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A simple analytical model to predict liquid unloading in the horizontal gas well

Journal of Hydrodynamics 2021年第5期33卷 1056-1064页

作者： Zhi-bin Wang jin-quan ling Tian-li Sun Hong-yan Shi Guo Zhu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChendu 610500China State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an 710049China No 2 Gas Production PlantSouthwest Oil and Gas CompanySINOPECLangzhong 637400China Infrastructure Department Southwest Oil and Gas CompanySINOPECChengdu 610041China

An accurate prediction of the critical gas velocity for the liquid loading is of great importance for operators to select the tubing diameter for the newly drilled gas wells,or to optimize the production rate for production *** is clear from previous experimental studies of the liquid entrainment rate in the gas core that the liquid is mainly carried in the form of film under the critical condition of the liquid loading *** is more reasonable to establish a mathematical model based on the film reversal rather than based on the droplet *** our previous paper entitled“Prediction of the critical gas velocity of liquid unloading in the horizontal gas well”,a new analytical model was established based on the force balance between the gas-liquid interfacial friction force and the bottom film gravity,but the model is not very convenient to use because of the complexity of calculating the average film *** the present study,a new method is proposed to calculate the average film thickness from the bubble drift velocity in the mixture,so the new analytical model becomes much easier to *** new analytical model is evaluated against 103 sets of experimental data,the data in 124 vertical gas wells and one horizontal gas ***,the effect ofthe liquid loading on the production of the horizontal gas well is also analyzed.

关键词： Horizontal gas well inclined annular flow liquid-film thickness liquid unloading

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina quan ling Wang jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang quan jin Haitao Zhang Zhao Liu Yuyang Wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

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长白山区全新世大暖期的氨基酸和碳同位素记录

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微体古生物学报 2001年第4期18卷 392-397页

作者：王金权刘金陵中国科学院南京地质古生物研究所现代古生物学及地层学开放实验室南京210008

根据长白山孤山屯沼泽沉积物的氨基酸、有机碳、有机氮和有机碳同位素 (1 3 C/ 1 2 C)垂直分布的研究 ,揭示了长白山区距今 13.5 ka以来的气候环境特征及其演变过程 :大约距今 13.5 - 12 .5 ka,气候严寒 ,不利于生物的繁衍 ,生物产量处... 详细信息

根据长白山孤山屯沼泽沉积物的氨基酸、有机碳、有机氮和有机碳同位素 (1 3 C/ 1 2 C)垂直分布的研究 ,揭示了长白山区距今 13.5 ka以来的气候环境特征及其演变过程 :大约距今 13.5 - 12 .5 ka,气候严寒 ,不利于生物的繁衍 ,生物产量处于较低值 ;距今 12 .5 - 9.5 ka,气温处于上升期 ,但年均温度仍低于现今温度 ;距今 9.5 - 4.0 ka,可判定为全新世大暖期 (Megatherm al) ,气候温暖潮湿 ,有利于生物的繁衍 ,生物产量较高。其中大约距今 8.6 - 7.5 ka期间 ,氨基酸、有机碳、有机氮分布均出现较高峰值 ,而有机碳同位素 (δ1 3 C)则出现较低峰值 ,可以推测这一时段为全新世大暖期的鼎盛期 (Megathermal Maximum) ,生物极为繁盛 ,生物产量处于最高值 ;距今 4.0 ka以来 ,气温有下降趋势 ,生物产量有所减少。

关键词：氨基酸有机碳同位素全新世大暖期长白山区东北中国沼泽沉积物古生态

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan lingqi Yu Xudong Zhuang Dongjing Wen jin He jingmei Hong Jiayu Xie Shengan ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： jing-Wen Xie Meng-Ting Wang Yan jin Si Li Jian-Hua Qin Shuang-quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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A parallel scheduling algorithm for reinforcement learning in large state space

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Frontiers of Computer Science 2012年第6期6卷 631-646页

作者： quan LIU Xudong YANG ling jinG jin LI Jiao LI Institute of Computer Science and Technology Soochow UniversitySuzhou 215006China Department of Computer Science and Technology Nanjing UniversityNanjing 210093China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchun 130012China

The main challenge in the area of reinforcement learning is scaling up to larger and more complex problems. Aiming at the scaling problem of reinforcement learning, a scalable reinforcement learning method, DCS-SRL, is proposed on the basis of divide-and-conquer strategy, and its convergence is proved. In this method, the learning problem in large state space or continuous state space is decomposed into multiple smaller subproblems. Given a specific learning algorithm, each subproblem can be solved independently with limited available resources. In the end, component solutions can be recombined to obtain the desired result. To ad- dress the question of prioritizing subproblems in the scheduler, a weighted priority scheduling algorithm is proposed. This scheduling algorithm ensures that computation is focused on regions of the problem space which are expected to be maximally productive. To expedite the learning process, a new parallel method, called DCS-SPRL, is derived from combining DCS-SRL with a parallel scheduling architecture. In the DCS-SPRL method, the subproblems will be distributed among processors that have the capacity to work in parallel. The experimental results show that learning based on DCS-SPRL has fast convergence speed and good scalability.

关键词： divide-and-conquer strategy parallel schedule scalability large state space continuous state space

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On the Integrality of Characteristic Elements in Nonabelian Iwasawa Theory

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Acta Mathematica Sinica,English Series 2008年第1期24卷 43-58页

作者： ling quan KONG School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

This paper is concerned with a conjecture formulated by Coates et al in [4] which describes the relation between the integrality of the characteristic elements and their evaluations in the noncommutative Iwasawa theor... 详细信息

关键词： p-adic Lie group K group characteristic element Iwasawa theory

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Complementary and alternative medicine during COVID-19 pandemic:What we have done

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Journal of Integrative Medicine 2022年第1期20卷 1-3页

作者： Chang-quan ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

At the end of 2019,the coronavirus disease 2019(COVID-19)epidemic broke out around the ***-19 is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2);its most common symptoms include fever,dry cough,and fatigue[1,2].The fast spread,high fatality rate,and continuous mutation of SARS-Co V-2 have brought huge challenges to public health and the global economy[3,4].

关键词： acute respiratory COV

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