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Curcumin attenuates ochratoxin A and hypoxia co‑induced liver injury in grass carp(Ctenopharyngodon idella)by dual targeting endoplasmic reticulum stress and apoptosis via reducing ROS content

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Journal of Animal Science and Biotechnology 2025年第1期16卷 408-423页

作者： Liangqin Wu Piao zhao Pei Wu Weidan Jiang Yang Liu Hongmei Ren Xiaowan jin Xiaoqiu Zhou Lin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengduSichuan 611130China

Background Ochratoxin A(OTA)is a toxin widely found in aquafeed ingredients,and hypoxia is a common prob-lem in fish *** practice,aquatic animals tend to be more sensitive to hypoxia while feeds are contaminated with OTA,but no studies exist in this *** research investigated the multiple biotoxicities of OTA and hypoxia combined on the liver of grass carp and explored the mitigating effect of curcumin(CUR).Methods A total of 720 healthy juvenile grass carp(11.06±0.05 g)were selected and assigned randomly to 4 experi-mental groups:control group(without OTA and CUR),1.2 mg/kg OTA group,400 mg/kg CUR group,and 1.2 mg/kg OTA+400 mg/kg CUR group with three replicates each for 60 ***,32 fish were selected,divided into nor-moxia(18 fish)and hypoxia(18 fish)groups,and subjected to hypoxia stress for 96 *** CUR can attenuate histopathological damage caused by coming to OTA and hypoxia by reducing vacu-olation and nuclear *** alleviation of this damage was associated with the attenuation of apoptosis in the mitochondrial pathway by decreasing the expression of the pro-apoptotic proteins Caspase 3,8,9,Bax,and Apaf1 while increasing the expression of the anti-apoptotic protein Bcl-2,and attenuation of endoplasmic reticulum stress(ERS)by reducing Grp78 expression and chop *** may be attributed to the fact that the addi-tion of CUR increased the levels of catalase(CAT)and glutathione reductase(GSH),increased antioxidant capacity,and ensured the proper functioning of respiratory chain complexes I and II,which in turn reduced the high produc-tion of reactive oxygen species(ROS),thus alleviating apoptosis and *** In conclusion,our data demonstrate the effectiveness of CUR in attenuating liver injury caused by the combination of OTA and *** study confirms the feasibility and efficacy of adding natural products to mitigate toxic damage to aquatic animals.

关键词： Apoptosis Curcumin Endoplasmic reticulum stress Grass carp Hypoxia Ochratoxin A Oxidative damage

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A multi-affinity supramolecular nanolayer reinforced PVDF-LLZTO composite polymer electrolyte for stable solid-state lithium batteries

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Nano Research 2025年第2期18卷 317-327页

作者： Changfei Liu Sailong Wang Zhengyi Lu Jiaqing zhao Yuchen Wu Chaojie Ren Ruizhi Yang Chao jin College of Energy Soochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhou 215006China

Technical breakthrough of composite polymer electrolyte(CPE)is one of the key factors that determines the commercial process of the current solid-state lithium ***,high interface impedance limits its electrochemical *** is crucial to optimize the design of multiphase interfaces among different components in CPE for regulating Li+***,a multi-affinity self-assembled 12-crown-4-TFSI(12C4-TFSI)supramolecular nanolayer is introduced into poly(vinylidene difluoride)-Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(PVDF-LLZTO)CPE as interface *** a result,enhanced Li+conductivity of 4.29×10^(-4)S·cm^(-1),Li+transfer number of 0.44,and stable electrochemical window voltage of 4.8 V ***/Li+at 30℃ are *** symmetric Li||Li cell exhibits an improved critical current density(CCD)of 1.2 mA·cm^(-2) and steady cycling at 0.2 mA·cm^(-2) for over 850 h without visible voltage *** assembled LiǁLiFePO4 coin solid-state cell delivers a high initial discharge capacity of 172.9 mAh·g^(-1) at 0.1 C,rate capability(up to 5.0 C)and outstanding cycling stability with a capacity retention of 87.2% after over 750 cycles at 1.0 *** associated LiǁLiFePO4 pouch cell presents an initial specific discharge capacity of 112.3 mAh·g−1 and successfully runs 30 cycles with a final capacity of 101.8 mAh·g^(-1).This work offers a facile strategy to optimize multiphase interfaces of PVDF-LLZTO CPE for stable solid-state lithium battery.

关键词： solid-state lithium battery composite polymer electrolyte interface impedance modifier supramolecular

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Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia

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Zoological Research 2025年第01期 177-192页

作者： Zhou Li Yi-Jian Xiang Zhi-Chuan Zou Yu-Ming Feng Hui Wang Wei-Qing Chen xie Ge jin-zhao Ma Jun jing Bing Yao Department of Reproductive Medicine Jinling Hospital Affiliated Hospital of Medical School Nanjing University State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medicine University

Increasing evidence implicates disruptions in testicular fatty acid metabolism as a contributing factor in nonobstructive azoospermia(NOA), a severe form of male infertility. However, the precise mechanisms linking fatty acid metabolism to NOA pathogenesis have not yet been fully elucidated. Multi-omics analyses, including microarray analysis, single-cell RNA sequencing(scRNA-seq), and metabolomics, were utilized to investigate disruptions in fatty acid metabolism associated with NOA using data from public databases. Results identified ACSL6, ACSBG2, and OLAH as key genes linked to fatty acid metabolism dysregulation, suggesting their potential causative roles in NOA. A marked reduction in omega-3 polyunsaturated fatty acids, especially docosahexaenoic acid(DHA), was observed, potentially contributing to the pathological process of NOA. Sertoli cells in NOA patients exhibited apparent fatty acid metabolic dysfunction, with PPARG identified as a key transcription factor(TF) regulating this process. Functional analyses demonstrated that PPARG is crucial for maintaining blood-testis barrier(BTB) integrity and promoting spermatogenesis via regulation of fatty acid metabolism. These findings reveal the pivotal role of fatty acid metabolism in NOA and identify PPARG as a potential therapeutic target.

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Convolutional Graph Neural Network with Novel Loss Strategies for Daily Temperature and Precipitation Statistical Downscaling over South China

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Advances in Atmospheric Sciences 2025年第1期42卷 232-247页

作者： Wenjie YAN Shengjun LIU Yulin ZOU Xinru LIU Diyao WEN Yamin HU Dangfu YANG Jiehong xie Liang zhao Central South University Changsha 410083China Hunan Expressway Information Technology Co. Ltd.Changsha 410053China Guangdong Climate Center Guangzhou 510610China Hong Kong Polytechnic University Shenzhen Research Institute Guangdong 518057China Jieyang Meteorological Bureau Jieyang 522031China State Key Laboratory of Numerical Modeling for Atmosphere Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Traditional meteorological downscaling methods face limitations due to the complex distribution of meteorological variables,which can lead to unstable forecasting results,especially in extreme *** overcome this issue,we propose a convolutional graph neural network(CGNN)model,which we enhance with multilayer feature fusion and a squeeze-and-excitation ***,we introduce a spatially balanced mean squared error(SBMSE)loss function to address the imbalanced distribution and spatial variability of meteorological *** CGNN is capable of extracting essential spatial features and aggregating them from a global perspective,thereby improving the accuracy of prediction and enhancing the model's generalization *** on the experimental results,CGNN has certain advantages in terms of bias distribution,exhibiting a smaller *** it comes to precipitation,both UNet and AE also demonstrate relatively small *** for temperature,AE and CNNdense perform outstandingly during the *** time correlation coefficients show an improvement of at least 10%at daily and monthly scales for both temperature and ***,the SBMSE loss function displays an advantage over existing loss functions in predicting the98th percentile and identifying areas where extreme events ***,the SBMSE tends to overestimate the distribution of extreme precipitation,which may be due to the theoretical assumptions about the posterior distribution of data that partially limit the effectiveness of the loss *** future work,we will further optimize the SBMSE to improve prediction accuracy.

关键词： statistical downscaling convolutional graph neural network feature processing SBMSE loss function

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Metabolic landscape of human alveolar type II epithelial cells undergoing epithelial-mesenchymal transition induced directly by silica exposure

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Journal of Environmental Sciences 2025年第3期149卷 676-687页

作者： jin Sun Na zhao Ruijia Zhang Yizheng Li Tiantian Yu Qiying Nong Li Lin Xubin Yang Tiangang Luan Baowei Chen Yongshun Huang Southern Marine Science and Engineering Guangdong Laboratory School of Marine SciencesSun Yat-Sen UniversityZhuhai 519082China Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China State Key Lab of Bioresource and Biocontrol School of Life ScienceSun Yat-sen UniversityGuangzhou 510275China Metabolic Innovation Center Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 540080China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Epithelial-mesenchymal transition(EMT)plays an irreplaceable role in the development of ***,molecular mechanisms of EMT induced by silica exposure still remain to be ***,metabolic profiles of human alveolar type II epithelial cells(A549 cells)exposed directly to silica were characterized using non-targeted metabolomic approaches.A total of 84 differential metabolites(DMs)were identified in silica-treated A549 cells undergoing EMT,which were mainly enriched in metabolisms of amino acids(e.g.,glutamate,alanine,aspartate),purine metabolism,glycolysis,*** number of DMs identified in the A549 cells obviously increased with the elevated exposure concentration of ***,glutamine catabolism was significantly promoted in the silica-treated A549 cells,and the levels of related metabolites(e.g.,succinate)and enzymes(e.g.,α-ketoglutarate(α-KG)dehydrogenase)were substantially up-regulated,with a preference toα-KG *** of glutamine into the cell culture could substantially enhance the expression levels of both EMT-related markers and Snail(zinc finger transcription factor).Our results suggest that the EMT of human alveolar epithelial cells directly induced by silica can be essential to the development of silicosis.

关键词： Silica exposure Human alveolar type II epithelial cells(ATII cells) Epithelial-mesenchymal transition (EMT) Metabolomics Glutamine

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen jin He jingmei Hong Jiayu xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Safety and effectiveness of balloon catheter-assiste d ultrasound-guide d percutaneous microwave ablation in difficult-site liver cancer

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 84-91页

作者： Qi-Yu zhao Teng Guo jing-jing Hu Li-Ting xie Wei-Lu Chai Guo Tian Tian-An Jiang Department of Ultrasound Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Ultrasound Medicine the First Affiliated HospitalZhejiang University School of MedicineLiangzhu BranchHangzhou 310003China Department of Ultrasound Medicine Ningbo No.2 HospitalNingbo 315010China

Background:Balloon catheter isolation is a promising auxiliary method for thermal ablation treatment of liver cancer. We aimed to explore the safety and effectiveness of balloon catheter isolation-assisted ultrasound-guided percutaneous microwave ablation (MWA) in treating liver cancer in difficult anatomical ***:Data of 132 patients with 145 difficult-site liver cancer treated with ultrasound-guided percutaneous MWA were retrospectively analyzed. Participants were classified into the isolation (n=40)and non-isolation (n=92) groups based on whether the patients were treated using a balloon catheter prior to ablation. The major complication rates, local tumor residuals (LTR), and tumor follow-up for local tumor progression (LTP) at 6 and 12 months post-ablation were compared between the two ***:The rates of major postoperative complications did not significantly differ between the isolation and non-isolation groups (2.5%vs. 4.3%, P=0.609). The postoperative LTR rates were significantly different between the isolation and non-isolation groups (4.8%vs. 17.5%, P=0.032). Balloon catheter isolation [odds ratio (OR)=0.225, 95%confidence interval (CI):0.085–0.595, P=0.009] and tumor diameter(OR=2.808, 95%CI:1.186–6.647, P=0.019) were identified as independent factors influencing LTR *** cumulative LTP rates at 6 and 12 months after ablation showed no significant differences between the isolation and non-isolation groups (2.6%vs. 7.9%, P=0.661;4.9%vs. 9.8%, P=0.676, respectively).Cox proportional hazards regression analysis showed that tumor diameter was an independent risk factor for cumulative LTP rate (OR=3.445, 95%CI:1.406–8.437, P=0.017).Conclusions:Balloon catheter isolation-assisted MWA was safe and effective in the treatment of difficultsite liver cancer. Additionally, tumor diameter significantly influenced LTR and LTP rates after ablation.

关键词： Liver cancer Microwave ablation Balloon catheter isolation

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Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum

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Chinese Journal of Natural Medicines 2025年第2期23卷 245-256页

作者： Jiaocen Guo Li Yang Luting Dai Qingyun Ma Jiaoyang Yan Qingyi xie Yougen Wu Haofu Dai Youxing zhao School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) Hainan University Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences

Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 2 6carbons,ganothenoids A-E（1-5）,and three lanostanoids,ganothenoids F-H（6-8）,along with 24 known ones（9-32）,were isolated from the fruiting bodies of Ganodrma *** structures of the novel compounds were elucidated using comprehensive spectroscopic methods,including electronic circular dichroism（ECD） and nuclear magnetic resonance（NMR） *** 1-32 were assessed for their neuroprotective effects against H2O2-induced damage in human neuroblastoma SH-SY5Y cells,as well as their inhibitory activities against protein tyrosine phosphatase 1B（PTP1B） and α-*** 4demonstrated the most potent neuroprotective activity against H2O2-induced oxidative stress by suppressing G0/G1phase cell cycle arrest,reducing reactive oxygen species（ROS） levels,and inhibiting cell apoptosis through modulation of B-cell lymphoma 2 protein（Bcl-2） and Bcl-2 associated X-protein（Bax） protein *** 26,12,and 28 exhibited PTP1B inhibitory activities with IC50values ranging from 13.92 to 56.94 μmol·L-1,while compound12 alone displayed significant inhibitory effects on α-glucosidase with an IC50value of 43.56μmol·***,enzyme kinetic analyses and molecular docking simulations were conducted for compounds 26 and 12 with PTP1B and α-glucosidase,respectively.

关键词： Ganoderma theaecolum Lanostane nortriterpenoids Neuroprotective effects PTP1B α-Glucosidase

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Development and Application of Cavity-based Absorption Spectroscopy in Atmospheric Chemistry:Recent Progress

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Advances in Atmospheric Sciences 2025年第4期42卷 605-622页

作者： Weixiong zhao Nana YANG Renzhi HU Bo FANG Jiacheng ZHOU Chuan LIN Feihu CHENG Pinhua xie Weijun ZHANG Anhui Institute of Optics and Fine Mechanics HFIPSChinese Academy of SciencesHefei 230031China School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Institute of Environment Hefei Comprehensive National Science CenterHefei 230601China

Atmospheric chemistry research and atmospheric measurement techniques have mutually promoted each other and developed rapidly in China in recent ***-based absorption spectroscopy,which uses a high-finesse cavity to achieve very long absorption path-length,thereby achieving ultra-high detection sensitivity,plays an extremely important role in atmospheric chemistry *** on the Beer–Lambert law,this technology has the unique advantages of being non-destructive,chemical-free,and highly *** does not require any sample preparation and can quantitatively analyze atmospheric trace gases in real time and in *** this paper,we review the following:(1)key technological advances in different cavity-based absorption spectroscopy techniques,including cavity ring-down spectroscopy,cavityenhanced absorption spectroscopy,cavity attenuated phase shift spectroscopy,and their extensions;and(2)applications of these techniques in the detection of atmospheric reactive species,such as total peroxy radical,formaldehyde,and reactive nitrogen(e.g.,NOx,HONO,peroxy nitrates,and alkyl nitrates).The review systematically introduces cavity-based absorption spectroscopy techniques and their applications in atmospheric chemistry,which will help promote further communication and cooperation in the fields of laser spectroscopy and atmospheric chemistry.

关键词： cavity-based absorption spectroscopy atmospheric chemistry atmospheric reactive species

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A single-pixel elemental imaging method using neutron-induced gamma-ray activation

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Nuclear Science and Techniques 2025年第1期36卷 1-12页

作者： Can Cheng Yong-Ji xie Xun-Rong Xia Jia-Yu Gu Dong zhao Yi-Ze Chen Ai-Yun Sun Xu-Wen Liang Wen-Bao Jia Da-Qian Hei Department of Ionizing Radiation and Medical Engineering Jiangsu Institute of MetrologyNanjing 210023China Institute of Nuclear Analytical Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China China Nuclear Power Engineering Co. LtdBeijing 100840China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Neutron-induced gamma-ray imaging is a spectroscopic technique that uses characteristic gamma rays to infer the elemental distribution of an ***,this technique requires the use of large facilities to supply a high neutron flux and a time-consuming detection procedure involving direct collimating *** this study,a new method based on low neutron flux was proposed.A single-pixel gamma-ray detector combined with random pattern gamma-ray masks was used to measure the characteristic gamma rays emitted from the *** of the elemental distribution in the sample,comprising 30×30 pixels,were reconstructed using the maximum-likelihood expectation-maximization *** results demonstrate that the elemental imaging of the sample can be accurately determined using this *** proposed approach,which eliminates the need for high neutron flux and scanning measurements,can be used for in-field imaging applications.

关键词： Elemental imaging Neutron-induced gamma-ray activation Single-pixel imaging

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