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基于颜色特征的牡丹皮贮藏年限鉴别及质量评价研究

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中药材 2016年第6期39卷 1232-1235页

作者：谢晋彭华胜张群林严安定陈飞虎安徽医科大学安徽合肥230032 安徽中医药大学安徽合肥230031

目的：探讨中药牡丹皮颜色特征与贮藏年限之间的相关性。方法：通过分光密度仪对不同贮藏年限牡丹皮进行色度测定,表述L＊、a＊、b＊值,利用HPLC法测定丹皮酚的含量。运用SPSS软件对色度与贮藏年限、丹皮酚含量进行相关性分析。结果：... 详细信息

目的：探讨中药牡丹皮颜色特征与贮藏年限之间的相关性。方法：通过分光密度仪对不同贮藏年限牡丹皮进行色度测定,表述L＊、a＊、b＊值,利用HPLC法测定丹皮酚的含量。运用SPSS软件对色度与贮藏年限、丹皮酚含量进行相关性分析。结果：贮藏年限与饮片颜色a＊值存在显著相关性,即随着贮藏年限增加,饮片颜色逐渐向红色方向移动;随着贮藏年限增加,丹皮酚含量逐年降低,二者存在一定的相关性,而硫磺熏制则显著降低这一相关性;丹皮饮片断面颜色b＊值与丹皮酚含量存在稳定的相关性。结论：牡丹皮色度与贮藏时间、丹皮酚含量存在直接相关性,利用药材色度鉴别牡丹皮贮藏年限可为快速评价中药质量提供参考。

关键词：牡丹皮颜色特征贮藏年限鉴别质量评价

二叠纪新小纺锤模式种Neofusulinella lantenoisi Deprat,1913在云南保山的发现(英文)

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古生物学报 2000年第4期39卷 457-465页

作者：周祖仁王玉净盛金章朱夔玉中国科学院南京地质古生物研究所南京210008 成都理工大学成都610059

NeofusulinellaDeprat,1912是一个有效属 ,但其模式标本遗失 ,最早发表的共模切面不正 ,加之手绘图影不清楚 ,长期未能准确地把握其属征。除原作者 (Deprat,1913)首次记述的模式种 (N .lantenoisiDeprat Thompson ,1934,p .2 92事后指... 详细信息

NeofusulinellaDeprat,1912是一个有效属 ,但其模式标本遗失 ,最早发表的共模切面不正 ,加之手绘图影不清楚 ,长期未能准确地把握其属征。除原作者 (Deprat,1913)首次记述的模式种 (N .lantenoisiDeprat Thompson ,1934,p .2 92事后指定 )以及Thompson和Foster(1937)和Pitakpaivan(196 5 )所记述的同种外 ,其余的有关鉴定均为误定。另外两个被广泛引用的属 ,即Le¨ellaDunbaretSkinner ,1937及HaoellaGong ,196 5 ,却是真正的Neofusulinella属 ,为后者的次异名 (juniorsynonym)。Neofusulinella的系统位置并非前人所认为的舒伯特科(Schubertellidae) ,而属于纺锤科 (Fusulinidae)的史塔夫亚科 (Staffellinae) ,代表该亚科中的进化类型。史塔夫类在分布上的排它性及对围岩原岩的选择性 ,亦间接表明该亚科系纺锤科在近滨局限海域里的一个特化分支。在原地埋葬的情况下 ,这一类壳体及其围岩普遍受到发育于该海域海底的“淡化混合水带”的成岩期硅化或白云岩化 (王尧 ,1990 ;沙庆安 ,1990 ) ,因而它们的旋壁与内部构造通常被“矿化”而模糊不清 ,甚至造成多样化旋壁的假像。　　Pitakpaivan (196 5 )所记述的Neofusulinellacf .lantenoisiDeprat采自泰国Nakhonsawan地区Takli (15°18’N ,10 0?

关键词： Neofusulinella 模式种 Ting类二叠纪云南

Improvement Study of Bonding Performance of Cold-Sprayed Silver Coatings on 316L Stainless Steel Based on Ni and Ti Interlayers

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Surface Technology 2025年第3期54卷 230-239页

作者： zhang, Yongliang zhang, Kejie Wei, sheng Lan, Haiming Li, Hongpan Li, Yihan Huang, Renzhong New Energy Branch Qinghai Huanghe Hydropower Development Co. Ltd. Xining810008 China Guangzhou Research Center Hubei Chaozhuo Aviation Technology Co. Ltd. Guangzhou510650 China

The application of cold spray technology to deposit silver coatings on the inner walls of polycrystalline silicon reduction furnaces offers significant advantages in terms of energy conservation and prevention of impurity elements contamination. However, directly fabricating high-bond-strength silver coatings on 316L stainless steel substrates remains a challenge. Based on previous studies, even with a nickel interlayer, the bonding strength and service life of coatings are limited. The work aims to propose a novel approach of utilizing a titanium interlayer to enhance the adhesion performance of silver coatings on 316L substrates. A comprehensive suite of characterization techniques, including optical microscopy (OM), microhardness testing, scanning electron microscopy (SEM), universal tensile testing, and white light interferometry was used to systematically investigate the effect of interlayer material (Ni and Ti) and powder morphology (irregular and spherical) on the microstructure, hardness, interfacial characteristics, surface morphology, and bonding strength of coatings. This comparative analysis elucidated the underlying mechanisms responsible for the differences in coating adhesion strength observed with different interlayer materials. The results demonstrated that direct cold spray deposition of silver coating on 316L substrate failed to achieve effective deposition, while all three interlayer materials — gas-atomized spherical nickel powder (Ni), gas-atomized spherical titanium powder (Ti(s)), and irregular titanium powder (Ti(I)) prepared via the hydride-dehydride method — produced relatively dense coatings with porosity less than 0.5%. The silver coatings deposited on these interlayers also exhibited similar density and microhardness values. However, significant variations were observed in the bonding strength of the coating systems. The 316L/Ni interface exhibited the highest bonding strength (71.3±4.6) MPa, surpassing that of 316L/Ti(S) (63.2±2.9) MPa

关键词： Tensile testing

开放式创新与企业绩效——学习导向与网络外溢的调节作用

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北京邮电大学学报（社会科学版） 2017年第2期19卷 53-58页

作者：季桓永金永生张静北京邮电大学经济管理学院北京100876 北京邮电大学公共管理学院北京100876

将学习导向和网络外溢作为内生及外生权变因素运用到开放式企业绩效机制研究当中,探讨其在两类开放式创新模式与企业绩效关系中所起的调节机制。通过中国211家企业样本的实证检验发现:(1)两类开放式创新均对企业绩效具有积极作用,外向... 详细信息

将学习导向和网络外溢作为内生及外生权变因素运用到开放式企业绩效机制研究当中,探讨其在两类开放式创新模式与企业绩效关系中所起的调节机制。通过中国211家企业样本的实证检验发现:(1)两类开放式创新均对企业绩效具有积极作用,外向型创新在内向型创新与企业绩效关系中起到正向调节作用;(2)学习导向及网络外溢在开放式创新与企业绩效的关系中均具有正向调节作用。研究结论是对现有开放式创新理论研究的拓展和延伸,为开放式创新在中国的发展和应用提供参考。

关键词：开放式创新学习导向网络外溢企业绩效

新型3,6-二取代三唑并噻二唑衍生物的合成及细胞分裂周期25B磷酸酶和蛋白酪氨酸磷酸酶1B抑制活性研究

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有机化学 2017年第2期37卷 485-495页

作者：李英俊李继阳彭立娜高立信靳焜盛丽张楠王思远李佳辽宁师范大学化学化工学院大连116029 中国科学院上海药物研究所国家新药筛选中心药物研究国家重点实验室上海201203 大连理工大学精细化工国家重点实验室大连116012

以邻苯二胺和一氯乙酸为初始原料,经多步反应,合成了一系列新型含苯并咪唑环和芳磺酰基的3,6-二取代三唑并噻二唑衍生物7a^7y.利用~1H NMR、IR和元素分析对新的中间体化合物3、4、6及目标产物7进行了结构表征.对所合成的目标化合物进行... 详细信息

以邻苯二胺和一氯乙酸为初始原料,经多步反应,合成了一系列新型含苯并咪唑环和芳磺酰基的3,6-二取代三唑并噻二唑衍生物7a^7y.利用~1H NMR、IR和元素分析对新的中间体化合物3、4、6及目标产物7进行了结构表征.对所合成的目标化合物进行了细胞分裂周期25B磷酸酶(Cdc25B)和蛋白酪氨酸磷酸酶1B(PTP1B)抑制活性筛选,实验结果显示,部分目标化合物对Cdc25B和PTP1B显示出良好的抑制活性,其中目标化合物7d对Cdc25B的抑制活性最高[IC50=(7.72±0.73)mg/m L],7u对PTP1B的抑制活性最高[IC50=(3.31±0.57)mg/m L].值得注意的是,化合物7b、7d、7l、7t和7u对Cdc25B和PTP1B均具有抑制活性.这些活性的目标化合物是潜在的Cdc25B和PTP1B抑制剂,在癌症和糖尿病治疗方面具有很好的应用前景.

关键词：三唑并噻二唑苯并咪唑芳磺酰基合成 Cdc25B和PTP1B抑制剂

Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling

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Cancer Biology & Medicine 2025年第02期 166-176页

作者： Wenhua Li Huan zhang Zhe Gong Yue Li Zhiyu Chen Xiaodong Zhu Mingzhu Huang Zhe zhang Chenchen Wang Lixin Qiu Qirong Geng jinjia Chang Xiaoying Zhao Xuedan sheng Wen zhang Tong Tong Weijian Guo Department of Medical Oncology Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Department of Radiology Fudan University Shanghai Cancer Center Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences

Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases(CLM).Methods: A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023. Functional MR was performed at baseline and after one cycle of chemotherapy. The diffusion kurtosis radiomic texture features were extracted and a signature model was built using the R package. The initial 100 cases were designated as the training set, the following 48 cases were designated as the validation set, and the final 48 cases were designated as the intervention validation ***: Good performance for the response prediction(AUC = 0.818 in the training set and 0.755 in the validation set) was demonstrated. The objective response rates(ORRs) in the high-risk subgroup were significantly lower than the low-risk subgroup in the training and validation sets. Worse progression-free survival and overall survival rates were noted in the high-risk population. In the intervention set 22.9%(11/48) of the chemotherapy regimens for patients were changed in response to the model-predicted results and the ORR reached 77.1%(37/48), which was significantly higher than the training and validation sets [47.97%(71/148); P = 0.000].Conclusions: A functional MR signature effectively predicted the chemotherapy response and long-term survival. The adjustment of the regimen guided by the model significantly improved the ORR.

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Distributions and Driving Factors of Hydrochemical Compositions in Different Types of Karst Groundwater in Qingjiang River Basin

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1417-1426页

作者： Xie, Hao Shen, Hao-Yong zhang, Hai-Dao Lin, Yong-sheng Li, Jun Liang, Hui-Ya Wang, Zhi-Heng Zhu, Tian-Long Zou, sheng-zhang Key Laboratory of Karst Dynamics Ministry of Natural Resources/Guangxi International Research Center on Karst under the Auspices of United Nations Educational Scientific and Cultural Organization Institute of Karst Geology Chinese Academy of Geological Sciences Guilin541004 China Guangxi Karst Resources and Environment Research Center of Engineering Technology Guilin541004 China Guangxi Pingguo Karst Ecosystem National Field Scientific Observation and Research Station Baise531406 China Hebei Key Laboratory of Water Quality Engineering and Comprehensive Utilization of Water Resources Hebei University of Architecture Zhangjiakou075000 China zhangjiakou Municipal Water Service Limited Liability Company Zhangjiakou075000 China

