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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： Bo Shi Cheng-Jie Lyu Zhen-Kai Le Hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang Huang Lin-Jun Yu Qiang Shu jin-fa.tou Deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may be essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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Intelligent casting:Empowering the future foundry industry

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China Foundry 2024年第5期21卷 409-426页

作者： jin-wu Kang Bao-lin Liu Tao jing Hou-fa Shen School of Materials Science and Engineering Key Laboratory for Advanced Materials Processing TechnologyTsinghua UniversityBeijing 100084China

Emerging technological advances are reshaping the casting sector in latest *** technology is evolving towards intelligent casting paradigm that involves automation,greenization and intelligentization,which attracts more and more attention from the academic and industry *** this paper,the main features of casting technology were briefly summarized and forecasted,and the recent developments of key technologies and the innovative efforts made in promoting intelligent casting process were ***,the technical visions of intelligent casting process were also put *** key technologies for intelligent casting process comprise 3D printing technologies,intelligent mold technologies and intelligent process control *** future,the intelligent mold that derived from mold with sensors,control devices and actuators will probably incorporate the Internet of Things,online inspection,embedded simulation,decision-making and control system,and other technologies to form intelligent cyber-physical casting system,which may pave the way to realize intelligent *** is promising that the intelligent casting process will eventually achieve the goal of real-time process optimization and full-scale control,with the defects,microstructure,performance,and service life of the fabricated castings can be accurately predicted and tailored.

关键词： intelligent casting 3D printing intelligent mold process control cyber-physical casting system embedded simulation

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A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

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Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： Ting-Ting Huang jin-fa Chen Juan Liu Tai-Bao Wei Hong Yao Bingbing Shi Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect

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新生儿坏死性小肠结肠炎手术后的营养管理

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中国实用儿科杂志 2024年第5期39卷 325-330页

作者：赖登明金静宜钭金法浙江大学医学院附属儿童医院新生儿外科、国家儿童健康与疾病临床医学研究中心、国家儿童区域医疗中心浙江杭州310052

坏死性小肠结肠炎(NEC)是导致新生儿死亡的首位肠道疾病,其中20%~50%患儿需要外科手术干预。短肠综合征是NEC术后最严重并发症,而营养管理是术后恢复及影响预后的重要因素。尽管目前儿童营养技术不断发展,但仍存在电解质紊乱、营养素失... 详细信息

坏死性小肠结肠炎(NEC)是导致新生儿死亡的首位肠道疾病,其中20%~50%患儿需要外科手术干预。短肠综合征是NEC术后最严重并发症,而营养管理是术后恢复及影响预后的重要因素。尽管目前儿童营养技术不断发展,但仍存在电解质紊乱、营养素失衡、静脉营养相关性肝病等营养相关并发症。该文从术后营养评估、方式选择、并发症防治等方面阐述NEC术后营养管理,为NEC的营养治疗和肠功能康复提供理论支持。

关键词：营养管理坏死性小肠结肠炎外科手术并发症肠功能

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Upcycling of Poly(butylene adipate-co-terephthalate)into Dual Covalent Adaptable Networks through Chain Breaking-Crosslinking Strategy

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Chinese Journal of Polymer Science 2024年第10期42卷 1505-1513,I0011页

作者： Bin-Bo Wang Rong Huang Xin Wang Tao Jiang Yi Wang Shuai Du fa-Lin Li jin Zhu Song-Qi Ma Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Divisions of Polymers and CompositesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(butylene adipate-co-terephthalate)(PBAT),a widely studied biodegradable material,has not effectively addressed the problem of plastic *** into consideration the cost-effectiveness,upcycling PBAT should take precedence over direct composting *** present work adopts a chain breaking-crosslinking strategy,upcycling PBAT into dual covalent adaptable networks(CANs).During the chainbreaking stage,the ammonolysis between PBAT and polyethyleneimine(PEI)established the primary crosslinked ***,styrene maleic anhydride copolymer(SMA)reacted with the hydroxyl group,culminating in the formation of dual covalent adaptable *** contrast to PBAT,the PBAT-dual-CANs exhibited a notable Young's modulus of 239 MPa,alongside an inherent resistance to creep and *** to catalysis from neighboring carboxyl group and excess hydroxyl groups,the PBAT-dual-CANs exhibited fast stress ***,they could be recycled through extrusion and hot-press reprocessing,while retaining their *** straightforward strategy offers a solution for dealing with plastic waste.

关键词： Poly(butylene adipate-co-terephthalate) Dynamic crosslinked networks Chain breaking-crosslinking strategy Upcycle Recycle

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Multiscale control of MnO_(2) growth via[WO_(6)]-perturbed[MnO_(6)]assembly toward a favorable balance between capacitance and rate performance

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Rare Metals 2024年第4期43卷 1658-1671页

作者： jin-Kang Liu Tian-Shuo Yang Zhi-Bin Ren Adekunle-Adedapo Obisanya Xin-Yi Tan Yan-Di Rao Jun-Shuang Zhou fa-Ming Gao Jian-Ren Wang Hebei Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao066004China

Although pseudocapacitive manganese dioxide(MnO_(2))integrates the high-power merit of carbonaceous materials with the high-energy merit of battery-type materials,it still has a long way to go in achieving a more satisfactory balance of higher energy and power density,and in decoupling the relationship of structural characteristics with energy storage *** realize such goals,a bottom-up[WO_(6)]-perturbed[MnO_(6)]assembly strategy has been developed here due to their similar structure,yet mismatched lattice *** facile protocol is capable of finely controlling the morphology and crystal structure of MnO_(2)by adjusting its internal[WO_(6)]***,the as-prepared W_xMnO_(2)is treated as an ideal platform to scrutinize the correlations of the structure with the energy storage *** operando Raman spectra and finite element analysis have fully demonstrated the superiority of the locally ordered defects-enriched structure of W_(0.02)-MnO_(2),which could reach a favorable balance between the ion diffusion equilibrium time and the number of active *** a result,the W_(0.02)-MnO_(2)is able to deliver a high capacitance of 292 F·g^(-1)at a current density of 1 A·g^(-1)and a remarkable rate performance with a 60%capacity retention at a current density of 50 A·g^(-1).The further unveiled structure-performance relationship provides a guideline for the design of better pseudocapacitive energy storage devices.

关键词： Supercapacitors Pseudocapacitive materials MnO_(2) Tungsten doping Crystal structure regulation

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Drug delivery with Mn-doped MoO_(2) for photothermalenhanced chemotherapy in fighting cancers

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Rare Metals 2024年第5期43卷 2230-2240页

作者： Ping Zhao Hai-fa Zheng Ju Peng Xing-Long Li fazal Raziq Xiao-Jun Liu Hao-Quan Yu jin-Lu Tang Yi-fan Kang Wen-Huan Huang School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900 ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'an 710021China

Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant *** used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing ***,Mn-doped MoO_(2)nanoparticles coated with ZrO_(2)and capped with Bi_(2)O_(3)have been designed as a DDS,namely *** possesses good magnetic properties,great photothermal conversion ability,sensitive tumor microenvironment(TME)responsiveness,and good biocompatibility in hemocompatibility in ***,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal combined ***@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in ***,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in *** contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

关键词： Mn-doped MoO_(2) Bi_(2)O_(3) Nanocarrier Photothermal Chemotherapy

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Genomic analysis of Nypa fruticans elucidates its intertidal adaptations and early palm evolution

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Journal of Integrative Plant Biology 2024年第4期66卷 824-843页

作者： Weihong Wu Xiao Feng Nan Wang Shao Shao Min Liu fa Si Linhao Chen Chuanfeng jin Shaohua Xu Zixiao Guo Cairong Zhong Suhua Shi Ziwen He State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Greater Bay Area Institute of Precision Medicine School of Life SciencesFudan UniversityGuangzhou 511462China Hainan Academy of Forestry(Hainan Academy of Mangrove) Haikou 571100China

Nypa fruticans(Wurmb),a mangrove palm species with origins dating back to the Late Cretaceous period,is a unique species for investigating long-term adaptation strategies to intertidal environments and the early evolution of ***,we present a chromosome-level genome sequence and assembly for *** integrated the genomes of *** and other palm family members for a comparative genomic analysis,which confirmed that the common ancestor of all palms experienced a whole-genome duplication event around 89 million years ago,shaping the distinctive characteristics observed in this *** also inferred a low mutation rate for the *** genome,which underwent strong purifying selection and evolved slowly,thus contributing to its stability over a long evolutionary ***,ancient duplicates were preferentially retained,with critical genes having experienced positive selection,enhancing waterlogging tolerance in ***,we discovered that the pseudogenization of Early Methionine-labelled 1(EM1)and EM6 in *** underly its crypto-vivipary characteristics,reflecting its intertidal *** study provides valuable genomic insights into the evolutionary history,genome stability,and adaptive evolution of the mangrove *** results also shed light on the long-term adaptation of this species and contribute to our understanding of the evolutionary dynamics in the palm family.

关键词： crypto-vivipary genome stability long-term adaptation mangrove Nypa fruticans palm

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Heavy neutral leptons in gauged U(1)Lμ-Lτ at muon collider

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Chinese Physics C 2024年第9期48卷 36-49页

作者： Ru-Yi He Jia-Qi Huang jin-Yuan Xu fa-Xin Yang Zhi-Long Han Feng-Lan Shao School of Physics and Technology University of JinanJinan 250022China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

Heavy neutral leptons N are the most appealing candidates to generate tiny neutrino *** studied the signature of heavy neutral leptons in gauged U(1)Lμ-Lτ at a muon *** under the U(1)Lμ-Lτ symmetry,the heavy neutral leptons can be pair produced via the new gauge boson Z' at the muon collider as μ^(+)μ^(-)→Z′*→NN AND μ^(+)μ^(-)→Z′(*)γ→NNγ.We then performed a detailed analysis on the lepton number violation signature μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■ and μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■γ at the 3 TeV muon collider,where the hadronic decays of W boson are treated as fat-jets *** lepton number violation signatures have quite clean backgrounds at the muon *** simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon *** instance,with new gauge coupling g'=0.6 and an integrated luminosity of 1000 fb^(-1),the μ^(±)μ^(±)JJ signal could probe m_(Z′)■13 ***,if the gauge boson mass satisfies 2m_(N)<√s,the μ^(±)μ^(±)JJγ signature would be more promising than the μ^(±)μ^(±)JJ signature.

关键词： heavy neutral leptons gauged U(1)_(Lμ-Lτ) muon collider lepton number violation

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Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO Ying-jie CAO Ya-xuan LI Wei-xia WANG Xiao-yan SI Chun-ying XIA Han ZHU Ming-jun TANG jin-fa WANG He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of Ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and Gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRING database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of Genes and Genomes(KEGG) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway Shuxuening Injection apoptosis Ginkgo biloba leaves

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