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Study of liver cirrhosis over twenty consecutive years in adults in Southern China

World Journal of Hepatology 2023年第12期15卷 1294-1306页

作者： Xing Wang jin-ni luo Xiao-Ying Wu Qi-Xian Zhang Bin Wu Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Patient Case Management Division The Third Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Liver cirrhosis(LC)is a prevalent and severe disease in *** burden of LC is changing with widespread vaccination of hepatitis B virus(HBV)and antiviral ***,the recent transition in etiologies and clinical features of LC cases requiring hospitalization is *** To identify the transition in etiologies and clinical characteristics of hospitalized LC patients in Southern *** In this retrospective,cross-sectional study we included LC inpatients admitted between January 2001 and December *** data indicating etiological diagnosis and LC complications,and demographic,laboratory,and imaging data were collected from our hospital-based *** etiologies of LC were mainly determined according to the discharge diagnosis,and upper gastrointestinal bleeding,ascites,hepatic encephalopathy,spontaneous bacterial peritonitis,hepatocellular carcinoma(HCC),portal vein thrombosis,hepatorenal syndrome,and acute-on-chronic liver failure(ACLF)were considered LC-related complications in our *** trends in the etiologies and clinical characteristics were investigated using logistic regression,and temporal trends in proportions of separated years were investigated using the Cochran-Armitage ***-hospital prognosis and risk factors associated with in-hospital mortality were also invest *** A total of 33143 patients were included in the study[mean(SD)age,51.7(11.9)years],and 82.2%were *** mean age of the study population increased from 51.0 years in 2001-2010 to 52.0 years in 2011-2020(P<0.001),and the proportion of female patients increased from 16.7%in 2001-2010 to 18.2%in 2011-2020(P=0.003).LC patients in the decompensated stage at diagnosis decreased from 68.1%in 2001-2010 to 64.6%in 2011-2020(P<0.001),and the median score of model for end-stage liver disease also decreased from 14.0 to 11.0(P<0.001).HBV remained the major etiology of LC(75.0%)and the dominant cause of viral hepatitis-LC(94.5%)during th

关键词： Liver cirrhosis Epidemiology Etiology Upper gastrointestinal bleeding Hepatocellular carcinoma In-hospital mortality

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Production of Functional Materials Derived from Regenerated Silk Fibroin by Utilizing 3D Printing and Biomimetic Enzyme-induced Mineralization

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Chinese Journal of Polymer Science 2024年第3期42卷 299-310,I0005页

作者： ni Chen Fei-Yu luo Gong-Wen Yang jin-Rong Yao Xin Chen Zheng-Zhong Shao State Key Laboratory of Molecular Engineering of Polymers Laboratory of Advanced Materials and Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Critical-sized bone defects, commonly encountered in clinical orthopedic surgery, present a significant challenge. One of the promising solutions is to prepare synthetic bone substitute materials with precise structural control, mechanical compatibility, and enhanced osteogenic induction performance, nevertheless the successful preparation of such materials remains difficult. In this study, a two-step technique,integrating an extrusion-based printing process with biomimetic mineralization induced by alkaline phosphatase(ALP), was developed. Initially,a pre-cured hydrogel of regenerated silk fibroin(RSF) with a small quantity of hydroxypropyl cellulose(HPC) and ALP was prepared through heating the mixed aqueous solution. This pre-cured hydrogel demonstrated thixotropic property and could be directly extruded into predetermined structures through a 3D-printer. Subsequently, the 3D-printed RSF-based materials with ALP underwent biomimetic in situ mineralization in calcium glycerophosphate(Ca-GP) mineralizing solution, utilizing the polymer chains of RSF as templates and ALP as a trigger for cleaving phosphate bonds of Ca-GP. The resulting 3D-printed RSF-mineral composites including hydrogel and sponge possessed adjustable compression modulus of megapascal grade and variable hydroxyapatite content, which could be controlled by manipulating the duration of the mineralization ***, these 3D-printed RSF-mineral composites demonstrated non-cytotoxicity towards rat bone marrow mesenchymal stem cells. Therefore, they may hold great potential for applications involving the replacement of tissues characterized by osteoinductivity and intricate structures.

关键词： Silk protein Alkaline phosphatase Extrusion-based printing Biomineralization

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TOFD detection of shallow subsurface defects in aluminum alloy thin plates by half-skip mode-converted wave

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Chinese Journal of Aeronautics 2024年第6期37卷 454-463页

作者： Shijie jin Zhicheng WANG Zhongbing luo NDT&E Laboratory Dalian University of TechnologyDalian 116085China

Aluminum alloy is widely applied to the aerospace ***,the inspection of thin plates using Time-of-Flight Diffraction(TOFD)technique is restricted by the near-surface dead zone because of the coupling between diffracted longitudinal wave and lateral *** halfskip mode-converted wave is introduced to decrease dead zone and detect defects in aluminum alloy thin plates by increasing ray path and propagation *** quantitative correlation for the diffracted shear wave from longitudinal back-wall wave is deduced in combination with the acoustic path,realizing the accurate location of shallow subsurface *** and experimental results indicate that the dead zone is decreased by 38% by the half-skip mode-converted wave,and the location errors are within 5% for the aluminum alloy plate with a thickness of 7.0 *** to other alternative TOFD techniques,half-skip mode-converted wave has better response amplitude and positioning accuracy,demonstrating strong applicability in TOFD inspection of thin plates.

关键词： Ultrasonic testing Time-of-Flight Diffraction(TOFD) Dead zone Half-skip mode-converted wave Quantitative detection

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Improving IEC thermal model for oil natural air natural transformers using optimised parameters based on dynamic simulation

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High Voltage 2024年第1期9卷 217-229页

作者： Lijing Zhang Yingting luo Gehao Sheng Zizhan ni Xiuchen Jiang Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghaiChina Electric Power Research Institute of Guangdong Power Grid Corporation GuangzhouChina

Accurate assessment of hot-spot temperature is essential for the safe operation of power *** dynamic thermal models cannot estimate hot-spot temperature accurately since some input parameters are roughly determined by transformer capacity and cooling mode while ignoring the effect of winding structure,tank dimensions,and material physical *** improve the accuracy of temperature assessment,empirical parameters of the IEC thermal model including thermal constants,winding and oil exponents are optimised with the help of numerical simulation in this *** on energy conservation and heat transfer theory,a computational fluid dynamic(CFD)model of a transformer in oil natural air natural(ONAN)cooling mode is *** CFD model simulates the entity's structure,sizes,and multi-stage heat dissipation processes realistically,so it can more precisely calculate the dynamic hot-spot *** to the simulated temperature curves at different operating conditions,the thermal constants and oil exponent are estimated using non-linear regression,and the winding exponent is optimised using linear regression.A case study is conducted on an ONAN *** shows the improved IEC model with optimised parameters can more accurately evaluate hot-spot temperature,and the absolute error is decreased by 2.4 K(38.7%)compared with traditional thermal models.

关键词： temperature properties. thermal

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Causal temporal graph attention network for fault diagnosis of chemical processes

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Chinese Journal of Chemical Engineering 2024年第6期70卷 20-32页

作者： Jiaojiao luo Zhehao jin Heping jin Qian Li Xu Ji Yiyang Dai School of Chemical Engineering Sichuan UniversityChengdu 610065China China Three Gorges Corporation Beijing 100038China

Fault detection and diagnosis(FDD)plays a significant role in ensuring the safety and stability of chemical *** the development of artificial intelligence(AI)and big data technologies,data-driven approaches with excellent performance are widely used for FDD in chemical ***,improved predictive accuracy has often been achieved through increased model complexity,which turns models into black-box methods and causes uncertainty regarding their *** this study,a causal temporal graph attention network(CTGAN)is proposed for fault diagnosis of chemical processes.A chemical causal graph is built by causal inference to represent the propagation path of *** attention mechanism and chemical causal graph were combined to help us notice the key variables relating to fault *** in the Tennessee Eastman(TE)process and the green ammonia(GA)process showed that CTGAN achieved high performance and good explainability.

关键词： Chemical processes Safety Fault diagnosis Causal discovery Attention mechanism Explainability

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Ceramic-based meta-material absorber with high-temperature stability

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Rare Metals 2024年第9期43卷 4433-4440页

作者： Xing-Cong Chen Wei-Jia luo Run-ni Zhao Yong-Zheng Wen Ji Zhou State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

With the continuous exploration of uncharted and extreme environments,enhanced temperature robustness of passive devices has become particularly *** this study,a ceramic-based meta-material absorber with exceptional temperature stability is developed using a fusion design approach that combines rare metal-based tungsten bronze structural ceramics and ***,the absorbance of the meta-material array based on Mie resonance exceeds 49.0%in both waveguides and free space,approaching the theoretical *** to impedance analysis,the absorption performance can be distinctly correlated with the dielectric loss(Q_(f)).Notably,the high-temperature robustness is verified to still be effective at 400℃.These advancements in our design allow for the use of monolithic materials in fabricating temperature-stable perfect absorbers,providing greater freedom in the dielectric performance and expanding their potential applications,including in space exploration and 5G millimeter-wave scenarios.

关键词： Temperature robustness Meta-material absorber Microwave absorption Rare metal-based ceramics Miniaturization

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Striking a growth–defense balance:Stress regulators that function in maize development

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Journal of Integrative Plant Biology 2024年第3期66卷 424-442页

作者： Shiyi Xie Hongbing luo Wei Huang Weiwei jin Zhaobin Dong Maize Engineering and Technology Research Center of Hunan Province College of AgronomyHunan Agricultural UniversityChangsha 410128China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingChina Agricultural UniversityBeijing 100193China Tianjin Key Laboratory of Intelligent Breeding of Major Crops Fresh Corn Research Center of BTHCollege of Agronomy&Resources and EnvironmentTianjin Agricultural UniversityTianjin 300384China

Maize(Zea mays)cultivation is strongly affected by both abiotic and biotic stress,leading to reduced growth and *** has recently become clear that regulators of plant stress responses,including the phytohormones abscisic acid(ABA),ethylene(ET),and jasmonic acid(JA),together with reactive oxygen species(ROS),shape plant growth and *** their well established functions in stress responses,these molecules play crucial roles in balancing growth and defense,which must be finely tuned to achieve high yields in crops while maintaining some level of *** this review,we provide an in-depth analysis of recent research on the developmental functions of stress regulators,focusing specifically on *** unraveling the contributions of these regulators to maize development,we present new avenues for enhancing maize cultivation and growth while highlighting the potential risks associated with manipulating stress regulators to enhance grain yields in the face of environmental challenges.

关键词： stress regulators maize development ABA ET JA ROS

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Experimental study of the damage characteristics of rocks containing non-penetrating cracks under cyclic loading

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International Journal of Mining Science and Technology 2024年第2期34卷 197-210页

作者： Jun Xu Xiaochun Xiao Lu Ma Sen luo Jiaxu jin Baijian Wu School of Mechanics and Engineering Liaoning Technical UniversityFuxin 123000China School of Civil Engineering Liaoning Technical UniversityFuxin 123000China Department of Engineering Mechanics Southeast UniversityNanjing 211189China

The damage evolution process of non-penetrating cracks often causes some unexpected engineering *** specimens containing non-penetrating crack(s)are used to study the damage evolution and characteristics under cyclic *** results show that under cyclic loading,the relationship between the number of non-penetrating crack(s)and the characteristic parameters(cyclic number,peak stress,peak strain,failure stress,and failure strain)of the pre-cracked specimens can be represented by a decreasing linear *** damage evolution equation is fitted by calibrating the accumulative plastic strain for each cycle,and the damage constitutive equation is proposed by the concept of effective ***,non-penetrating cracks are more likely to cause uneven stress distribution,damage accumulation,and local failure of *** local failure can change the stress distribution and relieve the inhibition of non-penetrating crack extension and eventually cause a dramatic destruction of the ***,the evolution process caused by non-penetrating cracks can be regarded as one of the important reasons for inducing *** results are expected to improve the understanding of the process of spalling formation and rockburst and can be used to analyze the stability of rocks or rock structures.

关键词： Damage characteristics Constitutive model Fissured rocks Non-penetrating crack Cyclic loading

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Self-Powered Piezo-Supercapacitors Based on ZnO@Mo-Fe-MnO2 Nanoarrays

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Energy & Environmental Materials 2024年第4期7卷 304-314页

作者： luo Sun Zhiguo Ye Xinyuan Peng Shaojie Zhuang Duosheng Li Zhong jin School of Materials Science and Engineering Nanchang Hangkong University State Key Laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic Chemistry MOE Key Laboratory of High Performance Polymer Materials and Technology Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University

The development of self-charging supercapacitor power cells （SCSPCs） has profound implications for smart electronic devices used in different ***,we epitaxially electrodeposited Mo-and Fe-codoped MnO2films on piezoe... 详细信息

关键词： MnO2 piezoelectric self-charging supercapacitors ZnO nanoarray

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Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

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World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-Hua Zhang Zhi-Hua Xu Shuang-Shuang ni Hong-Xia luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

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