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The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases

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Fundamental Research 2024年第2期4卷 226-236页

作者： Ke-qi Fan tao Huang Jian-shuai yu Yi-yuan Li jin jin MOE Laboratory of Biosystem Homeostasis and Protection and Life Sciences InstituteZhejiang UniversityHangzhou 310058China Department of Gastroenterology Sir Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016China Key Laboratory for Developmental Genes and Human Disease Ministry of EducationInstitute of Life SciencesJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China

According to a study from World Health Organization’s Global Burden of Disease,mental and neurological disorders have accounted for 13%of global diseases in recent years and are on the rise.Neuropsychiatric conditions or neuroinflammatory disorders are linked by the presence of an exaggerated immune response both peripherally and in the central nervous system(CNS).Cognitive dysfunction(CD)encompasses a complex group of diseases and has frequently been described in the field of autoimmune diseases,especially in multiple non-CNS-related autoimmune diseases.Recent studies have provided various hypotheses regarding the occurrence of cognitive impairment in autoimmune diseases,including that abnormally activated immune cells can disrupt the integrity of the blood-brain barrier(BBB)to trigger a central neuroinflammatory response.When the BBB is intact,autoantibodies and pro-inflammatory molecules in peripheral circulation can enter the brain to activate microglia,inducing CNS inflammation and CD.However,the mechanisms explaining the association between the immune system and neural function and their contribution to diseases are uncertain.In this review,we used clinical statistics to illustrate the correlation between CD and autoimmune diseases that do not directly affect the CNS,summarized the clinical features and mechanisms by which autoimmune diseases trigger cognitive impairment,and explored existing knowledge regarding the link between CD and autoimmune diseases from the perspective of the field of neuroimmunology.

关键词： Autoimmune diseases Neuroinflammation Central nervous system dysfunction Autoantibodies Inflammatory cytokines

Lizhong Decoction Ameliorates Ulcerative Colitis in Mice via Regulation of Plasma and Urine Metabolic Profiling

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Chinese Journal of Integrative Medicine 2022年第11期28卷 1015-1022页

作者： WANG Ling tao jin-hua CHEN Yi-fan SHEN yu-meng JIANG Shu School of Pharmacy Nantong UniversityNantong(226001)Jiangsu ProvinceChina School of Pharmacy Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To elucidate the mechanism of Lizhong Decoction(LZD)in treating dextran sodium sulfate(DSS)-induced colitis in mice based on metabonomics.Methods:Thirty-six mice were randomly divided into 6 groups,including normal,model,low-(1.365 g/kg),medium-(4.095 g/kg)and high dose(12.285 g/kg)LZD and salazosulfadimidine(SASP)groups,6 mice in each group.Colitis model mice were induced by DSS admistration for 7 days,and treated with low,medium and high dose LZD extract and positive drug SASP.Metabolic comparison of DSS-induced colitis and normal mice was investigated by using ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass(UPLC-Q-TOF/MS)combined with Metabolynxsoftware.Results:The metabolic profiles of plasma and urine in colitis mice were distinctly ameliorated after LZD treatment(P<0.05).Potential biomarkers(9 in serum and 4 in urine)were screened and tentatively identified.The endogenous metabolites were mainly involved in primary bile acid,sphingolipid,linoleic acid,arachidonic acid,amino acids(alanine,aspartate,and glutamate),butanoate and glycerophospholipid metabolism in plasma,and terpenoid backbone biosynthesis,glycerophospholipid and tryptophan metabolism in urine.After LZD treatment,these markers notably restored to normal levels.Conclusions:The study revealed the underlying mechanism of LZD on amelioration of ulcerative colitis based on metabonomics,which laid a foundation for further exploring the pathological and physiological mechanism,early diagnosis,and corresponding drug development of colitis.

关键词： Lizhong Decoction ulcerative colitis metabonomics biomarkers Chinese medicine

Max-margin based Bayesian classifier

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Frontiers of Information Technology & Electronic Engineering 2016年第10期17卷 973-981页

作者： tao-cheng HU jin-hui yu State Key Lab of CAD & CG Zhejiang University Hangzhou 310058 China

多分类学习中经常需要考虑在泛化性能和计算开销间进行权衡。本文提出一个生成式概率多分类器,综合考虑了泛化性和学习/预测速率。我们首先证明了我们的分类器具有最大间隔性质,这意味着对于未来数据的预测精度几乎和训练阶段一样高。此... 详细信息

多分类学习中经常需要考虑在泛化性能和计算开销间进行权衡。本文提出一个生成式概率多分类器,综合考虑了泛化性和学习/预测速率。我们首先证明了我们的分类器具有最大间隔性质,这意味着对于未来数据的预测精度几乎和训练阶段一样高。此外,我们消除了目标函数中的大量的局部变元,极大地简化了优化问题。通过凸分析和概率语义分析,我们设计了高效的在线算法,与经典情形的最大不同在于这个算法使用聚集而非平均化处理梯度。实验证明了我们的算法具有很好的泛化性能和收敛速度。

关键词：多类学习最大间隔学习在线算法

On the Downshift of Wave Frequency for Bragg Resonance

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China Ocean Engineering 2022年第1期36卷 76-85页

作者： PENG Ji tao Ai-feng FAN Jun ZHENG jin-hai LIU yu-ming Key Laboratory of Ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing 210098China Quality Supervision Department China Renewable Energy Engineering InstituteBeijing 100120China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridge 02139USA

For surface gravity waves propagating over a horizontal bottom that consists of a patch of sinusoidal ripples,strong wave reflection occurs under the Bragg resonance condition.The critical wave frequency,at which the peak reflection coefficient is obtained,has been observed in both physical experiments and direct numerical simulations to be downshifted from the well-known theoretical prediction.It has long been speculated that the downshift may be attributed to higher-order rippled bottom and free-surface boundary effects,but the intrinsic mechanism remains unclear.By a regular perturbation analysis,we derive the theoretical solution of frequency downshift due to third-order nonlinear effects of both bottom and free-surface boundaries.It is found that the bottom nonlinearity plays the dominant role in frequency downshift while the free-surface nonlinearity actually causes frequency upshift.The frequency downshift/upshift has a quadratic dependence in the bottom/free-surface steepness.Polychromatic bottom leads to a larger frequency downshift relative to the monochromatic bottom.In addition,direct numerical simulations based on the high-order spectral method are conducted to validate the present theory.The theoretical solution of frequency downshift compares well with the numerical simulations and available experimental data.

关键词： gravity surface wave Bragg resonance frequency downshift regular perturbation analysis

Surfactant Mediated Microphase Separation in Miscible Block Copolymer of Poly(4-vinyl pyridine-b-hydroxybutylacrylate)

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Chinese Journal of Polymer Science 2023年第6期41卷 897-904,I0007页

作者： Xiang-yun Xu yu-Tong Gao Ying-Ying Wang You-Shuang Zhou Bi-jin Xiong jin-tao Zhu Key Laboratory of Materials Chemistry for Energy Conversion and Storage(HUST)of Ministry of Education School of Chemistry and Chemical Engineering.Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory of Optoelectronic Chemical Materials and Devices(Ministry of Education) Jianghan UniversityWuhan 430056China Key Laboratory of Green Preparation and Application of Functional Materials(Ministry of Education) Hubei Key Laboratory of Polymer MaterialsFaculty of Materials Science and EngineeringHubei UniversityWuhan 430062China

