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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： jin-wei niu Guo-Chao Zhang Wu Ning Hai-Bin Liu Hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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Archiving data processing of WinCC V6

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微计算机信息 2005年第18期 56-57页

作者： (The State Key Lab of Rolling and Automation, Northeastern University, Shenyang110004, China) Zhen,Lidong wei,jin niu,Wenyong Li,Jianping

In practice, the process data is the most important. We need to manage the data with the certain format in both Online and Offline. Wincc V6 is powerful HMI system. With it, we configure the interface and archive the process data. Due to the archives in Wincc V6 are compressed and not stored in the main memory, so we must export them. With version 6, Wincc offers the design environment of Visual Basic Script (VBS). Use VBS, we can change the data format to certain format easily. This paper offers a solution to export data of archives into Ex- cel.

关键词： archiving data WinCC Excel

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《英语语言学概论》课程教学中内容依托式教学方式的应用分析

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汉江师范学院学报 2018年第2期38卷 136-140页

作者：吕铁金黄玮牛鹏远绥化学院外国语学院黑龙江绥化152000

《英语语言学概论》是高校英语专业教学中一门必修课程,在英语语言学的教学中发挥着基础性作用,也是英语专业学生必须熟悉的课程。但是从目前来看,许多英语专业学生对于《英语语言学概论》缺乏足够的兴趣,认为其对于自身的就业没有帮助... 详细信息

《英语语言学概论》是高校英语专业教学中一门必修课程,在英语语言学的教学中发挥着基础性作用,也是英语专业学生必须熟悉的课程。但是从目前来看,许多英语专业学生对于《英语语言学概论》缺乏足够的兴趣,认为其对于自身的就业没有帮助,导致课程教学效果不佳。基于此,可以考虑在《英语语言学概论》课程教学中引入内容依托式教学方式,推动传统教学模式的转变,通过激发学生学习兴趣的方式,促进教学效果的提高。

关键词：《英语语言学概论》内容依托式教学应用

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Energy Harvesting in Cognitive Networks with Cooperative Beamforming:Power Allocation and Stability Analysis

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Journal of Electronic Science and Technology 2019年第2期17卷 126-134页

作者： jin-Xin niu wei Guo National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China

Energy harvesting (EH) is a promising technology to improve both energy efficiency and spectral efficiency in cognitive radio (CR) networks. However, due to the randomness of the harvested energy and the interference constraint at the primary users (PUs), the limited transmission power of secondary users (SUs) may reduce the service rate of SUs. To solve this problem, this paper investigates a cooperative transmission method where a zero-forcing beamforming method is used in the EH based secondary network. Considering the transmission power constraint and energy causality, we derive the closed-form solution of the optimal transmission power for the secondary source and relays, which achieves the maximal stable throughput of the secondary network. Numerical results show the impact of different system parameters to the maximal stable throughput. In addition, compared with the traditional decode-and-forward (DF) scheme, the cooperative beamforming method achieves higher stable throughput under an high quality source-to-relay channel.

关键词： Cooperative beamforming energy harvesting power allocation stability analysis

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Boron-doped lamellar porous carbon supported copper catalyst for dimethyl oxalate hydrogenation

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Chinese Journal of Chemical Engineering 2023年第3期55卷 222-229页

作者： Peipei Ai Li Zhang jinchi niu Huiqing jin wei Huang State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China

Doping heteroatoms on carbon materials could bring some special advantages for using as catalyst *** this work, a boron doped lamellar porous carbon(B-LPC) was prepared facilely and utilized as carbonbased support to construct Cu/B-LPC catalyst for dimethyl oxalate(DMO) hydrogenation. Doping boron could make the B-LPC own more defects on surface and bigger pore size than B-free LPC, which were beneficial to disperse and anchor Cu nanoparticles. Moreover, the interaction between Cu species and B-LPC could be strengthened by the doped B, which not only stabilized the Cu nanoparticles, but also tuned the valence of Cu species to maintain more Cu^(+). Therefore, the B-doped Cu/B-LPC catalyst exhibited stronger hydrogenation ability and obtained higher alcohols selectivity than Cu/LPC, as well as high stability without decrease of DMO conversion and ethylene glycol selectivity even after 300 h of reaction at 240℃.

