检索结果-南通市图书馆

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第3期16卷 183-211页

作者： jin zhou Shenghan zhou Peidi Fan Xunjia Li Yibin Ying Jianfeng Ping Yuxiang Pan Laboratory of Agricultural Information Intelligent Sensing College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200People’s Republic of China

In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human ***,implantable electrochemical microsensors have emerged as a prominent area of *** microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for *** have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional *** development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated *** review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for *** this,we proceeded to explore the various implantation technologies employed for electrochemical *** addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease ***,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.

关键词： Electrochemical microsensors Implantable sensors In vivo monitoring Animal physiological information

Neural-field-assisted transport-of-intensity phase microscopy: partially coherent quantitative phase imaging under unknown defocus distance

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2024年第7期12卷 1494-1501页

作者： YANBO jin LINPENG LU SHUN zhou JIE zhou YAO FAN CHAO ZUO Smart Computational Imaging Laboratory(SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Smart Computational Imaging Research Institute(SCIRI)of Nanjing University of Science and Technology Nanjing 210019China Jiangsu Key Laboratory of Spectral Imaging&Intelligent Sense Nanjing 210094China

The transport-of-intensity equation(TIE) enables quantitative phase imaging(QPI) under partially coherent illumination by measuring the through-focus intensities combined with a linearized inverse reconstruction algorithm. However, overcoming its sensitivity to imaging settings remains a challenging problem because of the difficulty in tuning the optical parameters of the imaging system accurately and because of the instability to long-time measurements. To address these limitations, we propose and experimentally validate a solution called neural-field-assisted transport-of-intensity phase microscopy(NFTPM) by introducing a tunable defocus parameter into neural field. Without weak object approximation, NFTPM incorporates the physical prior of partially coherent image formation to constrain the neural field and learns the continuous representation of phase object without the need for training. Simulation and experimental results of He La cells demonstrate that NFTPM can achieve accurate, partially coherent QPI under unknown defocus distances, providing new possibilities for extending applications in live cell biology.

关键词： field coherent phase

Time-domain dynamic constitutive model suitable for mucky soil site seismic response

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 1-13页

作者： Dong Qing Chen Su jin Liguo zhou Zhenghua Li Xiaojun Architectural Engineering Institute Huaiyin Institute of TechnologyHuai’an 223600China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100020China Institute of Geophysics China Earthquake AdministrationBeijing 100089China College of Transportation Science and Engineering Nanjing Tech UniversityNanjing 211816China

Soil nonlinear behavior displays noticeable effects on the site seismic *** study proposes a new functional expression of the skeleton curve to replace the hyperbolic skeleton *** integrating shear modulus and combining the dynamic skeleton curve and the damping degradation coefficient,the constitutive equation of the logarithmic dynamic skeleton can be obtained,which considers the damping effect in a soil dynamics *** on the finite difference method and the multi-transmitting boundary condition,a 1D site seismic response analysis program called Soilresp1D has been developed herein and used to analyze the time-domain seismic response in three types of *** the same time,this study also provides numerical simulation results based on the hyperbolic constitutive model and the equivalent linear *** results verify the rationality of the new soil dynamic constitutive *** can analyze the mucky soil site nonlinear seismic response,reflecting the deformation characteristics and damping effect of the silty *** hysteresis loop area is more extensive,and the residual strain is evident.

关键词： seismic response time-domain dynamic constitutive model logarithmic dynamic skeleton dampening effect mucky soil

Identification and Expression Profile of a Neuropeptide LFRFamide-Like Gene During Different Stages of Gonadal Development in the Cephalopod Sepia pharaonis

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2024年第2期23卷 499-508页

作者： qiu Jiayin SUN Lianlian LI Shuang zhou Xu CHI Changfeng ZHENG Libing National and Provincial Joint Engineering Research Center for Marine Germplasm Resources Exploration and Utilization School of Marine Science and TechnologyZhejiang Ocean UniversityZhoushan 316022China

