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Chinese Journal of Aeronautics 2007年第2期20卷 107-110页

作者： ZHANG yu-xiang WANG jin-cheng YANG yu-juan YANG Gen-cang ZHOU Yao-he State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072 China

A phase-field method was employed to study the influence of elastic field on the nucleation and microstructure evolution. Two kinds of nucleation process were considered： one using fixed nucleation probability and the other calculated from the classical nucleation theory. In the latter case, the simulated results show that the anisotropic elastic strain field yields significant effects on the behavior of nucleation. With a large lattice misfit between the matrixes and the precipitates, the nucleation process does not appear fully random but displays some spatial correlation and has a preference for the elastic soft direction. However, with a small lattice misfit, this bias does not look quite clear. On the contrary, in the case of fixed nucleation probability, the elastic field has no influence on the nucleation process. The lattice mismatch also exerts influences on the microstructure morphology： with lattice mismatch becoming larger, the microstructure proves to align along the elastic soft direction.

关键词： elastic field nucleation phase-field method precipitation

Smac多肽对食管鳞状细胞癌耐药性调节机制的研究

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广东医学 2024年第4期45卷 425-432页

作者：杨勇伟艾力江·多力坤金澄宇新疆维吾尔自治区人民医院胸外科新疆乌鲁木齐830000

目的探究Smac多肽(Smac-N7)对食管癌鳞状细胞系Eca-109和紫杉醇(PTX)耐药株(Eca-109/PTX)耐药性的影响和作用机制。方法采用小剂量间歇诱导法建立Eca-109/PTX细胞株,CCK-8法检测PTX对Eca-109和Eca-109/PTX的半数抑制浓度(IC_(50))。使用PTX和Smac-N7分别或联合处理Eca-109或Eca-109/PTX细胞,并将细胞分为:Eca-109组、Eca-109+PTX组、Eca-109+Smac-N7组、Eca-109+PTX+Smac-N7组;Eca-109/PTX组、Eca-109/PTX+PTX组、Eca-109/PTX+Smac-N7组、Eca-109/PTX+PTX+Smac-N7组。采用流式细胞术、试剂盒和Western blot法分别检测各组Eca-109和Eca-109/PTX细胞的凋亡率和细胞中caspase-3活性与Bcl-2、Bax蛋白的表达水平。结果CCK-8法检测结果显示,随浓度的增加,PTX对Eca-109与Eca-109/PTX的生长抑制率均明显增加(P<0.05),且PTX对Eca-109的IC_(50)[(0.08±0.01)μg/mL]显著低于其对Eca-109/PTX的IC_(50)[(2.47±0.11μg/mL)](P<0.01)。与Eca-109组或Eca-109/PTX组相比,Eca-109+PTX组、Eca-109+PTX+Smac-N7组和Eca-109/PTX+Smac-N7组、Eca-109/PTX+PTX+Smac-N7组细胞中Bcl-2蛋白表达水平显著降低(P<0.05),但细胞凋亡率、细胞中caspase-3活性和Bax蛋白表达水平明显升高(P<0.05)。与Eca-109+PTX组或Eca-109/PTX+PTX组相比,Eca-109+PTX+Smac-N7组和Eca-109/PTX+PTX+Smac-N7组细胞中Bcl-2蛋白表达水平明显降低(P<0.05),而细胞凋亡率、细胞中caspase-3活性和Bax蛋白表达水平明显升高(P<0.05)。结论Smac-N7可在体外通过促进细胞凋亡来改善Eca-109细胞及其耐药株对PTX的敏感度。

关键词：食管鳞状细胞癌 Smac多肽耐药性

腹腔镜近端胃切除双通道吻合术与全胃切除Roux-en-Y消化道重建术的临床疗效观察比较

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医药论坛杂志 2024年第2期45卷 177-181页

作者：张洪彦范银亮程金玉商丘市第三人民医院普外科河南商丘476000

目的腹腔镜近端胃切除双通道吻合术与全胃切除Roux-en-Y消化道重建术的临床疗效观察比较。方法选取2019年5月至2021年7月商丘市第三人民医院收治50例近端胃癌患者作为研究对象,根据方法的不同将其分成试验组(n=25,采取腹腔镜近端胃切除... 详细信息

目的腹腔镜近端胃切除双通道吻合术与全胃切除Roux-en-Y消化道重建术的临床疗效观察比较。方法选取2019年5月至2021年7月商丘市第三人民医院收治50例近端胃癌患者作为研究对象,根据方法的不同将其分成试验组(n=25,采取腹腔镜近端胃切除双通道吻合术)和常规组(n=25,采取全胃切除Roux-en-Y消化道重建术),对比两组患者手术前后血清前蛋白水平及体质量指数情况;对比两组患者围手术期临床指标、术后1年并发症、生存质量、Visick分级及术后3年生存率。结果手术前两组体质量、血清血红蛋白、白蛋白、总蛋白含量比较无统计学意义(P>0.05),术后1年试验组体质量、血清血红蛋白、白蛋白、总蛋白含量分别为(19.05±2.25)kg/m^(2)、(122.35±21.23)g/L、(336.52±36.09)g/L和(75.27±18.29)g/L,均高于常规组(P0.05);试验组术后1年内并发症发生率12%,与常规组(32%)比较差异有统计学意义(P0.05)。结论对近端胃癌患者行腹腔镜近端胃切除双通道吻合术与全胃切除Roux-en-Y消化道重建术均能够达到较好手术效果,但腹腔镜近端胃切除双通道吻合术能更好地改善患者术后营养状态,提高生存质量,更适合近端胃癌手术患者。

