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运脾化痰通窍方提取工艺优化

世界科学技术-中医药现代化 2024年第3期26卷 591-600页

作者：余金凤艾璟栾宁闫明王振中肖伟于桂芳南京中医药大学康缘中药学院南京210023 江苏康缘药业股份有限公司连云港222001 中药制药过程控制与智能制造技术全国重点实验室连云港222001 南京中医药大学药学院南京210023

目的实现运脾化痰通窍方提取工艺优选,并建立组方指纹图谱。方法应用总量统计矩法,对提取液指纹图谱进行宏观表征和相似度分析,以黄芩苷、汉黄芩苷、迷迭香酸、甘草苷、甘草酸、出膏率为关键质量属性,以提取时间、加水倍量、提取次数为... 详细信息

目的实现运脾化痰通窍方提取工艺优选,并建立组方指纹图谱。方法应用总量统计矩法,对提取液指纹图谱进行宏观表征和相似度分析,以黄芩苷、汉黄芩苷、迷迭香酸、甘草苷、甘草酸、出膏率为关键质量属性,以提取时间、加水倍量、提取次数为关键工艺参数,采用AHP-独立性权重法进行综合评分,优选出最佳提取工艺,并进行验证。结果建立总量统计矩相似度评价方法,不同提取方法指纹图谱总量统计矩相似度均值为0.8807,工艺评价模型函数方差分析结果显示,P<0.0001、R2=0.9904,该模型具有统计学意义。优选得到最佳提取工艺为全方饮片加10倍量水,提取1.5 h,提取2次。结论优化的工艺稳定可靠,建立了符合该方提取液指纹图谱特点的总量统计矩分析方法,为该方后续工艺研究全过程质量控制奠定物质基础。

关键词：运脾化痰通窍方提取工艺 Box-Behnken设计-响应面法指纹图谱 AHP-独立性权重法质量控制

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Damage and fracture model for eutectic composite ceramics

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Acta Mechanica Sinica 2019年第1期35卷 190-200,I0006页

作者： jinfeng yu Xinhua Ni Xiequan Liu yunwei Fu Zhihong Du Department of Vehicle and Electric Engineering Army Engineering UniversityShijiazhuang 050003China Army Infantry College Nanchang 330000China Xichang Satellite Launch Center Xichang 615000China

Study of damage and fracture models to analyze the fracture mechanism of eutectic composite ceramics is of considerable importance because no accurate fracture models are available for these materials. Eutectic composite ceramics are composed of microcells with random direction. We present herein a model that predicts the damage and fracture of eutectic composite ceramics based on analysis of defect stability and the damage localization band. Firstly, given the microstructure of eutectic composite ceramics, a mesodomain and a microcell model are constructed. The local stress field in the mesodomain is then analyzed based on the interaction direct derivative estimate. Secondly, the stability of a defect around particles in a microcell is analyzed, and the stress intensity factor of an annular defect under the applied stress field and the residual stress field in the particle are calculated. The stress intensity factor of a defect is controlled by the residual stress when the defect extension is small. However, it is controlled by the applied stress when the defect extension is large. Finally, a model for the damage localization band at the crack tip is constructed based on the Dugdale-Barenblatt model. The residual intensity is the important factor affecting the length of the damage localization band. When the damage variables reach their largest value, the residual in ten sity and the length of the damage localization band attain their minimum value. This work provides the theoretical basis for further study of the damage mechanics of eutectic composite ceramics and guides the engineering applications of these materials.

关键词： Microcell Interaction direct derivative estimate Defect stability Damage localization band

Genome sequencing reveals the evolution and pathogenic mechanisms of the wheat sharp eyespot pathogen Rhizoctonia cerealis

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The Crop Journal 2023年第2期11卷 405-416页

作者： Lin Lu Feilong Guo Zhichao Zhang Xiuliang Zhu yu Hao jinfeng yu Wenwu Ye Zengyan Zhang National Key Facility for Crop Gene Resources and Genetic Improvement/Key Laboratory of Biology and Genetic Improvement of Triticeae Crops Ministry of Agriculture and Rural Affairs of the People’s Republic ChinaInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Department of Plant Pathology/Key Laboratory of Soybean Disease and Pest Control(Ministry of Agriculture and Rural Affairs of the People’s Republic China) The Key Laboratory of Plant ImmunityNanjing Agricultural UniversityNanjing 210095JiangsuChina College of Plant Protection Shandong Agricultural UniversityTai’an 271018ShandongChina

The necrotrophic fungus Rhizoctonia cerealis is the causal agent of devastating diseases of cereal crops including wheat(Triticum aestivum).We present a high-quality genome assembly of *** Rc207,a virulent strain causing wheat sharp *** assembly(56.36 Mb)is composed of 17.87%repeat sequences and 14,433 predicted protein-encoding *** Rc207 genome encodes a large and diverse set of genes involved in pathogenicity,especially rich in those encoding secreted proteins,carbohydrateactive enzymes(CAZymes),peptidases,nucleases,cytochrome P450,and secondary metabolismassociated *** secretory protein-encoding genes,including CAZymes,peroxygenases,dehydrogenases,and cytochrome P450,were up-regulated during fungal infection of *** identified 831 candidate secretory effectors and validated the functions of 10 up-regulated candidate effector *** them,nine were confirmed as necrotrophic pathogen’s effectors promoting fungal *** potential mobile or plastic genomic regions rich in repeat sequences suggest their roles in fungal adaption and virulence-associated genomic *** study provides valuable resources for further comparative and functional genomics on important fungal pathogens,and provides essential tools for development of effective disease control strategies.

