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The formation of autophagosomes at ER-PM contact sites in concert with the actin cytoskeleton and the endocytic machinery

The formation of autophagosomes at ER-PM contact sites in co...

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2018全国植物生物学大会

作者： Pengwei Wang Roman Pleskot Jingze Zang Joanna Winkler Jie Wang Klaas Yperman Jinli Gong Kun Wang Yajie Guan Patrick Duckney Christine Richardson Michael VANDorpe jindriska fiserova Daniel Van Damme Patrick J.Hussey Key Laboratory of Horticultural Plant Biology (MOE) College of Horticulture and Forestry SciencesHuazhong Agricultural University Department of Biosciences Durham University Ghent University Department of Plant Biotechnology and Bioinformatics Department of Biology of the Cell Nucleus Institute of Molecular Genetics CAS

Plants evolved their own strategy to form the essential link between the endoplasmic reticulum(ER) and the plasma membrane(PM) through a complex including NET3 C and VAP27(Wang et al 2014,Curr Biol).However,the function of plant ER-PM contact sites has not been fully *** this study,we have identified a function for ER-PM contact sites(EPCS) in plants and that is in the autophagosome biogenesis pathway,in concert with actin cytoskeleton and the Arabidopsis EH ***1 and AtEH2 are components of the endocytic TPLATE complex which is known to be essential for endocytosis in plants(Gadeyne et al.,2014,Cell).Both proteins(from now on termed AtEH/Pan1) share high sequence similarity with the yeast ARP2/3 complex activator,Pan1 *** AtEH/Panl proteins localise to the plasma membrane and autophagosomes,and their autophagosome membrane recruitment requires its N-terminal EH domains which interact with *** induction of autophagy,AtEH/Pan1 proteins recruit TPC and AP-2 subunitsand ARP2/3 proteins onto the autophagosome *** expression of AtEH1/Pan1 boosts autophagosome formation and suggest independent and redundant pathways for actin mediated autophagy in ***,AtEH/Pan1 regulated autophagosomes are found associated with EPCS where AtEH/Panl interacts with *** knock-down expression of either AtEH/Pan1 or VAP27-1 are more susceptible to nutrient depleted conditions,indicating defective *** conclusion,our results suggest that AtEH/Pan1 proteins regulate an autophagosome-dependent degradation pathway which starts at the EPCS through its interaction with VAP27-1 and merges with endocytic pathways.

关键词： Membrane contact sites Autophagy Actin cytoskeleton Panlp TPLATE

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