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Genome-wide and Interaction Linkage Scan for Nonsyndromic Cleft Lip with or without Cleft Palate in Two Multiplex Families in Shenyang,China

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Biomedical and Environmental Sciences 2010年第5期23卷 363-370页

作者： YUN WANG XIN LI WEN-LI ZHU jin-zhen guo XIAO-MING SONG SHU-QIN LI YONG LI Department of Nutrition and Food Hygiene School of Public HealthPeking University Health Science CentreBeijing 100191China Beijing Institute of Genomics Chinese Academy of Sciences Sheng-jing Hospital of China Medical University China

Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate （NSCL/P） in Northern Chinese people in Shenyang by using genomewide and interaction linkage *** Two multiplex families in Shenyang from North China were ascertained through probands with NSCL/*** of every member was drawn for DNA extraction and *** were available for 382 autosomal short tandem repeat （STR） markers from the ABI Prism Linkage Mapping Set version *** between markers and NSCL/P was assessed by 2-point parametric LOD scores,multipoint heterogeneity parametric LOD scores （HLODs）,and multipoint nonparametric linkage score （NPL）.Results The initial scan suggested linkage on Chromosomes 1,2,and *** subsequent fine mapping,1q32-q42 showed a maximum multipoint LOD score of 1.9（empirical P=0.013） and an NPL score of 2.35 （empirical P=0.053）.For 2p24-p25,the multipoint NPL increased to 2.94 （empirical P=0.007）.2-locus interaction analysis obtained a maximum NPL score of 3.73 （P=0.00078） and a maximum LOD score of 3 for Chromosome 1 （at 221 cM） and Chromosome 2 （at 29 cM）.Conclusion Both parametric and nonparametric linkage scores greatly increased over the initial linkage scores on 1q32-q42,suggesting a susceptibility locus in this *** linkage gave a strong evidence for a candidate region on chromosome *** superiority of 2-locus linkage scores compared to single-locus scores gave additional evidence for linkage on 1q32-q42 and 2p24-p25,and suggested that certain genes in the two regions may contribute to NCSL/P risks with interaction.

关键词： Nonsyndromic cleft lip with or without cleft palate Parametric linkage Nonparametric linkage Interaction

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Causes of severe neonatal hyperbilirubinemia: a multicenter study of three regions in China

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World Journal of Pediatrics 2021年第3期17卷 290-297页

作者： Xiao-Yue Dong Qiu-Fen Wei Zhan-Kui Li Jie Gu Dan-Hua Meng jin-zhen guo Xiao-Li He Xiao-Fan Sun Zhang-Bin Yu Shu-Ping Han Department of Neonatology Women's Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)NanjingChina Department of Neonatology Guangxi Maternal and Child Health Care HospitalNanningChina Department of Neonatology Northwest Women’s and Children’s HospitalXi’anChina Department of Neonatology Yinchuan Maternal and Child Health Care HospitalYinchuanChina

Background Available evidence suggests that our country bear great burden of severe ***,the causes have not been explored recently in different regions of China to guide necessary clinical and public health *** This was a prospective,observational study conducted from March 1,2018,to February 28,*** hospitals in three regions of China participated in the *** from infants with a gestational age≥35 weeks,birth weight>2000 g,and total serum bilirubin(TSB)level≥17 mg/dL(342μmol/L)were prospectively *** A total of 783 cases were *** were identified in 259 *** major causes were ABO incompatibility(n=101),glucose-6-phosphate dehydrogenase deficiency(n=76),and intracranial hemorrhage(n=70).All infants with glucose-6-phosphate dehydrogenase deficiency were from the central south *** from the central south region had much higher peak total bilirubin levels[mean,404μmol/L;standard deviation(SD),75μmol/L]than those from the other regions(mean,373μmol/L;SD,35μmol/L)(P<0.001).Conclusions ABO incompatibility was the leading cause in the east and northwest regions,but cases in the central south region were mainly caused by both ABO incompatibility and glucose-6-phosphate dehydrogenase deficiency,and infants in this region had a much higher peak total bilirubin *** hemorrhage may be another common *** thorough assessments and rigorous bilirubin follow-up strategies are needed in the central south region.

