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Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

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Research 2024年第1期2023卷 139-147页

作者： Xi Luan Xiaoxuan Zhang Min nie Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of PharmacyClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Traditional Chinese medicine,such as Tripterygium wilfordii and Paeonia lactiflora,has potential values in treating systemic sclerosis(SSc)and other autoimmune diseases,while their toxic side effect elimination and precise tropical drug delivery are still ***,we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus(BP)microneedles(MNs)with the desired features for the SSc *** employing a template-assisted layer-by-layer curing method,such MNs with triptolide(TP)/paeoniflorin(Pae)needle tips and BP-hydrogel needle bottoms could be well *** combined administration of TP and Pae can not only provide anti-inflammatory,detoxification,and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug ***,the additive BPs possess good biocompatibility and near-infrared(NIR)responsiveness,imparting the MN photothermal-controlled drug release *** on these features,we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia,reduce collagen deposition,and reduce epidermal thickness in the SSc mouse *** results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases.

关键词： needle precise template

Speed limit effect during lane change in a two-lane lattice model under V2X environment

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Chinese Physics B 2024年第3期33卷 718-722页

作者：金灿彭光含聂方彦 College of Physical Science and Technology Guangxi Normal UniversityGuilin 541004China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China Information and Modern Education Technology Center Hunan University of Arts and ScienceChangde 415000China Computer and Information Engineering College Guizhou University of CommerceGuiyang 550014China

Speed limit measures are ubiquitous due to the complexity of the road environment,which can be supplied with the help of vehicle to everything(V2X)communication ***,the influence of speed limit on traffic system will be investigated to construct a two-lane lattice model accounting for the speed limit effect during the lane change process under V2X ***,the stability condition and the mKdV equation are closely associated with the speed limit effect through theory ***,the evolution of density and hysteresis loop is simulated to demonstrate the positive role of the speed limit effect on traffic stability in the cases of strong reaction intensity and high limited speed.

关键词： traffic flow lattice model speed limit

Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 463-471页

作者： Yu nie jin-Bo Huang Shu-Jiao He Hua-Di Chen Jun-Jun Jia jing-jing Li Xiao-Shun He Qiang Zhao General Surgery Center Department of Hepatobiliary Surgery IIResearch Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou 510080China Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou 510080China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use

关键词： Primary non-function Early allograft failure Risk predicting model Liver transplantation

A reduced-order model for fast predicting ionized flows of hypersonic vehicles along flight trajectory

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Chinese Journal of Aeronautics 2024年第1期37卷 89-105页

作者： jingchao ZHANG Chunsheng nie jinsheng CAI Shucheng PAN School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle TechnologyBeijing 100076China Institute of Extreme Mechanics Northwestern Polytechnical UniversityXi’an 710072China

An improved Reduced-Order Model(ROM)is proposed based on a flow-solution preprocessing operation and a fast sampling strategy to efficiently and accurately predict ionized hypersonic *** ROM is generated in low-dimensional space by performing the Proper Orthogonal Decomposition(POD)on snapshots and is coupled with the Radial Basis Function(RBF)to achieve fast prediction ***,due to the disparate scales in the ionized flow field,the conventional ROM usually generates spurious negative ***,this issue is addressed by performing flow-solution preprocessing in logarithmic space to improve the conventional ***,extra orthogonal polynomials are introduced in the RBF interpolation to achieve additional improvement of the prediction *** addition,to construct high-efficiency snapshots,a trajectory-constrained adaptive sampling strategy based on convex hull optimization is *** evaluate the performance of the proposed fast prediction method,two hypersonic vehicles with classic configurations,i.e.a wave-rider and a reentry capsule,are used to validate the proposed *** two cases show that the proposed fast prediction method has high accuracy near the vehicle surface and the free-stream region where the flow field is *** with the conventional ROM prediction,the prediction results are significantly improved by the proposed method around the discontinuities,*** shock wave and the ionized *** a result,the proposed fast prediction method reduces the error of the conventional ROM by at least 45%,with a speedup of approximately 2.0×105compared to the Computational Fluid Dynamic(CFD)*** test cases demonstrate that the method developed here is efficient and accurate for predicting ionized hypersonic flows.

关键词： Reduced-order model Radial basis function Constrained sampling Transfer function Fast flow prediction Ionized hypersonic flows

Fault diagnosis of HVAC system with imbalanced data using multi-scale convolution composite neural network

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Building Simulation 2024年第3期17卷 371-386页

作者： Rouhui Wu Yizhu Ren Mengying Tan Lei nie School of Mechanical Engineering Hubei University of TechnologyWuhan430068China Industrial Research Institute of Xiangyang Hubei University of Technology Xiangyang441100China

Accurate fault diagnosis of heating,ventilation,and air conditioning(HVAC)systems is of significant importance for maintaining normal operation,reducing energy consumption,and minimizing maintenance ***,in practical applications,it is challenging to obtain sufficient fault data for HVAC systems,leading to imbalanced data,where the number of fault samples is much smaller than that of normal ***,most existing HVAC system fault diagnosis methods heavily rely on balanced training sets to achieve high fault diagnosis ***,to address this issue,a composite neural network fault diagnosis model is proposed,which combines SMOTETomek,multi-scale one-dimensional convolutional neural networks(M1DCNN),and support vector machine(SVM).This method first utilizes SMOTETomek to augment the minority class samples in the imbalanced dataset,achieving a balanced number of faulty and normal ***,it employs the M1DCNN model to extract feature information from the augmented ***,it replaces the original Softmax classifier with an SVM classifier for classification,thus enhancing the fault diagnosis *** the SMOTETomek-M1DCNN-SVM method,we conducted fault diagnosis validation on both the ASHRAE RP-1043 dataset and experimental dataset with an imbalance ratio of 1:*** results demonstrate the superiority of this approach,providing a novel and promising solution for intelligent building management,with accuracy and F1 scores of 98.45%and 100%for the RP-1043 dataset and experimental dataset,respectively.

关键词： fault diagnosis chiller imbalanced data SMOTETomek multi-scale neural networks

Fluid-structure interaction simulation for multi-body flexible morphing structures

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Chinese Journal of Aeronautics 2024年第2期37卷 137-147页

作者： Wenzhi GUO Yongtao SHUI Lu nie Gang CHEN State Key Laboratory of Strength and Vibration for Mechanic Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China China Academy of Launch Vehicle Technology Beijing 100076China China Academy of Aerospace Science and Innovation Beijing 100086China Shannxi Key Laboratory of Service Environment and Control for Flight Vehicles Xi’an Jiaotong UniversityXi’an 710049China

The multi-body flexible morphing airfoil can improve the aerodynamic characteristics based on different flight missions *** researches have focused on the unsteady aerodynamic characteristics of flexible wings under passive ***,the unsteady aerodynamic characteristics with the fluid-structure interaction effects in the multi-body active actuation process of morphing airfoil deserve further *** this paper,a fluid-structure coupled simulation method for multi-body flexible morphing airfoil with active actuation subsystem was investigated,and the aerodynamic characteristics during deformation were compared with different skin flexibility,flow field environment,actuation mode and actuation *** numerical results show that for the steady aerodynamic,the skin flexibility can improve the stability *** the unsteady process,the change trend of the transient lift coefficient and pitching moment are consistent with those of the active drive characteristics,while the instantaneous lift-drag ratio coefficient is greatly affected by the driving mode and can be improved by increasing the driving duration.

关键词： Fluid-structure interaction Multi-body dynamics modeling Flexible structures Aerodynamics Morphing wings

Bulging Distortion of Austenitic Stainless Steel Sheet on the Partially Penetrated Side of Non-Penetration Lap Laser Welding Joint

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 286-295页

作者： Chengwu Yao Enze Liu Jiaming Ni Binying nie Shanghai Key Laboratory of Materials Laser Processing and Modification School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Aerospace Precision Machinery Institute Shanghai 201600China Chemical and Biological Engineering College Yichun UniversityYichun 336000China

Non-penetration laser welding of lap joints in austenitic stainless steel sheets is commonly preferred in fields where the surface quality is of utmost ***,the application of non-penetration welded austenitic stainless steel parts is limited owing to the micro bulging distortion that occurs on the back surface of the partial penetration *** this paper,non-penetration lap laser welding experiments,were conducted on galvanized and SUS304 austenitic stainless steel plates using a fiber laser,to investigate the mechanism of bulging distortion.A comparative experiment of DC01 galvanized steel-Q235 carbon steel lap laser welding was carried out,and the deflection and distortion profile of partially penetrated side of the sheets were measured using a noncontact laser *** addition,the cold-rolled SUS304 was subjected to heat holding at different temperatures and water quenching after bending to characterize its microstructure under tensile and compressive *** results show that,during the heating stage of the thermal cycle of laser lap welding,the partial penetration side of the SUS304 steel sheet generates compressive stress,which extrudes the material in the heat-affected zone to the outside of the back of the SUS304 steel sheet,thereby forming a *** findings of these experiments can be of great value for controlling the distortion of the partial penetrated side of austenitic stainless steel sheet during laser non-penetration lap welding.

关键词： Non-penetration lap laser welding Bulging distortion Austenitic stainless steel Compressive stress Tension stress

Reverse metabolomics as a novel strategy to annotate the human metabolome

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Chinese Journal of Natural Medicines 2024年第4期22卷 289-290页

作者： YAN Tingting nie Liangliang HAO Haiping State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China Laboratory of Metabolic Regulation and Drug Target Discovery School of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Identifying chemical structures inhuman-derived samples presents significant challenges due to limited structural data obtained from untargeted metabolomics *** the chemical structures of molecules are closely related to the phenotypic status of human ecosystems,it becomes invaluable to devise a method for efficiently and systematically determining structures that correlate with the pathophysiological status of humans in a high-throughput approach.

关键词： Reverse metabolomics Human metabolome Combinational synthesis Bile amidates

From VIB‑to VB‑Group Transition Metal Disulfides:Structure Engineering Modulation for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第2期16卷 218-257页

作者： Junye Cheng Yongheng jin jinghan Zhao Qi jing Bailong Gu Jialiang Wei Shenghui Yi Mingming Li Wanli nie Qinghua Qin Deqing Zhang Guangping Zheng Renchao Che Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China

The laminated transition metal disulfides(TMDs),which are well known as typical two-dimensional(2D)semiconductive materials,possess a unique layered structure,leading to their wide-spread applications in various fields,such as catalysis,energy storage,sensing,*** recent years,a lot of research work on TMDs based functional materials in the fields of electromagnetic wave absorption(EMA)has been carried ***,it is of great significance to elaborate the influence of TMDs on EMA in time to speed up the *** this review,recent advances in the development of electromagnetic wave(EMW)absorbers based on TMDs,ranging from the VIB group to the VB group are *** compositions,microstructures,electronic properties,and synthesis methods are presented in ***,the modulation of structure engineering from the aspects of heterostructures,defects,morphologies and phases are systematically summarized,focusing on optimizing impedance matching and increasing dielectric and magnetic losses in the EMA materials with tunable EMW absorption *** as well as the challenges are also identified to guide the design of new TMDs based dielectric EMA materials with high performance.

关键词： Transition metal disulfides Electromagnetic wave absorption Impedance matching Structure engineering modulation