关键词： Effector Evolution Pathogenesis Rhizoctonia cerealis Secretory proteins Sharp eyespot Wheat(Triticum aestivum)

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Evaluating and visualizing QoS of service providers in knowledgeintensive crowdsourcing:a combined MCDM approach

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International Journal of Intelligent Computing and Cybernetics 2022年第2期15卷 215-240页

作者： Shixin Xie Xu Wang Biyu Yang Longxiao Li jinfeng yu College of Mechanical and Vehicle Engineering Chongqing UniversityChongqingChina School of Business and Administration Chongqing University of Science and TechnologyChongqingChina

Purpose-As the number of joined service providers(SPs)in knowledge-intensive crowdsourcing(KI-C)continues to rise,there is an information overload problem for KI-C platforms and consumers to identify qualified SPs to complete *** this end,this paper aims to propose a quality of service(QoS)evaluation framework for SPs in KI-C to effectively and comprehensively characterize the QoS of SPs,which can aid the efficient selection of qualified ***/methodology/approach-By literature summary and discussion with the expert team,a QoS evaluation indicator system for SPs in KI-C based on the SERVQUAL model is *** addition,the Decision Making Trial and Evaluation Laboratory(DEMATEL)method is used to obtain evaluation indicators’*** SPs are evaluated and graded by the Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)and rank-sum ratio(RSR),***-A QoS evaluation indicator system for SPs in KI-C incorporating 13 indicators based on SERVQUAL has been constructed,and a hybrid methodology combining DEMATEL,TOPSIS and RSR is applied to quantify and visualize the QoS of ***/value-The QoS evaluation framework for SPs in KI-C proposed in this paper can quantify and visualize the QoS of SPs,which can help the crowdsourcing platform to realize differentiated management for SPs and assist SPs to improve their shortcomings in a targeted *** this is the first paper to evaluate SPs in KI-C from the prospect of QoS.

关键词： Service provider Knowledge-intensive crowdsourcing QoS DEMATEL TOPSIS RSR

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轨道交通用6005A合金复杂断面生产工艺

铝加工 2024年第1期 37-40页

作者：王少鹏于金凤王琪曲兆金李庆龙口市丛林铝材有限公司龙口265705

挤压宽展比、宽厚比和壁厚差较大的型材多采用搅拌摩擦焊方式焊接,这对型材之间的对接焊间隙提出严格的要求,导致型材的生产难度较大。从模具结构、挤压工艺,尤其是在线淬火工艺方面解决壁厚差较大型材的生产难点,改善型材的整体侧弯问... 详细信息

挤压宽展比、宽厚比和壁厚差较大的型材多采用搅拌摩擦焊方式焊接,这对型材之间的对接焊间隙提出严格的要求,导致型材的生产难度较大。从模具结构、挤压工艺,尤其是在线淬火工艺方面解决壁厚差较大型材的生产难点,改善型材的整体侧弯问题。对型材部分位置的侧弯情况进行统计,明确侧弯典型位置,在定尺锯切环节进行避让,保证复杂截面型材的顺利供货。

关键词： 6005A合金壁厚差淬火

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Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

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Chinese Chemical Letters 2024年第6期35卷 474-479页

作者： yuanyi Zhou Ke Ma jinfeng Liu Zirun Zheng Bo Hu yu Meng Zhizhong Li Mingshan Zhu Postdoctoral Innovation Practice Base The First and Fifth Affiliated Hospital of Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan 517465China School of Environment Jinan UniversityGuangzhou 511443China Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China

Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROS)modulation would boost the prosperity of nanomedicine in cancer *** as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)***,Fe single atom-decorated graphene oxide(Fe_(1)-GO)nanosheet is developed to be a feasible autophagy inducer in RCC *** the well-dispersed O-Fe_(1)-O active sites,Fe_(1)-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ***-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS *** in vivo therapeutic effect of Fe_(1)-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89% reduction of tumor weight and good *** work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.

关键词： Fe single atom Autophagy Renal cell carcinoma Graphene oxide Cancer therapy

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Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^(-/-)Mice and Human Intrahepatic Cholangiocyte Organoid Models

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Research 2024年第2期2023卷 355-372页

作者： Qigu Yao Wenyi Chen Yingduo yu Feiqiong Gao Jiahang Zhou Jian Wu Qiaoling Pan jinfeng Yang Lingling Zhou Jiong yu Hongcui Cao Lanjuan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Cllaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affliated HospitalZhejang University School of Medicine79 Qingchun Rd.Hangzhou 310003China National Clinical Research Center for Infectious Diseases HangzhouChina Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province 79 Qingchun Rd.Hangzhou 310003China Jjinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Primary sclerosing cholangitis(PSC)is a biliary disease accompanied by chronic inflammation of the liver and biliary *** stem cells(MSCs)are used to treat liver diseases because of their immune regulation and regeneration-promoting *** study was performed to explore the therapeutic potential of human placental MSCs(hP-MSCs)in PSC through the Takeda G protein-coupled receptor 5(TGR5)receptor *** tissues were collected from patients with PSC and healthy donors(n=4)for RNA sequencing and intrahepatic cholangiocyte organoid ***-MSCs were injected via the tail vein into Mdr2^(-/-),bile duct ligation(BDL),and 3,5-diethoxycarbonyl-1,4-dihydrocollidine(DDC)mouse models or co-cultured with organoids to confirm their therapeutic effect on biliary *** in bile acid metabolic profile were analyzed by liquid chromatography/tandem mass spectrometry(LC-MS/MS).Compared with healthy controls,liver tissues and intrahepatic cholangiocyte organoids from PSC patients were characterized by inflammation and cholestasis,and marked downregulation of bile acid receptor TGR5 ***-MSC treatment apparently reduced the inflammation,cholestasis,and fibrosis in Mdr2^(-/-),BDL,and DDC model *** activating the phosphatidylinositol 3 kinase/extracellular signal-regulated protein kinase pathway,hP-MSC treatment promoted the proliferation of cholangiocytes,and affected the transcription of downstream nuclear factorκB through regulation of the binding of TGR5 and Pellino3,thereby affecting the cholangiocyte inflammatory phenotype.

关键词： inflammation TGR5 Human

Unreliability Tracing of Power Systems for Identifying the Most Critical Risk Factors Considering Mixed Uncertainties in Wind Power Output

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Protection and Control of Modern Power Systems 2024年第5期9卷 96-111页

作者： Siying Zhao Changzheng Shao jinfeng Ding Bo Hu Kaigui Xie Xueying yu Zihan Zhu Hubei Electric Power Planning Design and Research Institute Co.Ltd.Wuhan 430040China State Key Laboratory of Power Transmis-sion Equipment Technology School of Electrical EngineeringChongqing UniversityChongqing 400044China State Grid Chengdu Electric Power Supply Company Chengdu 610000China School of Electrical Engineering Si-chuan UniversityChengdu 610065China

For conventional power systems,the forced outage of components is the major cause of load *** tracing is utilized to allocate the total system load-shedding risk among individual components in ac-cordance with their different ***,critical components are identified and pertinent measures can be taken to improve system *** integra-tion of wind power introduces additional risk factors into power systems,causing previous unreliability tracing methods to become *** this paper,a novel unreliability tracing method is proposed that considers both aleatory and epistemic uncertainties in wind power output and their impacts on power system load-shedding ***,modelling methods for wind power output considering aleatory and epistemic uncertainties and component outages are ***,a variance-based index is proposed to measure the contributions of indi-vidual risk factors to the system load-shedding ***-nally,a novel unreliability tracing framework is devel-oped to identify the critical factors that affect power sys-tem *** studies verify the ability of the pro-posed method to accurately allocate load-shedding risk to individual risk factors,thus providing decision support for reliability enhancement.

关键词： Unreliability tracing epistemic uncer-tainty wind power multisource heterogeneous risk factors

Controlling the Reactivity of IBA-N_(3)by Switching Halogen Salts:Providing a Universal Strategy for Haloazidation of Alkenes

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Chinese Journal of Chemistry 2024年第16期42卷 1839-1845页

作者： Chen-Xi Xia Xin-Lei Sun jinfeng Zhang yue Ren Yan yu Kuai Wang Ling-Guo Meng Key Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of Education/School of Chemistry and Materials ScienceHuaibeiNormal UniversityHuaibeiAnhui 235000China

Although various routes have been reported for haloazidation,unavoidable problems exist,such as environmentally unfriendly monomer halogen,the need for in situ generation of unstable halogen azides(XN3),applicability to one type of haloazidation and inability to precisely control ***,we developed a universal strategy for haloazidation of alkenes through controlling the reactivity of IBA-N_(3) by switching halogen salts,allowing for the synthesis of a diversity of halogen azide *** studies have shown that by tuning the reactivity of IBA-N_(3) via switching halogen salts,different intermediates can be controllably produced to achieve regioselectivityand chemoselectivity in thehaloazidationof alkenes.

关键词： Haloazidation Alkene IBA-N_(3) Halogen salts Difunctionalization Selectivity Radicals Synthetic methods