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Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice

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Zoological Research 2022年第3期43卷 457-468页

作者： Meng-Li Wu Feng-Liang Liu jing Sun Xin Li Jian-Ru Qin Qi-Hong Yan Xia jin Xin-Wen Chen Yong-Tang Zheng jin-cun zhao Jian-Hua Wang College of Life Science Henan Normal UniversityXinxiangHenan 453007China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhouGuangdong 510530China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China University of Chinese Academy of Sciences Beijing 100049China

COVID-19 is an immune-mediated inflammatory disease caused by SARS-CoV-2 infection,the combination of anti-inflammatory and antiviral therapy is predicted to provide clinical *** recently demonstrated that mast cells(MCs)are an essential mediator of SARS-CoV-2-initiated *** also showed that spike protein-induced MC degranulation initiates alveolar epithelial inflammation for barrier disruption and suggested an off-label use of antihistamines as MC stabilizers to block degranulation and consequently suppress inflammation and prevent lung *** this study,we emphasized the essential role of MCs in SARS-CoV-2-induced lung lesions in vivo,and demonstrated the benefits of co-administration of antihistamines and antiviral drug remdesivir in SARS-CoV-2-infected ***,SARSCoV-2 spike protein-induced MC degranulation resulted in alveolar-capillary injury,while pretreatment of pulmonary microvascular endothelial cells with antihistamines prevented adhesion junction disruption;predictably,the combination of antiviral drug remdesivir with the antihistamine loratadine,a histamine receptor 1(HR1)antagonist,dampened viral replication and inflammation,thereby greatly reducing lung *** findings emphasize the crucial role of MCs in SARS-CoV-2-induced inflammation and lung injury and provide a feasible combination antiviral and anti-inflammatory therapy for COVID-19 treatment.

关键词： SARS-CoV-2 Mast cell Remdesivir Antihistamine Combinational therapy

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Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3455-3465页

作者： Yang Peng Shi-ying Chen zhao-ni Wang Zi-qing Zhou jing Sun Gui-an Zhang Jia Li Lei Wang jin-cun zhao Xiao Xiao Tang De-Yun Wang Nan-shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Otolaryngology Infectious Diseases Translational Research ProgramYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Guangzhou Laboratory GuangzhouChina

Repurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells(AECs)is a quick way to find novel treatments for *** screening has found dicoumarol(DCM),a natural anticoagulant,to be a potential SARS-CoV-2 inhibitor,but its inhibitory effects and possible working mechanisms remain *** air-liquid interface culture of primary human AECs.

关键词： Omi infection epithelium

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Alteration of the respiratory microbiome in COVID-19 patients with different severities

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Journal of Genetics and Genomics 2022年第3期49卷 258-261页

作者： Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie zhaoming Chen Airu Zhu Ruosu Ying Le Yu jin cun zhao Shuai Cheng Li Weiping Cai Feng Ye State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityNational Center for Respiratory MedicineGuangzhouGuangdong 510120China Department of Computer Sciences City University of Hong KongHong Kong 999077China Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhouGuangdong 510060China Beijing YuanShengKangTai(ProtoDNA)Genetech Co.Ltd. Beijing100190China

Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients.

关键词： patients respiratory clinical

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Preliminary Design of a System for Picking up Audio-Signals From Bubble Detectors GAO Si-ze1,NI Bang-fa,ZHANG Gui-ying,XIAO Cai-jin,LIU cun-xiong, CHEN Zhe1,NIE Peng,LIU Chao1,zhao Chang-jun (*** of Physics Science and Engineering Technology,Guang

Preliminary Design of a System for Picking up Audio-Signals ...

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作者： GAO Si-ze NI Bang-fa ZHANG Gui-ying XIAO Cai-jin LIU cun-xiong CHEN Zhe NIE Peng LIU Chao zhao Chang-jun College of Physics Science and Engineering Technology Guangxi University

This system is designed to pick up sound signals from large volume,low-threshold energy, low-background superheated droplets bubble detectors.A sound-sensitive bubble detector is composed of a container filled with a mixture of superheated droplets and gel,a temperature and pressure control system,and an audio acquisition system attached on the outer surface of the *** superheated droplets are in a metastable and superheated state at ambient temperature and *** the outside

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Scaling properties of Navier-Stokes turbulence

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第3期10卷 392-397页

作者： zhao-cun LIU School of Environment and Planning Henan University Kaifeng 475001 China

The property of the velocity field and the cascade process of the fluid flow are key problems in turbulence research. This study presents the scaling property of the turbulent velocity field and a mathematical description of the cascade process, using the following methods: (1) a discussion of the general self-similarity and scaling invariance of fluid flow from the viewpoint of the physical mechanism of turbulent flow; (2) the development of the relationship between the scaling indices and the key parameters of the She and Leveque (SL) model in the inertial range; (3) an investigation of the basis of the fractal model and the multi-fractal model of turbulence; (4) a demonstration of the physical meaning of the flowing field scaling that is related to the real flowing vortex. The results illustrate that the SL model could be regarded as an approximate mathematical solution of Navier-Stokes (N-S) equations, and that the phenomena of normal scaling and anomalous scaling is the result of the mutual interactions among the physical factors of nonlinearity, dissipation, and dispersion. Finally, a simple turbulent movement conceptional description model is developed to show the local properties and the instantaneous properties of turbulence.

关键词： Transformation equations Scaling Spiral structure Cascade Turbulence

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Velocity distribution and scaling properties of wall bounded flow

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 505-510页

作者： zhao-cun LIU Key Laboratory o finland Waterway Regulation of Communications Industry Chongqing Jiaotong University Chongqing 400074 China Key Laboratory of Waterway Engineering of Communication Ministry and Chongqing City Chongqing Jiaotong UniversityChongqing 400074 China

The scaling and similarity of wall bounded turbulent flow were studied. The properties of such flows and the relationship between a power law and a logarithmic type of velocity distribution were investigated. Based on the physical mechanism involved, our results show that the power law and the logarithmic distribution are only different forms with the same hypothesis and hold only in the outer flow zone. Thus, a universal explanation for various empirical formulae of velocity distribution was obtained. Manning’s formula was studied to explain theoretically the experiential result that the roughness coefficient is only a comprehensive parameter of the whole system without a corresponding physical factor. The physical mechanism of the velocity distribution of parallel to wall bounded flow was explored, the results show that the parameters in the formula of velocity distribution are indices of the system responding to flowing environmental factors to represent general case of boundary roughness and the flowing state, corresponding physical mechanism is vortex motion.

关键词： Velocity distribution Scaling Turbulence

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Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang Quan jin Haitao Zhang zhao Liu Yuyang Wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Study on Duality of Wave and Particle of Turbulence Using CML Models

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Communications in Theoretical Physics 2009年第5期51卷 857-864页

作者： LIU zhao-cun School of Environment and Planning Henan University Kaifeng 475001 China Southwest Engineering Research Institute for Waterway Chongqing Jiaotong University Key Waterway Laboratory of Chongqing City and Ministry of Communications Chongqing 400016 China

A family of coupled map lattice （CML） models has been developed to simulate the evolutional mechanism of interactions of convection, diffusion, and dispersion in both weakly and strongly coupled cases. Not only coherent and turbulent properties as well as their relations, but also the transitional states between convection dominating, diffusion dominating and dispersion dominating are analyzed to demonstrate the essential characteristics of any state. Numerical results show that the models are capable of simulating both layered coupling and stochastic mechanism, and lead us to understand whether or not turbulence coherent structure is formed by modulation of wave packet. The duality of wave and particle characters of turbulence is illustrated in the numerical simulation; a sketch picture is given to explain the questions associated with the turbulent inverse cascade, which is the result of the mutual interactions among the physical factors of nonlinearity, dissipation and dispersion.

关键词： CML model non-linearity dissipation dispersion duality of wave and particle

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In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

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Nano Research 2025年第1期18卷 382-394页

作者： Debin Luo Peng Zhou Xiaowei Lv Panpan Sun Xiaohua Sun Hewei zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

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