Neuropeptides are widely distributed in vertebrates and invertebrates,regulating a variety of physiological activities in the organisms,such as metabolism,feeding and *** this study,to explore the function of neuropeptide LFRFamide in Sepia pharaonis,the full-length cDNA of LFRFamide-like gene(named SpLFRFL,MG869822.1)was identified with rapid amplification of cDNA ends(RACE)*** sequence of SpLFRFL was 860 bp in length and encoded 188 amino acids containing 4 different mature peptides:1 copy of PHTPFRFamide,NSLFRFamide,TIFRFamide,and 3 copies of *** alignment and phylogenetic analysis results showed that SpLFRFL shared high identity with LFRFamides of Sepia officinalis and Sepiella japonica and had the closest relationship with *** quantitative Real-time PCR(qRT-PCR),it was found that the SpLFRFL gene was highly expressed in the optic lobe and brain at three different stages during gonad development in both ***,the four mature peptides at a concentration of 0.01μmol L^(−1) could inhibit the protein synthesis in the Chinese hamster ovary cell strain-K1(CHOK1)induced by *** data suggest that SpLFRFL might be involved in the development and reproduction of *** results can contribute to future studies on neuropeptide evolution and function and benefit the cuttlefish farming.

关键词： neuropeptide LFRFamide-like cephalopod cuttlefish Sepia pharaonis development reproduction

A robust triaxial localization method of AE source using refraction path

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2024年第4期34卷 521-530页

作者： Yichao Rui Jie Chen Jiongkun Chen Jiadong qiu Zilong zhou Wenzhong Wang jinyang Fan State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China School of Resources and Safety Engineering Central South UniversityChangsha 410083China Coal Geological Exploration Institute of Gansu Lanzhou 730030China

Acoustic emission(AE)localization algorithms based on homogeneous media or single-velocity are less accurate when applied to the triaxial localization *** the end,a robust triaxial localization method of AE source using refraction path is ***,the control equation of the refraction path is established according to the sensor coordinates and arrival ***,considering the influence of time-difference-of-arrival(TDOA)errors,the residual of the governing equation is calculated to estimate the equation ***,the refraction points in different directions are solved using Snell’s law and orthogonal ***,the source coordinates are iteratively solved by weighted correction *** feasibility and accuracy of the proposed method are verified by pencil-lead breaking *** simulation results show that the new method is almost unaffected by the refraction ratio,and always holds more stable and accurate positioning performance than the traditional method under different ratios and scales of TDOA outliers.

关键词： Acoustic emission(AE) Source localization Robust method Refraction paths Weight estimations

FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2730-2738页

作者： jin-Hang Xue qiu-Hong Sun Cheng Han Yuan-Dong Yang Shao-Jie Xu Qi-Peng Li jin-Jie Qian College of Life and Environmental Science Wenzhou UniversityWenzhou 325000China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325000China College of Chemistry and Chemical Engineering Zhaotong UniversityZhaotong 657000China

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and *** this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets(denoted as GCS-O).These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination ***,the growth of FeNi Prussian blue analogue(PBA)on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous *** resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·L^(-1).Meanwhile,it also achieves a high sensitivity of 2496μA·mmol^(-1)·L·cm^(-2),a limit of detection of 100nmol·L^(-1)(S/N=3),and commendable long-term *** relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation

Rts: learning robustly from time series data with noisy label

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第6期18卷 186332-186332页

作者： zhou Zhi jin Yi-Xuan Li Yu-Feng National Key Laboratory for Novel Software Technology Nanjing University

Significant progress has been made in machine learning with large amounts of clean labels and static data. However, in many real-world applications, the data often changes with time and it is difficult to obtain massive clean annotations, that is, noisy labels and time series are faced simultaneously. For example, in product-buyer evaluation, each sample records the daily time behavior of users, but the long transaction period brings difficulties to analysis, and salespeople often erroneously annotate the user’s purchase behavior. Such a novel setting, to our best knowledge, has not been thoroughly studied yet, and there is still a lack of effective machine learning methods. In this paper, we present a systematic approach RTS both theoretically and empirically, consisting of two components, Noise-Tolerant Time Series Representation and Purified Oversampling Learning. Specifically, we propose reducing label noise’s destructive impact to obtain robust feature representations and potential clean samples. Then, a novel learning method based on the purified data and time series oversampling is adopted to train an unbiased model. Theoretical analysis proves that our proposal can improve the quality of the noisy data set. Empirical experiments on diverse tasks, such as the house-buyer evaluation task from real-world applications and various benchmark tasks, clearly demonstrate that our new algorithm robustly outperforms many competitive methods.

关键词： weakly-supervised learning time-series classification class-imbalanced learning

Regulation of m^(6)Am RNA modification and its implications in human diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2024年第3期16卷 1-8页

作者： Hao jin zhouyuanjing Shi Tianhua zhou Shanshan Xie Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Cell Biology Zhejiang University School of MedicineHangzhou 310058China Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310020China Center for Medical Research and Innovation in Digestive System Tumors Ministry of EducationHangzhou 310020China

N6,2′-O-dimethyladenosine(m^(6)Am)is a prevalent modification frequently found at the 5′cap-adjacent adenosine of messenger RNAs(mRNAs)and small nuclear RNAs(snRNAs)and the internal adenosine of *** dynamic and reversible modification is under the regulation of methyltransferases phosphorylated CTD interacting factor 1 and methyltransferase-like protein 4,along with the demethylase fat mass and obesity-associated protein.m^(6)Am RNA modification plays a crucial role in the regulation of pre-mRNA splicing,mRNA stability,and translation,thereby influencing gene *** recent years,there has been growing interest in exploring the functions of m^(6)Am and its relevance to human *** this review,we provide a comprehensive overview of the current knowledge concerning m^(6)Am,with a focus on m^(6)Am-modifying enzymes,sequencing approaches for its detection,and its impacts on pre-mRNA splicing,mRNA stability,and translation ***,we highlight the roles of m^(6)Am in the context of obesity,viral infections,and cancers,unravelling its underlying regulatory mechanisms.

关键词： m^(6)Am RNA modification gene regulation obesity viral infection cancer

Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles:Sequential Embryo Transfer or Double-blastocyst Transfer?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第1期44卷 212-222页

作者： Qiao-hang ZHAO Yu-wei SONG Jian CHEN Xiang zhou Ji-lai XIE qiu-ping YAO Qi-yin DONG Chun FENG Li-ming zhou Wei-ping FU Min jin The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310052China Jiaxing Maternity and Child Health Care Hospital Jiaxing 314051China Huzhou Maternity and Child Care Hospital Huzhou 313002China Ningbo Women and Children's Hospital Ningbo 315000China

Objective Both sequential embryo transfer(SeET)and double-blastocyst transfer(DBT)can serve as embryo transfer strategies for women with recurrent implantation failure(RIF).This study aims to compare the effects of SeET and DBT on pregnancy *** Totally,261 frozen-thawed embryo transfer cycles of 243 RIF women were included in this multicenter retrospective *** to different embryo quality and transfer strategies,they were divided into four groups:group A,good-quality SeET(GQ-SeET,n=38 cycles);group B,poor-quality or mixed-quality SeET(PQ/MQ-SeET,n=31 cycles);group C,good-quality DBT(GQ-DBT,n=121 cycles);and group D,poor-quality or mixed-quality DBT(PQ/MQ-DBT,n=71 cycles).The main outcome,clinical pregnancy rate,was compared,and the generalized estimating equation(GEE)model was used to correct potential confounders that might impact pregnancy *** GQ-DBT achieved a significantly higher clinical pregnancy rate(aOR 2.588,95%CI 1.267–5.284,P=0.009)and live birth rate(aOR 3.082,95%CI 1.482–6.412,P=0.003)than PQ/***,the clinical pregnancy rate was significantly higher in GQ-SeET than in PQ/MQ-SeET(aOR 4.047,95%CI 1.218–13.450,P=0.023).The pregnancy outcomes of GQ-SeET were not significantly different from those of GQ-DBT,and the same results were found between PQ/MQ-SeET and PQ/*** SeET relative to DBT did not seem to improve pregnancy outcomes for RIF patients if the embryo quality was comparable between the two *** clinical pregnancy outcomes could be obtained by transferring good-quality embryos,no matter whether in SeET or *** quality plays a more important role in pregnancy outcomes for RIF patients.

关键词： recurrent implantation failure sequential embryo transfer frozen-thawed embryo transfer embryo transfer strategies