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Optimization, characterization and in vitro/vivo evaluation of azilsartan nanocrystals

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 344-352页

作者： jingjing Ma Yinxian Yang Yinghua Sun jin Sun Shenyang Pharmaceutical University

Azilsartan(AZL), a poorly soluble drug, was considered to be fit for nanocrystals to improve its solubility. Our study intended to prepare AZL nanocrystals by means of bead milling method. Eight stabilizers or their binary combination and the milling time were set to be variable factors to optimize AZL nanosuspension formulation, and six types of freezedrying supports were investigated to reduce the aggregation of particles during the solidification. AZL nanocrystals with or without sodium deoxycholate(NaDC) as combined stabilizer with Poloxamer 188(F68) were prepared owning mean particle sizes of about 300 nm and 460 nm. During the screening processes, the formulation containing NaDC showed a smaller particle size and better stability during lyophilization. The irregular shape and crystal form changing in AZL nanocrystals were discovered by various characterizations. And with physical mixture as reference, nanocrystals showed its improvement about in-vitro dissolution and in-vivo bioavailability. In conclusion, the nanocrystals of AZL could be prepared well in our study. Additionally, our results suggested that NaDC was an appreciated excipient on the nanocrystals platform, which can exhibit the abilities of size-reduction and stabilitymaintaining on freeze-drying.

关键词： Azilsartan Nanocrystals Sodium deoxycholate Freeze drying Dissolution Oral bioavailability

Primary-Tertiary Diamine/Brønsted Acid Catalyzed α-Allylation of Carbonyl Compounds with Allylic Alcohols

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Chinese Journal of Chemistry 2014年第8期32卷 673-677页

作者： Lingyun Cui Long Zhang Sanzhong Luo jin-Pei Cheng Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

A simple and directα-allylic alkylation of unmodified aldehydes with allylic alcohols catalyzed by primary amine/Brønsted acid has been *** N,N-dimethylethylenediamine/TfOH was identified as the optimal catalyst to promote this transformation via an enamine process in high yields(up to 88%)and with good diastereoselectivities(up to 9∶1).

关键词： organocatalysis enamine primary-tertiary diamine α-allylic alkylation

A New Method for Decreasing Mass Limit of Detection and Increasing Number of Theoretical Plates in Capillary Electrophoresis with Amperometric Detection

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Chinese Chemical Letters 2003年第4期14卷 404-406页

作者： Xue Mei SUN Qian Feng WENG Wen Rui jin School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100

A new method was developed to decrease the mass limit of detection (LOD) and increase the number of theoretical plates (N) in capillary electrophoresis with amperometric detection. When the single microcylinder electrode, the 10 um ID capillary with the etched detection end and the in-capillary alignment were used, the mass LOD for phenol was reduced 124 times and N was increased 36 times in comparison with the normal situation.

关键词： Capillary electrophoresis electrochemical detection microelectrode phenol.

Behavior of Corrosion-Repaired Concrete Beams Reinforced by Epoxy Mortar

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Transactions of Nanjing University of Aeronautics and Astronautics 2016年第3期33卷 395-402页

作者： Wu jin Tang jinzhi Li Hongming Shang Baokang Wang Zhe Department of Civil Engineering Nanjing University of Aeronautics and Astronautics

The performance of concrete beams repaired with epoxy mortar was investigated by constructing twelve beam *** the beam specimens were subjected to a constant current for accelerated *** specimens were corroded without subsequent reparation as a control group,and the other six beam specimens were corroded and repaired utilizing epoxy *** specimens were tested to *** test process,we focused on the failure pattern of beam specimens,structural cracks,mid-deflections,bearing capacity,and probed into the influence of corrosion degree and repair of epoxy mortar on the performance of beam *** was observed that corrosion-repaired beams in the loading test were in a bending failure *** is obvious that cracking loads and bending stiffness of repaired beams and corrosion-repaired beams were larger than those of unrepaired beams and secondly-corroded *** the mass loss of main steel bars was smaller than 10%,the bearing capacity of the repaired beams was similar to that of the unrepaired *** the mass loss of main steel bars was larger than 10%,the bearing capacity of the repaired beams increased significantly compared with that of the unrepaired beams.

关键词： corrosion steel bars concrete beams epoxy mortar loading test

Rate-Energy Tradeoff for Wireless Simultaneous Information and Power Transfer in Full-Duplex and Half-Duplex Systems

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Computers, Materials & Continua 2020年第11期65卷 1373-1384页

作者： Xiaoye Shi jin Sun Dongming Li Fei Ding Zhaowei Zhang Department of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing210003China Department of Electronic and Electrical Engineering University College LondonLondonWC1E 6BTUK

In this paper,we study the rate-energy tradeoff for wireless simultaneous in-formation and power transfer in full-duplex and half-duplex *** this end,the weighting function of energy efficiency and transmission rate,as rate-energy tradeoff metric is first introduced and the metric optimization problem is *** Karush-Kuhn-Tucker(KKT)conditions for Lagrangian optimality and a series of mathematical approximations,the metric optimization problem can be *** closed-form solution of the power ratio is obtained,building direct relationship between power ratio and the rate-energy tradeoff *** choosing power ratio,one can make the tradeoff between information rate and harvested power in a straightforward and efficient *** the method similar to the half duplex systems,the optimal power ratio can be obtained in the full duplex systems,so as to balance the information transmission rate and energy transmission *** results validate that the information rate is non-increasing with harvested power in half-duplex systems and the tradeoff of information rate and harvested power can be simply *** the full duplex systems,the power ratio solution of the rate-energy tradeoff metric optimization problem can be used as the approximate optimal solution of the optimization problem and the approximation error is negligible.

