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The effectiveness and safety of acupuncture for poor semen quality in infertile males： a systematic review and meta-analysis

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Asian Journal of Andrology 2014年第6期16卷 884-891页

作者： Ui Min Jerng Jun-Young Jo Seunghoon lee jin-moo lee Ohmin Kwon Class of Oncology Class of Gynecology Department of Clinical Korean Medicine Kyung Hee University Graduate School Seoul Korea Conmaul Hospital Seoul Korea Class of Acupuncture and Moxibustion Department of Clinical Korean Medicine Kyung Hee University Graduate School Seoul Korea Medical History and Literature Group Korea Institute of Oriental Medicine Daejeon Korea

The aim of this review is to evaluate the effectiveness and safety of acupuncture for poor semen quality in infertile men. We searched for relevant trials registered up to May 2013 in 14 databases. We selected randomized controlled trials （RCTs） that compared acupuncture, with or without additional treatment, against placebo, sham, no treatment, or the same additional treatment. Two reviewers independently performed the study selection, data extraction, risk of bias and reporting quality appraisal. Risk of bias and reporting quality were appraised by the Cochrane risk of bias tool, the consolidated standards of reporting trials and Standards for Reporting Interventions in Clinical Trials of Acupuncture. The outcomes were sperm motility, sperm concentration, pregnancy rate, and adverse events. Pregnancy was defined as a positive pregnancy test. Four RCTs met the eligibility criteria. Acupuncture increased the percentage of sperm with rapid progression （mean difference - 6.35, 95% confidence interval （CI）. 4.38-8.32, P〈 0.00001） and sperm concentration （mean difference - 6.42, 95% CI. 4.91-7.92, P〈 0.00001）, but these two outcomes were substantially heterogeneous among the studies （F = 72% and 58%, respectively）. No differences in pregnancy rate were found between acupuncture and control groups （odds ratio 1.60, 95% CI. 0.70-3.69, P= 0.27, F = 0%）. No participants experienced adverse events. The current evidence showing that acupuncture might improve poor semen quality is insufficient because of the small number of studies, inadequacy of procedures and/or insufficient information for semen analysis, high levels of heterogeneity, high risk of bias, and poor quality of reporting. Further large, well-designed RCTs are required.

关键词： acupuncture asthenozoospermia male infertility oligozoospermia sperm quality

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Reliability and validity of tongue color analysis in the prediction of symptom patterns in terms of East Asian Medicine

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Journal of Traditional Chinese Medicine 2016年第2期36卷 165-172页

作者： Young-Jae Park jin-moo lee Seung-Yeon Yoo Young-Bae Park Department of Diagnosis and Biofunctional Medicine College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Diagnosis and Biofunctional Medicine Kyung Hee University Hospital at GangdongSeoul 134-727Korea Department of Oriental Gynecology College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Women Health Clinic Kyung Hee University Hospital at GancldonaSeoul 134-727Knrpa

OBJECTIVE:To examine whether color parameters of tongue inspection(TI)using a digital camera was reliable and valid,and to examine which color parameters serve as predictors of symptom patterns in terms of East Asian medicine(EAM).METHODS:Two hundred female subjects'tongue substances were photographed by a mega-pixel digital *** with the photographs,the subjects were asked to complete Yin deficiency,Phlegm pattern,and Cold-Heat pattern *** three sets of digital imaging software,each digital image was exposure-and white balance-corrected,and finally L*(luminance),a*(red-green balance),and b*(yellow-blue balance)values of the tongues *** examine intra-and inter-rater reliabilities and criterion validity of the color analysis method,three raters were asked to calculate color parameters for 20 digital image ***,four hierarchical regression models were ***:Color parameters showed good or excellent reliability(0.627-0.887 for intra-class correlation coefficients)and significant criterion validity(0.523-0.718 for Spearman's correlation).In the hierarchical regression models,age was a significant predictor of Yin deficiency(β=0.192),and b*value of the tip of the tongue was a determinant predictor of Yin deficiency,Phlegm,and Heat patterns(β=-0.212,-0.172,and-0.163).Luminance(L*)was predictive of Yin deficiency(β=-0.172)and Cold(β=0.173)***:Our results suggest that color analysis of the tongue using the L*a*b*system is reliable and valid,and that color parameters partially serve as symptom pattern predictors in EAM practice.

关键词： Medicine East Asian Traditional Complementary therapies Tongue inspection Yin deficiency Symptom pattern

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Analyses on performances of heat and multilayer reflection insulators

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Journal of Central South University 2012年第6期19卷 1645-1656页

作者： lee moo-jin lee Kang-guk SEO Won-duck School of Architecture Kyungil UniversityGyeongsan 702701Korea Research Center for Urban Affair Kyungil UniversityGyeongsan 702701Korea Department of Architectural Design Joongbu UniversityGeumsan-gun 701140Korea

This research was conducted to study the performances of the heat and multilayer reflection insulators used for buildings in South Korea to realize eco-friendly, low-energy-consumption, green construction, and to contribute to energy consumption reduction in buildings and to the nation＇s greenhouse gas emission reduction policy （targeting 30% reduction compared to BAUCousiness as usual） by 2020）. The heat insulation performance test is about the temperatures on surfaces of test piece. The high air temperature and the low air temperature were measured to determine the overall heat transfer coefficient and thermal conductivity. The conclusions are drawn that the heat transmission coefficients for each type of existing reflection insulator are： A-1 （0.045 W/（m-K））, A-2 （0.031 W/（m.K））, A-3 （0.042 W/（m.K））, A-4 （0.078 W/（m.K））, and the average heat conductivity is 0.049 W/（m-K）; The heat conductivity for each type of Styrofoam insulator are 0.030 W/（m.K） for B-l, 0.032 W/（m-K） for B-2, 0.037 W/（m＇K） for B-3, 0.037 W/（m.K） for B-4, and the average heat conductivity is 0.035 W/（m＇K） regardless of the thickness of the insulator; The heat conductivity values of the multilayer reflection insulators are converted based on the thickness and type C-1 （0.020 W/（m.K））, C-2 （0.018 W/（m.K））, C-3 （0.016 W/（m.K））, and C-4 （0.012 W/（m.K））; The multilayer reflection insulator keeps the indoor-side surface temperature high （during winter） or low （in summer）, enhances the comfort of the building occupants, and conducts heating and moisture resistance to prevent dew condensation on the glass-outer-wall surface.

关键词： heat reflection insulator multilayer reflection insulator overall heat transfer coefficient thermal conductivity nonflammability vapor permeability eco-friendly construction

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Techniques for overcoming atretic changes of the portal vein in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 311-317页

作者： Jeong-moo lee Kwang-Woong lee Department of Surgery Seoul National University College of Medicine101 Daehak-roJongno-guSeoul 03080Korea

Background:Spontaneous diversion of the portal flow through collateral vessels into the systemic circulation is frequently observed in liver transplant recipients with severe portal *** induces main portal vein atretic change and modifies flow into the collateral even after donor graft *** atretic changes make liver transplantation *** this article we described several methods for overcoming this challenge by appropriate surgical ***:Three anastomotic techniques for living donor liver transplantation were performed in patients with atretic changes in the portal ***:The three techniques were(1)venoplasty to widen the diameter by using the recipient’s portal vein,and the diameter of the recipient’s portal vein was enlarged using their own portal vein stump patch;(2)conduit with cryopreserved vessels,and we dissected around the superior mesenteric vein and splenic vein junction and a conduit was built using the cryopreserved vessels;and(3)left gastric varix to portal vein anastomosis,if the recipients had large gastric varix and variceal wall was sufficiently thick for ***:Selection of optimal methods for portal vein anastomosis is essential in patients with atrophic change on the portal *** these methods are used aptly,they can be considered as favorable methods for overcoming each situation.

关键词： Atretic portal vein Liver transplantation Anastomosis

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Extracellular nucleoprotein exacerbates influenza viruspathogenesis by activating Toll-like receptor 4 and the NLRP3inflammasome

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Cellular & Molecular Immunology 2022年第6期19卷 715-725页

作者： Chang-Ung Kim Yu-jin Jeong Pureum lee moo-Seung lee Jong-Hwan Park Young-Sang Kim Doo-jin Kim Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)DaejeonSouth Korea Department of Biochemistry Chungnam National UniversityDaejeonSouth Korea Environmental Diseases Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)DaejeonSouth Korea University of Science and Technology(UST) DaejeonSouth Korea College of Veterinary Medicine Chonnam National UniversityGwangjuSouth Korea

Host immune responses, such as those initiated by pattern recognition receptor (PRR) activation, are important for viralclearance and pathogenesis. However, little is known about the interactions of viral proteins with surface PRRs or, moreimportantly, the association of innate immune activation with viral pathogenesis. In this study, we showed that internalinfluenza virus proteins were released from infected cells. Among these proteins, nucleoprotein (NP) played a critical role inviral pathogenesis by stimulating neighboring cells through toll-like receptor (TLR)2, TLR4, and the NLR family pyrin domaincontaining 3 (NLRP3) inflammasome. Through the activation of these PRRs, NP induced the production of interleukin (IL)-1β andIL-6, which subsequently led to the induction of trypsin. Trypsin induced by NP increased the infectivity of influenza virus,leading to increases in viral replication and pathology upon subsequent viral infection. These results reveal the role of releasedNP in influenza pathogenesis and highlight the importance of the interactions of internal viral proteins with PRRs in theextracellular compartment during viral pathogenesis.

关键词： Influenza virus Viral protein release Nucleoprotein Toll-like receptor Cyotkine-trypsin cycle

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Study on wear behavior of plasma electrolytic oxidation coatings on aluminum alloy

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Rare Metals 2006年第z2期25卷 141-145页

作者： KANG Suk-Bong lee Jung-moo Department of Materials Engineering Korean Institute of Machinery & Materials Gyeongnam 641831 Korea

Thick and hard ceramic coatings were fabricated on A356 aluminum alloy by using plasma electrolytic oxidation(PEO) technique. The microstructure and phase composition of the PEO coatings were examined by using SEM and XRD method. It is found that the PEO coatings are mainly composed of crystalline α-Al2O3 and mullite. The dry sliding wear test of PEO coatings were carried out on a ring-on-ring wear machine. Results shows that there is hardly no wear loss of polished PEO coatings while the wear rate of uncoated aluminum alloy is 4.3×10-5 mm3·(N·m)-1 at a speed of 0.52 m·s-1 and a load of 40 N.

关键词： aluminum alloy plasma electrolytic oxidation ceramic coating wear

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TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

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International Journal of Oral Science 2018年第4期10卷 232-243页

作者： Soyoun Um Joo-Hee lee Byoung-moo Seo Biotooth Engineering Lab Dental Research InstituteDental Regenerative BiotechnologyDepartment of Dental ScienceSchool of DentistrySeoul National University Biotooth Engineering Lab Department of Oral and Maxillofacial Surgery and Craniomaxillofacial Life ScienceDental Research InstituteSchool of DentistrySeoul ational University

Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by *** conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells(DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed. Currently, little is known about the relationship between the inflammatory environment and bone formation. Osteogenic differentiation of inflamed DFSCs resulted in decreased alkaline phosphatase(ALP) activity and alizarin red S staining compared to normal DFSCs. Additionally, in vivo transplantation of inflamed and normal DFSCs demonstrated severe impairment of osteogenesis by inflamed DFSCs. Protein profile analysis via liquid chromatography coupled with tandem mass spectrometry was performed to analyse the differences in protein expression in inflamed and normal tissue. Comparison of inflamed and normal DFSCs showed significant changes in the level of expression of transforming growth factor(TGF)-β2. Porphyromonas gingivalis(P.g.)-derived lipopolysaccharide(LPS) was used to create in vitro inflammatory conditions similar to periodontitis. The osteogenic differentiation of LPS-treated DFSCs was suppressed, and the cells displayed low levels of TGF-β1 and high levels of TGF-β2. DFSCs treated with TGF-β2 inhibitors showed significant increases in alizarin red S staining and ALP activity. TGF-β1 expression was also increased after inhibition of TGF-β2. By examining inflamed DFSCs and LPS-triggered DFSCs, these studies showed both clinically and experimentally that the increase in TGF-β2 levels that occurs under inflammatory conditions inhibits bone formation.

关键词： TGF downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

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EXPERIMENTAL AND NUMERICAL STUDY FOR HYDRODYNAMIC CHARACTERISTICS OF AN OSCILLATING HYDROFOIL

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Journal of Hydrodynamics 2008年第3期20卷 280-287页

作者： LIU Zhen HYUN Bcom-soo KIM moo-rong jin Ji-yuan College of Engineering Ocean University of China Qingdao 266100 China College of Ocean Science and Technology Korea Maritime University Busan 606791 Korea Maritime and Ocean Engineering Research Institute Daejeon 305-343 Korea

The present article reports the experimental Particle Image Velocimetry （PIV） investigation and the corresponding numerical simulation results about the water flow over the oscillating hydrofoil and its unsteady dynamic characters. The experimental study focuses on the effect of mean angles of attack. The comparison between the PIV results and numerical prediction about the flow field using Fluent well demonstrates the capability of CFD on the simulation of the water flow around the pitching hydrofoil. The numerical results indicate that the forced oscillating frequencies have evident effects on the flow separation and vortex shedding. The simulations about the hydrodynamic drag and lift coefficients were also performed.

关键词： Particle Image Velocimetry (PIV) oscillating hydrofoil numerical simulation Fluent flow field force characteristics

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Minimally invasive radical pancreatectomy for left-sided pancreatic cancer:Current status and future perspectives

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World Journal of Gastroenterology 2014年第9期20卷 2343-2351页

作者： Chang moo Kang Sung Hwan lee Woo Jung lee Department of Surgery Yonsei University College of Medicine Seoul 120-752 South Korea Pancreaticobiliary Cancer Clinic Institute of Gastroenterology Severance Hospital Seoul 120-752 South Korea

Minimally invasive distal pancreatectomy with splenectomy has been regarded as a safe and effective treatment for benign and borderline malignant pancreatic ***,its application for left-sided pancreatic cancer is still being *** clinical evidence for radical antegrade modular pancreatosplenectomy(RAMPS)-based minimally invasive approaches for leftsided pancreatic cancer was *** indications and surgical concepts for minimally invasive RAMPS were *** the limited clinical evidence for minimally invasive distal pancreatectomy in left-sided pancreatic cancer,the currently available clinical evidence supports the use of laparoscopic distal pancreatectomy under oncologic principles in wellselected left sided pancreatic cancers.A pancreasconfined tumor with an intact fascia layer between the pancreas and left adrenal gland/kidney positioned more than 1 or 2 cm away from the celiac axis is thought to constitute a good condition for the use of margin-negative minimally invasive *** use of minimally invasive(laparoscopic or robotic)anterior RAMPS is feasible and safe for margin-negative resection in wellselected left-sided pancreatic *** oncologic feasibility of the procedure remains to be determined;however,the currently available interim results indicate that even oncologic outcomes will not be inferior to those of open radical distal pancreatosplenectomy.

关键词： Pancreatic cancer Laparoscopic pancreatectomy Robotic pancreatectomy

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Heterojunction between bimetallic metal-organic framework and TiO_(2):Band-structure engineering for effective photoelectrochemical water splitting

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Nano Research 2022年第9期15卷 8502-8509页

作者： Ji Won Yoon Jae-Hyeok Kim Young-moo Jo Jong-Heun lee Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Bimetallic Fe/Ni-based metal-organic frameworks(MOFs)with different Fe/Ni ratios were coated on TiO_(2)nanorods(NRs),and the performances of the heterojunction photoanodes in photoelectrochemical water splitting were *** bandgaps and band positions of the MOFs could be modulated by changing the ratio of the Fe and Ni *** ideal band alignment was achieved between the TiO_(2)NRs and bimetallic MOFs with an optimum ratio of[Fe]/[Ni]=0.25/0.75,which allowed efficient light absorption and charge *** coating of NH_(2)-MIL(Fe)-88 layer on the TiO_(2)NRs decreased the photocurrent density by 33%.In comparison,TiO_(2)/NH_(2)-MIL(Ni)-88 showed a modest improvement in photocurrent density(0.85 mA·cm^(−2)at 1.23 V vs.a reversible hydrogen electrode(RHE)).When bimetallic NH_(2)-MIL(Fe_(0.25)Ni_(0.75))-88 was coated on the TiO_(2)NRs,the photocurrent density reached 1.56 mA·cm^(−2),which was an efficiency enhancement of 3.2 *** mechanism underlying high photoelectrochemical performance was investigated.

关键词： band-structure engineering bimetallic metal-organic frameworks(MOFs) solar water splitting TiO_(2)nanorods NH_(2)-MIL-88

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