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Endoscopic full-thickness resection for treating small tumors originating from the muscularis propria in the gastric fundus: An improvement in technique over 15 years

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1054-1064页

作者： Nan Ge jin-long hu Fei Yang Fan Yang Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

BACKGROUND The fundus of the stomach is regarded as a difficult area for endoscopic resection of small tumors originating from the muscularis propria(MP tumors).Three endoscopic resection techniques have been developed to treat these tumors,including ligation-assisted endoscopic full-thickness resection(L-EFTR),snareassisted EFTR(S-EFTR),and endoscopic submucosal dissection-assisted EFTR(EEFTR).To date,no studies have compared these *** We aimed to evaluate and compare S-EFTR with L-EFTR and E-EFTR for treating small MP tumors in the gastric *** We retrospectively reviewed patients with primary small MP tumors in the gastric fundus and treated by these three techniques between January 2016 and December 2018 at Shengjing Hospital,*** demographic and clinicopathologic data,including sex,age,tumor size,surgeon details,and pathological results,were *** regarding operation duration,cost,enbloc resection,and severe complications were also extracted and *** A total of 36 patients(27 women)with a mean age of 55.8±10.20 years were included in this *** mean tumor size was 9.0±3.98 *** the methods showed a 100%en-bloc resection rate and 0%severe complication *** was no statistically significant difference among the three groups in the operation duration(P=0.148).The cost comparison for the whole procedure was as follows:E-EFTR>L-EFTR>S-EFTR(5837.5±7212.96 CNY,5970.7±3465.27 CNY,5852.0±6438.25 CNY,respectively,P<0.001).CONCLUSION S-EFTR,L-EFT,and E-EFTR are all effective for resection of small MP tumors in the gastric fundus.S-EFTR is superior in terms of cost-effectiveness.

关键词： Endoscopic full-thickness resection Ligation Muscularis propria Snare Endoscopic submucosal dissection Cost

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Delayed perforation after endoscopic resection of a colonic laterally spreading tumor:A case report and literature review

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World Journal of Clinical Cases 2020年第16期8卷 3608-3615页

作者： Ge-Yu-Jia Zhou jin-long hu Sheng Wang Nan Ge Xiang Liu Guo-Xin Wang Si-Yu Sun jin-Tao Guo Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been widely used for the treatment of early gastrointestinal *** piecemeal mucosal resection(EPMR)is derived from the combination of EMR and *** perforation with peritonitis after colonic EPMR is a rare but severe complication,sometimes requiring *** are some associated risk factors,including patient-(location,diameter,and presence of fibrosis)and procedure-related *** recognition and timely treatment are crucial for its *** SUMMARY We report a case in which delayed perforation with peritonitis was treated using endoscopic closure.A 54-year-old man was diagnosed with a 30-mm-diameter laterally spreading tumor in the colonic hepatic *** hours after endoscopic resection,peritonitis caused by delayed perforation occurred and gradually *** treatment was ineffective and no obvious perforation was *** timely endoscopic closure,the patient was discharged on postoperative day *** In occasion of localized peritonitis aggravating without macroscopic perforation,endoscopic closure is an effective treatment for delayed perforation with stable vital signs in the early stage.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Endoscopic piecemeal mucosal resection Delayed perforation Endoscopic closure Case report

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Endoscopic resection of the pancreatic tail and subsequent wound healing mechanisms in a porcine model

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World Journal of Gastroenterology 2019年第21期25卷 2623-2635页

作者： Sheng Wang Kai Zhang jin-long hu Wei-Chao Wu Xiang Liu Nan Ge jin-Tao Guo Guo-Xin Wang Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