关键词： Power transfer full duplex optimization problem

An experimental and numerical study on the charring rate of timber beams exposed to three-side fire

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Science China(Technological Sciences) 2012年第12期55卷 3434-3444页

作者： ZHANG jin LIU ZengHui XU YiXiang MA ShuWei XU QingFeng Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China Department of Civil Engineering Strathclyde UniversityGlasgow G128QQUnited Kingdom Shanghai Key Laboratory of New Technology Research on Engineering Structure SRIBSShanghai 200032China

To investigate the charring rate of timber beams exposed to three-side fire, a total of fifteen new and used Douglas-Fir timber beams in four groups exposed to three-side fire were experimentally studied, together with the finite element analyses of the temperature distribution in the beam section. The durations of fire exposure were 0 (on a test piece), 10, 15, 20 and 30 min, according to the ISO 834 standard fire curve. The charring depth of each timber beam was calculated by averaging the values at one-third and two-thirds along each cross section to give the charring rate of timber beams. It was found that the timber beam's charring rate reduces as the duration of fire exposure increases and the vertical charring rate is slightly higher than the horizontal one. The areas of beam sections reduce due to charring and the strength and stiffness of the pyrolysis layer near the charring edge decrease owing to the high-temperature. The average horizontal and vertical charring rates are 0.98 and 1.08 mm/min, respectively. To take into account the difference between the test furnace temperature curve and the ISO 834 stand- ard fire curve, some corrections were made for these data to yield the solution for charring rate. With the help of the finite element software ANSYS, the temperature distribution of the wood's cross-section was analyzed. The longer the exposure time is, the greater the effect of density will impose on the distribution of temperature, but the moisture content has no effect.

关键词： timber beam charring rate exposed to three-sides fire charring layer pyrolysis layer

A New Pregnane Glycoside from Fermented Leaves of Agave americana

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Chinese Chemical Letters 2002年第12期13卷 1189-1192页

作者： Jian Ming jin Xi Kui LIU Chong Ren YANG State Key Laboratory of Phytochemistry and Plant Resources of West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

A new minor pregnane glycoside was isolated from the fermented leaves of Agave americana. Its structure was elucidated as (20S)-5a-pregnane-3? 20-diol 20-O--D-glucopyrano- side (1) by spectral methods.

关键词： Agave americana L. pregnane glycoside.

Undetected traumatic cardiac herniation like playing hide-and-seek-delayed incidental findings during surgical stabilization of flail chest:A case report

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World Journal of Clinical Cases 2022年第36期10卷 13396-13401页

作者： Su Young Yoon jin-Bong Ye Junepill Seok Department of Thoracic and Cardiovascular Surgery Chungbuk National University HospitalCheongju 28644South Korea Department of Trauma Surgery Chungbuk National University HospitalCheongju 28644South Korea

BACKGROUND Post-traumatic blunt pericardial injury is a rare condition with only a few reported cases which were generally diagnosed during initial examinations upon ***,pericardial injuries not bad enough to dislocate the heart may only cause intermittent electrocardiogram(ECG)changes or be *** SUMMARY In this case,we report a blunt pericardial injury undetected on preoperative transthoracic echocardiography and chest computed *** misjudged intermittent ECG changes and blood pressure fluctuations as minor symptoms resulting from cardiac contusion and did not provide intensive *** pericardial injury was found incidentally during surgical stabilization of rib fractures and was successfully *** Post-traumatic blunt pericardial ruptures should be considered in patients with blunt chest trauma showing abnormal vital signs and ECG changes.

关键词： Cardiac herniation Flail chest Multiple rib fractures Pericardial rupture Surgical stabilization of rib fractures Case report

Synthesis and Crystal Structure of (Bu_4N)_2Hg(i-mnt)_2

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Chinese Chemical Letters 2001年第2期12卷 185-186页

作者： He Gen ZHENG Qiong Hua jin Xin Quan XIN State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210093 Department of Chemistry Capital Normal UniversityBeijing 100037

The synthesis and the crystal structure of the title compound (Bu4N)(2)Hg(S2C=C(CN)(2))(2) 1 is reported herein. The crystal is attributed to trielinic system and space group P-1, fw=965.88. The crystal lattice parameters are a=9.45(1), b=15.827(2), c=17.619(2)Angstrom, alpha =108.12(2), beta =99.54(2), gamma =97.60(2)degrees, V=2421.9(8)Angstrom, mu (MoKalpha)=3.390mm(-1), Z=2, D-c=***(-3), F(000)=996, R=0.054, wR=0.058.

关键词： synthesis crystal structure mercury(II) complex isomaleonitrile dithiolate