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Defects and morphology engineering for constructing V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S nanotube heterojunction arrays toward efficient bifunctional electrocatalyst for overall water splitting

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Journal of Energy Chemistry 2024年第7期94卷 29-40页

作者： Wenyuan Sun Alan Meng Lei Wang Guicun Li jinfeng Cui Yongkai Sun Zhenjiang Li College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Key Laboratory of Optic-electric Sensing and Analytical Chemistryfor Life Science MOE College of Chemistry and Molecular EngineeringQingdao Universityof Science and TechnologyQingdao 266042ShandongChina College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Qingdao Huanghai University Qingdao 266000ShandongChina College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061ShandongChina

The development of highly active,stable and inexpensive electrocatalysts for hydrogen production by defects and morphology engineering remains a great ***,S vacancies-rich Ni_(3)S_(2)@Cu_(2)S nan-otube heterojunction arrays were in-situ grown on copper foam(V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF)for efficient electrocatalytic overall water *** the merits of nanotube arrays and efficient electronic mod-ulation drived by the OD vacancy defect and 2D heterojunction defect,the resultant V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF electrocatalyst exhibits excellent electrocatalytic activity with a low overpotential of 47 mV for the hydrogen evolution reaction(HER)at 10 mA cm^(-2) current density,and 263 mV for the oxygen evolution reaction(OER)at 50 mA cm^(-2) current density,as well as a cell voltage of 1.48 V at 10 mA cm^(-2).Moreover,the nanotube heterojunction arrays endows V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF with outstanding stability in long-term catalytic processes,as confirmed by the continuous chronopotentiom-etry tests at current densities of 10 mA cm^(-2) for 100 h.

关键词： Nanotubearrays Heterojunction Vacancy Bifunctional electrocatalyst Overall water splitting

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加拿大职业教育学徒制对我国高职教育的启示

职业技术教育 2015年第32期36卷 78-80页

作者：杨金凤贺州学院外国语学院大学英语教研室

现代学徒制因其具有提高企业员工技术技能、加强企业文化传承的特点,加拿大职业教育学徒制更加值得研究和借鉴。加拿大学徒制具有完善的制度保障体系、国家财政经费的大力支持、政府和民间机构双重管理、满足职业急需的课程设置、互利... 详细信息

现代学徒制因其具有提高企业员工技术技能、加强企业文化传承的特点,加拿大职业教育学徒制更加值得研究和借鉴。加拿大学徒制具有完善的制度保障体系、国家财政经费的大力支持、政府和民间机构双重管理、满足职业急需的课程设置、互利互惠的校企合作模式等特点,借鉴其经验我国高职教育应实行现代学徒制应积极构建学徒制制度保障体系、根据平均需求灵活设置课程、采用税款返还制度。

关键词：学徒制加拿大高职教育

How the surface Cu layer affected the activity of Ni foil for alkaline hydrogen evolution

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Journal of Materials Science & Technology 2024年第2期169卷 11-18页

作者： Qingfeng Hu Yuan Liu Xuerong Zheng jinfeng Zhang Jiajun Wang Xiaopeng Han Yida Deng Wenbin Hu School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China

Synthesizing bimetallic nanomaterials,with noble metals as the surface layers and inert metals as the substrates,has been proven to be an effective way to reduce the use of noble metals with maintained catalytic ***,an atomic diffusion from the inert substrate to the surface during the long-term operation has been reported to significantly decrease the *** this work,a series of catalysis-inert Cu-coated Ni foil were fabricated through electrodeposition and their activities for alkaline hydrogen evolution were ***,the Ni/Cu-60 sample showed a similar catalytic property with pure Ni foil and only a slight decrease in HER activity was *** X-ray photoelectron spectroscopy(XPS)results indicated a decreased electron concentration of Cu in Ni/Cu-60,and theoretical calculations further demonstrated the electron transfer between the Ni substrate and Cu *** results reveal that a specific composition or structure of an inert metal layer might not significantly decrease the electrocatalytic activity of active ***,there are more possibilities for the rational design of metal-based catalysts for electrocatalysis.

关键词： Bimetallic heterostructure Charge redistribution Water splitting Alkaline hydrogen evolution

An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping Zhou Ruixin Ge Xiaoshan Geng Zhihao yang Guo Li Linlin Zhang Jing Wang jinfeng Ma Cheng Dong Jun Zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PROTAC)for p53-R175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PROTACs,we successfully developed a selective p53-R175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-R175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-R175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-R175H-driven cancers.