关键词： Hydrogenation Cu-based catalyst Boron doping Porous carbon Catalyst support Alcohol

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Cloning and functional characterization of two peptidoglycan recognition protein isoforms (PGRP-LC) in Bactrocera dorsalis (Diptera: Tephritidae)

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Journal of Integrative Agriculture 2020年第12期19卷 3025-3034页

作者： wei Dong WANG Zhe XU Hui-qian niu jin-zhi WANG jin-jun Chongqing Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqing 400715P.R.China State Cultivation Base of Crop Stress Biology for Southern Mountainous Land Academy of Agricultural SciencesSouthwest UniversityChongqing 400715P.R.China

The innate immune system of insects is the front line of self-defense against pathogen invasion. Peptidoglycan recognition proteins (PGRPs) are important components and play key roles in insect immune systems by recognizing peptidoglycan (PGN) in bacterial cell walls. We characterized two isoforms of the PGRP-LC gene, BdPGRP-LCa and BdPGRP-LCb, from Bactrocera dorsalis (Hendel), an important fruit and vegetable pest worldwide. These two isoforms contain an open reading frames of 1 668 bp and 1 731 bp, encoding a protein of 555 and 576 amino acids, respectively. Quantitative real-time PCR results showed that both transcripts were prominently expressed in midgut and fat body of B. dorsalis adult. Inoculation of pathogens showed that both isoforms actively responded to Escherichia coli PGN. We also observed a light response to Staphylococcus aureus PGN. Upon Beauveria bassiana inoculation, the expression of BdPGRP-LCa was enhanced, but the expression of BdPGRP-LCb was suppressed. Suppression of both transcripts by RNA interference led to increased mortality of flies challenged by E. coli, indicating that the two isoforms are involved in sensing Gram-negative bacterial infections.

关键词： oriental fruit fly innate immunity PGRPs Gram-negative bacterium

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Investigation of FRP and SFRC Technologies for Efficient Tunnel Reinforcement Using the Cohesive Zone Model

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Structural Durability & Health Monitoring 2024年第2期18卷 161-179页

作者： Gang niu Zhaoyang jin wei Zhang Yiqun Huang China Communications Construction Investment Development Co. Ltd.Fuzhou350000China Rail Transit Branch of China Communications Construction Co. Ltd.Beijing101317China School of Civil Engineering Fujian University of TechnologyFuzhou350118China

Amid urbanization and the continuous expansion of transportation networks,the necessity for tunnel construction and maintenance has become *** this need requires the investigation of efficient,economical,and robust tunnel reinforcement *** paper explores fiber reinforced polymer(FRP)and steel fiber reinforced concrete(SFRC)technologies,which have emerged as viable solutions for enhancing tunnel *** is celebrated for its lightweight and high-strength attributes,effectively augmenting load-bearing capacity and seismic resistance,while SFRC’s notable crack resistance and longevity potentially enhance the performance of tunnel ***,current research predominantly focuses on experimental analysis,lacking comprehensive theoretical *** bridge this gap,the cohesive zone model(CZM),which utilizes cohesive elements to characterize the potential fracture surfaces of concrete/SFRC,the rebar-concrete interface,and the FRP-concrete interface,was employed.A modeling approach was subsequently proposed to construct a tunnel segment model reinforced with either SFRC or ***,the corresponding mixed-mode constitutive models,considering interfacial friction,were integrated into the proposed *** validation and numerical simulations corroborated the accuracy of the proposed ***,this study examined the reinforcement design of tunnel *** a numerical evaluation,the effectiveness of innovative reinforcement schemes,such as substituting concrete with SFRC and externally bonding FRP sheets,was assessed utilizing a case study from the Fuzhou Metro Shield Tunnel Construction Project.

关键词： Tunnel segment FRP SFRC cohesive zone model constitutive model fracture process

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