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Long non-coding RNAMIR22HG inhibits the adipogenesis of human bone marrow mesenchymal stem cells with the involvement of Wnt/β-catenin pathway

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BIOCELL 2022年第7期46卷 1717-1724页

作者： CHANYUAN jin ZIYAO ZHUANG LINGFEI JIA YUNFEI ZHENG Second Clinical Division Peking University School and Hospital of StomatologyBeijing100081China Department of Orthodontics Peking University School and Hospital of StomatologyBeijing100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081China National Center of Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing100081China

Osteoporosis is a frequently occurring bone remodeling disorder worldwide with one characteristic being decreasing bone mineral density and a predisposition to bone fracture,which diminishes patients’quality of *** studies showed that imbalance between the osteogenesis and adipogenesis of bone marrow mesenchymal stem cells(BMSCs)took part in the development of *** previous study,we found MIR22HG regulated the osteogenesis of human BMSCs *** this study,we found that MIR22HG was decreased during the adipogenesis of human BMSCs and exerted negative effects on adipogenesis with the involvement of Wnt/β-catenin signaling pathway both in vitro and in *** could inhibit Wnt signaling and relieve MIR22HG’s suppression on *** findings indicated that MIR22HG had great potential in clinical application for osteoporosis treatment and prevention.

关键词： BMSCs Osteoporosis MIR22HG Adipogenesis Wnt/β-catenin pathway

Asymmetric breakup of a droplet in an axisymmetric extensional flow

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Chinese Journal of Chemical Engineering 2016年第1期24卷 63-70页

作者： Dongming Yu Manman Zheng Taoming jin jingtao Wang School of Chemical Engineering and Technology Tianjin University Sinopec Shanghai Engineering Co. Ltd.

The asymmetric breakups of a droplet in an axisymmetric cross-like microfluidic device are investigated by using a three-dimensional volume of fluid(VOF) multiphase numerical model. Two kinds of asymmetries(droplet location deviation from the symmetric geometry center and different flow rates at two symmetric outlets) generate asymmetric flow fields near the droplet, which results in the asymmetric breakup of the latter. Four typical breakup regimes(no breakup, one-side breakup, retraction breakup and direct breakup) have been *** regime maps are plotted to describe the transition from one regime to another for the two types of different asymmetries, respectively. A power law model, which is based on the three critical factors(the capillary number,the asymmetry of flow fields and the initial volume ratio), is employed to predict the volume ratio of the two unequal daughter droplets generated in the direct breakup. The influences of capillary numbers and the asymmetries have been studied systematically in this paper. The larger the asymmetry is, the bigger the oneside breakup zone is. The larger the capillary number is, the more possible the breakup is in the direct breakup zone. When the radius of the initial droplet is 20 μm, the critical capillary numbers are 0.122, 0.128, 0.145,0.165, 0.192 and 0.226 for flow asymmetry factor AS= 0.05, 0.1, 0.2, 0.3, 0.4 and 0.5, respectively, in the flow system whose asymmetry is generated by location deviations. In the flow system whose asymmetry is generated by two different flow rates at two outlets, the critical capillary numbers are 0.121, 0.133, 0.145, 0.156 and 0.167 for AS= 1/21, 3/23, 1/5, 7/27 and 9/29, respectively.

关键词： Asymmetric breakup Droplet Volume of fluid method Axisymmetric extensional flow

DAIS: a method for identifying spatial domains based on density clustering of spatial omics data

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Journal of Genetics and Genomics 2024年第8期51卷 884-887页

作者： Qichao Yu Ru Tian Xin jin Liang Wu College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI Research ShenzhenGuangdong 518083China BGI ResearchChongqing 401329China BGI Research ShenzhenGuangdong 518083China BGI Research Chongqing 401329China

In multicellular organisms,the spatial arrangement of cells profoundly influences the biological functions of tissues,underscoring the importance of identifying spatial domains in *** advancements in spatial omics,particularly spatial transcriptomics(ST)(Bressan et al.,2023),have enhanced our understanding of tissue spatial organization(Zhang et al.,2022;Tian et al.,2023).

关键词： arrangement identifying domains

Development of an Instant Correction and Display System of Numerical Weather Prediction Products in China

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Chinese Geographical Science 2014年第6期24卷 682-693页

作者： ZHANG Lanhui WANG Shigong ZHANG Yu HE Chansheng jin Xin Center for Dryland Water Resources Research and Watershed Science Key Laboratory of West China's Environmental System of Ministry of EducationLanzhou University Key Laboratory of Arid Climate Change and Reducing Disaster of Gansu Province College of Atmospheric SciencesLanzhou University College of Earth and Environmental Sciences Lanzhou University Department of Geography Western Michigan University KalamazooMI 49008-5424USA

This paper presents the development of numerical prediction products(NPP) correction and display system(NPPCDS) for rapid and effective post-processing and displaying of the T213 NPP(numerical prediction products of the medium range numerical weather prediction spectral model T213L31) through instant correction method. The NPPCDS consists of two modules: an automatic correction module and a graphical display module. The automatic correction module automatically corrects the T213 NPP at regularly scheduled time intervals, while the graphical display module interacts with users to display the T213 NPP and its correction results. The system helps forecasters extract the most relevant information at a quick glance without extensive post-processing. It is simple, easy to use, and computationally efficient, and has been running stably at Huludao Meteorological Bureau in Liaoning Province of China for the past three years. Because of its low computational costs, it is particularly useful for meteorological departments that lack advanced computing capacity and still need to make short-range weather forecasting.

关键词： numerical prediction products (NPP) SharpMap post-processing instant correction method (ICM) numerical predictionproducts correction and display system (NPPCDS)

Origin of Li-F-rich granite: Evidence from high P-T experiments

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Science China Earth Sciences 2004年第7期47卷 639-650页

作者： LI Fuchun ZHU jinchu RAO Bing jin Zhangdong ZHANG Linsong School of Resource and Environment Sciences Nanjing Agriculture UniversityNanjing 210095China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210093China Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing 210008China

Though magmatic origin of Li-F-rich granite has been supported effectively by the existence of volcanic and subvolcanic rocks and melt inclusions trapped in them with similar chemical compositions, evidence from high T-P experiments is poor up to now. To simulate the evolution process of Li-F-rich granite and to interpret its forming mechanism, a series of melting-crystallization experiments were carried out. Under the conditions of 1×108 Pa and 570–700°C, a magmatic mineral association of quartz + alkali feldspar + lithium muscovite/ferromuscovite ± fluorite ± cassiterite is found in leucogranite-HF-H2O system. This indicates the following points: (i) Fluorite, light-colored muscovite and cassiterite can crystallize directly from the Li-F-rich granitic melt. (ii) The coexistence of dark-colored micas (e.g. biotite) and light-colored micas (e.g. lithium muscovite and ferromuscovite) suggests that the muscovite granite and two-mica granite can be formed under magmatic condition. The zonal texture of micas is not the sole feature for the micas of hydrothermal origin. (iii) As crystallization proceeds, the SiO2 concentration of the residual melt decreases, while the Al2O3 and F concentrations and A/CNK, NKA/Si ratios of the melt incerese, favoring the formation of Li-F-rich granites. Our experiment results are well consistent with the vertical zonation widely observed in rare metal bearing granites, and therefore provide strong experimental evidence for magmatic origin of Li-F-rich granite.

关键词： fluorite lithium muscovite ferromuscovite cassiterite melt evolution Li-F-rich granite high P-T experiment DOI: 10.1360/03yd0339

Decadal variations in the community status of economically important invertebrates in the Bohai Sea

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Acta Oceanologica Sinica 2019年第10期38卷 60-66页

作者： Qiang Wu Lisha Guan Zhongyi Li Xiujuan Shan Xianshi jin Key Laboratory for Sustainable Development of Marine Fisheries Ministry of Agriculture/Shandong Provincial Key Laboratory for Fishery Resources and Eco-environmentYellow Sea Fisheries Research InstituteAcademy of Fishery SciencesQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

With the decline of fish stocks,the proportions of economically important invertebrates like crustaceans and cephalopods have increased in the Bohai *** community structure and trophic level of economically important invertebrates were analyzed using the bottom trawl survey data collected by the Yellow Sea Fisheries Research Institute in the Bohai Sea in May and August of 1958–1959,1982,1992–1993,2004,2009 and 2015.A total of 37 species of economically important invertebrates,belonging to 5 orders,24 families,were *** biomass densities of economically important invertebrates in the Bohai Sea displayed an overall downward trend from 1982 to *** oratoria and Loligo *** the most dominant species in the past 30 years,the biomass proportion of *** increased gradually in both May and August from 1982 to ***,biodiversity indices of economically important invertebrates in the Bohai Sea appeared to decline from 1982 to 2004 and then increased in ***,the mean trophic level of economically important invertebrates declined from 1982 to 2004 and increased slightly in ***,although the proportions of invertebrates have increased,the biomass densities in the Bohai Sea have displayed an overall downward trend from 1982 to *** increases in the biodiversity and trophic level of economically important invertebrates after the 2000s,possibly benefit from stock enhancement projects implemented by governments at different levels and national fishery management measures such as the“double-control”of the total number and engine power of fishing vessels and summer moratorium of fishing.

