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Zoological Research 2023年第5期44卷 939-942页

作者： jin-zhao ke Zhi-Xin Wen Ming-Qiang Wang Anderson Feijó Tian Tian Lin Xia Qi-Sen Yang key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 10049China CAS key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Biodiversity Conservation key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengduSichuan 610041China

DEAR EDITOR,Mountainous regions are generally characterized by high species turnover,yet studies applying novel conceptual frameworks to analyze the spatial structure and organization of montane biota along elevational gradients remain *** on the zeta diversity framework—a novel turnover metric that focuses on average number of species shared across sites—and a comprehensive presence-absence dataset of small mammals collected from 22 elevational gradients in the Mountains of Southwest China(MSC).

关键词： mammals Mountains turnover

DNA Vaccine of SARS-Cov S Gene Induces Antibody Response in Mice

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Acta Biochimica et Biophysica Sinica 2004年第1期36卷 37-41页

作者： Ping zhao, jin-Shan ke, zhao-Lin QIN, Hao REN, Lan-Juan zhao, Jian-Guo YU, Jun GAO, Shi-Ying ZHU, and Zhong-Tian QI (Department of Microbiology, Second Military Medical University, Shanghai 200433, China Department of Infectious Diseases, PLA Hospital No.88, Tai'an 271000, China ) Department of Microbiology Second Military Medical University Shanghai 200433 China.

The spike (S) protein, a main surface antigen of SARS-coronavirus (SARS-CoV), is one of themost important antigen candidates for vaccine design. In the present study, three fragments of the truncated S protein were expressed in E. coli, and analyzed with pooled sera of convalescence phase of SARS patients. The full length S gene DNA vaccine was constructed and used to immunize BALB/c mice. The mouse serum IgG antibody against SARS-CoV was measured by ELISA with E. coli expressed truncated S protein or SARS-CoV lysate as diagnostic antigen. The results showed that all the three fragments of S protein expressed by E. coli was able to react with sera of SARS patients and the S gene DNA candidate vaccine could induce the production of specific IgG antibody against SARS-CoV efficiently in mice with seroconversion ratio of 75% after 3 times of immunization. These findings lay some foundations for further understanding the immunology of SARS-CoV and developing SARS vaccines.

关键词： severe acute respiratory syndrome-coronavirus (SARS-CoV) spike protein DNA vaccine antibody

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中国特色社会主义道路的文化意蕴

齐鲁学刊 2014年第2期 63-66页

作者：赵金科山东农业大学马克思主义学院山东泰安271018

中国特色社会主义道路,突破和超越了苏联传统社会主义模式,宣告了西方资本主义"历史终结论"神话的破产,冲破了西方文化(文明)优越性和中华文化(文明)劣等性形而上学思维的桎梏,颠覆了欧美世界"国强必霸"的所谓历史铁律,丰富和促进了人... 详细信息

中国特色社会主义道路,突破和超越了苏联传统社会主义模式,宣告了西方资本主义"历史终结论"神话的破产,冲破了西方文化(文明)优越性和中华文化(文明)劣等性形而上学思维的桎梏,颠覆了欧美世界"国强必霸"的所谓历史铁律,丰富和促进了人类对社会发展规律及其人类文明多样性的认识,其文化意蕴重大而深远。

关键词：中国特色社会主义道路文化意蕴传统社会主义模式历史终结论和平发展

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法家法律政治思想与新农村法制文化建设

齐鲁学刊 2008年第6期 102-105页

作者：赵金科刘煜山东农业大学文法学院山东泰安271000 曲阜师范大学政治与社会发展学院山东日照276826

中国古代法家法律政治思想是中华法律政治文化的主要渊源,客观、全面地剖析法家法律政治思想的积极因素和消极影响,汲取现代西方法律政治理论的精华,结合农村实际,走出一条有中国特色的社会主义法制文化建设之路,是当前我国新农村法制... 详细信息

中国古代法家法律政治思想是中华法律政治文化的主要渊源,客观、全面地剖析法家法律政治思想的积极因素和消极影响,汲取现代西方法律政治理论的精华,结合农村实际,走出一条有中国特色的社会主义法制文化建设之路,是当前我国新农村法制文化建设的关键之所在。

关键词：法家法律政治思想新农村法制文化建设

Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE Wei HUANG jin ZHU ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing zhao Xin Min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu Minghao Fang zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

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儒家的群己理论与社会主义群己关系的架构

齐鲁学刊 2011年第5期 36-40页

作者：赵金科林美卿山东农业大学马克思主义学院山东泰安271018

群己关系是不同社会关系之中居于统摄和支配地位的核心关系,也是社会主义核心价值体系的中心问题。以马克思主义"自由人联合体"理论为指导,扬弃和超越先秦儒家注重中道、和谐的理论向度和思维方式,克服群己关系形上思考的二元对立,构建... 详细信息

群己关系是不同社会关系之中居于统摄和支配地位的核心关系,也是社会主义核心价值体系的中心问题。以马克思主义"自由人联合体"理论为指导,扬弃和超越先秦儒家注重中道、和谐的理论向度和思维方式,克服群己关系形上思考的二元对立,构建一种以人为本、中庸和谐、群己兼顾、共生共荣的群己关系和社会秩序,应是指导我们进行社会主义核心价值体系以及和谐社会建设的当务之急。

关键词：群己关系个体主义整体主义中庸和谐忠恕之道自由人联合体

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新形势下石油制氢装置的工程应用

化工管理 2021年第5期 179-180页

作者：赵进科中海油气(泰州)石化有限公司江苏泰州225300

文章简要分析了在新形势下石油制氢装置工程的应用效果。制氢装置的选择在当前有着十分重要的意义,了解在制氢工艺使用的过程,其技术的转化点选择最佳的方式,并且提高平面布置的整体效果,能降低经济成本。

关键词：新形势石油制氢装置工程应用

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing Xue Yuejia Ma ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang Quan jin Haitao Zhang zhao Liu Yuyang Wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack