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A Prognostic Nomogram with High Accuracy Based on 2D-SWE in Patients with Acute-on-chronic Liver Failure

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 803-813页

作者： Lili Wu Jieyang Jin Taicheng Zhou Yuankai Wu Xinhua Li Xiangyong Li Jie Zeng jinfen wang Jie Ren Yutian Chong Rongqin Zheng Department of Medical Ultrasonics Third Affiliated Hospital of Sun Yat-Sen UniversityGuangdong Key Laboratory of Liver Disease ResearchGuangzhouGuangdongChina Department of Gastroenterological Surgery and Hernia Center Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesSupported by National Key Clinical DisciplineGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina

Background and Aims:Acute-on-chronic liver failure(ACLF)is associated with very high mortality.Accurate prediction of prognosis is critical in navigating optimal treatment decisions to improve patient survival.This study was aimed to develop a new nomogram integrating two-dimensional shear wave elastography(2D-SWE)values with other independent prognostic factors to improve the precision of predicting ACLF patient outcomes.Methods:A total of 449 consecutive patients with ACLF were recruited and randomly allocated to a training cohort(n=315)or a test cohort(n=134).2D-SWE values,conventional ultrasound features,laboratory tests,and other clinical characteristics were included in univariate and multivariate analysis.Factors with prognostic value were then used to construct a novel prognostic nomogram.Receiver operating curves(ROCs)were generated to evaluate and compare the performance of the novel and published models including the Model for EndStage Liver Disease(MELD),MELD combined with sodium(MELD-Na),and Jin’s model.The model was validated in a prospective cohort(n=102).Results:A ACLF prognostic nomogram was developed with independent prognostic factors,including 2D-SWE,age,total bilirubin(TB),neutrophils(Neu),and the international normalized ratio(INR).The area under the ROC curve(AUC)was 0.849 for the new model in the training cohort and 0.861 in the prospective validation cohort,which were significantly greater than those for MELD(0.758),MELD-Na(0.750),and Jin’s model(0.777,all p<0.05).Calibration curve analysis revealed good agreement between the predicted and observed probabilities.The new nomogram had superior overall net benefit and clinical utility.Conclusions:We established and validated a 2D-SWE-based noninvasive nomogram to predict the prognosis of ACLF patients that was more accurate than other prognostic models.

关键词： Acute-on-chronic liver failure Two-dimensional shear wave elastography Hepatitis B virus Prognosis

列宁在俄国发展道路问题上对自由主义民粹派的批判及其启示

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当代世界与社会主义 2024年第1期 83-89页

作者：王进芬杜倩雯广西师范大学马克思主义学院

19世纪末20世纪初,“俄国向何处去”成为俄国思想界激烈争论的焦点问题。自由主义民粹派主张俄国不经过资本主义,而是通过完善俄国村社直接过渡到社会主义。列宁对此进行了深刻的批判,围绕俄国发展道路提出了一系列重要的思想主张:批判... 详细信息

19世纪末20世纪初,“俄国向何处去”成为俄国思想界激烈争论的焦点问题。自由主义民粹派主张俄国不经过资本主义,而是通过完善俄国村社直接过渡到社会主义。列宁对此进行了深刻的批判,围绕俄国发展道路提出了一系列重要的思想主张:批判自由主义民粹派贬低资本主义历史作用和崇尚农村公社的错误观点,阐明资本主义在俄国社会发展中的必然性和进步性;批判自由主义民粹派主张“农民主体论”和“知识分子领导论”的错误倾向,强调无产阶级及其先进代表才是推动俄国社会发展的领导力量;批判自由主义民粹派虚假的人民性,主张俄国发展道路的选择要以实现人民群众利益和依靠人民群众为出发点,具有重要的现实指导意义。

关键词：列宁俄国社会发展道路自由主义民粹派

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考虑极地船舶航行风险的A*路径规划算法

中国航海 2024年第2期47卷 19-24页

作者：张金奋王志康吴达韩冰武汉理工大学国家水运安全工程技术研究中心武汉理工大学智能交通系统研究中心中国远洋海运集团有限公司院士工作站

传统A*算法没有考虑海冰带来的航行风险因素，无法直接应用于北极船舶路径规划。针对这一问题，引入极地航行限制评估风险指标系统（POLARIS）风险模型，通过分析网格化的海冰密集度和海冰厚度数据，建立北极通航风险模型，制作航行风... 详细信息

