检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

周林与中国敦煌吐鲁番学会

社会科学战线 2024年第6期 152-159,282页

作者：刘进宝浙江大学历史学院浙江杭州310030

周林是中国敦煌吐鲁番学会成立的关键人物。1981年出现“敦煌在中国,敦煌学在日本”的误传。邓小平考察敦煌后,时任教育部副部长的周林便积极协调,筹组中国敦煌吐鲁番学会。在1983年8月的成立大会上,周林作了《团结起来,促进我国敦煌吐... 详细信息

周林是中国敦煌吐鲁番学会成立的关键人物。1981年出现“敦煌在中国,敦煌学在日本”的误传。邓小平考察敦煌后,时任教育部副部长的周林便积极协调,筹组中国敦煌吐鲁番学会。在1983年8月的成立大会上,周林作了《团结起来,促进我国敦煌吐鲁番学的更大发展》的报告,全面阐述了成立学会的意义和今后工作的方向。

关键词：周林敦煌吐鲁番学教育部顾问中国敦煌吐鲁番学会

Stabilization of MYC G-quadruplex DNA by ruthenium(II)complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第2期10卷 399-402页

作者： Yuening Sun Xin Chen Siyan Liao Aochu liu Huan Zhou Liling Jiang Wa Ding Wenjie Mei jinbao liu Xianping Shi Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseAffiliated Cancer Hospital of Guangzhou Medical University School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 510120China Guangdong Province Engineering Technology Center for Molecular Probe and Biomedicine Imaging Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China

The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.

关键词： myeloid overcome resistance

KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第10期13卷 4217-4233页

作者： Cancan Zheng Xiaomei Yu Taoyang Xu Zhichao liu Zhili Jiang Jiaojiao Xu Jing Yang Guogeng Zhang Yan He Han Yang Xingyuan Shi Zhigang Li jinbao liu Wen Wen Xu Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education Institutesthe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University.Shanghai 200030China Department of Radiation Oncology the Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory Diseaseand School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511495China

Increasing evidences suggest the important role of calcium homeostasis in hallmarks of cancer,but its function and regulatory network in metastasis remain unclear.A comprehensive investigation of key regulators in cancer metastasis is urgently needed.Transcriptome sequencing(RNA-seq)of primary esophageal squamous cell carcinoma(ESCC)and matched metastatic tissues and a series of gain/loss-of-function experiments identified potassium channel tetramerization domain containing 4(KCTD4)as a driver of cancer metastasis.KCTD4 expression was found upregulated in metastatic ESCC.High KCTD4 expression is associated with poor prognosis in patients with ESCC and contributes to cancer metastasis in vitro and in vivo.Mechanistically,KCTD4 binds to CLIC1 and disrupts its dimerization,thus increasing intracellular Ca^(2+)level to enhance NFATc1-dependent fibronectin transcription.KCTD4-induced fibronectin secretion activates fibroblasts in a paracrine manner,which in turn promotes cancer cell invasion via MMP24 signaling as positive feedback.Furthermore,a lead compound K279-0738 significantly suppresses cancer metastasis by targeting the KCTD4-CLIC1 interaction,providing a potential therapeutic strategy.Taken together,our study not only uncovers KCTD4 as a regulator of calcium homeostasis,but also reveals KCTD4/CLIC1-Ca^(2+)-NFATc1-fibronectin signaling as a novel mechanism of cancer metastasis.These findings validate KCTD4 as a potential prognostic biomarker and therapeutic target for ESCC.