BACKGROUND Laparoscopic resection of the pancreatic body and tail is the predominant methodology to remove lesions in these locations;its safety and surgical planning are relatively mature, but it remains a complex and high-precision surgical operation, requiring abundant experience and skills in laparoscopic surgery, with a 10% rate of complications. AIM To verify the feasibility and safety, as well as to examine the complications of endoscopic pancreatectomy and healing mechanisms of pancreatic wounds after endoscopic resection. METHODS Transgastric endoscopic resections of varying sizes of pancreases were performed in 15 healthy Bama miniature pigs. The technical success rate, the incidence of serious complications, and the survival of the animals were studied. The healing of the wounds was evaluated by sacrificing the animals at various time points. Finally, the expression of transforming growth factor-β1 and Smad3/Smad7 in the surgical site was examined by immunohistochemistry to explore the role of these factors in wound healing of the pancreas. RESULTS Partial and total resections were successfully performed in two groups of animals, respectively. The technical success rate and the survival rate of the pigs were both 100%. We obtained 12 pancreatic tissue samples by endoscopic resection. The pancreatic wounds were closed with metal clips in one group and the wounds healed well by forming scars. There was a small amount of pancreatic leakage in the other group, but it can be fully encapsulated. The level of transforming growth factor-β1 (TGF-β1) in the wounds increased during the inflammatory and fibrous hyperplasia phases, and decreased in the scar phase. The expression of Smad3 paralleled that of TGF-β1, while the expression of Smad7 had an inverse relationship with the expression of TGF-β1. CONCLUSION Purely transgastric endoscopic resection of the pancreas is a safe, effective, and feasible procedure, but the incidence of pancreatic leakage in total pancre

关键词： Pancreatic resection Endoscopy Wound healing Transforming growth factor-β1 Smad

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A high-capacity graphene/mesocarbon microbead composite anode for lithium-ion batteries

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2020年第5期21卷 392-400页

作者： Inna SMOLIANOVA jin-long hu Xin-yue ZHAO Viacheslav DEMENTIEV Ling-zhi ZHANG CAS Key Laboratory of Renewable Energy Guangdong Provincial Key Laboratory of New and Renewable Energy Research and DevelopmentGuangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China FESCOM Technologies Ltd. Territory of the Innovation Center SkolkovoMoscow 143026Russia

The graphene/mesocarbon microbead(MCMB)composite is assessed as an anode material with a high capacity for lithium-ion *** composite electrode exhibits improved cycling stability and rate capability,delivering a high initial charge/discharge capacity of 421.4 mA·h/g/494.8 mA·h/g as well as an excellent capacity retention over 500 cycles at a current density of 40 mA/*** a higher current density of 800 mA/g,the electrode still retains 35%of its initial capacity which exceeds the capacity retention of pure graphene or MCMB reference *** voltammetry and electrochemical impedance spectroscopy reveal that the composite electrode favors electrochemical kinetics as compared with graphene and MCMB *** electrochemical properties suggest a strong synergetic effect between highly conductive graphene and MCMB.

关键词： Graphene Mesocarbon microbead(MCMB) Composite anode materials Lithium-ion batteries

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Regorafenib combined with programmed cell death-1 inhibitor against refractory colorectal cancer and the platelet-to-lymphocyte ratio’s prediction on effectiveness

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 920-934页

作者： Yu-Jie Xu Peng Zhang jin-long hu Hong Liang Yan-Yan Zhu Yao Cui Po Niu Min Xu Ming-Yue Liu Department of Oncology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina Department of Gastrointestinal Surgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina Department of Hepatology The Third People's Hospital of ZhengzhouZhengzhou 450003Henan ProvinceChina

BACKGROUND The effectiveness of regorafenib plus programmed cell death-1(PD-1)inhibitor in treating microsatellite stable(MSS)metastatic colorectal cancer(mCRC)remains *** To investigate the benefits of regorafenib combined with PD-1 inhibitor in treating MSS mCRC and explore indicators predicting *** This retrospective study included a total of 30 patients with microsatellite stable metastatic colorectal cancer treated with regorafenib combined with programmed cell death-1 inhibitor at Henan Provincial People’s Hospital between December 2018 and December *** a 4-wk treatment cycle,regorafenib was performed for 3 continuous ***-1 inhibitor was intravenously injected starting on the first day of the oral intake of *** reviewed tumor response,progression-free survival(PFS),overall survival,and treatment-related adverse events(TRAEs)and evaluated association between platelet-tolymphocyte ratio(PLR)and outcomes in this retrospective *** Stable disease and progressive disease were found in 18(60.0%)and 12(40.0%)patients,*** disease control rate was 60.0%.The median follow-up time was 12.0 mo,and median PFS was 3.4 mo[95%confidence interval(CI):2.2-4.6 mo].Of the 12 patients with progressive disease,10(83.3%)had liver metastasis before starting the combined *** the 18 patients with SD,10(55.6%)did not have liver *** patient without liver metastases at baseline was found with a substantially prolonged PFS of 11.2 *** liver metastasis,the choice of programmed cell death-1 inhibitor other than nivolumab or pembrolizumab and previous exposure to regorafenib was’t associated with treatment *** median PFS in the low-PLR group was 4.2 mo(95%CI:3.5-4.9 mo),compared with 2.8 mo(95%CI:1.4-4.2 mo)in the high-PLR group(P=0.005).The major TRAEs included hand-foot syndrome(33.3%),hypertension(23.3%),malaise(20.0%),and gastrointestinal reaction(16.7%).The incidence of grade 3 TRAE

关键词： Colorectal neoplasms Microsatellite stable Programmed cell death-1 inhibitor Platelet-tolymphocyte ratio Regorafenib Progression-free survival

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Endoscopic ultrasound guided gastroenterostomy:Technical details updates,clinical outcomes,and adverse events

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World Journal of Gastrointestinal Endoscopy 2023年第11期15卷 634-640页

作者： Jian Wang jin-long hu Si-Yu Sun Department of Gastroenterology People's Hospital of Shenyang Economic and Technological Development ZoneShenyang 110001Liaoning ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has been transformed from an innovative technique,into a viable alternative to enteral stenting and surgical gastrointestinal anastomosis for patients with gastric outlet *** EUS-GE guided ERCP and EUS-guided gastrointestinal anastomosis for the treatment of afferent loop syndrome have been performed,giving patients more less invasive ***,EUS-GE is still a technically challenging *** order to improve EUS-GE,several techniques have been reported to improve the technical *** EUS-GE widely performed,more data about EUS-GE’s clinical outcomes have been *** aim of the current review is to describe technical details updates,clinical outcomes,and adverse events of EUS-GE.

关键词： Gastric outlet obstruction Endoscopic ultrasound guided gastroenterostomy Endoscopic ultrasound Retrievable anchor Duodenal stent Surgical gastroenterostomy

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Internal phase control of fiber laser array based on photodetector array

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Chinese Physics B 2024年第7期33卷 320-326页

作者：靳凯凯龙金虎常洪祥粟荣涛张嘉怡陈思雨马阎星周朴 College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China

Coherent beam combining(CBC) of fiber laser array is a promising technique to realize high output power while maintaining near diffraction-limited beam quality. To implement CBC, an appropriate phase control feedback structure should be established to realize phase-locking. In this paper, an innovative internal active phase control CBC fiber laser array based on photodetector array is proposed. The dynamic phase noises of the laser amplifiers are compensated before being emitted into free space. And the static phase difference compensation of emitting laser array is realized by interference measurement based on photodetector array. The principle of the technique is illustrated and corresponding simulations are carried out, and a CBC system with four laser channels is built to verify the technique. When the phase controllers are turned on, the phase deviation of the laser array is less than λ/20, and ~ 95% fringe contrast of the irradiation distribution is obtained. The technique proposed in this paper could provide a reference for the system design of a massive high-power CBC system.

关键词： fiber laser laser array coherent beam combining internal phase control

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Evaluation of appendiceal mucinous neoplasms by curved lineararray echoendoscope:A preliminary study

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World Journal of Gastrointestinal Endoscopy 2023年第12期15卷 699-704页

作者： jing-Chao Zhang Yang-Yang Ma Yong-Zhen Lan Shuang-Biao Li Xiao Wang jin-long hu Endoscopy Center Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western MedicineCangzhou 061000Hebei ProvinceChina Department of Gastrointestinal Surgery Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western MedicineCangzhou 061000Hebei ProvinceChina Department of Pathology Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western MedicineCangzhou 061000Hebei ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Preoperative diagnosis of appendiceal mucinous neoplasms is challenging,and there are few reports regarding the endosonographic characteristics of these *** To provide a retrospective assessment of the imaging features of appendiceal mucinous neoplasms using endoscopic ultrasound(EUS)by curved linear-array *** A database of all patients with appendiceal mucinous neoplasms who had received EUS examination at our hospital between January 2018 and July 2023 was retrospectively *** EUS characteristics and patients’clinical data were *** Twenty-two patients were included in the *** linear-array echoendoscope successfully reached the ileocecal region in every *** the endoscopic view,we could observe the protrusion in the appendiceal orifice in all patients.A volcano sign was observed in two patients,and an atypical volcano sign was seen in two *** showed that all 22 lesions were submucosal cystic hypoechoic lesions with clear *** wall nodules were observed,but an onion-peeling sign was observed in 17 *** Linear-array echoendoscope is safe to reach the ileocecal region under the guidance of *** features on endoscopic and echoendosonograhic views could be used to diagnose appendiceal mucinous neoplasms.