传统A*算法没有考虑海冰带来的航行风险因素，无法直接应用于北极船舶路径规划。针对这一问题，引入极地航行限制评估风险指标系统（POLARIS）风险模型，通过分析网格化的海冰密集度和海冰厚度数据，建立北极通航风险模型，制作航行风险地图，从添加风险损失函数和优化启发函数两个方面改进传统A*算法，提出Risk-A*路径规划算法，实现风险和效率不同偏好下的最优航线规划。仿真结果表明：Risk-A*路径规划算法在航线长度、穿过风险水域的数量等方面与传统算法相比具有较大的优势，可为船舶北极航行提供安全高效的路径。

关键词：路径规划海冰密集度 A~*算法极地航行限制评估风险指标系统通航风险

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西北自驾旅游流转移扩散规律研究

干旱区资源与环境 2024年第1期38卷 200-208页

作者：张瑶吴晋峰王子豪屈雪雅石晓腾陕西师范大学地理科学与旅游学院西安710119

西北地区远离中国主要旅游客源市场区,为什么近年来越来越受自驾旅游者青睐?距离衰减规律失灵了吗?应用UGC和问卷调查数据,对西北自驾旅游流转移扩散规律进行研究。发现:1)西北地区自驾游空间广阔,80%以上的自驾线路“行游比”介于0.5-... 详细信息

西北地区远离中国主要旅游客源市场区,为什么近年来越来越受自驾旅游者青睐?距离衰减规律失灵了吗?应用UGC和问卷调查数据,对西北自驾旅游流转移扩散规律进行研究。发现:1)西北地区自驾游空间广阔,80%以上的自驾线路“行游比”介于0.5-0.7之间,具备吸引长途自驾旅游者的客观条件。2)西北地区自然和文化景观优美独特,对1500km以外地区的远程出游市场具有强大吸引力,导致距离衰减规律表面上“失灵”。3)90%的西北自驾游线路距离超过2000km,用时8-10天,平均串连9个目的地,主要模式为“区域环游式”和“锁链式”。4)西北自驾旅游流的扩散场在“胡线”东南,以京津唐、长三角和珠三角为核心区,集聚场以“大环线”为骨架,以西宁、海西州、海南州、酒泉等12个节点为枢纽,呈现“嘉峪关阻断”现象。

关键词：西北地区自驾旅游流旅游流网络扩散

Flexible and biocompatible nanopaper-based electrode arrays for neural activity recording

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Nano Research 2018年第10期11卷 5604-5614页

作者： Yichuan Guo Zhiqiang Fang Mingde Du Long Yang Leihou Shao Xiaorui Zhang Li Li Jidong Shi Jinsong Tao jinfen wang Hongbian Li Ying Fang CAS Key Laboratory for Biomedical Effects of Nanomatefials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China Department of Neurobiology David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA CAS Center for Excellence in Brain Science and Intelligence Technology 320 Yue Yang Road Shanghai 200031 China

Advances in neural electrode technologies can have a significant impact on both fundamental and applied neuroscience. Here, we report the development of flexible and biocompatible neural electrode arrays based on a nanopaper substrate. Nanopaper has important advantages with respect to polymers such as hydrophilicity and water wettability, which result in significantly enhanced biocompatibility, as confirmed by both in vitro viability assays and in vivo histological analysis. In addition, nanopaper exhibits high flexibility and good shape stability. Hence, nanopaper-based neural electrode arrays can conform to the convoluted cortical surface of a rat brain and allow stable multisite recording of epileptiform activity in vivo. Our results show that nanopaper-based electrode arrays represent promising candidates for the flexible and biocompatible recording of the neural activity.

关键词： nanopaper neural electrode biocompatibility flexible epilepsy

Direct generation of 3.17 mJ green pulses in a cavity-dumped Ho^(3+)-doped fiber laser at 543 nm

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Photonics Research 2023年第3期11卷 413-419页

作者： TIANRAN LI ZIYU wang JINHAI ZOU jinfen HONG QIUJUN RUAN HANG wang ZHIPENG DONG ZHENGQIAN LUO Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen UniversityXiamen 361005China Department of Electronic Engineering Xiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518129China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

High-energy pulsed lasers in the green spectral region are of tremendous interest for applications in space laser ranging,underwater detection,precise processing,and scientific research.Semiconductor pulsed lasers currently are difficult to access to the so-called“green gap,”and high-energy green pulsed lasers still heavily rely on the nonlinear frequency conversion of near-IR lasers,precluding compact and low-cost green laser systems.Here,we address this challenge by demonstrating,for the first time to the best of our knowledge,millijoule-level green pulses generated directly from a fiber laser.The green pulsed fiber laser consists of a 450 nm pump laser diode,a Ho^(3+)-doped ZBLAN fiber,and a cavity-dumping module based on a visible wavelength acousto-optic modulator.Stable pulse operation in the cavity-dumping regime at 543 nm is observed with a tunable repetition rate in a large range of 100 Hz–3 MHz and a pulse duration of 72–116 ns.The maximum pulse energy of 3.17 mJ at 100 Hz is successfully achieved,which is three orders of magnitude higher than those of the rare-earth-doped fiber green lasers previously reported.This work provides a model for compact,high-efficiency,and high-energy visible fiber pulsed lasers.