关键词： Cancermetastasis Calcium homeostasis NFAT signaling Fibroblasts Esophageal cancer

Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第7期19卷 1061-1077页

作者： Leyi Yao Qian Zhao Ding Yan Ziying Lei Yali Hao Jinghong Chen Qian Xue Xiaofen Li Qingtian Huang Daolin Tang QPing Dou Xin Chen jinbao liu Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseSchool of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511436China Institute of Digestive Disease of Guangzhou Medical University The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China School of Public Health Guangzhou Medical UniversityGuangzhou511436China Department of Surgery UT Southwestern Medical CenterDallasTX 75390USA Barbara Ann Karmanos Cancer Institute and Departments of Oncology Pharmacology&PathologySchool of MedicineWayne State UniversityDetroitMI 48201USA

Objective:Sorafenib is a first-line drug for advanced hepatocellular carcinoma(HCC).Unfortunately,most patients with HCC do not respond to sorafenib,mainly because of the frequent development of drug resistance.Bilirubin is an end metabolite of heme catabolism and an indicator of liver function,but its direct role in regulating the anticancer activity of sorafenib in HCC cells is unclear.In the current study,we aimed to investigate the mechanism of action of bilirubin in sorafenib-mediated tumor suppression in HCC.Methods:A retrospective observational cohort of 100 patients receiving sorafenib was conducted to evaluate the potential role of bilirubin in predicting the prognosis of patients with HCC.Human HCC cell lines were treated with sorafenib in the absence or presence of bilirubin,and cell proliferation,apoptosis,and signaling pathways were assayed.The antagonistic effect of bilirubin toward sorafenib was assessed in nude mice bearing HCC xenografts.Results:Serum levels of bilirubin(including total,direct,and indirect bilirubin)negatively correlated with the overall survival of patients with HCC treated with sorafenib(P<0.05).Both in vitro and in vivo analyses demonstrated that bilirubin significantly abrogated sorafenib-mediated proliferation inhibition and apoptosis induction in HCC cells(P<0.05).Mechanically,bilirubin inhibited sorafenib-induced activation of GSK-3βand subsequent downstream MCL-1 degradation.Conclusions:Our study provides experimental evidence of the antagonistic effect of bilirubin toward sorafenib-mediated anticancer activity in HCC,and it suggests that bilirubin could be used to predict the efficacy of sorafenib treatment.

关键词： Apoptosis bilirubin hepatocellular carcinoma MCL-1 sorafenib

Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第6期10卷 2222-2225页

作者： Qingtian Huang Na Zhang Jiangtuan Wang Hua Xu Leyi Yao Qianqian Yang Ding Yan Xi Chen Qian Xue Min Xiao Jiawen Wu Xueheng Wu Qin liu Daolin Tang Xin Chen Xiaofen Li jinbao liu Affiliated Cancer Hospital&Institute of Guangzhou Medical University GuangzhouGuangdong 510095China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 511436China Institute of Digestive Disease The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuanGuangdong 511518China Department of Pathology Dongguan People's Hospital Affiliated to Southern Medical UniversityDongguanGuangdong 523059China Department of Surgery UT Southwestern Medical CenterDallasTX 75390USA

As one of the leading causes of cancer deaths worldwide,the pathogenesis of lung cancer is still not completely understood.Bilirubin,a product of heme metabolism,has long been considered a waste product of the body.Increasing evidence suggests that bilirubin has additional antioxidant,anti-inflammatory,and proteasome inhibitory activities.However,the specific role of bilirubin in the formation and development of lung cancer has not been elucidated.

关键词： lung metabolism cancer

血清微量元素与营养素对骨坏死因果效应的孟德尔随机化分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2024年第33期28卷 5326-5332页

作者：刘艺刘源刘金豹李念虎朱巍明许波山东中医药大学山东省济南市250300 山东中医药大学附属医院山东省济南市250014 天津中医药大学天津市300000

背景:多项临床研究观察表明血清微量元素和营养素与骨坏死之间存在密切关系,但血清微量元素和营养素与骨坏死之间是否存在遗传因果效应尚不清楚。目的:通过孟德尔随机化方法探讨血清微量元素与营养素对骨坏死的因果效应。方法:暴露因素... 详细信息

背景:多项临床研究观察表明血清微量元素和营养素与骨坏死之间存在密切关系,但血清微量元素和营养素与骨坏死之间是否存在遗传因果效应尚不清楚。目的:通过孟德尔随机化方法探讨血清微量元素与营养素对骨坏死的因果效应。方法:暴露因素血清微量元素和维生素的单核苷酸多态性来自已发表的UK Biobank数据库以及全基因组关联研究公开数据库。结局事件骨坏死全基因组关联研究数据来自FinnGen Biobank数据库。采用孟德尔随机化方法探讨7种微量元素和3种营养素与骨坏死之间的因果关系。利用逆方差加权、MR-Egger和加权中位数等方法进行因果推断,计算F值统计量以确保工具变量的稳健性,采用Cochran’s Q统计法和留一法进行异质性检验,采用MR-Egger回归法、MR-PRESSO进行水平多效性检验。使用PhenoScanner数据库剔除具有水平多效性的单核苷酸多态性,以确保结果的可靠性。结果与结论:经过孟德尔随机化分析发现,血清硒、磷酸盐以及维生素C、维生素E与骨坏死之间存在明显的因果关系。血清硒、维生素C、维生素E对骨坏死有保护作用,磷酸盐摄入过多会增加骨坏死的风险。研究过程中没有发现异质性和水平多效性,孟德尔随机化统计效力(Power值>80%)显示上述4项结果可靠,研究结果对于开发有针对性的预防及治疗骨坏死的措施具有重要临床意义。

关键词：孟德尔随机化微量元素营养素骨坏死单核苷酸多态性逆方差加权法

Error Sensitivity Analysis in 10–30-Day Extended Range Forecasting by Using a Nonlinear Cross-Prediction Error Model

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2017年第3期31卷 567-575页

作者： zhiye xia lisheng xu hongbin chen yongqian wang jinbao liu wenlan feng college of resources and environment chengdu university of information technologyChengdu 610225 plateau atmosphere and environment key laboratory of sichuan province Chengdu 610225 key laboratory of middle atmosphere and global environment observation institute of atmospheric physicschinese academy of sciencesBeijing 100029

Extended range forecasting of 10-30 days, which lies between medium-term and climate prediction in terms of timescale, plays a significant role in decision-making processes for the prevention and mitigation of disastrous met- eorological events. The sensitivity of initial error, model parameter error, and random error in a nonlinear cross- prediction error （NCPE） model, and their stability in the prediction validity period in 1 0-30-day extended range fore- casting, are analyzed quantitatively. The associated sensitivity of precipitable water, temperature, and geopotential height during cases of heavy rain and hurricane is also discussed. The results are summarized as follows. First, the initial error and random error interact. When the ratio of random error to initial error is small （10＂5-10-2）, minor vari- ation in random error cannot significantly change the dynamic features of a chaotic system, and therefore random er- ror has minimal effect on the prediction. When the ratio is in the range of 10-1-2 （i.e., random error dominates）, at- tention should be paid to the random error instead of only the initial error. When the ratio is around 10 2-10-1, both influences must be considered. Their mutual effects may bring considerable uncertainty to extended range forecast- ing, and de-noising is therefore necessary. Second, in terms of model parameter error, the embedding dimension m should be determined by the factual nonlinear time series. The dynamic features of a chaotic system cannot be depic- ted because of the incomplete structure of the attractor when m is small. When m is large, prediction indicators can vanish because of the scarcity of phase points in phase space. A method for overcoming the cut-off effect （m 〉 4） is proposed. Third, for heavy rains, precipitable water is more sensitive to the prediction validity period than temperat- ure or geopotential height; however, for hurricanes, geopotential height is most sensitive, followed by precipitable water.

关键词： extended range forecasting random error initial error model parameter error sensitivity

在线全文

学校读者我要写书评

暂无评论

含水率影响下煤体巴西劈裂特性与弱化机制

采矿与安全工程学报 2024年第2期41卷 362-371页

作者：张村王磊王潇杰刘金保崔舒畅陈见行中国矿业大学(北京)共伴生能源精准开采北京市重点实验室北京100083 中国矿业大学(北京)能源与矿业学院北京100083 中国矿业大学(北京)厚煤层绿色智能开采教育部工程研究中心北京100083

利用废弃矿井采空区作为储水空间对矿区生态环境和经济发展具有重要作用,但在不同含水率影响下,煤岩体强度会出现一定的弱化,进而影响地下储库的稳定性。以关闭的大台矿井-710 m开采水平3#煤层煤样为研究对象,研究不同含水率煤样巴西劈... 详细信息

利用废弃矿井采空区作为储水空间对矿区生态环境和经济发展具有重要作用,但在不同含水率影响下,煤岩体强度会出现一定的弱化,进而影响地下储库的稳定性。以关闭的大台矿井-710 m开采水平3#煤层煤样为研究对象,研究不同含水率煤样巴西劈裂强度弱化程度、劈裂破坏特征和声发射演化规律;借助CT扫描浸水前后煤样孔隙特征,探究其内在影响机制。研究结果表明:干燥煤样圆盘表面的主要裂纹沿劈裂面存在,而饱和煤样的裂纹偏离劈裂面,形成许多不规则的剪切裂纹。随着含水率的增加,圆盘表面劈裂裂隙平整度降低,从干燥到饱和,裂隙分形维数由1.066升高至1.298;煤样抗拉强度随含水率增加呈线性减小,但峰值应变则呈先增大后减小的抛物线变化;煤样声发射累计计数随含水率增加而逐渐减小,破坏阶段低含水率煤样产生张拉为主的拉剪复合裂隙且尺度较大,高含水率煤样产生小尺度张拉裂隙。煤样浸水后原生裂隙扩张,孔隙率提高2.55%,煤样孔隙率升高使煤样损伤发育加速,进而导致在劈裂过程中更易形成贯通裂隙;水的存在弱化了原生裂隙胶结强度,使劈裂裂隙沿强度较小的节理裂隙面扩张,初始劈裂面粗糙度增加。新增裂隙的减小也同样使声发射强度降低。

关键词：废弃矿井含水率巴西劈裂抗拉强度声发射弱化机制

在线全文

学校读者我要写书评

暂无评论

基于多空间属性信息融合的序列推荐

计算机科学 2024年第3期51卷 102-108页

作者：王子泓邵蓥侠何吉元刘金宝北京邮电大学计算机学院北京100876 美团平台搜索推荐算法部北京100102

序列推荐旨在从用户的历史行为中建模用户不断变化的兴趣,从而做出与用户兴趣相关的推荐。近年来,物品属性信息被证明可以提升序列推荐的性能,很多工作基于属性信息融合去提升序列推荐的性能,都取得了成效但仍存在一定的不足。首先,它... 详细信息

序列推荐旨在从用户的历史行为中建模用户不断变化的兴趣,从而做出与用户兴趣相关的推荐。近年来,物品属性信息被证明可以提升序列推荐的性能,很多工作基于属性信息融合去提升序列推荐的性能,都取得了成效但仍存在一定的不足。首先,它们没有显式地建模出用户对物品属性的偏好或者只建模了一个属性偏好向量,无法充分表达用户的偏好。其次,它们的物品属性信息融合过程未考虑用户个性化信息的影响。因此,针对上述不足,提出了基于多空间属性信息融合的序列推荐(MAIF-SR)。文中提出了多空间属性信息融合框架,在不同的属性空间下融合属性序列并建模出用户对不同属性的偏好,用多维兴趣充分表达用户的偏好;设计了个性化属性注意力机制,在融合信息的过程中引入用户个性化信息,增强融合信息的个性化效果。在两个公开数据集以及一个工业私有数据集上进行实验,结果表明,MAIF-SR优于用于对比的基于属性信息融合的序列推荐。

关键词：序列推荐物品属性信息融合用户个性化注意力机制多维兴趣