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Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1496-1509页

作者： Yanhua Liu Xin Zhang Shu Yang Zhi Zhou Lu Tian Wanfang Li jinfeng wei Zeper Abliz Zhonghua Wang Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) National Ethnic Affairs CommissionBeijing100081China Center for Imaging and Systems Biology College of Life and Environmental SciencesMinzu University of ChinaBeijing100081China New Drug Safety Evaluation Center Institute of Materia MedicaPeking Union Medical CollegeBeijing100050China Key Laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing100081China

Diabetic cardiomyopathy(DCM)is a metabolic disease and a leading cause of heart failure among people with diabetes.Mass spectrometry imaging(MSI)is a versatile technique capable of combining the molecular specificity of mass spectrometry(MS)with the spatial information of imaging.In this study,we used MSI to visualize metabolites in the rat heart with high spatial resolution and sensitivity.We optimized the air flow-assisted desorption electrospray ionization(AFADESI)-MSI platform to detect a wide range of metabolites,and then used matrix-assisted laser desorption ionization(MALDI)-MSI for increasing metabolic coverage and improving localization resolution.AFADESI-MSI detected 214 and 149 metabolites in positive and negative analyses of rat heart sections,respectively,while MALDI-MSI detected 61 metabolites in negative analysis.Our study revealed the heterogenous metabolic profile of the heart in a DCM model,with over 105 region-specific changes in the levels of a wide range of metabolite classes,including carbohydrates,amino acids,nucleotides,and their derivatives,fatty acids,glycerol phospholipids,carnitines,and metal ions.The repeated oral administration of ferulic acid during 20 weeks significantly improved most of the metabolic disorders in the DCM model.Our findings provide novel insights into the molecular mechanisms underlying DCM and the potential of ferulic acid as a therapeutic agent for treating this condition.

关键词： Mass spectrometry imaging Diabetic cardiomyopathy Metabolic reprogramming Ferulic acid

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Coagulant compounds in Rubia cordifolia L.

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Journal of Future Foods 2023年第3期3卷 220-224页

作者： Peiqing Wang Jiajia Wang Fatma MEl-Demerdash jinfeng wei Huaihe Hospital Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Department of Environmental Studies Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria 21526Egypt Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China Henan Kaifeng College of Science Technology and Communication Kaifeng 475004China

Rubia cordifolia L.belongs to Rubiaceae family.Its medicinal parts are mainly root and rhizome,which is included in the Chinese Pharmacopoeia(2020),has the effect of cooling blood and stopping bleeding,removing stasis and channeling menstruation.However,studies on the hemostatic effect of R.cordifolia mainly focus on extracts,and the hemostatic components are less studied.Therefore,chemical constituents and coagulant activity of R.cordifolia were investigated in this paper.Eleven compounds were isolated and identified from R.cordifolia,including 1-hydroxy-2-methyl-9,10-anthraquinone(1),1,4-dihydroxy-2-methylanthraquinone(2),palmitic acid(3),tricosanoic acid(4),ω-hydroxypachybasin(5),ursolic acid(6),oleanolic acid(7),rubilactone(8),β-sitosterol(9),cordifoliol(10),1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone(11).ω-Hydroxypachybasin was isolated from Rubia genus for the first time.1,4-Dihydroxy-2-methylanthraquinone,rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time in vitro,thus indicating that they had procoagulant activity.

关键词： Rubia cordifolia L. Chemical constituents Coagulant activity

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Humic acid-mediated transport of a typical soil passivation remediation product(chloropyromorphite)in saturated porous media

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Journal of Environmental Sciences 2024年第7期141卷 51-62页

作者： Xinying Li Mengjia Zhang Siyuan Li wei wei School of Environment Jiangsu Engineering Lab of Water and Soil Eco-remediationJiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response TechnologyNanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China

Conversion of labile Pb species into chloropyromorphite(CPY)using phosphorus-bearing amendments was considered to be an ideal strategy in soil passivation remediation.However,the fate and transport of CPY in the soil are poorly understood.This study aims to fill the knowledge gap by evaluating the fate and transport of CPY under environmentally relevant conditions of humic acid(HA),pH,electrolyte concentration,and species through the saturated sandy medium.Results showed that bare CPY colloids are basically immobile in sandy porous media while the co-existence of HA made the transport of CPY improved by30%-93.5%.Facilitated transport of CPY was attributed to the increased stability of CPY and the repulsive interaction between CPY particles and sands due to HA adsorption.The mobility of CPY was also increased with increasing pH from 5.0 to 9.0.When the pH was 9 with a10 mmol/L NaCl background solution,the stronger energy barrier between CPY and sand led to enhanced transport behavior.The divalent Ca^(2+)had a more dramatic effect than monovalent Na^(+)on the aggregation and sedimentation of CPY colloids due to its effectivescreening of the surface charge of CPY and bridging interaction with CPY particles.Derjaguin-LandauVerwey-Overbeek theory and attachment efficiency calculation indicated that high energy barriers were responsible for the high mobility of CPY colloids,while the retention of CPY in sands was mainly caused by secondary energy minimum and physically straining.The findings of this work can help to evaluate the fate of soil passivation remediation products in natural water and soil.

关键词： Chloropyromorphite DLVO theory Stability Saturated porous medium Transport

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From Liquid to Solid‑State Lithium Metal Batteries:Fundamental Issues and Recent Developments

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Nano-Micro Letters 2024年第2期16卷 68-125页

作者： Zhao Zhang wei‑Qiang Han School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density requirements.Lithium metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density batteries.In this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in LMBs.Furthermore,we propose improved strategies involving interface engineering,3D current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these challenges.The utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing them.This review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid electrolytes.Particularly noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal batteries.Based on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.

关键词： Lithium metal batteries All-solid-state lithium metal battery Li dendrite Solid electrolyte Interface

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On-surface synthesis and characterization of polyynic carbon chains

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National Science Review 2024年第3期11卷 192-199页

作者： Wenze Gao wei Zheng Luye Sun Faming Kang Zheng Zhou wei Xu Interdisciplinary Materials Research Center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne

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A comprehensive review on mechanism of natural products against Staphylococcus aureus

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Journal of Future Foods 2022年第1期2卷 25-33页

作者： Yingying Zhao jinfeng wei Changqin Li Adel F.Ahmed Zhenhua Liu Changyang Ma National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Henan Kaifeng College of Science Technology and Communication(Minsheng College Henan University)Kaifeng 475004China Functional Food Engineering Technology Research Center of Henan Province Kaifeng 475004China Medicinal and Aromatic Plants Researches Department Horticulture Research InstituteAgricultural Research CenterCairo 11435Egypt Joint International Research Laboratory of Food&Medicine Resource Function of Henan Province Henan UniversityKaifeng 475004China

The abuse of antibiotics seriously threatens the therapeutic effect.Natural products from plants,antimicrobial peptides and micro-organisms have antibacterial activity against Staphylococcus aureus.The mechanism of natural products reported in recent years on S.aureus includes six types,which are the acting on bacterial cell wall,cytomembrane,metabolic pathway,protein,nucleic acid,biofilm and quorum sensing system to achieve antibacterial effect.This article summarized the mechanism of natural products reported in recent years on S.aureus.It is found that the natural products acting on cell wall or cell wall synthesis pathway key enzymes are relatively safe and highly selective.It has the prospect of developing into medicine and provides the clue to investigate and utilize natural products in antibacterial activity.

关键词： Natural products Staphylococcus aureus Antibacterial mechanism Enzymes Cell wall

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Nutrient transport following water transfer through the world's largest water diversion channel

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Journal of Environmental Sciences 2024年第1期135卷 703-714页

作者： Yuanhui Cheng Hong Zhang wei Yin State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085 China Changjiang Water Resources Protection Institute Wuhan 430051China University of Chinese Academy of Sciences Beijing 100049China

Nutrient levels in the artificial channel constructed for the Middle Route Project are significant indicators of water quality safety and aquatic ecological integrity for this large,interbasin scheme.However,the distribution and transport of nutrients along the channel were poorly understood.Based on a time-series dataset as well as mass balance and material flow analysis methods,the water and nutrient transport fluxes in the Middle Route of the South-to-North Water Diversion Project were identified in this study.The results indicate that the nutrient concentrations varied considerably with time,but there was no significant difference among the 30 stations of the main channel.Seasonal temperature difference was the major factor in the large fluctuations of water quality indicators over time.The nutrient loadings varied with the water volume outputs from the main channel to the waterreceiving cities.Atmospheric deposition was an important source of nutrients in the main channel,accounting for 9.13%,20.6%,and 0.635%of the nitrogen,phosphorus,and sulfur input from the Danjiangkou Reservoir,respectively.In 2021,a net accumulation of 988 tons of N,29 tons of P,and 2,540 tons of S,respectively,were present in the main channel.The increase of these external and internal nutrient loadings would cause water quality fluctuation and deterioration in some local sections of the main channel.Our study quantified the spatial and temporal patterns of nutrient transport in the Middle Route and revealed the ecological effects on the aquatic environment,assisting authorities on the project to develop effective water conservation strategies.

关键词： Nutrient transport Spatiotemporal patterns The Middle Route The South-to-North Diversion Project Hydro-ecological effects Water-receiving cities

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Comparison of antimony and arsenic behaviour at the river-lake junction in the middle of the Yangtze River Basin

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Journal of Environmental Sciences 2024年第2期136卷 189-200页

作者： Huiji Liu wei Zeng Ziyang Lai Mengchang He Chunye Lin wei Ouyang Xitao Liu State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

As typical metalloid toxic elements widely distributed in environmental media,the geochemical behaviour of antimony(Sb)and arsenic(As)affects environmental safety.We selected the surface waters and sediments at the river-lake junction of Dongting Lake as the research objects,analysed the concentration and chemical partitioning of Sb and As,assessed its contamination and ecological risk levels,and discussed its sources and potential influencing factors.The concentrations of dissolved Sb and As in surface waters were low(<5.46μg/L),and the concentrations of Sb and As in surface sediments were 2.49-22.65mg/kg and 11.10-136.34 mg/kg,respectively.Antimony and As in sediments were mainly enriched in the fraction of residues,but the proportion of As in bioavailability was significantly higher than that of Sb.Although the contamination level of Sb was higher than that of As,the risk assessment code(RAC)showed that the ecological risk level of As was higher than that of Sb.Rainwater erosion and mining activities(in the midstream of Zijiang River)were the main contaminated sources of Sb,while As was affect mainly by rainwater erosion.The contamination and ecological risk of Sb in the inlet of the Zijiang River should receive considerable attention,while those of As in the inlet of the Xiangjiang River should also be seriously considered.This study highlights the need for multi-index-based assessments of contamination and ecological risk and the importance of further studies on the environmental behaviour of metalloids in specific hydrological conditions,such as river-lake junctions.

关键词： Contamination Ecological risks Antimony(Sb) Arsenic(As) River-lake junction Dongting Lake

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The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating Link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： wei LIN School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the links.Based on this result,he was able to argue the hyperbolicity of non-split prime alternating links in S3.Adams et al.showed that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of L.The author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

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High Speed Sintering:Assessing the Influence of Energy Input on Microstructure and Mechanical Properties of Polyether Block Amide(PEBA)Parts

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Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： Jiang-Tao Sun Zhi-Yong Fan Yi-wei Mao wei Li wei Zhu Dao-Sheng Cai Qing-Song wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer powders.The presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy input.This study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA parts.The parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to high.Subsequebtly,they underwent testing using Archimedes’method,followed by tensile testing.The porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore formation.Using the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,respectively.When the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

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