检索结果-南通市图书馆

Chinese Journal of Natural Medicines 2017年第12期15卷 928-937页

作者： ZOU Yu YAN Chang LIU jing-Chao HUANG Zhang-Jian XU jin-Yi ZHOU jin-Pei ZHANG Hui-Bin ZHANG Yi-Hua State Key Laboratory of National Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University Nanjing 210009 China

Considering that high levels of nitric oxide(NO) exert anti-cancer effect and the derivatives of oleanolic acid(OA) have shown potent anti-cancer activity, new O^2-vinyl diazeniumdiolate-based NO releasing derivatives(5a–l, 11a–l) of OA were designed, synthesized, and biologically evaluated in the present study. These derivatives could release different amounts of NO in liver cells. Among them, 5d, 5i, 5j, 11g, 11h, and 11j released more NO in SMMC-7721 cells and displayed stronger proliferative inhibition against SMMC-7721 and Hep G2 cells than OA and other tested compounds. The most active compound 5j showed almost 20-fold better solubility than OA in aqueous solution, released larger amounts of NO in liver cancer cells than that in normal ones, and exhibited potent anti-hepatocellular carcinoma activity but little effect on the normal liver cells. The inhibitory activity against the cancer cells was significantly diminished upon addition of an NO scavenger, suggesting that NO may contribute, at least in part, to the activity of 5j.

关键词： Oleanolic acid O^2-Vinyl diazeniumdiolate Cytochrome P450 NO release Anti-hepatocellular carcinoma activity

A New Benzylisoquinoline Alkaloid from Sabia parviflora

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2002年第5期13卷 426-427页

作者： jin CHEN Bin CHEN Jun TIAN Feng E WU Laboratory of Natural Materia Medica Chengdu Institute of BiologyAcademia SinicaChengdu 610041

A new benzylisoquinoline alkaloid, 1, 2, 3, 4-tetrahydro-5-hydroxyl-8-methoxyl-2- methyl-4'-methoxyl-benzylisoquinoline, was isolated from the arial parts of Sabia parviflora. Its structure was established on the bas... 详细信息

关键词： Sabia parviflora benzylisoquinoline alkaloid 1, 2, 3, 4-tetrahydro-5-hydroxyl-8- methoxyl-2-methyl-4'-methoxyl-benzylisoquinoline.

Homopolymerization of N-pyrimidinyl acrylamide

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第9期18卷 1141-1144页

作者： De Cheng Wan Hong Ting Pu Gen jin Yang Institute of Functional Polymers School of Materials Science&EngineeringTongji UniversityShanghai 200092China School of Pharmacy The Second Military Medical UniversityShanghai 200433China

Homopolymerization of N-pyrimidinyl acrylamide (NPA) was reported for the first time. The polymer (polyNPA) was soluble only in acidic media and fluoroalcohols, and only in fluoroalcohol was homogeneous polymerization of NPA feasible. 1H NMR analysis proved that a 1:1 H-bonding complex could be formed between NPA and α,α-bis(trifluoromethyl)phenyl propan-2-ol (BTMP). Cumyl dithiobenzoate mediated reversible addition-fragmentation chain transfer (RAFT) polymerization of NPA in BTMP was carried out. 1H NMR analyses proved that the molecular weight increased linearly with the monomer conversion. The polymer prepared in conventional solvents was atactic while in protic media the syndiotacticity was slightly enhanced.

关键词： N-pyrimidinyl acrylamide H-Bonding Fluoroalcohol Homopolymerization RAFT

Two new steroidal glycosides from Ophiopogon japonicus

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第9期19卷 1086-1088页

作者： YiFeng Zhou jin Qi Dan Ni Zhu BoYang Yu Department of Complex Prescription of TCM China Pharmaceutical University 1 Shennong Road Nanjing 210038 China

Two new C27-steroidal glycosides were isolated from the fibrous roots of Ophiopogon japonicus. The spectral analysis and chemical evidence revealed their chemical structures to be （25R）-spirost-5,14-dien-3β-yl-O-α-L-rhamnopyranosyl-（1 → 2）-β-D- xylopyranosyl-（1 → 4）-β-D-glucopyranoside （1） and ophiogenin 3-O-β-D-glucopyranoside （2）.

关键词： Ophiopogon japonicus Liliaceae C27-steroidal glycoside

Synthesis of new N-alkylsulfonamide-containing phenylazopyrazolone dyes and their application to unmodified polypropylene fiber

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第9期18卷 1145-1147页

作者： Zhi Hua Cui Shu Fen Zhang jin Zong Yang State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China

Three new N-alkylsulfonamide-containing phenylazopyrazolone dyes have been synthesized by reaction of sulfonyl chloride intermediates with different saturated aliphatic amines and their molecular structures were confirmed by FTIR, (1)H NMR and MS. The dyes were applied to unmodified polypropylene fabric. These dyes showed high exhaustion as well as higher levels of fastness to washing, sublimation and rubbing compared with C.I. Disperse Yellow 16. The results showed the N-alkylsulfonamide-containing dyes were suitable for dyeing unmodified PP fiber and exhibited good color depth and fastness properties.

关键词： N-Alkylsulfonamide-containing dye Unmodified polypropylene Dyeing properties

Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第5期16卷 591-603页

作者： jin-Bo Wang Ming-Wei Du Yan Zheng Internal Medicine of Traditional Chinese Medicine Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Institute of Cardiovascular Disease Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key Laboratory of Molecular Medical Mycology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai 201203China Department of Hepatic The Xixi Hospital of Hangzhou Affiliated to Zhejiang University of Traditional Chinese MedicineHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Aplastic anemia(AA)presents a significant clinical challenge as a life-threatening condition due to failure to produce essential blood cells,with the current the-rapeutic options being notably *** To assess the therapeutic potential of ginsenoside Rg1 on AA,specifically its protective effects,while elucidating the mechanism at *** We employed a model of myelosuppression induced by cyclophosphamide(CTX)in C57 mice,followed by administration of ginsenoside Rg1 over 13 *** invest-igation included examining the bone marrow,thymus and spleen for pathological changes via hematoxylin-eosin ***,orbital blood of mice was collected for blood routine *** cytometry was employed to identify the impact of ginsenoside Rg1 on cell apoptosis and cycle in the bone marrow of AA ***,the study further evaluated cytokine levels with enzyme-linked immunosorbent assay and analyzed the expression of key proteins in the MAPK signaling pathway via western *** Administration of CTX led to significant damage to the bone marrow’s structural integrity and a reduction in hematopoietic cells,establishing a model of *** Rg1 successfully reversed hematopoietic dysfunction in AA *** comparison to the AA group,ginsenoside Rg1 provided relief by reducing the induction of cell apoptosis and inflammation factors caused by ***,it helped alleviate the blockade in the cell *** with ginsenoside Rg1 significantly alleviated myelosuppression in mice by inhibiting the MAPK signaling *** This study suggested that ginsenoside Rg1 addresses AA by alleviating myelosuppression,primarily through modulating the MAPK signaling pathway,which paves the way for a novel therapeutic strategy in treating AA,highlighting the potential of ginsenoside Rg1 as a beneficial intervention.

关键词： Aplastic anemia Ginsenoside Rg1 Myelosuppression MAPK signaling pathway Bone marrow Hematopoietic stem cells

Open Winding-permanent Magnet/Magnet Reluctance Hybrid Rotor Double Stator Synchronous Motor SVPWM Control

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CES Transactions on Electrical Machines and Systems 2024年第4期8卷 426-435页

作者： Yufeng Pang Shi jin Wuhen jin Siyang Yu Shenyang University of Technology Shenyang110870China IEEE

Coal mine conveyor belt and other low-speed large torque system,the torque density and torque stability of the motor requirements are higher,permanent magnet/magnet reluctance hybrid rotor double stator synchronous motor(PM/MRHRDSSM)is just adapted to this requirement,however,the traditional close winding single inverter vector control system control PM/MRHRDSSM provides large torque ripple,high speed fluctuation and large total harmonic distortion(THD)of the current,difficult to be used in actual production and life,this paper proposes a large torque open winding-permanent magnet/magnet reluctance hybrid rotor double stator synchronous motor(OW-PM/MRHRDSSM)based on SVPWM dual inverter control strategy,and analysis of open winding double inverter structure,and its voltage vector mathematical model,using the existing two-level inverter as a basis,the bilateral inverter separately discussed its role and control method,as well as the decomposition method of synthetic voltage vector and the inverter device in the small sector on-time,the end of this paper through simulation to compare the traditional close winding single inverter vector control system control PM/MRHRDSSM and the large torque OW-PM/MRHRDSSM based on SVPWM dual inverter control strategy to prove the effectiveness of the proposed method in reducing torque ripple,speed fluctuation and THD of current during motor operation.

关键词： SVPWM Dual stator motor Hybrid rotor Open winding motor

AN IMPROVED NUMERICAL METHOD FOR CALCULATIONS IN WAVE KINEMATICS

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2009年第6期21卷 826-834页

作者： SUN Yi-yan LIU Shu-xue LI jin-xuan State Kay Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024

The prediction of wave kinematics is a necessary basis for ocean engineering design. In this article, an improved method to calculate the wave kinematics especially in the crest region is presented. This method is based on the local approximation method. According to one measured wave surface, the proposed solution focuses on a Fourier series expansion in a somewhat larger segment of the wave surface record. The horizontal and vertical kinematics under the wave crest can be directly predicted. Good agreement between the numerical results and the theoretical Stokes waves verifies the validity of the numerical model. The effectiveness of the numerical method is also proved by the calculation of the wave kinematics of the laboratory focused wave groups.

关键词： Fourier series expansion wave kinematics focused wave

The Performance of Dual-Frequency Polarimetric Scatterometer in Sea Surface Wind Retrieval

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2019年第5期18卷 1051-1060页

作者： LIU Shubo WEI Enbo jin Xu LV Ailing DANG Hongxing Xi’an Institute of Space Radio Technology China Academy of Space TechnologyXi’an 710100China National Key Laboratory of Science and Technology on Space Microwave Xi’an 710100China Institute of Oceanology and Center for Ocean Mega-Science Chinese Academy of Sciencesand Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

The wind retrieval performance of HY-2 A scanning scatterometer operating at Ku-band in HH and VV polarizations has been well evaluated in the wind speed range of 0–25 m s^-*** order to obtain more accurate ocean wind field,a potential extension of dual-frequency(C-band and Ku-band)polarimetric measurements is investigated for both low and very high wind speeds,from 5 to 45 m s^-*** on the geophysical model functions of C-band and Ku-band,the simulation results show that the polarimetric measurements of Ku-band can improve the wind vector retrieval over the entire scatterometer swath,especially in nadir area,with the wind direction root-mean-square error(RMSE)less than 12?in the wind speed range of 5–25 m s^-***,the results also show that C-band cross-polarization plays a very important role in improving the wind speed retrieval,with the wind speed retrieval accuracy better than 2 m s^-1 for all wind conditions(0–45 m s^-1).For extreme winds,the C-band HH backscatter coefficients modeled by CMOD5.N(H)and the ocean co-polarization ratio model at large incidence are used to retrieve sea surface wind *** result reveals that there is a big decrease of wind direction retrieval RMSE for extreme wind fields,and the retrieved result of C-band HH polarization is nearly the same as that of C-band VV polarization for low-to-high wind speed(5–25 m s^-1).Thus,to improve the wind retrieval for all wind conditions,the dual-frequency polarimetric scatterometer with C-band and Ku-band horizontal polarization in inner beam,and C-band horizontal and Ku-band vertical polarization in outer beam,can be used to measure ocean *** study will contribute to the wind retrieval with merged satellites data and the future spaceborne scatterometer.

关键词： dual-frequency polarimetric scatterometer wind vector retrieval

A novel ocean bathymetry technology based on an unmanned surface vehicle

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2018年第9期37卷 99-106页

作者： jin Jiucai ZHANG Jie SHAO Feng LYU Zhichao WANG Dong The First Institute of Oceanography State Oceanic Administration College of Information and Control Engineering China University of Petroleum College of Underwater Acoustic Engineering Harbin Engineering University College of Electronics and Information Engineering Harbin Institute of Technology

In ocean bathymetry, the instantaneous depth measured by survey ships or by unmanned surface vehicles（USVs）cannot be directly taken as the chart depth because of the effect of waves and the tide. A novel ocean bathymetry technology is proposed based on the USV, the aim is to evaluate the potential of the USV using a real-time kinematic（RTK） and a single beam echo sounder for ocean bathymetry. First, using the RTK height of the USV with centimeter-level precision, the height of the sea level is obtained by excluding wave information using a low pass filter. Second, the datum distance between the reference ellipsoid and the chart depth is obtained by a novel method using tide tables and the height of the sea level from the USV. Previous work has usually achieved this using long-term tidal observation from traditional investigations. Finally, the chart depth is calculated using the transformation between the instantaneous depth of the USV measurement and the datum of the chart *** were performed around the Wuzhizhou Island in Hainan Province using the unmanned surface bathymetry vehicle to validate the proposed technology. The successful results indicate the potential of the bathymetry technology based on the USV.

关键词： unmanned surface vehicle bathymetry attitude correction tidal observation