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Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： jinbo hu Wen Liu Yi Zou Chenyang Jiao Jiazhen Zhu Qiang Xu Jianjun Zou Yang Sun Wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator

A Catalog of ^(13)CO Clumps from the MWISP in l=10°–20°

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Research in Astronomy and Astrophysics 2024年第5期24卷 218-234页

作者： Xiaoyu Luo Sheng Zheng Zhibo Jiang Zhiwei Chen Yao huang Shuguang Zeng Xiangyun Zeng Rui Zhang Chen Long Guangrong Zhou jinbo hu Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443000China College of Electrical Engineering and New Energy China Three Gorges UniversityYichang 443000China College of Science China Three Gorges UniversityYichang 443000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

In this study, we present a catalog of molecular clumps extracted from ^(13)CO(J=1-0) emission data of the Milky Way Imaging Scroll Painting(MWISP) project. The data covers the inner Milky Way within the longitude range10°≤l≤20° and the latitude strip of |b|≤ 5°. 25. The workflow for the extraction of clumps, namely Facet-SS-3DClump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3DClump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s^(-1). We observe a significant deviation of the mean Galactic latitude for clumps within |b|≤ 2° from the midplane, with b=-0°.110. We found that 82.3% of the dust clumps correspond to ^(13)CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect ^(13)CO clumps in the entire MWISP data.

关键词： ISM molecules methods data analysis-stars formation

Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions

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CCS Chemistry 2024年第1期6卷 165-176页

作者： huanhuan Song Weihao Li Xiaoying Wang Kaiteng Wang Jingwen Li Shuai Liu Pin Gao Xin-hua Duan jinbo hu Mingyou hu School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Key Laboratory of Sustainable Energy Material ChemistryXi’an Jiaotong UniversityXi’an 710049 Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032

A general method for the synthesis of bench-stable bis(difluoromethyl)pentacoordinate phosphoranes has been *** reaction is rapid,operationally simple,and easily *** pentacoordinate phosphoranes can generate both difluoromethyl radical(·CF_(2)H)and difluorocarbene(:CF_(2))***,a variety of fluoroalkylation transformations havebeen achieved by·CF_(2)H,such asoxidativedifluoromethylation of electron-deficient heterocycles,nickel/photoredox dual-catalyzed difluoromethylation of aryl bromides,and photoredox difluoromethylation of alkenes,or by:CF_(2),such as gem-difluorocyclopropanation of alkenes,base-promoted difluoromethylation of heteroatom nucleophiles,Pd-catalyzed difluoromethylation of arylboronic acids,and Cu-mediated trifluoromethylation of aryl iodides(via:CF_(2) and recombined CF_(3)-).These fluoroalkylation methods have been successfully applied to late-stage fluoroalkylation of drugs and drug-like molecules.

关键词： pentacoordinate phosphorane difluoromethyl radical difluorocarbene difluoromethylation fluoroalkylation

原发性醛固酮增多症合并亚临床库欣综合征的临床特征及预后分析

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中华内科杂志 2024年第4期63卷 378-385页

作者：廖云艳宋颖胡金波杨淑敏郑燕李启富重庆医科大学附属第一医院内分泌科重庆400016 重庆垫江县人民医院内分泌科重庆408300

目的分析原发性醛固酮增多症(PA)合并亚临床库欣综合征(SCS)患者的临床特征及预后。方法回顾性队列研究。收集2014年1月至2022年12月重庆医科大学附属第一医院收治的PA患者的临床资料。根据1 mg过夜地塞米松抑制试验结果将患者分成单纯P... 详细信息

目的分析原发性醛固酮增多症(PA)合并亚临床库欣综合征(SCS)患者的临床特征及预后。方法回顾性队列研究。收集2014年1月至2022年12月重庆医科大学附属第一医院收治的PA患者的临床资料。根据1 mg过夜地塞米松抑制试验结果将患者分成单纯PA组和PA合并SCS(PA/SCS)组,分析两组间的人口学信息、激素水平及随访结果等。采用独立样本t检验、χ^(2)检验、Mann-WhitneyU检验等进行组间比较。结果共纳入489例PA患者,其中109例(22.3%)为PA/SCS患者。与单纯PA组相比,PA/SCS组年龄更大[(54.4±10.7)岁比(47.4±11.0)岁,P<0.001],女性比例更多[69.7%(76/109)比57.4%(218/380),P=0.020],高血压病程更长[96(36,180)个月比60(12,120)个月,P=0.001]。单纯PA组和PA/SCS组分别有215例和51例完成手术及随访。PA/SCS组皮质醇自主分泌完全缓解率为85.3%(29/34),醛固酮自主分泌完全缓解率与单纯PA组相当[94.1%(48/51)比94.4%(203/215),P=1.000];而PA/SCS组的临床完全缓解率低于单纯PA组[39.2%(20/51)比61.9%(133/215),P=0.003]。结论在PA患者中SCS较为多见(22.3%),其术后临床完全缓解率较低。推荐对所有PA患者采用1 mg过夜地塞米松抑制试验进行筛查。

关键词：醛固酮增多症预后亚临床库欣综合征临床特征

Mn对Ru/SiO_(2)催化2,5-己二酮与伯胺合成N-取代-2,5-二甲基吡咯烷的促进作用

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石油化工 2024年第7期53卷 940-946页

作者：胡锦波钟齐锋陈诗怡吴海梅刘迎新浙江工业大学药学院浙江杭州310014

采用共浸渍法制备了Mn掺杂的Ru/SiO_(2)催化剂,将其用于2,5-己二酮与伯胺经Paal-Knorr/加氢级联反应合成N-取代-2,5-二甲基吡咯烷,利用XRD,TEM,NH3-TPD,XPS等方法探究了Mn对催化剂结构和性质的影响,并考察了催化剂的稳定性与适用性。实... 详细信息

采用共浸渍法制备了Mn掺杂的Ru/SiO_(2)催化剂,将其用于2,5-己二酮与伯胺经Paal-Knorr/加氢级联反应合成N-取代-2,5-二甲基吡咯烷,利用XRD,TEM,NH3-TPD,XPS等方法探究了Mn对催化剂结构和性质的影响,并考察了催化剂的稳定性与适用性。实验结果表明,Mn掺杂可提高催化剂中Ru纳米粒子的分散度和催化剂的酸性位,进而提高催化剂的性能。当Ru/Mn摩尔比为1∶2时,催化剂的催化活性最高,在H2O溶剂中130℃、氢气压力3 MPa下反应90 min,2,5-己二酮转化率和N-丁基-2,5-二甲基吡咯烷的收率均达到100%。催化剂重复使用9次后仍保持高活性,且催化剂具有良好的普适性,为N-取代吡咯烷类化合物的绿色合成提供了一种新思路。

关键词： 2,5-己二酮 N-取代吡咯烷 RuMn/SiO_(2)催化剂级联反应生物质

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浅谈达芬奇机器人器械的保养方法

赤峰学院学报（自然科学版） 2024年第2期40卷 23-26页

作者：胡金波倪伟侠邵亚东赤峰市医院内蒙古赤峰024000 赤峰学院内蒙古赤峰024000

随着科技的进步和社会经济的发展,达芬奇机器人被广泛应用于外科手术中。为了减少达芬奇机器人器械臂发生故障、降低科室维护费用,本文分析了达芬奇机器人的使用现状,并据此提出了注重器械规范化使用、提升培训人员专业技能、采取责任... 详细信息

随着科技的进步和社会经济的发展,达芬奇机器人被广泛应用于外科手术中。为了减少达芬奇机器人器械臂发生故障、降低科室维护费用,本文分析了达芬奇机器人的使用现状,并据此提出了注重器械规范化使用、提升培训人员专业技能、采取责任制管理模式以及创建专业化消毒供应中心等一系列措施。多样化的解决措施能够有效减少对器械的损害,延长机械臂的使用寿命。同时,本文总结了保养达芬奇机器人器械臂及其他配套设施的相关经验,供初步开展机器人手术的护理同仁借鉴。

关键词：达芬奇机器人器械臂保养维护清洗消毒

Switching from 2-pyridination to difluoromethylation:ligand-enabled nickel-catalyzed reductive difluoromethylation of aryl iodides with difluoromethyl 2-pyridyl sulfone

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中国科学:化学英文版 2023年第10期66卷 2785-2790页

作者： Wei Du Qinyu Luo Zhiqiang Wei Xiu Wang Chuanfa Ni jinbo hu Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China

The divergent reductive cross-coupling with an ambident electrophile is ***,we demonstrated a nickel-catalyzed reductive 2-pyridination of aryl iodides with difluoromethyl 2-pyridyl sulfone(2-Py SO_(2)CF_(2)H)via selective C(sp^(2))-S bond cleavage of the sulfone by using a phosphine *** this communication,we report a novel nickel-catalyzed reductive coupling of aryl iodides and 2-Py SO_(2)CF_(2)H reagent,which constitutes a new method for aromatic *** use of a tridentate terpyridine ligand is pivotal for the selective C(sp^(3))-S bond cleavage of the *** method employs readily available nickel catalyst and 2-Py SO_(2)CF_(2)H as the difluoromethylation reagent,providing a facile access to difluoromethylarenes under mild reaction conditions without pre-generation of arylmetal reagents.

关键词： nickel catalysis difluoromethylation 2-PySO_(2)CF_(2)H reductive cross-coupling

Coordinate-Parametric Matrix Model Inspired Square-Conjoint Pattern in Cross Woven for Conventional Bamboo Mat

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Journal of Renewable Materials 2023年第12期11卷 4025-4038页

作者： Ye Fu Liwen Deng jinbo hu Ti Li Shanshan Chang College of Furniture and Art Design Central South University of Forestry and TechnologyChangsha410004China College of Materials Science and Engineering Central South University of Forestry and TechnologyChangsha410004China hunan Taohuajiang Bamboo Science&Technology Co. Ltd.Yiyang413400China

In the study,it is proposed that a coordinate-parametric matrix model is performed to a square-conjoint pattern of cross woven(SCPCW)in the bamboo *** patterns of SCPCW are firstly detected according to the perspective of configuration,which is divided into the basic-monomer shape and the basic combination ***,the compositions of design patterns in SCPCW are analyzed to attain the trend of curve *** on the coordinate-parametric matrix model,the specimens of SCPCW are subsequently accomplished to elaborate the woven logic of bamboo *** digital innovation of SCPCW,defined by a mathematical resolution,is implemented by the software of Grasshopper(GH),which plays a crucial role in capturing image information by the Image Sampler ***,the weaving logic of coordinated matrix is referred to apply in the computing component of Grasshopper ***,the computer simulation could demonstrate that the coordinate-parametric matrix model of SCPCWwould be realized to analyze the micro-weaving structure and overall weaving effect in the bamboo mat.

关键词： Cross woven configuration and composition coordinated parametrization weaving model

406例原发性醛固酮增多症患者手术预后及影响因素分析

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中华内分泌代谢杂志 2024年第3期40卷 228-234页

作者：张益鑫宋颖胡金波杨淑敏冯正平何文雯李启富赵文睿重庆医科大学附属第一医院内分泌科重庆400016

目的评估单侧原发性醛固酮增多症(简称原醛症)术后生化和临床缓解率,分析相关影响因素。方法回顾性纳入2013年11月至2022年3月在重庆医科大学附属第一医院内分泌科明确分型并接受肾上腺切除术且完成随访的406例原醛症患者,记录基线和术... 详细信息

目的评估单侧原发性醛固酮增多症(简称原醛症)术后生化和临床缓解率,分析相关影响因素。方法回顾性纳入2013年11月至2022年3月在重庆医科大学附属第一医院内分泌科明确分型并接受肾上腺切除术且完成随访的406例原醛症患者,记录基线和术后的临床资料及生化指标。根据原发性醛固酮增多症手术预后(Primary Aldosteronism Surgical Outcome,PASO)标准进行临床和生化疗效评估。采用多因素logistic回归分析评估影响原醛症术后临床缓解的主要因素。结果406例原醛症患者术后的生化完全缓解率为96.31%(391/406),生化部分缓解率为0.99%(4/406),生化未缓解率为2.71%(11/406);临床完全缓解率为53.45%(217/406),临床部分缓解率为46.55%(189/406)。相比于临床部分缓解组,临床完全缓解组年龄较小,女性占比更大,体重指数较低,高血压病程更短,降压药的限定日剂量更低,估算的肾小球滤过率(eGFR)更高,高血压家族史和糖尿病病史所占比例较低。多因素logistic回归分析进一步显示,性别(OR=2.49,95%CI 1.42~4.35,P=0.001)、体重指数(OR=1.16,95%CI 1.05~1.28,P=0.003)、降压药限定日剂量(OR=1.83,95%CI 1.37~2.44,P<0.001)、高血压家族史(OR=2.16,95%CI 1.22~3.83,P=0.008)、糖尿病病史(OR=2.47,95%CI 1.15~5.29,P=0.021)和eGFR(OR=0.98,95%CI 0.97~0.99,P=0.001)是影响原醛症术后取得临床完全缓解的独立因素。结论单侧原醛症术后的生化完全缓解率较高,但仅有约一半患者实现临床完全缓解。

关键词：原发性醛固酮增多症单侧肾上腺切除术预后