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Science Bulletin 2017年第11期62卷 748-751页

作者： Lanzhi He Ping Yin Yakun Meng jinfa tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao China Military Institute of Chinese Medicine 302 Military Hospital Beijing 100039 China School of Pharmacy Hunan University of Traditional Chinese Medicine Changsha 410208 China Integrative Medical Center 302 Military Hospital Beijing 100039 China

Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ-

关键词：肝损伤二苯乙烯苷增效机制异性反式免疫临床病例毒性剂量

New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions

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Frontiers of Medicine 2020年第1期14卷 68-80页

作者： Yuan Gao Zhilei Wang jinfa tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China China Military Institute of Chinese Materia the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000China School of Pharmacy Jiangxi University of Traditional Chinese MedicineJiangxi 330004China National Institutes for Food and Drug Control Beijing 100050China Research Center for Clinical and Translational Medicine the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China Integrative Medical Centre the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China

Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent *** pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)*** present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS *** function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated ***,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated ***,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic ***,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 *** addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic ***,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions.

关键词： Epimedii Folium Psoraleae Fructus idiosyncratic hepatotoxicity traditional Chinese medicine incompatibility

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,Polygonum multiflorum

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Frontiers of Medicine 2021年第2期15卷 330-332页

作者： Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng jinfa tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang China Military Institute of Chinese Medicine 302 Military HospitalBeijing 100039China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Integrative Medical Center 302 Military HospitalBeijing 100039China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Diagnosis and Treatment Center for Non-infectious Diseases 302 Military HospitalBeijing 100039China Beijing Union University Beijing 100101China Shanxi University of Traditional Chinese Medicine Taiyuan 030619China

Erratum to Frontiers of Medicine 201711(2):253–265 https://***/10.1007/s11684-017-0508-9 The original version of this article unfortunately contained some *** panel of“LPS–/drug–”in Fig.3B(Page 259),the panels of“LPS–/EtoAc+”and“LPS–/Residue+”in Supplementary Fig.3(Page 7 in the online supplementary materials)should be *** authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.

关键词： Medicine hepato corrected

Fuyang City Countryside Potable Water *** Situation and Improvement Safety of Water Measure No Matter What Golden Law

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Fuyang City Countryside Potable Water *** Situation and Impr...

2007中国科协年会

作者： Ren jinfa tang Lanjuan Zhejiang Province Fuyang City Centers for Disease Control and Prevention(311400)

goal:Since understood the 80’s have developed the countryside to change the water the inhabitant tap water water quality present situation and the potable water difficult ***:Through hygienic,the water conservation water and electricity department investigation and 8 year countryside tap water monitor;grasps the countryside tap water ***:The counnyside potable water existence water source pollution serious,water technology backwardness,the disinfection facility not entire and lose security hidden dangers and so on distribution network of water supply ***:And creates“lacks the water”many kinds of reasons in view of the potable water security hidden danger,proposed the near future effective will guard against system countermeasure and in three years solves 226 villages,182,000 human of potable water difficult problems with emphasis.

关键词： The countryside changes the water Water pollution The potable water difficult problem Security measure

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薄膜晶体管液晶投影仪中的偏振分色薄膜

光学学报 1999年第6期19卷 791-794页

作者：章岳光顾培夫刘旭唐晋发浙江大学现代光学仪器国家重点实验室

介绍了用于薄膜晶体管液晶投影仪显示的偏振光分色系统，用多层光学薄膜实现了分色功能，并对薄膜的设计。

关键词：光学薄膜液晶大屏幕显示偏振分色薄膜晶体管

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薄膜滤光片的光学稳定性研究

光子学报 2001年第5期30卷 576-580页

作者：白胜元顾培夫刘旭唐晋发浙江大学现代光学仪器国家重点实验室浙江大学光电系310027

薄膜滤光片中心波长的稳定性是非常重要的参量 .这不仅取决于膜层的聚集密度 ,而且与薄膜材料和基板的折射率温度系数及线性膨胀系数有着紧密的关系 .本文根据滤光片的实验参量 ,分析计算了它们对滤光片中心波长漂移影响的大小。

关键词：光学薄膜带通滤光片光学稳定性波长薄膜滤光片漂移聚集密度折射率温度系数线性膨胀系数

用稀土金属铽的有机配合物Tb(acac)_2(AA)phen做发光层的电致发光薄膜的研究

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光子学报 2001年第3期30卷 304-310页

作者：范希智陈君凌启淡刘旭顾培夫唐晋发浙江大学现代光学仪器国家重点实验室杭州310027 浙江大学高分子化学与工程学系杭州310027

研究了稀土铽的有机配合物 (Tb(acac) 2 (AA) phen的光致发光特性 ,用 Tb(acac) 2(AA) phen做发光层 ,分别用 N,N′-双 (3-甲苯 ) - N,N′-二苯联苯胺 (TPD)和聚乙烯基咔唑(PVK)做空穴传输层研制了有机电致发光薄膜器件 ,研究了它们的... 详细信息

研究了稀土铽的有机配合物 (Tb(acac) 2 (AA) phen的光致发光特性 ,用 Tb(acac) 2(AA) phen做发光层 ,分别用 N,N′-双 (3-甲苯 ) - N,N′-二苯联苯胺 (TPD)和聚乙烯基咔唑(PVK)做空穴传输层研制了有机电致发光薄膜器件 ,研究了它们的电致发光特性 .

