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Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

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Acta Pharmaceutica Sinica B 2023年第2期13卷 598-617页

作者： Yin Feng Yefan Han Anni hu Yi Qu Yili hu Hao Wu Xinzhi Wang Li He College of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China China Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics Nanjing 210046China Experiment Center for Science and Technology Nanjing University of Chinese MedicineNanjing 210046China Department of Hematology Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Although NPM1 mutations are frequently found in acute myeloid leukemia patients,therapeutic strategies are scarce and unsuitable for those who cannot tolerate intensive *** we demonstrated that heliangin,a natural sesquiterpene lactone,exerts favorable therapeutic responses in NPM1 mutant acute myeloid leukemia cells,with no apparent toxicity to normal hematogenous cells,by inhibiting their proliferation,inducing apoptosis,causing cell cycle arrest,and promoting ***-depth studies on its mode of action using quantitative thiol reactivity platform screening and subsequent molecular biology validation showed that the ribosomal protein S2(RPS2)is the main target of heliangin in treating NPM1 mutant *** covalent binding to the C222 site of RPS2,the electrophilic moieties of heliangin disrupt pre-rRNA metabolic processes,leading to nucleolar stress,which in turn regulates the ribosomal proteins-MDM2-p53 pathway and stabilizes *** data shows that the pre-rRNA metabolic pathway is dysregulated in acute myeloid leukemia patients with the NPM1 mutation,leading to a poor *** found that RPS2 plays a critical role in regulating this pathway and may be a novel treatment *** findings suggest a novel treatment strategy and lead compound for acute myeloid leukemia patients,especially those with NPM1 mutations.

关键词： Acute myeloid leukemia Heliangin NPM1-mutation Differentiation Pre-rRNA Covalent RPS2 p53 stabilization

Flow measurement and parameter optimization of right-angled flow passage in hydraulic manifold block

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Journal of Central South University 2019年第4期26卷 852-864页

作者： hu Jian-jun CHEN jin QUAN Ling-xiao KONG Xiang-dong School of Mechanical Engineering Yanshan University School of Civil Engineering and Mechanics Yanshan University Engineering Research Center of Advanced Forging & Stamping Technology and Science Built by Central Government and Local Government Yanshan University

This study was conducted to investigate the flow field characteristics of right-angled flow passage with various cavities in the typical hydraulic manifold block.A low-speed visualization test rig was developed and the flow field of the right-angled flow passage with different cavity structures was measured using 2D-PIV *** model was established to simulate the three-dimensional flow *** eddy viscosity turbulence models were investigated in predicting the flow field by comparing against the particle image relocimetry(PIV)measurement *** defining the weight error function K,the S-A model was selected as the appropriate turbulence ***,a three-factor,three-level response surface numerical test was conducted to investigate the influence of flow passage connection type,cavity diameter and cavity length-diameter ratio on pressure *** results show that the Box-Benhnken Design(BBD)model can predict the total pressure loss *** optimal factor level appeared in flow passage connection type II,14.64 mm diameter and 67.53%cavity length-diameter *** total pressure loss decreased by 11.15%relative to the worst factor level,and total pressure loss can be reduced by 64.75%when using an arc transition right-angled flow passage,which indicates a new direction for the optimization design of flow passage in hydraulic manifold blocks.

关键词： flow measurement particle image relocimetry right-angled flow passage parameter optimization

Evolution of Cloud Operating System： From Technology to Ecosystem

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Journal of Computer Science & Technology 2017年第2期32卷 224-241页

作者： Zuo-Ning Chen Kang Chen jin-Lei Jiang Lu-Fei Zhang Song Wu Zheng-Wei Qi Chun-Ming hu Yong-Wei Wu Yu-Zhong Sun Hong Tang Ao-Bing Sun Zi-Lu Kang Department of Computer Science and Technology Tsinghua University Beijing 100084 China Jiangnan Institute of Computing Technology Wuxi 214083 China School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China School of Software Shanghai Jiao Tong University Shanghai 200240 Schiena School of Computer Science and Engineering Beihang University Beijing 100191 China Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China Alibaba Cloud Computing Inc. Hangzhou 310024 China G-Cloud Technology Inc. Dongguan 523808 China Institute of Technology of Intevnet of Things Information Science Academy of China Electronics Technology Group Corporation Beijing 100081 China

The cloud operating system （cloud OS） is used for managing the cloud resources such that they can be used effectively and efficiently. And also it is the duty of cloud OS to provide convenient interface for users and applications. However, these two goals are often conflicting because convenient abstraction usually needs more computing resources. Thus, the cloud OS has its own characteristics of resource management and task scheduling for supporting various kinds of cloud applications. The evolution of cloud OS is in fact driven by these two often conflicting goals and finding the right tradeoff between them makes each phase of the evolution happen. In this paper, we have investigated the ways of cloud OS evolution from three different aspects： enabling technology evolution, OS architecture evolution and cloud ecosystem evolution. We show that finding the appropriate APIs （application programming interfaces） is critical for the next phase of cloud OS evolution. Convenient interfaces need to be provided without scarifying efficiency when APIs are chosen. We present an API-driven cloud OS practice, showing the great capability of APIs for developing a better cloud OS and helping build and run the cloud ecosystem healthily.