关键词： Appendiceal mucinous neoplasm Endoscopic ultrasound Appendix Endoscopy Colonoscopy

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基于QEPAS技术的乙炔微量气体高灵敏度检测研究

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光谱学与光谱分析 2017年第9期37卷 2869-2872页

作者：马欲飞佟瑶张立功何应张静波王龙龙金虎于欣孙锐哈尔滨工业大学可调谐(气体)激光技术重点实验室黑龙江哈尔滨150001 哈尔滨工业大学动力工程及工程热物理博士后流动站黑龙江哈尔滨150001

石英增强光声光谱(QEPAS)是近年来发展起来的一种痕量气体探测技术,具有系统体积小、价格低廉、探测灵敏度高等优点。乙炔(C_2H_2)是一种化学性质活泼的有毒气体,对它进行高灵敏度检测在变压器故障诊断、环境监测等领域有着重要的意义,... 详细信息

石英增强光声光谱(QEPAS)是近年来发展起来的一种痕量气体探测技术,具有系统体积小、价格低廉、探测灵敏度高等优点。乙炔(C_2H_2)是一种化学性质活泼的有毒气体,对它进行高灵敏度检测在变压器故障诊断、环境监测等领域有着重要的意义,基于此,采用QEPAS技术对C_2H_2微量气体展开高灵敏度检测研究。采用输出波长为1.53μm的连续波分布反馈半导体激光器作为激发光源。为了提高信噪比和简化数据处理过程,QEPAS传感器系统采用波长调制和2次谐波探测技术。为了提高QEPAS系统信号幅值,相比于常见的共振频率为32.768kHz的石英音叉,采用了共振频率较低的30.72kHz石英音叉作为声波传导器,同时还优化了石英音叉与激光束的空间位置、激光波长调制深度,并添加了声波微共振腔,选择的微共振腔长度为4mm、内径为0.5mm,最终获得了2.7ppm的优异检测极限,归一化噪声等效吸收系数为1.3×10^(-8) cm^(-1)·W·Hz^(-1/2)。

关键词： QEPAS C_2H_2气体共振频率微共振腔

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Dynamically self-adjustable liquid-liquid and self-adaptive softcontact solid-solid triboelectric nanogenerator for wave energy harvesting

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Nano Research 2025年第1期18卷 404-414页

作者： Yong long Bingqi Zhao Jianan Niu Yuxiu Liu Wei Sha Jiangwen Wang Zhong Lin Wang Weiguo hu Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Water wave energy exhibits great potential toalleviate the global energy crisis. However, harvesting andutilizing wave energy are challenging due to its irregularity,randomness, and low frequency. Triboelectric nanogenerators(TENGs) have gained significant attention for harvesting waveenergy with high efficiency. This study presents a novelellipsoidal, pendulum-like TENG integrating both liquid-liquid(L-L) and solid-solid (S-S) triboelectricity (LS-TENG). Thisinnovative design enables continuous wave energy harvestingand self-powered marine environment monitoring under variousconditions, including temperature, humidity, and light intensity. The binary immiscible liquids within the LS-TENG’s innersoft balloon create dynamic, and self-adjustable L-L contact interfaces, significantly increasing the L-L contact area andenhancing L-L contact electrification (CE). The unique self-adaptive, soft S-S contact increases the S-S contact areacompared to traditional hard point contact, better adapting to the irregular movements of waves and promoting efficient S-SCE. The LS-TENG achieves highly efficient wave energy harvesting by coupling L-L and S-S CE. Furthermore, the uniquesoft contact design protects the S-S interfaces from mechanical wear and damage during long-term work. The LS-TENG’snovel structure provides an innovative and effective way for water wave energy harvesting.

关键词： self-adaptive soft-contact solid-solid liquid-liquid self-adjustable triboelectric nanogenerator

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