关键词： P53 Aptamer PROTAC Cancer Drug resistance

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全固态硝酸根离子选择电极

环境工程学报 2014年第12期8卷 5546-5550页

作者：宋小娟杨金凤杨慧中江南大学轻工过程先进控制重点实验室无锡214122

研究了一种以玻碳电极为基底电极,以聚吡咯为中间体,以聚氯乙烯(PVC)为敏感基膜的全固态硝酸根离子选择电极。结果表明,电极在1×10-5~1×10-1mol/L的硝酸钠溶液中呈现近能斯特响应,响应斜率为(-54±1.0)m V/dec,检测下限为3.16×10-6mo... 详细信息

研究了一种以玻碳电极为基底电极,以聚吡咯为中间体,以聚氯乙烯(PVC)为敏感基膜的全固态硝酸根离子选择电极。结果表明,电极在1×10-5~1×10-1mol/L的硝酸钠溶液中呈现近能斯特响应,响应斜率为(-54±1.0)m V/dec,检测下限为3.16×10-6mol/L。该电极的响应时间短,稳定性及重复性较好,对硝酸根具有很好的选择性。用于实验室水样中硝酸根的回收率测定,结果令人满意。该电极制作简单,机械强度高,使用寿命超过3个月,对用于水中硝酸根的在线分析与测定有重要意义。

关键词：全固态离子选择电极硝酸根检测聚吡咯

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma Yue Zhang jinfeng Li Xiaojuan Hou Yixin yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Tailoring component incorporation for homogenized perovskite solar cells

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Science Bulletin 2024年第16期69卷 2555-2564页

作者： Wenhan yang Junmin Xia Yuexin Lin Hao Gu Fengqiang Ma Yumin Ren Fenqi Du Dejian Yu jinfeng Liao Yiwang Chen Guojia Fang Shengchun yang Chao Liang MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of PhysicsNational Innovation Platform(Center)for Industry-Education Integration of Energy Storage TechnologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacao 999078China Shandong Zhixin Intelligent Equipment Co. LTDJinan 250101China School of Chemistry Xi’an Jiaotong UniversityXi’an 710049China National Engineering Research Center for Carbohydrate Synthesis Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationJiangxi Normal UniversityNanchang 330022China Key Laboratory of Artificial Micro/Nano Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072China

Deep-level traps at the buried interface of perovskite and energy mismatch problems between the perovskite layer and heterogeneous interfaces restrict the development of ideal homogenized films and efficient perovskite solar cells(PSCs)using the one-step spin-coating ***,we strategically employed sparingly soluble germanium iodide as a homogenized bulk in-situ reconstruction inducing material preferentially aggregated at the perovskite buried interface with gradient doping,markedly reducing deep-level traps and withstanding local lattice strain,while minimizing non-radiative recombination losses and enhancing the charge carrier lifetime over 9μ***,this gradient doping assisted in modifying the band diagram at the buried interface into a desirable flattened alignment,substantially mitigating the energy loss of charge carriers within perovskite films and improving the carrier extraction *** a result,the optimized device achieved a champion power conversion efficiency of 25.24% with a fill factor of up to 84.65%,and the unencapsulated device also demonstrated excellent light stability and humidity *** work provides a straightforward and reliable homogenization strategy of perovskite components for obtaining efficient and stable PSCs.

关键词： Homogenized perovskite films Lattice strain relaxation Deep-level traps Carrier extraction equilibrium Perovskite solar cells

聚集蛋白代谢通路基因多态性与腰椎间盘突出严重程度的相关性

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中国组织工程研究 2019年第31期23卷 4939-4944页

作者：杨金丰马三辉定州市人民医院骨科

背景:椎间盘突出是一种复杂的脊柱疾病,与椎间盘退变密切相关,而聚集蛋白聚糖的代谢途径的候选基因可能与腰椎间盘突出的严重程度相关。目的:评估单核苷酸变异和慢性机械性腰痛患者腰椎间盘突出严重程度的蛋白聚糖的代谢途径的基因的关... 详细信息

背景:椎间盘突出是一种复杂的脊柱疾病,与椎间盘退变密切相关,而聚集蛋白聚糖的代谢途径的候选基因可能与腰椎间盘突出的严重程度相关。目的:评估单核苷酸变异和慢性机械性腰痛患者腰椎间盘突出严重程度的蛋白聚糖的代谢途径的基因的关联。方法:对60例慢性机械性腰痛患者进行了分类描述研究。T2加权正中矢状位腰椎MRI扫描评估椎间盘突出和椎间盘退变的严重程度。对凝集素代谢途径的2个候选基因(蛋白聚糖和基质金属蛋白酶3)的20个外显子单核苷酸变异进行了基因分型。对年龄、性别、体质量指数和椎间盘退变程度进行多元线性回归分析。试验于2015-03-01经定州市人民医院伦理委员会批准(批准号2015002)。结果与结论:蛋白聚糖的rs2272023、rs938609、rs2882676、rs698621、rs3825994、rs1042630和rs3817428突变体及其单倍型与腰椎间盘突出的严重程度有关。若要确定这些重要的单核苷酸变异在椎间盘突出症的发病机制中的作用,有必要进行功能遗传方面的研究。

关键词：椎间盘突出聚集蛋白基因多态性遗传基质金属蛋白酶慢性机械性腰痛蛋白聚糖基因分型

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa