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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： jingxiang zhang Xia sheng Quanju Ding Yujun Wang Jiwei Zhao jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

A Highly Efficient and Recyclable Catalyst for Asymmetric Dihydroxylation of Olefins

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A Highly Efficient and Recyclable Catalyst for Asymmetric Di...

中国化学会第四届有机化学学术会议

作者： SUN, Xiao-Li jin, Ying zhang, sheng-Yong (Department of Chemistry, Fourth Military Medical University, Xi''an 710032)

＜正＞Asymmetric dihydroxylation （AD） is one of the most efficient methods for the synthesis of chiral vicinal diols. Although the reactions offer a number of processes that can be applied to the synthesis of chiral drug intermediates, natural products, chemicals, etc., the high cost of osmium and the ligands as well as the high toxicity and volatility of the osmium component has prevented their application in large-scale industry. In order to explore the recoverable and reusable ligand and/or osmium, several attempts have been made. One possible solution is to anchor the ligand on an polymer. Despite the advantages of easy separation, the use of polymer-supported ligands usually suf-

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EPDM材料热解后准静态压缩力学性能

航空动力学报 2017年第1期32卷 114-119页

作者：蒋晶陈雄许进升张中水杜红英南京理工大学机械工程学院南京210094 晋西工业集团有限责任公司技术中心太原030027

为研究三元乙丙(EPDM)包覆层材料热解过程及其热解后的力学行为,采用热重分析(TGA)对EPDM的热稳定性进行分析,基于其TGA曲线与热降解温度,通过电阻炉设定不同的温度进行热解实验,然后利用万能实验机完成准静态单轴压缩实验.结果表明:EPD... 详细信息

为研究三元乙丙(EPDM)包覆层材料热解过程及其热解后的力学行为,采用热重分析(TGA)对EPDM的热稳定性进行分析,基于其TGA曲线与热降解温度,通过电阻炉设定不同的温度进行热解实验,然后利用万能实验机完成准静态单轴压缩实验.结果表明:EPDM材料的抗压性能随着热解温度的升高呈先减小再升高而后降低的趋势,可大体分为3个阶段.通过分阶段建立模型来更好地描述材料不同热解程度下的力学行为,采用2阶Polynomial超弹模型与温度相关项相结合等方式预测不同温度热解后EPDM材料的力学响应,对比实验结果发现模型拟合精度良好.

关键词：三元乙丙热重分析热解力学性能本构模型

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-Tang Liang Yu-Gang Ma Xin-Li sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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同时存在温度和盐度梯度的分层流的数值模拟

水动力学研究与进展（A辑） 1991年第4期6卷 72-78页

作者：金海生张书农河海大学环境水利研究所

本文对同时存在温度和盐度梯度的一类密度分层流进行了数值模拟,其中紊流平均量控制方程中的紊动项由一个简化的紊流应力/通量代数模型计算。计算结果正确地反映了分层及紊动特征,与实测结果吻合较好,而用k-ε紊流模型计算的结果与实测... 详细信息

本文对同时存在温度和盐度梯度的一类密度分层流进行了数值模拟,其中紊流平均量控制方程中的紊动项由一个简化的紊流应力/通量代数模型计算。计算结果正确地反映了分层及紊动特征,与实测结果吻合较好,而用k-ε紊流模型计算的结果与实测结果不符。

关键词：分层流紊流温度盐度数值模拟

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-Fang Wu Yi-sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

APC and K-ras gene mutation in aberrant crypt foci of human colon

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World Journal of Gastroenterology 2001年第3期7卷 352-356页

作者： Ping Yuan~1 Meng Hong Sun~2 jin sheng zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published. Department of Pathology Medical College of Fudan University Shanghai 200032 China.

AIM:To study the genetic alteration in ACF and to define the possibility that ACF may be a very early morphological lesion with molecular changes,and to explore the relationship between ACF and colorectal adenoma even carcinoma. METHODS: DNA from 35 CRC, 15 adenomas, 34 ACF and 10 normal mucus was isolated by means of microdissection. Direct gene sequencing of K-ras gene including codon 12, 13 and 61 as well as the mutation cluster region (MCR) of APC gene was performed. RESULTS: K-ras gene mutation frequency in ACF, adenoma and carcinoma was 17.6% (6/34), 13.3% (2/15), and 14.3% (5/35) respectively, showing no difference (P > 0.05) in K-ras gene mutation among three pathologic procedures. The K-ras gene mutation in adenoma, carcinoma and 4 ACF restricted in codon 12 (GGT GAT), but the other 2 mutations from ACF located in codon 13 (GGC GAC). K-ras gene mutation was found more frequently in older patients and patients with polypoid cancer. No mutation in codon 61 was found in the three tissue types. Mutation rate of APC gene in adenoma and carcinoma was 22.9% (8/35) and 26.7% (4/15), which was higher than ACF (2.9%) (P <0.05). APC gene mutation in carcinoma was not correlated with age of patients, location, size and differentiation of tumor. CONCLUSION: ACF might be a very early morphological lesion in the tumorogenesis of colorectal tumor. The morphological feature and gene mutation status was different in ACF and adenoma. ACF is possibly putative microadenoma that might be the precursor of adenoma. In addition, the development of a subgroup of colorectal carcinomas might undergo a way of normal epithelium ACF carcinomas .

关键词： Genes, APC Adenoma Colorectal Neoplasms DNA Mutational Analysis Gene Frequency Genes, ras Humans Point Mutation Research Support, Non-U.S. Gov't

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei jin Liu Tao Zhu Cheng Zhou Donghang zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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冈底斯成矿带东段的电性结构特征研究

地球物理学报 2017年第8期60卷 2993-3003页

作者：王刚魏文博金胜张乐天董浩谢成良郭泽秋中国地质大学(北京)地球物理与信息技术学院北京100083 地质过程与矿产资源国家重点实验室北京100083

冈底斯成矿带为我国著名的成矿区域,其东段存在一系列规模较大的矿床.为了研究冈底斯成矿带东段的电性结构特征,对覆盖主要矿集区的大地电磁测深数据进行全面的处理分析,通过二维与三维反演的综合对比得到了可靠的电性结构模型.结合其... 详细信息

冈底斯成矿带为我国著名的成矿区域,其东段存在一系列规模较大的矿床.为了研究冈底斯成矿带东段的电性结构特征,对覆盖主要矿集区的大地电磁测深数据进行全面的处理分析,通过二维与三维反演的综合对比得到了可靠的电性结构模型.结合其他地质与地球物理资料,对电性结构模型进行分析得到冈底斯成矿带东段的矿床分布规律:矿床主要分布在地壳浅表的电性分界面附近;中地壳高导体可能通过上地壳隐伏的南-北向断裂控制着与地壳伸展作用有关的矿床;南-北向张性构造与东-西向逆冲-推覆构造的交汇部位可能是冈底斯成矿带东段重要的成矿区域;下地壳可能受到软流圈物质上涌的影响发生部分熔融,从而与中地壳的高导体共同影响地壳浅部的成矿作用.

关键词：冈底斯成矿带东段电性结构大地电磁测深矿床分布规律