关键词： decadal variations community structure trophic level economically important invertebrates BohaiSea

Ground pressure and overlying strata structure for a repeated mining face of residual coal after room and pillar mining

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International Journal of Mining Science and Technology 2016年第4期26卷 645-652页

作者： Jiang Bangyou Wang Lianguo Lu Yinlong Sun Xiaokang jin Gan State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology Xuzhou 221008 China

To investigate the abnormal ground pressures and roof control problem in fully mechanized repeated mining of residual coal after room and pillar mining, the roof fracture structural model and mechanical model were developed using numerical simulation and theoretical analysis. The roof fracture characteristics of a repeated mining face were revealed and the ground pressure law and roof supporting condi- tions of the repeated mining face were obtained. The results indicate that when the repeated mining face passes the residual pillars, the sudden instability causes fracturing in the main roof above the old goal and forms an extra-large rock block above the mining face. A relatively stable ＂Voussoir beam＂ structure is formed after the advance fracturing of the main roof. When the repeated mining face passes the old goaf, as the large rock block revolves and touches gangue, the rock block will break secondarily under overburden rock loads. An example calculation was performed involving an integrated mine in Shanxi province, results showed that minimum working resistance values of support determined to be reason- able were respectively 11,412 kN and 10,743 kN when repeated mining face passed through residual pillar and goaf. On-site ground pressure monitoring results indicated that the mechanical model and support resistance calculation were reasonable.

关键词： Residual coal after room and pillar mining Repeated mining Fully mechanized caving face Roof control Support resistance

A Review of Research on Galvanic Corrosion of Aluminum Alloys

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Fluid Dynamics & Materials Processing 2023年第7期19卷 1907-1923页

作者： Huixin Zhu Mingzhe Leng Guofeng jin Heyang Miao Xi’an Institute of High Technology Xi’an710038China

When aluminum alloys are coupled with dissimilar materials,they often act as corrosion anodes and are suscepted to accelerated ***,deepening our knowledge of such corrosion phenomena,related mechanisms,and elaborating new prediction model is of great theoretical and practical *** this paper,such mechanisms are explained from both macroscopic and microscopic points of view by considering several aspects such as the second phase particle type,grain size,and environmental *** specifically,different perspectives on such a problem are elaborated,which take into account:the properties of the coupling pair materials,geometrical characteristics,environmental media characteristics,the corrosion regularity of different types of aluminum alloys,the influence of area ratio on anode corrosion current density,the interference of the solution primary ions represented by Cl-and the accompanying ions represented by Al3+.A review is also conducted of the standard test methods used in the study of aluminum alloys galvanic corrosion and of research methods such as the Wire Beam Electrodes Technology(WBE),the Scanning Kelvin Probe Force Microscopy(SKPFM)***,three kinds of inhibition technologies are discussed,including the anodic oxidation treatment,the corrosion inhibitor treatment and the coating protection method.

关键词： Aluminum alloy microgalvanic corrosion influencing factors first principles calculations

Early Pleistocene formation of the asymmetric east-west pattern of upper water structure in the equatorial Pacific Ocean

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Chinese Science Bulletin 2011年第21期56卷 2251-2257页

作者： jin HaiYan JIAN ZhiMin CHENG XinRong GUO JianQing State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China

Surface-and subsurface-dwelling planktonic foraminifera from the upper 43 m of Hole A at the Ocean Drilling Program (ODP) Site 807,which was recovered from the western Pacific warm pool during ODP Leg 130,were analyzed for stable oxygen and carbon *** comparing these results with data from ODP Site 851 in the eastern equatorial Pacific,this study has reconstructed the paleoceanographic changes in upper ocean waters in the equatorial Pacific since 2.5 *** the period from 1.6-1.4 Ma,the oxygen isotopes of surface and subsurface waters were found to markedly change in the western and eastern equatorial Pacific,further confirming the final formation of the well-defined asymmetric east-west (E-W) pattern at that *** feature was similar to the zonal temperature gradient (sea surface temperature is higher in the west and lower in the east) and the asymmetric upper water structure (thermocline depth is deeper in the west and shallower in the east) in the modern equatorial *** zonal gradient change of subsurface water δ18O was greater than that of surface water δ18O,indicating that the formation of the asymmetric E-W pattern in the equatorial Pacific should be much more related to the shoaled thermocline and markedly decreased subsurface water temperature in the eastern equatorial ***,since ～1.6 Ma,the carbon isotopic differences between surface and subsurface waters clearly decreased in the equatorial Pacific,and their long-term eccentricity periods changed from 400 ka to ～500 ka,reflecting the reorganization of the ocean carbon *** probably resulted from the deep water reorganization in the Southern Ocean at that time and its enhanced influence on the tropical Pacific (especially subsurface water).Our study demonstrates that the tropical ocean plays an important role in global climate change.

关键词：赤道太平洋非对称早更新世结构模式上层水体碳同位素分析大洋钻探计划