关键词：电致发光有机薄膜稀土金属有机配合物光致发光铽配合物

The　Optical　Implementation　of　High　Efficiency　Packed　Redundant　Binary　Number　Addition　Based　on　Boolean　Polarization－encoded　Logic　Algebra

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Chinese Journal of Lasers 1996年第3期 268-275页

作者： WANG Bin YU Feihong LIU Xu GU Peifu tang jinfa(State Key Laboratory of Modern Optical Instrument, Optical Engineering Department,Zhejiang University, Hangzhou 310027, China)

Ｔｈｅ　Ｏｐｔｉｃａｌ　Ｉｍｐｌｅｍｅｎｔａｔｉｏｎ　ｏｆ　Ｈｉｇｈ　Ｅｆｆｉｃｉｅｎｃｙ　Ｐａｃｋｅｄ　Ｒｅｄｕｎｄａｎｔ　Ｂｉｎａｒｙ　Ｎｕｍｂｅｒ　Ａｄｄｉｔｉｏｎ　Ｂａｓｅｄ　ｏｎ　Ｂｏｏｌｅａｎ　Ｐｏｌａｒ... 详细信息

Ｔｈｅ　Ｏｐｔｉｃａｌ　Ｉｍｐｌｅｍｅｎｔａｔｉｏｎ　ｏｆ　Ｈｉｇｈ　Ｅｆｆｉｃｉｅｎｃｙ　Ｐａｃｋｅｄ　Ｒｅｄｕｎｄａｎｔ　Ｂｉｎａｒｙ　Ｎｕｍｂｅｒ　Ａｄｄｉｔｉｏｎ　Ｂａｓｅｄ　ｏｎ　Ｂｏｏｌｅａｎ　Ｐｏｌａｒｉｚａｔｉｏｎ－ｅｎｃｏｄｅｄ　Ｌ...

关键词： packed redundant binary number boolean polarization-encoded logic algebra optical computing

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光学薄膜吸收损耗的研究

光学学报 1989年第8期9卷 741-745页

作者：吴周令范正修唐晋发中国科学院上海光学精密机械研究所浙江大学光仪系

用横向光热偏转技术研究光学薄膜的吸收损耗.结果表明:对ZrO_2、MgF_2、ZnS等单层膜,薄膜-基底界面吸收、空气-薄膜界面吸收以及薄膜体内吸收三者处于同一量级,而对TiO_2、Ta_2O_5、SiO_2等样品,薄膜-基底界面吸收远大于空气-薄膜界面... 详细信息

用横向光热偏转技术研究光学薄膜的吸收损耗.结果表明:对ZrO_2、MgF_2、ZnS等单层膜,薄膜-基底界面吸收、空气-薄膜界面吸收以及薄膜体内吸收三者处于同一量级,而对TiO_2、Ta_2O_5、SiO_2等样品,薄膜-基底界面吸收远大于空气-薄膜界面吸收及薄膜体内吸收,是吸收损耗的主要来源.

关键词：吸收损耗光热偏转光谱光学薄膜

树鼩黑质至上丘的γ氨基丁酸能和多巴胺能阳性纤维投射

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解剖学杂志 2001年第1期24卷 57-60页

作者：李燕华檀进发柯明华广西医科大学解剖学教研室南宁530021

目的 :研究树黑质至上丘的γ 氨基丁酸 (γ aminobutyricacid ,GABA)能和多巴胺 (Depamine ,DOPA)能阳性纤维投射。方法 :采用荧光金 (Fluoro Gold ,FG)逆行追踪分别与GABA和DOPA免疫组化相结合技术。结果 :在树双侧黑质的致密部、... 详细信息

目的 :研究树黑质至上丘的γ 氨基丁酸 (γ aminobutyricacid ,GABA)能和多巴胺 (Depamine ,DOPA)能阳性纤维投射。方法 :采用荧光金 (Fluoro Gold ,FG)逆行追踪分别与GABA和DOPA免疫组化相结合技术。结果 :在树双侧黑质的致密部、网状部和外侧部均观察到FG逆行标记细胞 ;双侧黑质的网状部除向上丘发出GABA能纤维投射外 ,同侧黑质网状部还向上丘发出DOPA能纤维投射。此外 ,在同侧黑质的致密部 ,还观察到少量的向上丘投射的DOPA能神经元。结论 :黑质向上丘的GABA和DOPA能阳性纤维投射为阐明黑质的生理功能提供形态学依据。

关键词：黑质上丘树Qu γ-氨基丁酸能多巴胺能纤维投射神经元