Miscible disordered block copolymers(BCPs)are rarely studied due to the limits in self-assembly into ordered microstructures.Herein,we proposed a facile method for the transformation of disordered miscible BCPs to comb-like BCPs with well-ordered microphase separation structures via blending with amphiphilic surfactants.In this work,poly(4-vinyl pyridine-b-hydroxybutylacrylate)(P4VP-b-P4HBA)was applied as a model of miscible disordered BCPs and the microphase separation was induced via blending with surfactants of dodecylbenzene sulfonic acid(DBSA)and 3-pentadecylphenol(PDP).The ordered microstructures including spherical and cylindrical morphologies were confirmed by transmission electron microscopy(TEM)and small angle X-ray scattering(SAXS)investigation.These ordered microstructures thermal sensitive,in which ordered and disordered transformation(ODT)was observed in the blend of P4VP-b-P4HBA and PDP whereas it disappeared in the blend of P4VP-b-P4HBA and DBSA.The results show that the thermal stability of the ordered microstructures are strongly depends on the interactions between the miscible BCPs and surfactants,which investigated by in situ SAXS and Fourier transform infrared spectrometer(FTIR).The combination of miscible BCPs and surfactant creates a feasible strategy to fabricate ordered nanostructures,which could be employed to develop complicated nanomaterials.

关键词： ordered disordered vinyl

Glutamatergic Neurons in the Caudal Zona Incerta Regulate Parkinsonian Motor Symptoms in Mice

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Neuroscience Bulletin 2022年第1期38卷 1-15页

作者： Li-Xuan Li yu-Lan Li jin-tao Wu Ji-Zhou Song Xiao-Ming Li Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou310003China NHC and CAMS Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhou310030China Department of Engineering Mechanics Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou310063China

Parkinson’s disease(PD)is the second most common and fastest-growing neurodegenerative disorder.In recent years,it has been recognized that neurotransmitters other than dopamine and neuronal systems outside the basal ganglia are also related to PD pathogenesis.However,little is known about whether and how the caudal zona incerta(ZIc)regulates parkinsonian motor symptoms.Here,we showed that specific glutamatergic but not GABAergic ZIc^(VgluT2) neurons regulated these symptoms.ZIc^(VgluT2) neuronal activation induced time-locked parkinsonian motor symptoms.In mouse models of PD,the ZIc^(VgluT2) neurons were hyperactive and inhibition of their activity ameliorated the motor deficits.ZIc^(VgluT2) neurons monosynaptically projected to the substantia nigra pars reticulata.Incerta-nigral circuit activation induced parkinsonian motor symptoms.Together,our findings provide a direct link between the ZIc,its glutamatergic neurons,and parkinsonian motor symptoms for the first time,help to better understand the mechanisms of PD,and supply a new important potential therapeutic target for PD.

关键词： Parkinson's disease Caudal zona incerta Glutamate Substantia nigra pars reticulata Parkinsonian motor symptoms

Expression and regulatory network of long noncoding RNA in rats after spinal cord hemisection injury

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Neural Regeneration Research 2022年第10期17卷 2300-2304页

作者： Wei Liu jin-Cheng tao Sheng-Ze Zhu Chao-Lun Dai Ya-Xian Wang Bin yu Chun Yao yu-yu Sun Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Medical College Nantong UniversityNantongJiangsu ProvinceChina Department of Orthopedics Nantong Third People’s HospitalNantong UniversityNantongJiangsu ProvinceChina

Long noncoding RNAs(lncRNAs)participate in a variety of biological processes and diseases.However,the expression and function of lncRNAs after spinal cord injury has not been extensively analyzed.In this study of right side hemisection of the spinal cord at T10,we detected the expression of lncRNAs in the proximal tissue of T10 lamina at different time points and found 445 lncRNAs and 6522 mRNA were differentially expressed.We divided the differentially expressed lncRNAs into 26 expression trends and analyzed Profile 25 and Profile 2,the two expression trends with the most significant difference.Our results showed that the expression of 68 lncRNAs in Profile 25 rose first and remained high 3 days post-injury.There were 387 mRNAs co-expressed with the 68 lncRNAs in Profile 25.The co-expression network showed that the co-expressed genes were mainly enriched in cell division,inflammatory response,FcγR-mediated cell phagocytosis signaling pathway,cell cycle and apoptosis.The expression of 56 lncRNAs in Profile2 first declined and remained low after 3 days post-injury.There were 387 mRNAs co-expressed with the 56 lncRNAs in Profile 2.The co-expression network showed that the co-expressed genes were mainly enriched in the chemical synaptic transmission process and in the signaling pathway of neuroactive ligand-receptor interaction.The results provided the expression and regulatory network of the main lncRNAs after spinal cord injury and clarified their co-expressed gene enriched biological processes and signaling pathways.These findings provide a new direction for the clinical treatment of spinal cord injury.

关键词： bioinformatic analysis biological process gene ontology analysis inflammatory response Kyoto encyclopedia of genes and genomes analysis long noncoding RNAs regulatory network RNA sequencing spinal cord injury synaptic transmission

Interaction Mechanism of Nano-silicon Dioxide Modified by Poly（amidoamine） Dendrimers

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Chinese Journal of Chemical Physics 2012年第5期25卷 592-604,I0004页

作者： tao jin Xiao-yu Li College of Material Science and Engineering Shandong University of Science and TechnologyQingdao 265590China College of Material Science and Engineering Beijing University of Chemical TechnologyBeifing100020China

获得卓见进Si+( SC )离子的附件(认为是客人)到最低产生，终止NH2 poly ( amidoamine )( PAMAM ) dendrimers (认为是主人)在液体阶段，密度功能的理论被用来调查主人客人建筑群的结构和 energetics 。结构和 energetics 上的溶剂的... 详细信息

获得卓见进Si+( SC )离子的附件(认为是客人)到最低产生，终止NH2 poly ( amidoamine )( PAMAM ) dendrimers (认为是主人)在液体阶段，密度功能的理论被用来调查主人客人建筑群的结构和 energetics 。结构和 energetics 上的溶剂的效果也被调查。到 PAMAM 的离子界限的各种各样的起始的配置被测试，并且二稳定的 conformers 被发现即，类型 A (Si+ 被绑在胺地点) 并且 C (Si+ 被绑在酰胺地点) 。类型 A 和 C 由于罪恶的化学契约形成是最稳定的 ? 敯浨琠瑩慲楴湯 ?? 慲? 桰瑯敯敬瑣潲 ? 灳 ' 虪?愠摮 ? 畯楲牥琠慲獮潦浲椠普慲敲 ? 灳 '

关键词：树枝状高分子聚酰胺分子作用最低能量构象硅改性二氧化 PAMAM 纳米

Heteroatom-Induced Accelerated Kinetics on Nickel Selenide for Highly Efficient Hydrazine-Assisted Water Splitting and Zn-Hydrazine Battery

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Nano-Micro Letters 2023年第9期15卷 492-504页

作者： Hao-yu Wang Lei Wang jin-tao Ren Wen-Wen Tian Ming-Lei Sun Zhong-Yong yuan School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350People’s Republic of China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071People’s Republic of China

Hydrazine-assisted water electrolysis is a promising energy conversion technology for highly efficient hydrogen production.Rational design of bifunctional electrocatalysts,which can simultaneously accelerate hydrogen evolution reaction(HER)/hydrazine oxidation reaction(HzOR)kinetics,is the key step.Herein,we demonstrate the development of ultrathin P/Fe co-doped NiSe_(2) nanosheets supported on modified Ni foam(P/Fe-NiSe_(2)) synthesized through a facile electrodeposition process and subsequent heat treatment.Based on electrochemical measurements,characterizations,and density functional theory calculations,a favorable“2+2”reaction mechanism with a two-step HER process and a two-step HzOR step was fully proved and the specific effect of P doping on HzOR kinetics was investigated.P/Fe-NiSe_(2) thus yields an impressive electrocatalytic performance,delivering a high current density of 100 mA cm^(−2) with potentials of−168 and 200 mV for HER and HzOR,respectively.Additionally,P/Fe-NiSe_(2) can work efficiently for hydrazine-assisted water electrolysis and Zn-Hydrazine(Zn-Hz)battery,making it promising for practical application.

关键词： Water electrolysis Hydrogen production Hydrazine oxidation Bifunctional electrocatalyst Heteroatom doping