The karst groundwater resource is the key water supply for native residents and industrial and agricultural production in karst regions of southwest China and is even the only water supply for rural regions. Understanding the formation mechanism of hydrochemical compositions is practically imperative to the sustainable development and utilization of karst groundwater resources. The hydrochemical ions of 34 karst spring samples and 12 underground river water samples from the Qingjiang River Basin were measured and analyzed in this study. On the basis of investigating the distribution characteristics of hydrochemical components,methods such as hierarchical clustering analysis,Gibbs model,and relationships between hydrochemical components were used to comprehensively reveal the chemical genesis mechanism of karst groundwater from the perspectives of water-rock interaction and anthropogenic activities,especially in the disturbance mechanism of acidic pollutants on the natural dissolution of carbonate rocks. The results showed that the karst groundwater in the Qingjiang River Basin was weakly alkaline(7.12 ≤pH ≤ 8.69),and the overall water quality was good. Only the maximum concentration of NO3− in the karst spring(80.2 mg·L−1) exceeded the maximum acceptable limit for drinking purposes(10 mg·L−1 as N). The Ca2+ and HCO3− were identified as the dominant ions,associated with the main water phrase of HCO3-Ca·Mg in approximately 97.1% of karst spring samples and all underground river water samples. The dominant ions were derived from the strong dissolution of calcite,whereas Mg2+、SO42−,and F− were controlled by the weak dissolution of dolomite,gypsum,and fluorite,respectively. Karst groundwater NO3− was derived from the agricultural fertilizers and rainwater input,whereas the H2SO4 acid rain input was identified as another important source of karst groundwater SO42−. In addition,the carbonate rocks in the study area were mainly naturally dissolved;however,the input of exoge

关键词： Groundwater pollution

Adult split liver transplantation to treat liver cancer: a single-center retrospective study

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World Journal of Emergency Medicine 2025年第1期16卷 57-62页

作者： Qiang Sun Haoze Cao Xuesong Bai Xin Han Wanlu You Zhongquan Sun Yixin zhang Xiaochang Wu Feng Fang Fan Wu Lianyue Yang sheng Yan Yuan Ding Weilin Wang Department of Hepatobiliary Pancreatic Surgery the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Hepatobiliary Surgery Huzhou Central HospitalZhejiang University Huzhou HospitalHuzhou 313002China Department of General Surgery Xiangya HospitalCentral South UniversityChangsha 410008China

BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center. METHODS: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT). Clinical data were analyzed and compared between patients who underwent SLT and ***: SLT and WGLT were successfully performed, with no intraoperative transplantrelated mortality. Postoperatively, no significant differences in total bilirubin(TB, P=0.266), alanine transaminase(ALT, P=0.403) and aspartate transaminase(AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery(P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery(P=1.000). There were no significant differences in overall survival(OS) and progress-free survival(PFS) between the SLT and WGLT groups(P=0.910, P=0.190). CONCLUSION: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.

关键词： Adult Split liver transplantation Liver cancer Prognosis Retrospective

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江西乐平鸣山矿区上二叠统长兴阶的类

微体古生物学报 1984年第1期 30-48页

作者：盛金章芮琳中国科学院南京地质古生物研究所

一、前言鸣山矿区位于江西省乐平县城之西约7.5公里处,为萍乐拗陷带东段的一个小型向斜盆地,是乐平组官山段、老山段、狮子山段和王潘里段的标准剖面所在地。区内乐平组出露完好,但其上的长兴期地层往往被第四纪浮土所覆盖,仅在盆地的... 详细信息

一、前言鸣山矿区位于江西省乐平县城之西约7.5公里处,为萍乐拗陷带东段的一个小型向斜盆地,是乐平组官山段、老山段、狮子山段和王潘里段的标准剖面所在地。区内乐平组出露完好,但其上的长兴期地层往往被第四纪浮土所覆盖,仅在盆地的东侧有零星出露。1977年江西省煤炭局223地质队在这个地区发现了一个完整的晚二叠世长兴期的地层钻井剖面,系统采集了(竹筳)类标本。这批材料经笔者鉴定,计有7属34种,其中6个新种和5个未定种。Gallowayinella,Palaeofusulina和Parananlingella三属是当前这个(竹筳)类动物群中

关键词：上二叠统蜓类长兴期图版灰岩长兴阶乐平组盛金章包卷江西