关键词： Causes Hyperbilirubinemia Jaundice Neonate

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li zhen Ma jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu jing Wu Guang Yin Fan‑zhen Jiao Zhong‑zhen Yu jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： jin-Peng Wang guo-Cui Mao Hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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机房桌面云建设与应用

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价值工程 2016年第25期35卷 85-87页

作者：金国镇浙江省机电技师学院信息科研处义乌322000

如今云计算作为一个热门话题已经越来越多的被业界提起,小到私有云大到公共云,无时无刻不在影响着我们的生活。未来教育信息化的发展必定是教育与云计算的相结合。虚拟化将是构筑这一时代的基石,并将扮演着重要的核心角色。目前,云计算... 详细信息

如今云计算作为一个热门话题已经越来越多的被业界提起,小到私有云大到公共云,无时无刻不在影响着我们的生活。未来教育信息化的发展必定是教育与云计算的相结合。虚拟化将是构筑这一时代的基石,并将扮演着重要的核心角色。目前,云计算与教育相结合得最成功的是校园机房桌面云方案的应用。利用桌面云可有效把数据中心和物理终端相隔离,部署安全可靠的虚拟桌面为校园数据保驾护航,使学校迈向云时代。

关键词：云桌面机房建设云建设

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大数据环境下高校智慧校园建设探讨

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价值工程 2020年第26期39卷 192-193页

作者：金国镇浙江省机电技师学院义乌322000

电子信息技术和网络平台的构建,给教育事业注入了时代的气息,在一定程度上推动了教学工作的进一步完善。现阶段互联网平台和技术在教育工作中的影响不断扩大,教育模式也出现了适应性的变化,新的教学模式简称为智慧校园。以大数据技术为... 详细信息

电子信息技术和网络平台的构建,给教育事业注入了时代的气息,在一定程度上推动了教学工作的进一步完善。现阶段互联网平台和技术在教育工作中的影响不断扩大,教育模式也出现了适应性的变化,新的教学模式简称为智慧校园。以大数据技术为背景的教育工作,书本不再是课堂教学的唯一工具,网络化的教学模式逐步盛行。借助大数据技术开展的教育工作,对学生的个性有更好的保护作用。笔者从大数据角度出发,对高效智慧校园的建设进行了研究,希望能为高校教育事业的发展提供有意义的参考。

关键词：大数据环境智慧校园建设研究智慧教学

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谈高师声乐教学中如何把集体课与小组课结合起来

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吉林师范大学学报(人文社会科学版) 2007年第2期35卷 117-119页

作者：金镇国吉林师范大学音乐学院吉林四平136000

高师声乐教学需要构建具有“师范性”的教学模式。声乐集体课在高师声乐教学中具有其他教学模式无法代替的重要作用。如果利用集体课的优势,弥补小组课的不足,把声乐集体课与声乐小组课有机结合起来,就能够有效地提高高师声乐课的教学... 详细信息

高师声乐教学需要构建具有“师范性”的教学模式。声乐集体课在高师声乐教学中具有其他教学模式无法代替的重要作用。如果利用集体课的优势,弥补小组课的不足,把声乐集体课与声乐小组课有机结合起来,就能够有效地提高高师声乐课的教学质量和课堂教学效果。

关键词：声乐集体课声乐小组课结合综合能力师范性

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物联网技术下智慧校园的建设研究

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价值工程 2019年第22期38卷 263-264页

作者：金国镇浙江省机电技师学院

在当今“万物皆媒”时代,物联网技术应用越来越广泛,在为各行各业提供便利的同时,使得“万物互联”,有效提升工作及管理效率。与此同时,智慧校园概念的提出,更加大了物联网技术与智慧校园的结合,在校园建设管理过程中,依托物联网技术实... 详细信息

在当今“万物皆媒”时代,物联网技术应用越来越广泛,在为各行各业提供便利的同时,使得“万物互联”,有效提升工作及管理效率。与此同时,智慧校园概念的提出,更加大了物联网技术与智慧校园的结合,在校园建设管理过程中,依托物联网技术实现智慧校园建设逐步成为建设重点。基于此,十分有必要就当下智慧校园构建情况以及优化措施进行探析,以期促进校园管理向着更加智慧化的方向发展。

关键词：物联网智慧校园建设

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计算机网络专业MOOC教学体系研究

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价值工程 2016年第12期35卷 220-221页

作者：金国镇浙江省机电技师学院信息科研处义乌322000

本文将先进的MOOC引入计算机网络专业教学中,真正运用网络技术来改革计算机网络传统教学模式长期存在的"教学方法落后"、"理论化"、"上机实践形式化"的问题,并通过教学实践来验证该MOOC教学体系的实效性。

关键词： MOOC 计算机网络教学教育信息化

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