ovary granulosa cells,aging”为英文检索词,最终纳入67篇文献进行分析。结果与结论:①总结了5种卵巢颗粒细胞衰老的机制:DNA损伤和修复能力下降、氧化应激、线粒体功能受损、炎症反应、激素水平变化;②整理了当前干细胞治疗卵巢颗粒细胞衰老的5种机制:促进增殖和抑制凋亡、分化潜能及再生能力、分泌因子、抗氧化、抗炎症反应和免疫调节;③目前有多种类型的干细胞可通过多种方式协同治疗卵巢颗粒细胞衰老,干细胞疗法在恢复女性生育能力方面具有广阔前景。

关键词：干细胞卵巢颗粒细胞衰老机制氧化应激抑制凋亡细胞因子抗氧化抗炎症反应

Influence of the Northeast Cold Vortex on Flooding in Northeast China in Summer 2013

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Journal of Meteorological Research 2018年第2期32卷 172-180页

作者： jing gao Hui gao Inner Mongolia Climate Center Hohhot 010051 National Climate Center China Meteorological Administration Beijing 100081

Severe flooding occurred in Northeast China（NEC） in summer 2013. Compared with the rainfall climatology of the region, the rainy season began earlier in 2013 and two main rainy periods occurred from late June to early July and from mid July to early August, respectively. During the summer season of 2013, the western Pacific subtropical high（WPSH） was located farther westward, which strengthened the southerly winds on its west side in the lower troposphere. Under this circulation pattern, more water vapor was transported to North China and NEC. Another moisture transport pathway to NEC was traced to the cross-equatorial flow over the Bay of Bengal. In mid–high latitudes in summer 2013, the Northeast Cold Vortex（NECV） was much stronger and remained stable over NEC. Thus, the cold air flow from its northwest side frequently met with the warm and wet air from the south to form stronger moisture convergence at lower levels in the troposphere, resulting in increased precipitation over the region. Correlation analysis indicated that the NECV played a more direct role than the WPSH. Synoptic analyses of the two heaviest flood cases on 2 and 16 July confirmed this conclusion. The four wettest summers in NEC before 2000 were also analyzed and the results were consistent with the conclusion that both the WPSH and the NECV led to the intense rainfall in NEC, but the NECV had a more direct role.

关键词： flood Northeast China Northeast Cold Vortex westem Pacific subtropical high

AN AFFINE SCALING DERIVATIVE-FREE TRUST REGION METHOD WITH INTERIOR BACKTRACKING TECHNIQUE FOR BOUNDED-CONSTRAINED NONLINEAR PROGRAMMING

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Journal of Systems Science & Complexity 2014年第3期27卷 537-564页

作者： gao jing ZHU Detong Department of Mathematics Shanghai Normal University

This paper proposes an arlene scaling derivative-free trust region method with interior backtracking technique for bounded-constrained nonlinear programming. This method is designed to get a stationary point for such a problem with polynomial interpolation models instead of the objective function in trust region subproblem. Combined with both trust region strategy and line search technique, at each iteration, the affine scaling derivative-free trust region subproblem generates a backtracking direction in order to obtain a new accepted interior feasible step. Global convergence and fast local convergence properties are established under some reasonable conditions. Some numerical results are also given to show the effectiveness of the proposed algorithm.

关键词： Affine scaling backtracking technique box constrains derivative-free optimization non-linear programming trust region method.

Temperature effect on luteinizing hormone secretion of Eurasian Skylark(Alauda arvensis) and Great Tit(Parus major) in China

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Avian Research 2018年第1期9卷 81-87页

作者： Lijun gao jing gao Shuping Zhang College of Life and Environment Sciences Minzu University of China

Background: Global warming caused trophic mismatch has affected the breeding success, and even the survival, of some bird *** ability of birds to accelerate their reproduction onset in the warmer spring could be critical to the survival of some *** activation of the reproductive endocrine axis in birds is a key physiological process that determines the onset of *** birds change the HPG axis endocrine rhythm under the temperature rising condition?Methods: Using plasma LH level as an indicator of initiation of the reproductive endocrine and artificially controlling temperature, we compared variations in the timing of activation of the reproductive endocrine axis in response to temperature in two Chinese bird species, the Eurasian Skylark(Alauda arvensis) and the Great Tit(Parus major) at both the population and individual ***: At the population level, temperature only significantly influenced LH level in the Eurasian Skylark, and had no significant effect on the LH levels in the Great *** LH level of Eurasian Skylarks in the 20 ℃ group was higher than that of those in the 15 ℃ group throughout the *** individual variations in the timing of peak LH levels were observed in the high and the low temperature groups of both Eurasian Skylarks and Great ***: These results indicate that the effects of temperature differ among ***, there appears to be a degree of within population polymorphism in the timing of reproductive endocrine axis activation in some *** polymorphism could provide the variation required for bird populations to cope with the possible change of their food peak under the climate warming condition.

关键词： Reproductive endocrine rhythm Temperature Climate warming Eurasian Skylark Great Tit

Calcium sulfate whisker prepared by flue gas desulfurization gypsum:A physical–chemical coupling production process

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2221-2226页

作者： jing gao Qiang Li Fuli Liu College of Mining Liaoning Technical UniversityFuxin 123000China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China College of Chemical and Environmental Engineering China University of Mining and TechnologyBeijing 100083China

In this paper,the solid waste desulfurization gypsum produced by coal-fired power plants was used as a raw material to prepare calcium sulfate whiskers with high application *** sulfate whiskers with uniform morphology and high aspect ratio can be prepared by hydrothermal method in sulfuric acid solution.A new process of desulfurization gypsum activated by high-energy grinding to reduce the reaction temperature and sulfuric acid concentration was *** the comparison of product morphology,the best grinding time was determined to be 3.5 *** mechanism of desulfurization gypsum through physical–chemical coupling to reduce energy consumption was *** activation of desulfurization gypsum by grinding and the acidic environment provided by the sulfuric acid solution made the calcium sulfate solution reached rapid saturation and accelerated the nucleation *** calculating the conversion and crystallization rate of calcium sulfate whiskers,it was found that there were obvious"autocatalytic"kinetic characteristics during the crystallization process.

关键词： Flue gas desulfurization gypsum Calcium sulfate whiskers Crystallization kinetic Physical–chemical coupling

Lithiated Nafion-garnet ceramic composite electrolyte membrane for solid-state lithium metal battery

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Journal of Energy Chemistry 2020年第7期29卷 237-247,I0008页

作者： jing gao Qinjun Shao Jian Chen Advanced Rechargeable Battery Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Single-ion conducting solid polymer electrolytes are expected to play a vital role in the realization of solid-state Li metal *** this work,a lithiated Nafion(Li-Nafion)-garnet ceramic Li6.25La3 Zr2 Al0.25O12(LLZAO)composite solid electrolyte(CSE)membrane with 30μm thickness was prepared for the first *** employing X-ray photoelectron spectroscopy and transmission electron microscope,the interaction between LLZAO and Li-Nafion was *** is found that the LLZAO interacts with the Li-Nafion to form a space charge layer at the interface between LLZAO and *** space charge layer reduces the migration barrier of Li-ions and improves the ionic conductivity of the CSE *** CSE membrane containing 10 wt%LLZAO exhibits the highest ionic conductivity of2.26×10-4 S cm-1 at 30℃among the pristine Li-Nafion membrane,the membrane containing 5 wt%,20 wt%,and 30 wt%LLZAO,*** also exhibits a high Li-ion transference number of 0.92,and a broader electrochemical window of 0-+4.8 V ***+/Li than that of 0-+4.0 V ***+/Li for the pristine Li-Nafion *** is observed that the CSE membrane not only inhibits the growth of Li dendrites but also keeps excellent electrochemical stability with the Li *** from the above merits,the solid-state LiFePO4/Li cell fabricated with the CSE membrane was practically charged and discharged at 30℃.The cell exhibits an initial reversible discharge specific capacity of 160 mAh g-1 with 97%capacity retention after 100 cycles at 0.2 C,and maintains discharge specific capacity of 126 mAh g-1 after500 cycles at 1 *** CSE membrane prepared with Li-Nafion and LLZAO is proved to be a promising solid electrolyte for advanced solid-state Li metal batteries.

关键词： Single-ion conductor Composite solid electrolyte Lithiated Nafion Garnet ceramic Solid-state Li metal battery

Dirichlet characters, Gauss sums and arithmetic Fourier transforms

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Applied Mathematics(A Journal of Chinese Universities) 2014年第3期29卷 307-316页

作者： gao jing LIU Hua-ning School of Mathematics and Statistics Xi’an Jiaotong University School of Mathematics Northwest University

In this paper, a general algorithm for the computation of the Fourier coefficients of 2π-periodic （continuous） functions is developed based on Dirichlet characters, Gauss sums and the generalized MSbius transform. It permits the direct extraction of the Fourier cosine and sine coefficients. Three special cases of our algorithm are presented. A VLSI architecture is presented and the error estimates are given.

关键词： Dirichlet characters Gauss sums arithmetic Fourier transforms generalized MSbius transform

Small-divisor Equation of Higher Order with Large Variable Coefficient and Application to the Coupled KdV Equation

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Acta Mathematica Sinica,English Series 2011年第10期27卷 2005-2032页

作者： Mei Na gao jing ZHANG School of Mathematical Sciences Fudan University Shanghai 200433 P. R. China

In this paper, we establish an estimate for the solutions of small-divisor equation of higher order with large variable coefficient. Then by formulating an infinite-dimensional KAM theorem which allows for multiple normal frequencies and unbounded perturbations, we prove that there are many periodic solutions for the coupled KdV equation subject to small Hamiltonian perturbations.

关键词： KAM theorem small-divisor equation with large variable coefficient coupled KdV equation

Local Atomic Configuration in Pristine and A-Site Doped Silver Niobate Perovskite Antiferroelectrics

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Research 2022年第2期2022卷 203-212页

作者： jing gao Wei Li Jue Liu Qian Li jing-Feng Li State Key Laboratory of New Ceramis and Fine Processing School of Materials Science and Engineering Tsinghua UniversityBeijing 10084China Neutron Scattering Division Onk Ridge National LaboratoryOak RidgeTenessee 37831USA

Antiferroelectrics have attracted increasing research interests in recent years due to both their great potential in energy storage applications and intriguing structural ***,the links between the electrical properties and structural characteristics of distorted perovskite antiferroelectrics are yet to be fully ***,we adopt local-structure methods to elucidate the nanoscale atomic structure of AgNbO,-based antiferroelectrics and their structural evolution upon La *** local structural features including interatomic distance distributions and atomic displacements have been analyzed using neutron small-box pair distribution function(PDF)refinement in conjunction with large-box Reverse Monte Carlo *** results highlight the correlation of cation displacements in AgNbo,and its disruption by the incorporation of La,apparently in corroboration with the observed anomalous dielectric *** ordering of cation vacancies is observed in La-doped AgNbo,samples,which coordinates with oxygen octahedral tilting to relieve lattice *** results provide renewed insights into the atomic structure and antiferroelectric phase instabilities of AgNbO,and relevant perovskite materials,further lending versatile opportunities for enhancing their functionalities.

关键词： properties. perovskite Configuration