关键词： fiber laser pump

3.6 W compact all-fiber Pr3+-doped green laser at 521 nm

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Advanced Photonics 2022年第5期4卷 6-14页

作者： Jinhai Zou jinfen Hong Zhuang Zhao Qingyuan Li Qiujun Ruan Hang wang Yikun Bu Xianchao Guan Min Zhou Zhiyong Feng Zhengqian Luo Xiamen University School of Electronic Science and EngineeringFujian Key Laboratory of Ultrafast Laser Technology and ApplicationsXiamenChina Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) XiamenChina Huawei Technologies Co. Ltd.ShenzhenChina Xiamen University Shenzhen Research InstituteShenzhenChina

Green semiconductor lasers are still undeveloped,so high-power green lasers have heavily relied on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost green laser systems.Here,we report the first Watt-level all-fiber CW Pr3t-doped laser operating directly in the green spectral region,addressing the aforementioned difficulties.The compact all-fiber laser consists of a double-clad Pr3t-doped fluoride fiber,two homemade fiber dichroic mirrors at visible wavelengths,and a 443-nm fiber-pigtailed pump source.Benefitting from>10 MW∕cm2 high damage intensity of our designed fiber dielectric mirror,the green laser can stably deliver 3.62-W of continuous-wave power at∼521 nm with a slope efficiency of 20.9%.To the best of our knowledge,this is the largest output power directly from green fiber lasers,which is one order higher than previously reported.Moreover,these green all-fiber laser designs are optimized by using experiments and numerical simulations.Numerical results are in excellent agreement with our experimental results and show that the optimal gain fiber length,output mirror reflectivity,and doping level should be considered to obtain higher power and efficiency.This work may pave a path toward compact high-power green all-fiber lasers for applications in biomedicine,laser display,underwater detection,and spectroscopy.

关键词： fiber laser high power Pr3+-doped fiber green light

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列宁维护党的集中统一的历史经验

马克思主义理论学科研究 2022年第12期8卷 67-76页

作者：王进芬广西师范大学马克思主义学院广西桂林541004 广西马克思主义理论研究和建设工程(广西师范大学)基地

列宁在维护无产阶级政党的集中统一方面,积累了宝贵的历史经验,包括坚持以马克思主义原则为基础的思想统一;坚持民主集中制原则基础上的组织统一;坚决维护党中央权威以实现党的行动统一;完善党的领导制度和加强集体领导,防止党的高层发... 详细信息

列宁在维护无产阶级政党的集中统一方面,积累了宝贵的历史经验,包括坚持以马克思主义原则为基础的思想统一;坚持民主集中制原则基础上的组织统一;坚决维护党中央权威以实现党的行动统一;完善党的领导制度和加强集体领导,防止党的高层发生分裂等,这些经验对中国共产党的建设和发展产生了深远影响。

关键词：列宁集中统一历史经验

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先进典型对新时代爱国主义教育的引领作用

长白学刊 2022年第3期 26-32页

作者：王进芬林意章广西师范大学马克思主义学院广西桂林541000

先进典型是最坚定最忠实的爱国者,他们承载着重要的爱国主义教育功能,是党在新时代开展爱国主义教育的重要资源。先进典型以鲜明的政治属性、强烈的民族精神、平凡的群众气息以及显著的导向功能等基本特征成为爱国主义教育的特殊载体。... 详细信息

先进典型是最坚定最忠实的爱国者,他们承载着重要的爱国主义教育功能,是党在新时代开展爱国主义教育的重要资源。先进典型以鲜明的政治属性、强烈的民族精神、平凡的群众气息以及显著的导向功能等基本特征成为爱国主义教育的特殊载体。先进典型是具有“人格化”的爱国主义教育的生动教材,他们为中华民族奋力向前提供的精神动力是爱国主义教育的宝贵财富,他们在思想和行动上为人民热爱祖国树立了榜样。营造新时代爱国主义教育的浓厚氛围,应遵循树立、宣传和学习先进典型的逻辑理路,在坚持真实性、代表性、扶持性等原则上树立先进典型,通过确定宣传对象、明确宣传需求、选择宣传渠道和设立宣传目标等宣传先进典型,并且明确学习先进典型的主要内容和基本要求,以此强化先进典型在新时代爱国主义教育中的引领作用。

关键词：榜样先进典型爱国主义爱国主义教育精神财富