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Defence Technology（防务技术） 2024年第1期31卷 158-162页

作者： Xue yang Qijun liu Yundan Gan Lei yang Zhengtang liu Fusheng liu Bond and Band Engineering Group School of Physical Science and TechnologySouthwest Jiaotong UniversityChengdu 610031People's Republic of China Xi'an Modern Chemistry Research Institute Xi'an 710065People's Republic of China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072People's Republic of China

As an energetic material of great interest,the work capacity of dihydroxylammonium 5,5’-bistetrazole-1,1’-diolate(TKX-50)has been questioned *** some research groups have explored the reasons for the low working ability of TKX-50,the plane impact experiment on powdered TKX-50 is obviously closer to the practical application,and the conclusions based on this are more ***,we performed shock Hugoniot measurements of powdered TKX-50 between 5.65 and 16.29 *** plane impact experiments of powdered TKX-50 were carried out and the shocked Raman spectra were *** Raman spectroscopy analysis,a new peak of powdered TKX-50 was found between19.47 GPa and 24.96 GPa,which may be caused by decomposition/phase transition and was related with the low work capacity.

关键词： Powdered TKX-50 Hugoniot Raman Decomposition Phase transition

Revealing the correlation between adsorption energy and activation energy to predict the catalytic activity of metal oxides for HMX using DFT

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Defence Technology（防务技术） 2024年第1期31卷 262-270页

作者： Xiurong yang Chi Zhang Wujing jin Zhaoqi Guo Hongxu Gao Shiyao Niu Fengqi Zhao Bo liu Haixia Ma Xi'an Key Laboratory of Special Energy Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Science and Technology on Combustion and Explosion Laboratory Xi'an Modern Chemistry Research InstituteXi'an710065China Rocket Force University of Engineering Xi'an 710025China

Traditional selection of combustion catalysis is time-consuming and *** calculation is expected to resolve this *** adsorption energy of HMX and O atoms on 13 metal oxides was calculated using DMol3,since HMX and O are key substances in decomposition *** the relationship between the adsorption energy of HMX,O on metal oxides(TiO_(2),Al_(2)O_(3),PbO,CuO,Fe_(2)O_(3),Co_(3)O_(4),Bi_(2)O_(3),NiO)and experimental T30 values(time required for the decomposition depth of HMX to reach 30%)was depicted as volcano ***,the T30 values of other metal oxides was predicted based on their adsorption energy on volcano plot and validated by previous experimental ***,the adsorption energy of HMX on ZrO_(2)and MnO_(2)was predicted based on the linear relationship between surface energy and adsorption energy,and T30 values were estimated based on volcano *** apparent activation energy data of HMX/MgO,HMX/SnO_(2),HMX/ZrO_(2),and HMX/MnO_(2)obtained from DSC experiments are basically consistent with our predicted T30 values,indicating that it is feasible to predict the catalytic activity based on the adsorption calculation,and it is expected that these simple structural properties can predict adsorption energy to reduce the large quantities of computation and experiment cost.

关键词： Density functional theory HMX Metal oxides Adsorption energy Activation energy

A stable staggered-grid finite-difference scheme for acoustic modeling beyond conventional stability limit

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Petroleum Science 2024年第1期21卷 182-194页

作者： jing-Yi Xu yang liu National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China China University of Petroleum(Beijing) Karamay CampusKaramay 834000XinjiangChina

Staggered-grid finite-difference(SGFD)schemes have been widely used in acoustic wave modeling for geophysical *** improved methods are proposed to enhance the accuracy of numerical ***,these methods are inevitably limited by the maximum Courant-Friedrichs-Lewy(CFL)numbers,making them unstable when modeling with large time sampling intervals or small grid *** solve this problem,we extend a stable SGFD scheme by controlling SGFD dispersion relations and maximizing the maximum CFL ***,to improve modeling stability,we minimize the error between the FD dispersion relation and the exact relation in the given wave-number region,and make the FD dispersion approach a given function outside the given wave-number area,thus breaking the conventional limits of the maximum CFL ***,to obtain high modeling accuracy,we use the SGFD scheme based on the Remez algorithm to compute the FD *** addition,the hybrid absorbing boundary condition is adopted to suppress boundary reflections and we find a suitable weighting coefficient for the proposed *** derivation and numerical modeling demonstrate that the proposed scheme can maintain high accuracy in the modeling process and the value of the maximum CFL number of the proposed scheme can exceed that of the conventional SGFD scheme when adopting a small maximum effective wavenumber,indicating that the proposed scheme improves stability during the modeling.

关键词： Acoustic wave Staggered-grid finite-difference(SGFD) modeling Courant-friedrichs-lewy(CFL)number Stability

Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal Vasomotion

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Engineering 2024年第7期38卷 133-143页

作者： Shuang yang Yixiu Zhao Xiaoling Cheng Tingting Zhan Jiaying Tian Xue liu Chunyue Ma Zhiqi Wang Luying jin Qian liu Yanli Wang Jian Huang jinhui Wang Yan Zhang Baofeng yang Department of Pharmacology&Key Laboratory of Cardiovascular Medicine Research Ministry of Education of the People’s Republic of ChinaCollege of PharmacyHarbin Medical UniversityHarbin 150081China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Harbin Medical UniversityHarbin 150081China Department of Medicinal Chemistry and Natural Medicine Chemistry College of PharmacyHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zones Chinese Academy of Medical SciencesHarbin 150081China

Myocardial ischemia is a serious threat to human health,and vascular dysfunction is its main *** Tongyu(BXTY)Granule is an effective traditional Chinese medicine(TCM)for treating myocardial ***,the underlying mechanism of BXTY is still *** this study,we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase(sGC)-30,50-cyclic guanosine monophosphate(cGMP)-protein kinase G(PKG)signaling pathway in vascular smooth muscle cells(VSMCs)to dilate the *** was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of *** results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice,including electrocardiogram abnormalities and changes in plasma *** addition,BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent *** effects were eliminated by preincubating vascular rings with the sGC inhibitors NS 2028 or ODQ,or with the PKG inhibitor KT ***,BXTY increased the protein expression of sGC-b1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells(MOVAs).NS 2028 or ODQ reversed these effects of *** expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with *** 2028,ODQ,or KT 5823 also reversed this effect of *** conclusion,BXTY can improve the symptoms of acute myocardial ischemia in mice,and activating the sGC-cGMP-PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

关键词： Myocardial ischemia Vasomotion Soluble guanylate cyclase Buxu Tongyu Granule

Single-cell RNA sequencing analysis of the retina under acute high intraocular pressure

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Neural Regeneration Research 2024年第11期19卷 2522-2531页

作者： Shaojun Wang Siti Tong Xin jin Na Li Pingxiu Dang yang Sui Ying liu Dajiang Wang Division of Ophthalmology The Third Medical Center of PLA General HospitalBeijingChina Department of Ophthalmology Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

High intraocular pressure causes retinal ganglion cell injury in primary and secondary glaucoma diseases,yet the molecular landscape characteristics of retinal cells under high intraocular pressure remain *** models of acute hypertension ocular pressure were established by injection of cross-linked hyaluronic acid hydrogel(Healaflow■).Single-cell RNA sequencing was then used to describe the cellular composition and molecular profile of the retina following high intraocular *** results identified a total of 12 cell types,namely retinal pigment epithelial cells,rod-photoreceptor cells,bipolar cells,Müller cells,microglia,cone-photoreceptor cells,retinal ganglion cells,endothelial cells,retinal progenitor cells,oligodendrocytes,pericytes,and *** single-cell RNA sequencing analysis of the retina under acute high intraocular pressure revealed obvious changes in the proportions of various retinal cells,with ganglion cells decreased by 23%.Hematoxylin and eosin staining and TUNEL staining confirmed the damage to retinal ganglion cells under high intraocular *** extracted data from retinal ganglion cells and analyzed the retinal ganglion cell cluster with the most distinct *** found upregulation of the B3gat2 gene,which is associated with neuronal migration and adhesion,and downregulation of the Tsc22d gene,which participates in inhibition of *** study is the first to reveal molecular changes and intercellular interactions in the retina under high intraocular *** data contribute to understanding of the molecular mechanism of retinal injury induced by high intraocular pressure and will benefit the development of novel therapies.

关键词： apoptosis axon degeneration high intraocular pressure microglia ocular hypertension photoreceptor cells retina retinal degeneration retinal ganglion cells single-cell RNA sequencing

Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota

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Journal of Animal Science and Biotechnology 2024年第1期15卷 277-294页

作者： Xinyue yang Depeng Li Meihong Zhang Yuqing Feng Xiaolu jin Dan liu Yuming Guo Yongfei Hu State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Ginkgo biloba extract(GBE)is evidenced to be effective in the prevention and alleviation of metabolic disorders,including obesity,diabetes and fatty liver ***,the role of GBE in alleviating fatty liver hemorrhagic syndrome(FLHS)in laying hens and the underlying mechanisms remain to be ***,we investigated the effects of GBE on relieving FLHS with an emphasis on the modulatory role of GBE in chicken gut *** The results showed that GBE treatment ameliorated biochemical blood indicators in high-fat diet(HFD)-induced FLHS laying hen model by decreasing the levels of TG,TC,ALT and *** lipid accumulation and pathological score of liver were also relieved after GBE ***,GBE treatment enhanced the antioxidant activity of liver and serum by increasing GSH,SOD,T-AOC,GSH-PX and reducing MDA,and downregulated the expression of genes related to lipid synthesis(FAS,LXRα,GPAT1,PPARγand Ch REBP1)and inflammatory cytokines(TNF-α,IL-6,TLR4 and NF-κB)in the *** profiling analysis revealed that GBE treatment reshaped the HFD-perturbed gut microbiota,particularly elevated the abundance of Megasphaera in the ***,targeted metabolomic analysis of SCFAs revealed that GBE treatment significantly promoted the production of total SCFAs,acetate and propionate,which were positively correlated with the GBE-enriched gut ***,we confirmed that the GBE-altered gut microbiota was sufficient to alleviate FLHS by fecal microbiota transplantation(FMT).Conclusions We provided evidence that GBE alleviated FLHS in HFD-induced laying hens through reshaping the composition of gut *** findings shed light on mechanism underlying the anti-FLHS efficacy of GBE and lay foundations for future use of GBE as additive to prevent and control FLHS in laying hen industry.

关键词： Antioxidation Fecal microbiota transplantation FLHS Ginkgo biloba extract Inflammation Megasphaera

Recent progress on copper catalysts with different surface states for CO_(2)electroreduction

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Journal of Energy Chemistry 2024年第1期88卷 10-27,I0001页

作者： Wenjun Zhang yang yang Donggang Guo Lu liu Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Shanxi Laboratory for Yellow River College of Environment and ResourceShanxi UniversityTaiyuan 030006ShanxiChina

The electrochemical carbon dioxide reduction reaction(eCO_(2)RR),which converts CO_(2)into various hydrocarbons or alcohols,has been extensively researched because it promises a sustainable energy ***,only copper(Cu)can currently achieve stable and efficient hydrocarbon conversion in the eCO_(2)***,understanding the catalytic mechanisms and summarizing the research progress on synthesis strategies of Cu catalysts are essential for the eCO_(2)*** paper reviews Cu catalysts with different surface states of Cu catalysts:oxide-derived Cu,Cu nanoparticles,Cu single atoms,and Cu *** then reviews the development and progress of different Cu-catalyst preparation methods in recent years,focusing on the activity and selectivity of *** revealing the tendencies of catalytic selection and deep reactive mechanisms of Cu catalysts with four different surface states,this review can guide the subsequent construction of catalysts and provides an understanding of catalytic mechanisms.

关键词： eCO_(2)RR Oxide-derived Cu Cu nanoparticles Cu single atoms Cu nanoclusters

Characteristics of bioaerosols under high-ozone periods,haze episodes,dust storms,and normal days in Xi'an,China

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Particuology 2024年第7期90卷 140-148页

作者： Yiming yang liu yang Xiaoyan Hu Zhenxing Shen Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an710049China Key Lab of Aerosol Chemistry&Physics SKLLQGInstitute of Earth EnvironmentChinese Academy of SciencesXi’an710049China

The characteristics of bioaerosols and their effects on human beings'health have become a major public concern in the recent *** study compared the characteristics of bioaerosols under different types of pollution(high-ozone[HO]episodes,haze episodes,and dust storms[DSs]),with those of bioaerosols on normal days(NDs)in Xi'an,*** concentrations,diurnal variations,and size distribution of bacteria,fungi,and total airborne microbes(TAMs)were *** results showed that the bacterial and fungal concentrations were the highest during DSs and on NDs,reaching 425.2 and 956.9 colony-forming units/m^(3),*** concentration of TAMs was the highest during HO episodes,reaching 10.7×10^(6)cells/m^(3),which was significantly higher than that during the other *** maximum concentrations of bacteria and fungi during HO episodes were observed in the morning,while they appeared separately in the morning and evening during haze *** and TAMs during DSs reached peak concentrations in the morning and evening,which is opposite to the particulate matter(PM)distribution *** NDs,temperature and relative humidity had significant effects on *** size distributions of airborne bacteria exhibited bimodal patterns,whereas unimodal distributions were observed for *** mainly attached in fine particles(<2.1μm)with proportions of 67.4%and 60.5%during haze episodes and DSs,respectively,which means that fungi were easily penetrated into the human respiratory *** evaluation of influence factors revealed that PM_(2.5) and PM10 had negative effects on fungal concentration during DSs,and ozone concentration and temperature were inversely correlated with fungal concentration during HO *** results provide valuable reference data for elucidating the formation and evolution of bioaerosols under different types of pollution.