关键词：腹腔镜近端胃切除全胃切除 Roux-en-Y消化道重建术胃癌效果

索拉非尼在碘难治性分化型甲状腺癌中耐药机制现状

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中国临床药理学杂志 2024年第13期40卷 1986-1990页

作者：张恩涛诸昊楠温正则张涔慧赵义欢茅颖杰吴俊朴金煜城金欣绍兴文理学院医学院浙江绍兴312000

大多数分化型甲状腺癌症患者在放射性碘-131治疗后预后良好,但仍有少数患者对放射性碘治疗不敏感,甚至依然出现疾病进展。目前,一些可以提高放射性碘难治性分化型甲状腺癌症患者无进展生存率的靶向药物,如索拉非尼和乐伐替尼,已被批准... 详细信息

大多数分化型甲状腺癌症患者在放射性碘-131治疗后预后良好,但仍有少数患者对放射性碘治疗不敏感,甚至依然出现疾病进展。目前,一些可以提高放射性碘难治性分化型甲状腺癌症患者无进展生存率的靶向药物,如索拉非尼和乐伐替尼,已被批准用于治疗放射性碘难治性分化型癌症(RAIR-DTC)。然而,由于原发性和继发性耐药的存在,药物对这些患者的疗效并不理想。本综述就丝裂原活化蛋白激酶(MAPK)和磷脂酰肌醇3-激酶(PI3K)通路介绍索拉非尼继发性耐药机制并提出相关治疗策略,以期为索拉非尼类似药物耐药机制与放射性碘难治性分化型甲状腺癌的有效治疗提供参考依据。

关键词：放射性碘难治性分化型甲状腺癌索拉非尼耐药机制协同作用丝裂原活化蛋白激酶信号通路磷脂酰肌醇3-激酶信号通路

Dynamic compressive property and failure behavior of extruded Mg-Gd-Y alloy under high temperatures and high strain rates

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Journal of Magnesium and Alloys 2015年第2期3卷 134-141页

作者： jin-cheng yu Zheng Liu Yang Dong Zhi Wang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

For the purpose of investigating the dynamic deformational behavior and failure mechanisms of magnesium under high strain rates,the Split Hopkinson Pressure Bar(SHPB)was used for investigating dynamic mechanical properties of extruded Mg-Gd-Y Magnesium alloy at ambient temperature(300 K),200℃(473 K)and 300℃(573 K)*** samples after compression were analyzed by scanning electron microscope(SEM)and metallographic *** mechanical properties,crack performance and plastic deformation mechanism of extruded Mg-Gd-Y Magnesium alloy along the extrusion direction(ED)were *** results show that,extruded Mg-Gd-Y Magnesium alloy has the largest dynamic compressive strength which is 535 MPa at ambient temperature(300 K)and strain rate of 2826 s^(−1).When temperature increases,dynamic compressive strength decreases,while ductility *** dynamic compression fracture mechanism of extruded Mg-Gd-Y Magnesium alloy is multi-crack propagation and intergranular quasi-cleavage fracture at both ambient temperature and high *** dynamic compressive deformation mechanism of extruded Mg-Gd-Y Magnesium alloy is a combination of twinning,slipping and dynamic recrystallization at both ambient temperature and high temperature.

关键词： Extruded Mg-Gd-Y magnesium alloy Split Hopkinson Pressure Bar Dynamic compressive property Failure behavior High strain rates High temperature

Dynamic tensile and compressive properties of vacuum and ordinary die-casting AT72 magnesium alloy at high strain rates

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Journal of Magnesium and Alloys 2013年第2期1卷 150-162页

作者： Zheng Liu Yang Dong Ping-li Mao jin-cheng yu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

To investigate dynamic tensile and compressive properties of AT72 magnesium alloys under high strain rates,the Split Hopkinson tensile Bar(SHTB)and the Split Hopkinson Pressure Bar apparatus was used at ambient *** specimens after dynamic tension and dynamic compression were analyzed by scanning electron microscope(SEM)and metallographic *** mechanical properties and fracture mechanism were discussed in this *** results show that at approximate tensile strain rate,the dynamic tensile strength of ordinary die-casting AT72 and vacuum die-casting AT72 is very similar,but the dynamic failure strain is of great ***72 magnesium alloys under dynamic compressive yield continuously,and have the slight positive strain rate *** dynamic compressive behaviors of ordinary die-casting AT72 and vacuum die-casting AT72 are nearly the *** dynamic tensile fracture mechanism of both vacuum die-casting AT72 and ordinary die-casting AT72 is inter-granular *** dynamic compressive fracture mechanism of both vacuum die-casting AT72 and ordinary die-casting AT72 is quasi-cleavage intra-crystalline *** pores have an important effect on dynamic properties of die casting magnesium alloys.

关键词： AT72 Magnesium alloy SHPB SHTB Microstructure Fracture mechanism

Dual modification of LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2) cathode materials by K^(+) doping and Li_(3)PO_(4) coating for lithium ions batteries

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Rare Metals 2024年第7期43卷 3007-3018页

作者： Wei Xiao Jia-Le Wang Zhi-cheng Yi cheng-jin Liu Chang Miao yu Xin Shu-Qing Nie College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou 434023China

Li_(3)PO_(4)@Li_(0.99)K_(0.01)Ni_(0.83)Co_(0.11)Mn_(O.06)O_(2)(NCM-KP) cathode powders are synthesized via K^(+)doping in calcination processes and H_3PO_4 coating in sol-gel processes.K^(+) precisely enters into the lattice to widen the(003) plane to 0.4746 nm with a lower cationic disordered degree of 1.87%.Moreover,the surface residual lithium salts are treated by H_3PO_4 to generate a uniform Li_(3)PO_(4) coating layer of approximately 11.41 nm,which completely covers on the surface of secondary spherical particles to improve the interfacial *** 25℃,the NCM-KP electrode delivers a discharge specific capacity of 148.9 mAh·g^(-1) with a remarkable capacity retention ratio of 84.1% after 200 cycles at 1.0C and retains a high reversible specific capacity of 154.4 mAh·g^(-1) at *** at 1.0C and 60℃,it can maintain a reversible discharge specific capacity of 114.6 mAh·g^(-1) with 0.21% of capacity decay per cycle after 200 cycles,which is significantly lower than 0.40% for the pristine NCM ***,the charge transfer resistance of 238.89 Ω for the NCM-KP electrode is significantly lower than 947.41 Ω for the pristine NCM one by restricting the interfacial side ***,combining K+doping and Li_(3)PO_(4) coating is an effective strategy to enable the significant improvement of the electrochemical property of high-nickel cathode materials,which may be mainly attributed to the widened diffusion pathway and the formed Li_(3)PO_(4) protective layer,thus promoting Li~+diffusion rate and preventing the erosion of HF.

关键词： High-nickel cathode material Residual lithium K^(+)doping Li_(3)PO_(4)coating Lithium ions battery

A long-term histological research on human frontalis muscle flap specimens from recurrent blepharoptosis patients

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1161-1163页

作者： Lu Zhou yu-cheng Yan jin-Cai Fan Department of Plastic and Reconstructive Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China

Dear Editor,We present two patients with recurrent severe blepharoptosis after frontalis muscle(FM)flap *** we describe long-term histological changes of the FM flaps observed in revision *** flap suspension is widely applied in treating severe ptosis with poor levator function(<4 mm),and its effect is relatively stable and lasting[1].FM flap suspension is reliable and recurrent cases are observed only *** longterm research about FM flap is rare,we investigated tissue samples of revision surgery flaps which could reflect trends of morphological changes within the functioning FM flaps to some extent.

关键词： patients histological surgery

Effect of pre-rolling path on mechanical properties of rolled ZK60 alloys

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Transactions of Nonferrous Metals Society of China 2021年第5期31卷 1322-1338页

作者： Bo SONG Zhi-wen DU Qing-shan YANG Ning GUO Sheng-feng GUO jin-cheng yu Ren-long XIN School of Materials and Energy Southwest UniversityChongqing 400715China School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China School of Mechanical Technology Wuxi Institute of TechnologyWuxi 214121China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Pre-cold rolling with low reductions(<3%)was used to improve the mechanical properties of rolled ZK60 *** effects of rolling path on mechanical properties were investigated in *** pre-cold rolling along the transverse direction(TD)and pre-cold rolling along the normal direction(ND)can increase the yield ***,pre-cold rolling along the TD is more effective than pre-cold rolling along the ND in improving the comprehensive mechanical *** pre-cold rolling to 3%reduction,the sample rolled along the TD and the sample rolled along the ND have similar tensile yield strength(~270 MPa).However,the former has a higher compressive yield strength,lower yield asymmetry and larger toughness than the ***,pre-cold rolling can also enhance precipitation hardening ***,aging treatment cannot further improve the yield strength of pre-cold rolled ***,the related mechanism is discussed.

关键词： ZK60 alloy pre-cold rolling dislocation twin aging mechanical properties

Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei SHI Xia MA Xin yu Jun Lei XU jin Chuan QIAN cheng cheng HU Zhi Dong ZHANG Hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples