检索结果-南通市图书馆

Abnormal function of EPHA2/p.R957P mutant in congenital cataract

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： jing-jin Zhang Zong-Fu Cao Bi-Ting Zhou Ju-Hua Yang zhong Li Shuang Lin xiao-Le Chen Nan-Wen Zhang Qin Ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transient AC Overvoltage Suppression Orientated Reactive Power Control of the Wind Turbine in the LCC-HVDC Sending Grid

引用

CES Transactions on Electrical Machines and Systems 2024年第2期8卷 152-161页

作者： Bo Pang xiao jin Quanwang Zhang Yi Tang Kai Liao Jianwei Yang Zhengyou He IEEE College of Electrical Engineering Southwest Jiaotong UniversityChengdu 610031China State Grid Zhejiang Electric Power Company HangzhouChina

High-voltage direct current(HVDC) transmission is a crucial way to solve the reverse distribution of clean energy and loads. The line commutated converter-based HVDC(LCCHVDC) has become a vital structure for HVDC due to its high technological maturity and economic advantages. During the DC fault of LCC-HVDC, such as commutation failure, the reactive power regulation of the AC grid always lags the DC control process, causing overvoltage in the AC sending grid, which brings off-grid risk to the wind power generation based on power electronic devices. Nevertheless, considering that wind turbine generators have fast and flexible reactive power control capability, optimizing the reactive power control of wind turbines to participate in the transient overvoltage suppression of the sending grid not only improves the operational safety at the equipment level but also enhances the voltage stability of the system. This paper firstly analyses the impact of wind turbine's reactive power on AC transient overvoltage. Then, it proposes an improved voltage-reactive power control strategy, which contains a reactive power control delay compensation and a power command optimization based on the voltage time series prediction. The delay compensation is used to reduce the contribution of the untimely reactive power of wind turbines on transient overvoltage, and the power command optimization enables wind turbines to have the ability to regulate transient overvoltage, leading to the variation of AC voltage, thus suppressing the transient overvoltage. Finally, the effectiveness and feasibility of the proposed method are verified in a ±800kV/5000MW LCC-HVDC sending grid model based on MATLAB/Simulink.

关键词： Commutation failure LCC-HVDC Transient overvoltage Wind power

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Composite Elastomer with Photo-responsive Shape Memory and Programmable Hygroscopic Actuation Functionalities

引用

Chinese Journal of Polymer Science 2024年第10期42卷 1470-1478页

作者： Xiang-Xi Cui Li Shang zhong-Wen Liu Zhao-Tie Liu jin-Qiang Jiang Guo Li Key Laboratory of Syngas Conversion of Shaanxi Province School of Chemistry and Chemical Engineering Shaanxi Normal University

Developing hydroscopic actuators with simultaneous high elasticity, shape programmability and tunable actuating behaviors are highly desired but still challenging. In this study, we propose an orthogonal composite design to develop such a material. The developed composite elastomer comprises carboxyl group-grafted polystyrene-block-poly(ethylene-co-butylene)-block-polystyrene(SEBS-g-COOH) as the elastic substrate, and a synthesized azobenzene derivative as the functional filler(Azo12). By surface treatment using acidic and base solutions, the carboxyl groups on the surface can reversibly transform into carboxylate groups, which render the composite tunable hygroscopic actuating functionality. On another aspect, the added filler undergoes trans-to-cis isomerization when exposed to UV light irradiation, leading to liquefaction of the crystalline aggregates formed by Azo12 molecules. The liquefied Azo12 molecules can autonomously resotre their trans form and reform the crystalline structure. This reversible change in crystralline structure is utilized to realize the shape memory property, and 5 wt% of Azo12addition is adequate for the composite to exhibit photo-responsive shape memory behavior without compromising much of the elasricity. The regualtion of external geometry by shape memory effect is effective in altering the actuating behavior. The proposed method can be extend to designing different composites with the demonstrated functionalities.

关键词： Actuator Azobenzene Hygroscopic responsive Photo-responsive Shape memory

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Automatic velocity picking based on optimal key points tracking algorithm

引用

Petroleum Science 2024年第2期21卷 903-917页

作者： Yong-Hao Wang Wen-Kai Lu Song-Bai jin Yang Li Yu-Xuan Li xiao-Feng Gu The Institute for Artificial Intelligence(THUAI) Tsinghua UniversityBeijing100084China State Key Laboratory of Intelligent Technology and Systems Tsinghua UniversityBeijing100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing100084China The Department of Automation Tsinghua UniversityBeijing100084China

Picking velocities from semblances manually is laborious and necessitates experience. Although various methods for automatic velocity picking have been developed, there remains a challenge in efficiently incorporating information from nearby gathers to ensure picked velocity aligns with seismic horizons while also improving picking accuracy. The conventional method of velocity picking from a semblance volume is computationally demanding, highlighting a need for a more efficient strategy. In this study, we introduce a novel method for automatic velocity picking based on multi-object tracking. This dynamic tracking process across different semblance panels can integrate information from nearby gathers effectively while maintaining computational efficiency. First, we employ accelerated density clustering on the velocity spectrum to discern cluster centers without the requirement for prior knowledge regarding the number of clusters. These cluster centers embody the maximum likelihood velocities of the main subsurface structures. Second, our proposed method tracks key points within the semblance volume. Kalman filter is adopted to adjust the tracking process, followed by interpolation on these tracked points to construct the final velocity model. Our synthetic data example demonstrates that our proposed algorithm can effectively rectify the picking errors of the clustering algorithm. We further compare the performances of the clustering method(CM), the proposed tracking method(TM), and the variational method(VM) on a field dataset from the Gulf of Mexico. The results attest that our method offers superior accuracy than CM, achieves comparable accuracy with VM, and benefits from a reduced computational cost.

关键词： Velocity picking Multi-object tracking Density clustering Kalman filter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

引用

Journal of Iron and Steel Research International 2024年第4期31卷 956-966页

作者： Yue Chen Shao-min Lv Xing-fei Xie xiao-can Wen Jng-long Qu jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Beijing GAONA Materials and Technology Co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging Co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was *** to the different cooling conditions of various regions during the solidification of ingots,significant cooling rate variations may lead to the occurrence of hot *** scanning laser microscope was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range cooling *** characteristics of L→γ transformation were analysed,and the growth rates of at each stage were *** segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental *** sensitivity coefficient for hot cracking was modified,and cracking sensitivity coefficient values for the alloy under different cooling rates were computed,revealing that the alloy is most susceptible to hot cracking at 10℃/min cooling ***,controlling the cooling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of baryon number transport dynamics and strangeness conservation effects using Ω-hadron correlations

引用

Nuclear Science and Techniques 2024年第7期35卷 147-156页

作者： Wei-Jie Dong xiao-Zhou Yu Si-Yuan Ping Xia-Tong Wu Gang Wang Huan-zhong Huang Zi-Wei Lin Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Department of Physics East Carolina UniversityGreenvilleNC 27858USA

In nuclear collisions at RHIC energies, an excess of Ω hyperons over ■ is observed, indicating that Ω has a net baryon number despite s and s quarks being produced in pairs. The baryon number in Ω may have been transported from the incident nuclei and/or produced in the baryon-pair production of Ω with other types of anti-hyperons such as Ξ. To investigate these two scenarios, we propose to measure the correlations between Ω and K and between Ω and anti-hyperons. We use two versions, the default and string-melting, of a multiphase transport(AMPT) model to illustrate the method for measuring the correlation and to demonstrate the general shape of the correlation. We present the Ω-hadron correlations from simulated Au+Au collisions at ■ =7.7 and 14.6 Ge V and discuss the dependence on the collision energy and on the hadronization scheme in these two AMPT versions. These correlations can be used to explore the mechanism of baryon number transport and the effects of baryon number and strangeness conservation on nuclear collisions.

关键词： Baryon number transport Strangeness conversation Correlation Gluon junction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the atmospheric heat engine efficiency and heat source characteristics of the Qinghai-Tibet Plateau in summer

引用

Science China Earth Sciences 2024年第1期67卷 117-133页

作者： Yujie LI xiaoqing GAO Yaoming MA Zeyong HU Zhenchao LI Liwei YANG xiao jin Xiyin ZHOU Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions of Chinese Academy of Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Tianjin Key Laboratory for Oceanic Meteorology Tianjin Institute of Meteorological ScienceTianjin 300074China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

There are many types of atmospheric heat engines in land-air *** accurate definition,calculation and interpretation of the efficiency of atmospheric heat engines are key to understanding energy transfer and transformation of landair *** atmosphere over the Qinghai-Tibet Plateau(QTP)in summer can be regarded as a positive heat *** study of the heat engine efficiency is helpful to better understand land-air interaction and thermal-dynamic processes on the *** also provides a new perspective to explain the impact of the QTP on the climate of China,East Asia and even the *** this paper,we used MOD08 and ERA5 reanalysis data to calculate the atmospheric heat engine efficiency,surface heat source and atmospheric heat source on the QTP in summer(May to September)from 2000 to *** average atmospheric heat engine efficiency on the QTP in summer from 2000 to 2020 varies between 1.2%and 1.5%,which is less than 1.6%;the heat engine efficiency in summer is higher than that in June,July and August;the Qaidam Basin is the region with the highest atmospheric heat engine efficiency,followed by the western *** mean surface heat source on the QTP in summer from 2000 to 2020 is 96.0 W m^(−2),the atmospheric heat source is 90.7 W m^(−2),and the release of precipitation condensation latent heat is the most important component of the atmospheric heat source on the QTP in *** is a strong and significant positive correlation between the atmospheric heat engine efficiency and the surface heat source on the QTP in *** precipitation condensation latent heat is the most important component of the atmospheric heat source in summer and can reflect the precipitation *** is a strong and significant negative correlation between the atmospheric heat engine efficiency and the atmospheric heat source on the QTP in summer.

关键词： Qinghai-Tibet Plateau Climate change Land-air system Atmospheric heat engine Heat source on the Qinghai-Tibet Plateau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microbial Fertilizer: A Sustainable Strategy for Medicinal Plants Production

引用

Phyton-International Journal of Experimental Botany 2024年第6期93卷 1221-1236页

作者： Chuang Liu jing Xie Hao Liu Can zhong Gen Pan Shuihan Zhang Jian jin Hunan Academy of Chinese Medicine Hunan University of Chinese MedicineChangsha410036China Institute of Chinese Medicine Resources Hunan Academy of Chinese MedicineChangsha410013China

Medicinal plants have aroused considerable interest as an alternative to chemical drugs due to the beneﬁcial effects of their active secondary ***,the extensive use of chemical fertilizers and pesticides in pursuit of yield has caused serious pollution to the environment,which is not conducive to sustainable devel-opment in theﬁeld of medicinal *** fertilizers are a type of“green fertilizer”containing speciﬁc microorganisms that can improve the soil microbial structure,enhance plant resistance to biological and abiotic stresses,and increase the yield of medicinal *** root exudates of medicinal plants attract different micro-organisms to the rhizosphere,which then migrate further to the plant *** microbes can increase the levels of soil nutrients,and improve the physical and chemical properties of soil through nitrogenﬁxation,and phosphorus and potassium *** addition,soil microbes can promote the synthesis of hormones that increase plant growth and the accumulation of active compounds,eventually improving the quality of med-icinal *** 2022,the total value of the global microbial fertilizer market was$4.6 billion and is estimated to reach$10.36 billion by *** this review,we have summarized the types of microbial fertilizers,the coloniza-tion and migration of microorganisms to plant tissues,and the beneﬁcial effects of microbial *** addi-tion,the prospects of developing microbial fertilizers and their application for medicinal plants have also been *** aims to provide a reference for the rational application of microbial fertilizers in theﬁeld of med-icinal plants and the green and sustainable development of medicinal plant resources.

关键词： Microbial fertilizers market overview rhizosphere microorganisms endophytic bacteria beneﬁcial effects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanism of high-energy pulsed current-assisted rolling of 08AL carbon steel ultra-thin strip

引用

Journal of Iron and Steel Research International 2024年第2期31卷 416-427页

作者： zhong-kai Ren Ya-nan Xu Jia-zhao Chen He Li Rui-lin Yuan Zhen-hua Wang Tao Wang xiao Liu College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment(Ministry of Education) Taiyuan University of TechnologyTaiyuan030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710016ShaanxiChina

To improve the plastic deformation performance of a 08AL carbon steel ultra-thin strip,a pulsed electric field was integrated into the plastic processing of the ultra-thin strip,and the effects of high-energy current on its deformation ability were ***-assisted tensile tests were employed,and the results clarified that the pulsed current could reduce the activation energy of faults and promoted dislocation slip within grains and at grain boundaries,leading to a decrease in the deformation resistance of the metal and an increase in its plastic *** the current density of 2.0 A/mm2,the yield strength,tensile strength,and elongation of the rolled sample reached 425 MPa,467 MPa,and 12.5%,*** the rolling process,it was found that the pulsed current promoted the dynamic recrystallization of the ultra-thin strip,reduced its dislocation density and deformation resistance,and promoted the coordinated deformation of the metal.

关键词： 08AL ultra-thin strip High-energy pulsed current Mechanical property Dislocation density Dynamic recrystallization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sensitizing photoactive metal-organic frameworks via chromophore for significantly boosting photosynthesis

引用

Chinese Chemical Letters 2024年第5期35卷 519-522页

作者： Lihua Ma Song Guo Zhi-Ming Zhang jin-zhong Wang Tong-Bu Lu Xian-Shun Zeng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institute for New Energy Materials and Low Carbon Technologies School of Material Science&EngineeringTianjin University of TechnologyTianjin 300384China

Photosensitization related to energy/electron transfer process is of great importance to natural ***,we proposed a promising strategy to improve the sensitizing ability of the typical photoactive MOFs(UiO-Ir)by engineering its metal coordination center with NBI(1,8-naphthalenebenzimidizole)*** resulting MOFs(UiO-Ir-NBI)exhibited a strong sensitizing ability for significantly boosting ***,the catalytic yield of 2-chloroethyl ethyl sulfoxide with UiO-Ir-NBI can reach 99%,over 6 times higher than that with UiO-Ir(16.4%).Moreover,UiO-Ir-NBI exhibited an excellent catalytic stability and a broad substrate tolerance,highlighting its great application *** investigations revealed that the strong visible light absorption,long excited state lifetime and efficient electron-hole separation of UiO-Ir-NBI greatly contributed to harvesting visible light and facilitating interface electron/energy transfer for efficient solar energy *** work provides a new horizon to boost photosythesis of MOFs by engineering their metal sensitizing centers at a molecular level.

关键词： Metal-organic framework Photocatalysis Excited state Strong visible absorption Iridium complex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：