关键词： cloud computing operating system architecture evolution virtualization cloud ecosystem

Corrosion Behavior of Ni–20Cr–18W–1Mo Superalloy in Supercritical Water

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Acta Metallurgica Sinica(English Letters) 2014年第6期27卷 1046-1056页

作者： jingqing Zhang Rui hu Jian Wang jinshan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The corrosion behavior of Ni–20Cr–18 W–1Mo superalloy in supercritical water 500 °C/25 MPa for 200 h is investigated using gravimetry, SEM/EDS, XPS, and TEM. The oxide films show a layered structure with Ni rich in the outer layer, and Cr rich in the inner layer, consisting of an outer Ni（OH）2and NiO layer, including some Cr（OH）3, and an inner Cr2O3, Ni Cr2O4, and WO3 layer. Mo elements are not oxidized. The oxide films grow via a mixed mechanism,namely metal dissolution/oxide precipitation mechanism and solid-state growth mechanism. The effects of secondary and primary carbides on the weight-gain trend and oxide formation are discussed.

关键词： Ni–20Cr–18 W–1Mo Corrosion behavior Corrosion mechanism Supercritical water Oxide film

Research on the stability of nearly zero flattened dispersion of photonic crystal fibers

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Optoelectronics Letters 2008年第2期4卷 117-120页

作者： hu Jie WANG Jian Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optical Information School of Science Beijing Jiaotong University Beijing 100044 China

To analyze the stability of nearly zero flattened dispersion, the dispersion deviations for three kinds of PCFs are calculated when the hole diameters deviate from their designed values. Numerical results show that around the wavelength of 1.55 μm, the dispersion deviations of both the PCF with three-fold symmetry core and the PCF with hexagonal lattice are much less than that of the PCF with different hole diameters in different rings. Therefore, the stabilities of nearly zero flattened dispersion of the first two kinds of PCFs are much better than that of the last one. Considering the confinement loss, the PCF with three-fold symmetry core is preferable to practical use.

关键词：稳定性光泽度光子晶体纤维光纤元件

SYNTHESIS OF 3-PER(POLY)FLUOROALKYLPYRAZOLES

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Chinese Chemical Letters 1995年第4期6卷 281-284页

作者： Tang, XQ hu, CM Chinese Acad Sci Shanghai Inst Organ Chem Shanghai 200032 Peoples R China

The reaction of the adducts of per(poly)fluoroalkyl iodides and vinyl acetate with hydrazine monohydrate to give the corresponding 3-per(poly)fluoroalkylpyrazoles in excellent yields is described. The reaction might g... 详细信息

关键词： V

Numerically Reproduction of Spatio-Temporal Evolution of Surface Plasmon Polaritons at Dielectric-Plasma Interface

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Chinese Physics Letters 2011年第4期28卷 144-147页

作者： CHEN Zhao-Quan LIU Ming-Hai ZHOU Qi-Yan hu Ye-Lin YANG An Zhu long-Ji hu Xi-Wei College of Electrical and Information Engineering Anhui University of Science and TechnologyHuainan 232001 College of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074

Discharges in planar-type overdense plasmas caused by resonant excitation of surface plasmon polaritons(SPPs)are *** spatio-temporal evolution of surface waves of SPPs at the dielectric-plasma interface is reproduced *** is found that different discharge light patterns are excited by different spatio-temporal wave ***,the corrugation surface included in the proposed plasma sources plays a significant role in producing large-ares uniform plasmas.

关键词： resonant excited excitation

Nanotechnology-based tumor metabolic reprogramming:Insights into nutrient-delivery and metabolism reactivation therapy

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4619-4621页

作者： Xi hu Daishun Ling School of Pharmacy Anhui University of Chinese MedicineHefei 230038China Institute of Pharmaceutics Anhui Academy of Chinese MedicineHefei 230038China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui University of Chinese MedicineHefei 230038China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China WLA Laboratories Shanghai 201203China

Metabolic reprogramming in cancer is not only a core hallmark but also exposes treatment *** key processes required for tumor initiation and progression—continuous self-renewal,survival,and proliferation—are known to be under metabolic control^(1).Therapeutic opportunities arise from dysregulated metabolism and metabolic crosstalk,as tumor cells become heavily dependent on specific metabolic pathways such as glucose,amino acid,and fatty acid metabolism,as well as nucleotide synthesis^(2).However,many anti-metabolite drugs,including glycolysis inhibitors,have not been successfully applied in clinical settings due to their low specificity and undesirable side effects.

关键词： Metabolic therapy Metabolic reprogramming Cancer metabolism Metabolism reactivation therapy Melanin metabolism Nutrient-delivery Tumor therapy Nanotechnology

Green Inefficiency for Regions in China

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Journal of Environmental Protection 2010年第3期1卷 330-336页

作者： Tsz-Yi Ke jin-Li hu Wen-Ju Yang 不详

We used the directional output distance function to derive estimates of green inefficiency, shadow prices, and waste costs of three wastes (waste water, waste gas, and solid waste) for thirty regions in China during the 1996-2003 periods. There is an upward trend in green inefficiency in Chinese regions from 1996 to 2003. The green inefficiency score in west area is the lowest but in central and east areas are higher. The costs of wastes have an upward trend in east and central areas but downward trend in west area in the last two observation years.

关键词： Green Inefficiency Environment Waste Directional Output Distance Function Shadow Price China