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Chinese Journal of Structural Chemistry 2006年第11期25卷 1297-1302页

作者： guo jin-Yu zhang Tong-Lai zhang Jian-guo LIU Yan-Hong QIAO Xiao-jing YANG Li State Key Laboratory of Explosion Science and Technology Beij＇ing Institute of Technology Beij＇ing 100081 China

A dinuclear complex Cd2（dnba）4（pyridine）4 （dnba = 3,5-dinitrobenzoate） has been synthesized by hydrothermal method and characterized by X-ray single-crystal diffraction, elemental analysis, FT-IR spectroscopy, DSC and TG-DTG techniques. The complex with empirical formula C48H32Cd2NI2024 （Mr = 692.83） crystallizes in monoclinic, space group P21/n with a - 12.0344（14）, b = 10.5752（13）, c = 21.578（3） A, β = 104.150（2）°, V = 2662.8（6） A^3, Z = 2, D, = 1.728 g/cm^3,μ（MoKa） = 0.897 mm^-1, F（000） = 1384, S = 1.016 and （△/σ）max = 0.001. R = 0.0638 and wR = 0.0737 for all data; the final R = 0.0337 and wR = 0.0644. In this complex, four carboxylates are bidentate-or chelate-coordinated with the Cd（Ⅱ） centers to give the dinuclear structure. The other coordination positions of Cd（Ⅱ） are occupied by the lone pair electrons from N of four pyridines. Thermal analyses DSC and TG-DTG have been used to determine the thermal decomposition mechanism of the title complex.

关键词： hydrothermal synthesis dinuclear complex crystal structure thermal analysis

Improving dehydrogenation properties of Mg/Nb composite films via tuning Nb distributions

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Rare Metals 2017年第7期36卷 574-580页

作者： Wen-Cheng Huang Jun Yuan jin-guo zhang Jiang-Wen Liu Hui Wang Liu-zhang Ouyang Mei-Qin Zeng Min Zhu Key Laboratory of Advanced Energy Storage Materials of Guangdong Province School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

t To investigate the effect of Nb on the dehydro- genation properties of Mg-Nb composite films, Mg/Nb eight- layer film and Mg- 10 at% Nb alloy film with the similar Mg- to-Nb atomic ratio were prepared by magnetron sputtering. Results show that both Mg/Nb eight-layer film and Mg- 10 at% Nb alloy film exhibit excellent de/hydrogenation properties. Mg- 10 at% Nb alloy film starts to release hydrogen at 108 ℃, and its desorption peak temperature is lower to 146 ℃, which is much better than that of pure MgH2 under the same condi- tion. Scanning electron microscopy （SEM） results demon- strate that the dispersive Nb nanoparticles in Mg/Nb eight- layer film may serve as nucleation sites for Mg ←→ MgH2 reactions, which can provide channels for H diffusion. For Mg- 10 at% Nb alloy film, the uniform distributions of Nb can accelerate the hydrogen diffusion and effectively improve the dehydrogenation kinetics for MgH2. This study provides an enlightening way for designing and preparing Mg-based composite films with excellent dehydrogenation properties.

关键词： Hydrogen storage Mg-Nb Sputtering Thinfilm Kinetics

Energy Consumption by Rural Households in Northern Hunan

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湖南大学学报（自然科学版） 2009年第S1期36卷 182-185页

作者： LI Lin,ZHOU jin,zhang guo-qiang(Research Center for Building Environment and Energy Saving,Hunan University,Changsha,Hunan 410082,China) Research Center for Building Environment and Energy Saving Hunan University Changsha 410082 China

This study was conducted to investigate the household energy consumption in rural districts in northern Hunan and to help explore the sustainable and ecological energy *** were used to acquire the details of energy consumption,and the electricity equivalent calculation was used in the energy statistics in four *** energy consumption in these four villages is influenced by the economic condition,geographic position and landform and the local *** traditional biomass energy and coal briquette are the primary energy source for cooking and heating,but they are used in a very low efficiency and result in poor *** sustainability,further measures should be taken to optimize the energy consumption with the efficient use of biomass energy,coal and electricity.

关键词： structure amount rural energy consumption northern Hunan

Structure and Magnetostriction of (Dy_(0.7)Tb_(0.3))_(0.5)Pr_(0.5)Fe_x Alloys (1.10≤x≤1.85)

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Journal of Materials Science & Technology 2000年第2期16卷 177-178页

作者： Bowen WANG, Weili LIU, Guang jin and Jianzhi BI (Department of Materials Enginerring, Shenyang Institute of Technology, Shenyang 110015, China) Ximei jin, Zhijun guo and Zhidong zhang (Institute of Metal Research, Chinese Academy of Seiences, Shenyang 11 Department of Materials Enginerring Shenyang Institute of Technology Shenyang 110015 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

The structure and magnetostriction of R_0.5Pr_0.5Fex (R = Dy_0.7Tb_0.3,1.10 ≤x≤1.85) alloys were investigated. It was found that the matrix of arc-melting R_0.5Pr_0.5Fe_x alloys is the (Dy, Tb, Pr) Fe_2 phase with the MgCu_2-type cubic structure and the second phase is rare earth-rich phase when x1.55. The crystalline structure of mechanically grinding R_0.5Pr_0.5Fe_x alloys is similar to that of the arc-melted alloys. The magnetostriction of the alloys increases with increasing Fe content when x ≤1.25 and decreases when x >1.25.

关键词： Structure and Magnetostriction of Fe_x Alloys Pr Tb Dy

Independent prognostic value of the congestion and renal index in patients with acute heart failure

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Journal of Geriatric Cardiology 2023年第7期20卷 516-526页

作者： Run-Qing JI Bin WANG jin-guo zhang Shu-Hong SU Li LI Qin YU Xian-YanJIANG Xin FU Xue-Hua FANG Xiao-Wen MA Ao-Xi TIAN jing LI National Clinical Research Center for Cardiovascular Diseases NHC Key Laboratory of Clinical Research for Cardiovascular MedicationsState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNational Center for Cardiovascular DiseasesBeijingChina Fuwai Hospital Chinese Academy of Medical SciencesShenzhenChina Department of Cardiology Affiliated Hospital of Jining Medical UniversityJiningChina Department of Cardiology Xinxiang Central HospitalXinxiangChina Department of Cardiology Shanxi Fenyang HospitalFenyangChina Department of Cardiology Affiliated Zhongshan Hospital of Dalian UniversityDalianChina Heart Center Qingdao Fuwai Cardiovascular HospitalQingdaoChina Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Cardiology Beijing Liangxiang HospitalBeijingChina Department of Cardiology Qinyang People’s HospitalQinyangChina

BACKGROUND Clinical outcomes are poor if patients with acute heart failure(AHF)are discharged with residual congestion in the presence of renal ***,there is no single indication to reflect the combined effects of the two related pathophysiological ***,therefore,proposed an indicator,congestion and renal index(CRI),and examined the associations between the CRI and one-year outcomes and the incremental prognostic value of CRI compared with the established scoring systems in a multicenter prospective cohort of *** We enrolled AHF patients and calculated the ratio of thoracic fluid content index divided by estimated glomerular filtration rate before discharge,as *** we examined the associations between CRI and one-year *** A total of 944 patients were included in the analysis(mean age 63.3±13.8 years,39.3%women).Compared with patients with CRI≤0.59 mL/min per kΩ,those with CRI>0.59 mL/min per kΩhad higher risks of cardiovascular death or HF hospitalization(HR=1.56[1.13-2.15])and all-cause death or all-cause hospitalization(HR=1.33[1.01-1.74]).CRI had an incremental prognostic value compared with the established scoring *** In patients with AHF,CRI is independently associated with the risk of death or hospitalization within one year,and improves the risk stratification of the established risk models.

关键词： patients acute index

一个新现象发现的故事——我的科学人生和趣事

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生理科学进展 2007年第3期38卷 193-198页

作者：金国章中国科学院

金国章教授是我国著名的药理学家,中国科学院院士。他致力于中药延胡索的研究,从其有效成分、构效关系的研究,直至新型药理学作用机制的发现,以及创新性假设的提出,形成了自己完整的科研思路与研究体系。他几十年如一日,针对一种中药,... 详细信息

金国章教授是我国著名的药理学家,中国科学院院士。他致力于中药延胡索的研究,从其有效成分、构效关系的研究,直至新型药理学作用机制的发现,以及创新性假设的提出,形成了自己完整的科研思路与研究体系。他几十年如一日,针对一种中药,不遗余力地进行科学研究,最终取得原始创新性成果。他的科研故事告诉我们:成功来自于"汗水、理念、机遇",且这一切则取决于自身的努力,用自己的智慧抓住良机。青年人多梦想,常为人所鼓励。能否梦想成真,决定于两个因素:一是自己的努力,二是客观所赋予的机遇。机遇总是垂青有准备之人。有青年人的梦想,才有本文要介绍的故事。这故事的全过程记录在国家自然科学基金研究专著《中药延胡索研究中的新发现》中(2001),该书总结了四氢原小檗碱同类物(THPBs)作用在脑内多巴胺(DA)受体的神经药理作用,使它在中国土地上生根、发芽、开花、结果的故事,并突出左旋千金藤啶碱(l-SPD)对DA受体独特的新型双重作用。评审专家们指出,该书是国际上第一本这方面的专著(1999),有创新性,令作者感到欣慰。

关键词：国家自然科学基金故事趣事人生研究专著药理作用青年人小檗碱

Screening and evaluation of human single-chain fragment variable antibody against hepatitis B virus surface antigen

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 237-241页

作者： Jian-Lin zhang, Jian-jin guo, Zi-Yan zhang, Yi-Xin jing, Lin zhang, Rui guo, Ping Yan, Niu-Liang Cheng, Bo Niu and Jun Xie Department of Biochemistry and Molecular Biology, Shanxi Medical University ,Taiyuan 030001,China Department of Biochemistry and Molecular Biology Shanxi Medical University Taiyuan 030001China.

BACKGROUND: Phage display technology has become a vital tool in studies aimed at identifying molecules binding to a specific target. It enables the rapid generation and selection of high affinity, fully human antibody product candidates to essentially any disease target appropriate for antibody therapy. In this study, we prepared the recombinant single-chain fragment variable ( ScFv) antibody to hepatitis B virus surface antigen (HBsAg) by the phage display technology for obtaining a virus-targeting mediator. METHODS: mRNA was isolated from B-lymphocytes from a healthy volunteer and converted into cDNA. The fragment variables of heavy and light chain were amplified separately and assembled into ScFv DNA with a specially constructed DNA linker by polymerase chain reaction. The ScFv DNA was ligated into the phagmid vector pCANT-AB5E and the ligated sample was transformed into competent E. coli TG1. The transformed cells were infected with M13K07 helper phage to form a human recombinant phage antibody library. The volume and recombinant rate of the library were evaluated by bacterial colony count and restriction analysis. After two rounds of panning with HBsAg. the phage clones displaying ScFv of the antibody were selected by enzyme-linked immunosorbant assay ( ELISA) from the enriched phage clones. The antigen binding affinity of the positive clone was detected by competition ELISA. HB2151 E. coli was transfected with the positive phage clone demonstrated by competition ELISA for production of a soluble form of the anti-HBsAg ScFv. ELISA assay was used to detect the antigen binding affinity of the soluble anti-HBsAg ScFv. Finally, the relative molecular mass of soluble anti-HBsAg ScFv was measured by SDS-PAGE. RESULTS: The variable heavy ( VH ) and variable light (VL) and ScFv DNAs were about 340bp, 320bp and 750bp, respectively. The volume of the library was up to 2 × 106 and 8 of 10 random clones were recombinants. Two phage clones could strongly compete with the or

关键词： phage display technology phage antibody library hepatitis B virus surface antigen single-chain fragment variable

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dl-四氢巴马汀抗大鼠胃溃疡作用

中国药学杂志 2005年第12期40卷 902-904页

作者：张仲苗耿宝琴雍定国金国章浙江大学医学院附属第二医院临床药学室浙江杭州310009 浙江大学医学院药理教研室浙江杭州310031 中国科学院上海药物研究所上海200032

目的研究dl-四氢巴马汀(dl-THP)对大鼠急、慢性溃疡的保护作用,并初步分析其机制。方法胃黏膜损伤由吲哚美辛、束缚应激、结扎幽门和胃浆膜下注入醋酸引起。dl-THP15,30,45mg·kg-1灌胃,1日2次,共5次。测定大鼠胃溃疡数目、面积、胃酸... 详细信息

