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Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets

Animal Nutrition 2024年第2期17卷 188-207页

作者： Xuebing Han Xiangdong Hu Wei jin gang liu Department of Urology Shengjing Hospital of China Medical University College of Bioscience and Biotechnology Hunan Agricultural University Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry State Key Laboratory of Subtropical Silviculture Zhejiang A&F University

Weaning is a critical transitional point in the life cycle of piglets. Early weaning can lead to post-weaning syndrome, destroy the intestinal barrier function and microbiota homeostasis, cause diarrhea and threaten the health of piglets. The nutritional components of milk and solid foods consumed by newborn animals can affect the diversity and structure of their intestinal microbiota, and regulate post-weaning diarrhea in piglets. Therefore, this paper reviews the effects and mechanisms of different nutrients,including protein, dietary fiber, dietary fatty acids and dietary electrolyte balance, on diarrhea and health of piglets by regulating intestinal function. Protein is an essential nutrient for the growth of piglets;however, excessive intake will cause many harmful effects, such as allergic reactions, intestinal barrier dysfunction and pathogenic growth, eventually aggravating piglet diarrhea. Dietary fiber is a nutrient that alleviates post-weaning diarrhea in piglets, which is related to its promotion of intestinal epithelial integrity, microbial homeostasis and the production of short-chain fatty acids. In addition, dietary fatty acids and dietary electrolyte balance can also facilitate the growth, function and health of piglets by regulating intestinal epithelial function, immune system and microbiota. Thus, a targeted control of dietary components to promote the establishment of a healthy bacterial community is a significant method for preventing nutritional diarrhea in weaned piglets.

关键词： Diarrhea Intestinal barrier Dietary protein Dietary fiber Dietary fatty acid Dietary electrolyte balance

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Preparation of Modified Composite Nanofiltration Membrane Synergistically Using Carboxylic Multi- walled Carbon Nanotube and β-cyclodextrin

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 232-239页

作者： liu Peng MAO Junpeng FANG Yanfeng YU Yunwu CHEN Changxiu TANG Ning WAN Ye GU Yaxin liu Yunxue WANG Lihua School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new modified blend ultrafiltration(UF)membrane with good hydrophilicity,high porosity and excellent anti-fouling performance was developed by using carboxylic multi-walled carbon nanotube(CMWCNT)as casting solution ***,a composite nanofiltration(NF)membrane with large water flux and good retention rate was fabricated by using the PVDF/CMWCNT blend UF membrane as the substrate,and polyvinyl alcohol(PVA),β-cyclodextrin(β-CD)and polyethylenimine(PEI)as the coating *** results show that with the appropriate addition of CMWCNT in the casting solution,the surface roughness,porosity and recovery rate of the PVDF/CMWCNT blend UF membrane is obviously *** water flux of blend UF membrane is significantly improved when the CMWCNT content increases from 0 wt%to 0.2 wt%.The water flux of blend UF membrane with 0.2 wt%CMWCNT is 162.7 L/(m^(2)·h),which is 44.3%higher than that of the pure PVDF ***β-CD content is 0.8 wt%,the retention rate of Congo red by PVDF/CMWCNT/β-CD composite NF membrane reaches 98.7%,which is 28.3%higher than that of single PVA/PEI modified *** research will provide a new idea and simple method for developing novel high-performance composite NF membranes.

关键词： CMWCNT cyclodextrin nanofiltration membrane

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老年桡骨远端不稳定骨折手术与保守治疗的效果比较

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中国实用医药 2017年第6期12卷 48-49页

作者：张金刚刘大伟王天枢李爽黑龙江省佳木斯市中心医院骨外科 154003 黑龙江省佳木斯大学附属第一医院

目的分析探讨老年桡骨远端不稳定骨折手术与保守治疗的效果,为老年桡骨远端不稳定骨折患者的治疗提供理论支持和科学指导。方法 100例老年桡骨远端不稳定骨折患者,随机分成实验组和对照组,每组50例。对照组患者采取保守治疗,实验组患者... 详细信息

目的分析探讨老年桡骨远端不稳定骨折手术与保守治疗的效果,为老年桡骨远端不稳定骨折患者的治疗提供理论支持和科学指导。方法 100例老年桡骨远端不稳定骨折患者,随机分成实验组和对照组,每组50例。对照组患者采取保守治疗,实验组患者采取手术治疗。比较两组患者腕部功能恢复情况、腕关节功能(PRWE)评分。结果实验组患者腕部功能恢复优26例,良20例,可3例,差1例,优良率为92.0%;对照组患者腕部功能恢复优20例,良17例,可10例,差3例,优良率为74.0%。实验组患者腕部功能恢复优良率明显高于对照组,差异具有统计学意义(P<0.05);实验组患者PRWE评分为(31.2±2.3)分,明显高于对照组的(25.4±2.1)分,差异具有统计学意义(P<0.05)。结论临床上,在对老年桡骨远端不稳定骨折患者进行治疗时,采取手术方式进行治疗能有效的提高治疗的总有效率,对患者的腕部功能恢复和上肢功能的恢复都有很大的帮助,有利于患者的恢复,从而提高患者的生活质量,值得在临床上推广应用。

关键词：老年桡骨远端不稳定骨折手术治疗保守治疗

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伤损焊头处插短轨的闪光焊施工方法

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科技创新与生产力 2015年第5期 57-58,60页

作者：陈宽军靳刘刚嵇民田海蒙济南铁路局济南工务机械段山东济南250022

文中介绍了蓝烟上行线(莱西—蓝村)段,在探伤作业中发现一处伤损焊接接头,现场确认后,及时采用闪光焊(线上焊)对伤损焊接接头插短轨处进行焊轨施工,经现场施工检验和后期的探伤检验,无质量问题。此次施工得出无缝线路出现伤损焊接接头时... 详细信息

文中介绍了蓝烟上行线(莱西—蓝村)段,在探伤作业中发现一处伤损焊接接头,现场确认后,及时采用闪光焊(线上焊)对伤损焊接接头插短轨处进行焊轨施工,经现场施工检验和后期的探伤检验,无质量问题。此次施工得出无缝线路出现伤损焊接接头时,可紧急采用闪光焊对伤损焊接接头插短轨处置并及时恢复线路,效果良好。

关键词：闪光焊无缝线路伤损焊接接头插短轨焊轨施工

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Identification and functional analysis of heterogeneous FOXP3^+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma

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Science Bulletin 2018年第15期63卷 972-981页

作者： gang Yi Shiwei Guo Wenyu liu Huan Wang Rendong liu Andy Tsun gang jin Bin Li Shanghai Key Laboratory of Bio-energy Crops School of Life Science Shanghai University Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine CAS Center for Excellence in Molecular Cell Science Unit of Molecular Immunology Institute Pasteur of Shanghai Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Medical School Chinese Academy of Sciences Department of General Surgery Changhai Hospital Second Military Medical University

CD4^＋ CD25^＋ regulatory T （Treg） cells express the transcription factor FOXP3 and play an essential role in preventing autoimmunity. Abundant Treg cell accumulation in tumors and tumor draining lymph nodes （TDLNs） has been reported to correlate with both poor and favorable prognosis in various cancers, which suggests that Tregs may have multiple effects on antitumor immunity. However, the heterogeneity of tumor- and TDLN-infiltrating Treg cells remains unclear. Here we provide heterogeneity analysis of tumor infiltrating human CD4^＋ Treg cells and their matched adjacent tissues and TDLNs. We defined three different subpopulations of tumor- and TDLN-infiltrating Treg cells by Helios and CCR8 expression in pancreatic ductal adenocarcinoma （PDAC） and confirmed their functional heterogeneity. Helios^＋ CCR8^＋ Treg cells with potent suppressor function and limited IL-2 and IFN-7 secretion were identified in tumors and TDLNs. On the contrary, Helios^- CCR8^- Treg cells have impaired suppressive activity, and elevated expression of pro-inflammatory cytokines. More advanced grades of PDAC have predominantly Helios^＋ CCR8^＋ Treg cells and few Helios^- CCR8^- Treg cells both in tumors and TDLNs that suggests poor prognosis. These data could help further define the role of Treg cells and their functional role in tumors and TDLNs.

关键词： Pancreatic ductal adenocarcinoma Regulatory T cells Heterogeneity Tumor draining lymph nodes

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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期68卷 103-115页

作者： Xizi Luo Nan Zhang Yuntao liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词： SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition

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CQS550道岔清筛机道岔全抛施工方法

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科技创新与生产力 2015年第3期 50-52页

作者：靳刘刚蒋习龙江乐陈宽军济南铁路局工务机械段山东济南250001

以济南铁路局管内辛泰线燕家庄站内2号道岔全抛施工为例,是国内首次既有线道岔清筛作业,利用道岔清筛机对既有线道岔进行道床全抛的的施工工艺,在封锁天窗为180 min的条件下对施工中主要工序及控制要点进行研究,形成了一套完整的施工方... 详细信息

以济南铁路局管内辛泰线燕家庄站内2号道岔全抛施工为例,是国内首次既有线道岔清筛作业,利用道岔清筛机对既有线道岔进行道床全抛的的施工工艺,在封锁天窗为180 min的条件下对施工中主要工序及控制要点进行研究,形成了一套完整的施工方法,经现场施工检验,效果良好,可为相关工程施工提供参考。

关键词：道岔清筛机道岔既有线全抛

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Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期68卷 21-25页

作者： Leyu liu Zhaoming Xia Zeyu Wang Yinjuan Chen Hai Xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng liu Xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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Water Modeling of Optimizing Tundish Flow Field

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Journal of Iron and Steel Research International 2007年第3期14卷 13-19页

作者： liu jin-gang YAN Hui-cheng liu liu WANG Xin-hua Shougang Research Institute of Technology Beijing 100041 China Department of Metallurgical Technology Central Iron and Steel Research Institute Beijing 100081 China Metallurgical and Ecological Engineering School University of Science and Technology Beijing Beijing 100083 China

In the water modeling experiments, three cases were considered, i. e, , a bare tundish, a tundish equipped with a turbulence inhibitor, and a rectangular tundish equipped with weirs （dams） and a turbulence inhibitor. Comparing the RTD curves, inclusion separation, and the result of the streamline experiment, it can be found that the tundish equipped with weirs （dams） and a turbulence inhibitor has a great effect on the flow field and the inclusion separation when compared with the sole use or no use of the turbulent inhibitor or weirs （dams）. In addition, the enlargement of the distance between the weir and dam will result in a better effect when the tundish equipped with weirs （dam） and a turbulence inhibitor was used.

关键词： tundish flow field turbulence inhibitor weir dam water modeling experiment

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