关键词： Bacteria Fungi Total airborne microbe Different air pollution types Influence factors

Silencing of early auxin responsive genes MdGH3-2/12 reduces the resistance to Fusarium solani in apple

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Journal of Integrative Agriculture 2024年第9期23卷 3012-3024页

作者： Qianwei liu Shuo Xu Lu jin Xi Yu Chao yang Xiaomin liu Zhijun Zhang Yusong liu Chao Li Fengwang Ma State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYangling 712100China

Apple replant disease(ARD)has led to severe yield and quality reduction in the apple *** solani(***)has been identified as one of the main microbial pathogens responsible for ***(indole-3-acetic acid,IAA),an endogenous hormone in plants,is involved in almost all plant growth and development processes and plays a role in plant immunity against *** Hagen3(GH3)is one of the early/primary auxin response *** aim of this study was to evaluate the function of MdGH3-2 and MdGH3-12 in the defense response of *** by treating MdGH3-2/12 RNAi plants with *** results show that under *** infection,RNAi of MdGH3-2/12 inhibited plant biomass accumulation and exacerbated root *** inoculation with ***,MdGH3-2/12 RNAi inhibited the biosynthesis of acid-amido *** led to the inhibition of free IAA combining with amino acids,resulting in excessive free IAA *** excessive free IAA altered plant tissue structure,accelerated fungal hyphal invasion,reduced the activity of antioxidant enzymes(SOD,POD and CAT),increased the reactive oxygen species(ROS)level,and reduced total chlorophyll content and photosynthetic ability,while regulating the expression of PR-related genes including PR1,PR4,PR5 and *** also changed the contents of plant hormones and amino acids,and ultimately reduced the resistance to *** conclusion,these results demonstrate that MdGH3-2 and MdGH3-12 play an important role in apple tolerance to *** and ARD.

关键词： Fusarium solani early auxin responsive gene apple replant disease plant hormone antioxidant

RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium

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Journal of Genetics and Genomics 2024年第5期51卷 543-553页

作者： Ting Hu Lan liu He Wang Mei yang Bocheng Xu Hanbing Xie Ziyuan Lin Xiaolei jin Ping Wang Yanyan liu Huaqin Sun Shanling liu Department of Medical Genetics West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengduSichuan 610041China Medical College Tibet UniversityLhasaTibet 850000China SCU-CUHK Joint Laboratory for Reproductive Medicine West China Second University HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine Sichuan UniversityChengduSichuan 610041China

Noncompaction of the ventricular myocardium(NVM),the third most diagnosed cardiomyopathy,is characterized by prominent trabeculae and intratrabecular ***,the genetic etiology of 40%–60%of NVM cases remains ***,we identify two infants with NVM,in a nonconsanguineous family,with a typical clinical presentation of persistent bradycardia since the prenatal period.A homozygous missense variant(R223L)of RCAN family member 3(RCAN3)is detected in both infants using whole-exome *** the zebrafish model,marked cardiac dysfunction is detected in rcan3 deficiency(MO-rcan3^(ATG)-injected)and rcan^(−/−) *** dysplasia of both endocardial and myocardial layers is also detected in rcan3-deficient ***3 R223L variant mRNAs can not rescue heart defects caused by rcan3 knockdown or knockout;however,hRCAN3 mRNAs rescue these ***-seq experiments show that several genes involved in cardiomyopathies are significantly regulated through multiple signaling pathways in the rcan3-knockdown zebrafish *** human cardiomyocytes,RCAN3 deficiency results in reduced proliferation and increased apoptosis,together with an abnormal mitochondrial ***,we suggest that RCAN3 is a susceptibility gene for cardiomyopathies,especially NVM and that the R223L mutation is a potential loss-of-function variant.

关键词： Cardiomyopathy NVM RCAN3 Mitochondrial structure Heartdefects