目的研究dl-四氢巴马汀(dl-THP)对大鼠急、慢性溃疡的保护作用,并初步分析其机制。方法胃黏膜损伤由吲哚美辛、束缚应激、结扎幽门和胃浆膜下注入醋酸引起。dl-THP15,30,45mg·kg-1灌胃,1日2次,共5次。测定大鼠胃溃疡数目、面积、胃酸分泌、胃蛋白酶活性以及胃黏膜血流。结果dl-THP15,30,45mg·kg-1能抑制大鼠胃黏膜损伤,且呈剂量依赖性;dl-THP30mg·kg-1对大鼠慢性胃溃疡的抑制率为75.8%,与雷尼替丁30mg·kg-1的67.7%相仿。dl-THP可增加胃黏膜血流,但对胃酸和胃蛋白酶分泌无影响。结论dl-THP具有明显抗实验性胃溃疡作用,可能与其增加胃黏膜血流有关,亦可能部分通过阻滞胃黏膜DA受体而发挥作用。

关键词： dl-四氢巴马汀胃溃疡胃酸胃蛋白酶胃黏膜血流

左旋千金藤啶碱D1激动作用增加6—OHDA损毁大鼠的DARPP—32磷酸化效应

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生理学报 1999年第1期51卷 65-72页

作者：刘健王博成中国科学院上海药物研究所核医学国家重点实验室

为了进一步阐明ＳＰＤ对大鼠纹状体突触后Ｄ１受体的激动作用特性，本文应用反磷酸化在体内测定及放射配体结合方法，分别观察ＳＰＤ对６ＯＨＤＡ损毁大鼠纹状体ＤＡＲＰＰ３２体内磷酸化作用及突触后Ｄ１受体密度的影响。结果表明... 详细信息

为了进一步阐明ＳＰＤ对大鼠纹状体突触后Ｄ１受体的激动作用特性，本文应用反磷酸化在体内测定及放射配体结合方法，分别观察ＳＰＤ对６ＯＨＤＡ损毁大鼠纹状体ＤＡＲＰＰ３２体内磷酸化作用及突触后Ｄ１受体密度的影响。结果表明：皮下给予ＳＰＤ（２０，４０ｍｇ／ｋｇ，２１ｄ），损毁侧纹状体ＤＡＲＰＰ３２体外［３２Ｐ］的掺入量较健侧下降５０％（Ｐ＜００１）。换言之，损毁侧纹状体内ＤＡＲＰＰ３２的磷酸化程度增加了。然而，ＳＰＤ使损毁导致Ｄ１受体上调的作用减弱（Ｂｍａｘ从３８５０±２６１ｆｍｏｌ／ｍｇ降至３１９７±２０１ｆｍｏｌ／ｍｇ水平）。因此，ＳＰＤ激动Ｄ１受体，使６ＯＨＤＡ损毁大鼠纹状体内ＤＡＲＰＰ３２磷酸化作用加强，而受体密度减少。这是ＳＰＤ调节脑内Ｄ１受体信号转导功能的重要机制。

关键词：左旋千金藤啶碱 DARPP-32 磷酸化 6-OHDA

Synthesis, characterization and catalytic application of H4SiW12O40/MCM-48 in the esterification of methacrylic acid with n-butyl alcohol

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Journal of Chemistry and Chemical Engineering 2009年第1期3卷 61-65页

作者： YANG Shui-jin YIN guo-jun zhang Yi-jun WANG Dong-ming Hubei Key Laboratory of Pollutant Analysis ＆ Reuse Technology College of Chemistry and Environmental Engineering Hubei Normal University Huangshi 435002 China

A novel environmental friendly catalyst, H4SiW12O40/MCM-48, was prepared by impregnation method. The catalysts were characterized by means of XRD and FT-IR. The synthesis of n-butyl methacrylate catalyzed by H4SiW12O40/MCM-48 was studied with methacrylic acid and n-butyl alcohol as reactants. H4SiW12O40/MCM-48 was an excellent catalyst for the synthesis of n-butyl methacrylate and Keggin structure ofH4SiW12O40 kept unchanged after impregnated on surface of the molecular sieve support. Effects of n（methacrylic acid）： n（n-butyl alcohol）, catalyst dosage, cyclohexane （water-stripped reagent） and reaction time on the yields of the product were investigated. The optimum conditions have been found, that is, molar ratio of acid to alcohol is 1：1.5, mass ratio of catalyst used to the reactant is 1.5%, cyclohexane is 10 mL and reaction time is 1.5h. Under these conditions, the yield of n-butyl methacrylate can reach 73.2%.

关键词： MCM-48 molecular sieve silicotungstic acid n-butyl methacrylate catalysis