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Prevalence of fatty liver disease and the economy in China: A systematic review

World Journal of Gastroenterology 2015年第18期21卷 5695-5706页

作者： jin-zhou zhu Qin-Yi zhou Yu-Ming Wang Yi-Ning Dai Jiang zhu Chao-Hui Yu You-Ming Li Department of Gastroenterology The First Affiliated Hospital College of Medicine Zhejiang University Department of Statistics Columbian College of Arts and Science The George Washington University Bureau of Statistics Municipal GovernmentSuqian

AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in China's Mainland. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to crosssectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. The gross domestic product(GDP) per capita was chosen to assess the economic status. Multiple linear regression and Loess regression were chosen to fit the data and calculate the 95%CIs. Fitting and overfitting of the models were considered in choosing the appropriate models. RESULTS: There were 27 population-based surveys from 26 articles included in this study. The pooled mean prevalence of FLD in China was 16.73%(95%CI: 13.92%-19.53%). The prevalence of FLD was correlated with the GDP per capita and survey years in the country(adjusted R2 = 0.8736, P GDP per capita = 0.00426, P years = 0.0000394), as well as in coastal areas(R2 = 0.9196, P GDP per capita = 0.00241, P years = 0.00281). Furthermore, males [19.28%(95%CI: 15.68%-22.88%)] presented a higher prevalence than females [14.1%(95%CI: 11.42%-16.61%), P = 0.0071], especially in coastal areas [21.82(95%CI: 17.94%-25.71%) vs 17.01%(95%CI: 14.30%-19.89%), P = 0.0157]. Finally, the prevalence was predicted to reach 20.21% in 2020, increasing at a rate of 0.594% per year. CONCLUSION: This study reveals a correlation between the economy and the prevalence of FLD in China's Mainland.

关键词： Fatty liver disease Epidemiology Gross domestic product per capita Prevalence Economy

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Pancreatic cancer incidence and mortality patterns in 2006-2015 and prediction of the epidemiological trend to 2025 in China

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World Journal of Clinical Cases 2022年第14期10卷 4404-4413页

作者： Min-Yue Yin Li-Ting Xi Lu Liu jin-zhou zhu Li-Juan Qian Chun-Fang Xu Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Due to dietary patterns,the aging population,and other high-risk factors,the occurrence of pancreatic cancer(PC)has been rapidly increasing in *** To present the epidemiological trends of PC in China over the past decade and the estimated trend in 2025 and to compare the international differences in PC morbidity and *** This study used a series of nationally representative data from the National Central Cancer Registry of China(NCCR),the International Agency for Research on Cancer and the Institute for Health Metrics and Evaluation *** data of the PC incidence and mortality from 2006 to 2015 in China were extracted from the NCCR *** regression models were used to estimate the incidence and mortality rates of PC in *** The age-standardized rates of PC in China increased from 3.65 per 100000 in 2006 to 4.31 per 100000 in 2015 and were estimated to reach up to 5.52 per 100000 in *** mortality went from 3.35 per 100000 in 2006 to 3.78 per 100000 in 2015,estimated to reach up to 4.6 per 100000 in *** number of new cases and deaths was low before 45 years and the peak age of onset was 85-89 *** incidence and mortality rates in men were higher than those in women regardless of the region in *** addition,the incidence and mortality rates in China were higher than the average level around the ***,disabilityadjusted life years attributed to PC in China were 197.22 years per 100000,above the average level around the *** This study presented an increasing trend of PC in China and differences in morbidity,mortality and disability-adjusted life years between Chinese and global *** need to be made to decrease the PC incidence and improve patient outcomes.

关键词： Pancreatic cancer China Epidemiology Incidence Mortality

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Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3507-3520页

作者： Wen Liu Hong-Yu Wu Jia-Xi Lin Shu-Ting Qu Yi-Jie Gu jin-zhou zhu Chun-Fang Xu Department of Gastroenterology Changzhou Hospital of Traditional Chinese MedicineChangzhou 213000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Suzhou Ninth Hospital Affiliated to Soochow UniversitySuzhou 215200Jiangsu ProvinceChina

BACKGROUND Lymph node ratio(LNR)was demonstrated to play a crucial role in the prognosis of many ***,research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm(NEN)patients was *** To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic *** A total of 286 patients from the Surveillance,Epidemiology,and End Results database were divided into the training set and validation set at a ratio of 8:2.92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test *** regression analysis was used to explore the relationship between LNR and disease-specific survival(DSS)of gastric NEN *** survival forest(RSF)algorithm and Cox proportional hazards(CoxPH)analysis were applied to develop models to predict DSS respectively,and compared with the 8th edition American Joint Committee on Cancer(AJCC)tumornode-metastasis(TNM)*** Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of *** RSF model exhibited the best performance in predicting DSS,with the C-index in the test set being 0.769[95%confidence interval(CI):0.691-0.846]outperforming the CoxPH model(0.744,95%CI:0.665-0.822)and the 8th edition AJCC TNM staging(0.723,95%CI:0.613-0.833).The calibration curves and decision curve analysis(DCA)demonstrated the RSF model had good calibration and clinical ***,the RSF model could perform risk stratification and individual prognosis prediction *** A higher LNR indicated a lower DSS in postoperative gastric NEN *** RSF model outperformed the CoxPH model and the 8th edition AJCC TNM staging in the test set,showing potential in clinical practice.

关键词： Gastric neuroendocrine neoplasm Lymph node ratio Disease-specific survival Random survival forest Predictive model

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Clinical guidelines of non-alcoholic fatty liver disease: A systematic review

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World Journal of Gastroenterology 2016年第36期22卷 8226-8233页

作者： jin-zhou zhu Kelseanna Hollis-Hansen Xing-Yong Wan Su-Juan Fei Xun-Lei Pang Fan-Dong Meng Chao-Hui Yu You-Ming Li Department of Gastroenterology The First Affiliated Hospital School of Medicine Zhejiang University Systems-oriented Global Childhood Obesity Intervention Program Department of Epidemiology and Environmental Health University at Buffalo The State University of New York Department of Gastroenterology The Affiliated Hospital Xuzhou Medical University Department of Endocrinology The Affiliated Hospital Xuzhou Medical University

AIM To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease(NAFLD).METHODS A database search was conducted on Pub Med for guidelines published before May 2016, supplemented by reviewing relevant websites. The Appraisal of Guidelines for Research and Evaluation(ARGEE) instrument Ⅱ was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally. it was used to appraise the quality of guidelines in this study. The inclusion criteria include: clinical NAFLD guidelines for adults, published in English, and released by governmental agencies or key *** Eleven guidelines were included in this study. Since 2007, guidelines have been released in Asia(3 in China, 1 in South Korea, and 1 in Japan), Europe(1 in italy),America(1 in United States and 1 in Chile) and three international agencies [European associations joint, Asia-Pacific Working Party and World Gastroenterology Organization(WGO)]. Using the ARGEE Ⅱ instrument, we found US 2012 and Europe 2016 had the highest scores, especially in the areas of rigor of development and applicability. Additionally, italy 2010 and Korea 2013 also presented comprehensive content, rigorous procedures and good applicability. And WGO 2014 offered various algorithms for clinical practice. Lastly, a practical algorithm for the clinical management was developed, based on the recommended *** This is the first systematic review of NAFLD guidelines. it may yield insights for physicians and policy-makers in the development and application of guidelines.

关键词： Diagnosis Management Non-alcoholic fatty liver disease Systematic review Treatment

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基于支持向量回归的腔体滤波器机电耦合建模与优化

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电子与信息学报 2011年第11期33卷 2780-2784页

作者：周金柱黄进薛欣西安电子科技大学电子装备结构设计教育部重点实验室西安710071 西安电子科技大学天线与微波技术国家重点实验室西安710071

为了提高装配后的滤波器电性能和成品率,该文提出了一种基于支持向量回归的腔体滤波器机电耦合建模和优化方法。该方法根据工程中积累的经验数据,首先应用改进的多核线性规划支持向量回归算法建立了制造精度对滤波器电性能影响的机电耦... 详细信息

为了提高装配后的滤波器电性能和成品率,该文提出了一种基于支持向量回归的腔体滤波器机电耦合建模和优化方法。该方法根据工程中积累的经验数据,首先应用改进的多核线性规划支持向量回归算法建立了制造精度对滤波器电性能影响的机电耦合模型,然后应用此模型优化了滤波器的制造精度,从而获得了最优的机械结构尺寸。实际滤波器的实验结果验证了该方法的有效性。该方法可用于批量生产的腔体滤波器的计算机辅助制造系统中。

关键词：腔体滤波器机电耦合线性规划支持向量回归多核

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LuGre摩擦模型对伺服系统的影响与补偿

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控制理论与应用 2008年第6期25卷 990-994页

作者：周金柱段宝岩黄进西安电子科技大学电子装备结构教育部重点实验室陕西西安710071 西安电子科技大学机电工程学院陕西西安710071

摩擦是影响伺服系统性能的一个主要因素.为了研究摩擦的影响与补偿,本文首先建立了基于动态LuGre摩擦的机电伺服系统模型.根据LuGre模型,构造了一个非线性观测器来估计摩擦力矩.然后,积分反步自适应控制算法被设计从而实现了摩擦补偿和... 详细信息

摩擦是影响伺服系统性能的一个主要因素.为了研究摩擦的影响与补偿,本文首先建立了基于动态LuGre摩擦的机电伺服系统模型.根据LuGre模型,构造了一个非线性观测器来估计摩擦力矩.然后,积分反步自适应控制算法被设计从而实现了摩擦补偿和负载扰动估计,并使用Lyapunov函数证明了闭环系统的稳定性.仿真结果表明:LuGre摩擦会对伺服系统产生极限环振荡以及低速爬行的影响,并且提出的补偿方法能够降低摩擦对伺服系统性能的影响以及提高了系统的跟踪精度和鲁棒性.

关键词： LuGre摩擦模型摩擦补偿积分反步自适应控制伺服系统

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Protection of ghrelin postconditioning on hypoxia/ reoxygenation in gastric epithelial cells

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World Journal of Gastroenterology 2012年第38期18卷 5377-5388页

作者： Zhang-Bo Liu Su-Juan Fei Sheng-Ping zhu jin-zhou zhu Hong-Xia Han Qiu-Ju Dong Jian-Fu Zhang DepartmentofGastroenterol-ogy TheAffiliatedHospitalofXuzhouMedicalCollege99WestHuaihaiRoadXuzhou221002JiangsuProvinceChina Department of Physiology Xuzhou MedicalCollege Xuzhou 221002 Jiangsu Province China

AIM: To investigate the protective effect and mechanisms of ghrelin postconditioning against hypoxia/reoxygenation (H/R)-induced injury in human gastric epithelial cells. METHODS: The model of H/R injury was established in gastric epithelial cell line (GES-1) human gastric epithelial cells. Cells were divided into seven groups: normal control group (N); H/R postconditioning group; DMSO postconditioning group (DM); ghrelin postconditioning group (GH); D-Lys3-GHRP-6 + ghrelin postconditioning group (D + GH); capsazepine + ghrelin postconditioning group (C + GH); and LY294002 + ghrelin postconditioning group (L + GH). 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to detect GES-1 cell viability. Hoechst 33258 fluorochrome staining and flow cytometry were conducted to determine apoptosis of GES-1cells. Spectrophotometry was performed to determine release of lactate dehydrogenate (LDH). Protein expression of Bcl-2, Bax, Akt, and glycogen synthase kinase (GSK)-3β was determined by western blotting. Expression of vanilloid receptor subtype 1 (VR1), Akt and GSK-3β was observed by immunocytochemistry. RESULTS: Compared with the H/R group, cell viability of the GH group was significantly increased in a dosedependent manner (55.9% ± 10.0% vs 69.6% ± 9.6%, 71.9% ± 17.4%, and 76.3% ± 13.3%). Compared with the H/R group, the percentage of apoptotic cells in the GH group significantly decreased (12.38% ± 1.51% vs 6.88% ± 0.87%). Compared with the GH group, the percentage of apoptotic cells in the D + GH group, C + GH group and L + GH groups significantly increased (11.70% ± 0.88%, 11.93% ± 0.96%, 10.20% ± 1.05% vs 6.88% ± 0.87%). There were no significant differences in the percentage of apoptotic cells between the H/R and DM groups (12.38% ± 1.51% vs 13.00% ± 1.13%). There was a significant decrease in LDH release following ghrelin postconditioning compared with the H/R group (561.58 ± 64.01 U/L vs 1062.45 ± 105.29 U/L). There was a significant

关键词： Protection of ghrelin postconditioning on hypoxia/ reoxygenation in gastric epithelial cells

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei jin Liu Tao zhu Cheng zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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甲状腺乳头状癌的超声图像特点

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声学技术 2005年第4期24卷 233-236页

作者：周进祝冯亮朱晓红上海职工医学院医学影像教研室上海200237 上海交通大学附属第六人民医院超声医学科上海200233

探讨超声检查对甲状腺乳头状癌诊断的临床价值。对病理证实的37例甲状腺乳头状癌及20例甲状腺腺瘤超声图像表现进行回顾性分析。甲状腺乳头状癌超声表现以圆形或类圆形实性低回声为主,部分可见钙化,多数结节边界不清、无包膜,彩色血流... 详细信息

探讨超声检查对甲状腺乳头状癌诊断的临床价值。对病理证实的37例甲状腺乳头状癌及20例甲状腺腺瘤超声图像表现进行回顾性分析。甲状腺乳头状癌超声表现以圆形或类圆形实性低回声为主,部分可见钙化,多数结节边界不清、无包膜,彩色血流信号显示率为48.5%(16/33)。37例甲状腺乳头状癌中,超声诊断恶性肿瘤的符合率为70.3%(26/37)。甲状腺乳头状癌声像图表现有其特征性,其中边界不清、无包膜、低回声及微小钙化是诊断要点,超声检查有助于本病的临床诊断。

关键词：甲状腺乳头状癌超声检查

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伺服系统摩擦的支持向量回归建模与反步控制

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控制理论与应用 2009年第12期26卷 1405-1409页

作者：周金柱段宝岩黄进刁玖胜西安电子科技大学电子装备结构教育部重点实验室陕西西安710071

研究了一种伺服系统摩擦建模和控制的新方法.首先,根据实验数据,提出了基于支持向量机回归的自适应库仑摩擦和固定库仑摩擦建模方法,以解决在速度为零时摩擦力矩不连续导致的建模不准确问题.然后应用所建立的摩擦模型,使用反步法设计了... 详细信息

研究了一种伺服系统摩擦建模和控制的新方法.首先,根据实验数据,提出了基于支持向量机回归的自适应库仑摩擦和固定库仑摩擦建模方法,以解决在速度为零时摩擦力矩不连续导致的建模不准确问题.然后应用所建立的摩擦模型,使用反步法设计了控制器从而实现了摩擦的自适应补偿.通过使用Lyapunov理论证明了闭环系统的稳定性.仿真结果验证了该方法的有效性.

关键词：支持向量回归反步法摩擦伺服系统

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