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Enhancer of zeste homolog 2 contributes to apoptosis by inactivating janus kinase 2/signal transducer and activator of transcription signaling in inflammatory bowel disease

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World Journal of Gastroenterology 2021年第22期27卷 3073-3084页

作者： Jie Zhou Yang Yang yi-Ling Wang Yue Zhao Wen-jing Ye Si-Yao Deng jin-yi lang Shun Lu Department of Radiation Oncology Sichuan Cancer HospitalChengdu 610041Sichuan ProvinceChina Department of Oncology The Third People's Hospital of ChengduChengdu 255415Sichuan ProvinceChina Department of School of Medicine University of Electronic Science and Technology of ChinaChengdu 397992Sichuan ProvinceChina Department of Radiological Protection Radiation Oncology Key Laboratory of Sichuan ProvinceChengdu 229717Sichuan ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)is a prevalent worldwide health problem featured by relapsing,chronic gastrointestinal *** of zeste homolog 2(EZH2)is a critical epigenetic regulator in different pathological models,such as cancer and ***,the role of EZH2 in the IBD development is still *** To explore the effect of EZH2 on IBD progression and the underlying *** The IBD mouse model was conducted by adding dextran sodium sulfate(DSS),and the effect of EZH2 on DSS-induced colitis was assessed in the *** function of EZH2 in regulating apoptosis and permeability was evaluated by Annexin V-FITC Apoptosis Detection Kit,transepithelial electrical resistance analysis,and Western blot analysis of related markers,including Zona occludens 1,claudin-5,and occludin,in NCM460 and fetal human colon(FHC)*** mechanical investigation was performed by quantitative reverse transcriptionpolymerase chain reaction,Western blot analysis,and chromatin immunoprecipitation *** The colon length was inhibited in the DSS-treated mice and was enhanced by the EZH2 depletion in the *** treatment caused a decreased histological score in the mice,which was reversed by EZH2 *** inflammatory cytokines,such as tumor necrosis factor-α,interleukin-6,and interleukin-1β,were induced in the DSS-treated mice,in which the depletion of EZH2 could reverse this ***,the tumor necrosis factor-αtreatment induced the apoptosis of NCM460 and FHC cells,in which EZH2 depletion could reverse this effect in the ***,the depletion of EZH2 attenuated permeability of colonic epithelial ***,the depletion of EZH2 or EZH2 inhibitor GSK343 was able to enhance the expression and the phosphorylation of janus kinase 2(JK2)and signal transducer and activator of transcription in the NCM460 and FHC ***,EZH2 inactivated JAK2 expression by regulating histone ***2 inhibitor

关键词： Inflammatory bowel disease Apoptosis Enhancer of zeste homolog 2 JAK2 Permeability Inflammatory bowel disease therapy

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Shor's algorithm does not factor large integers in the presence of noise

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Science China(Information Sciences) 2024年第7期67卷 305-320页

作者： jin-yi CAI College of Letters and Science University of Wisconsin

We consider Shor's quantum factoring algorithm in the setting of noisy quantum gates. Under a generic model of random noise for(controlled) rotation gates, we prove that the algorithm does not factor integers of the form pq when the noise exceeds a vanishingly small level in terms of n—the number of bits of the integer to be factored, where p and q are from a well-defined set of primes of positive density. We further prove that with probability 1-o(1) over random prime pairs(p, q), Shor's factoring algorithm does not factor numbers of the form pq, with the same level of random noise present.

关键词： random noise Shor’s algorithm rotation gates quantum computing prime factorization

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New Evidence and Perspectives on the Management of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 169-176页

作者： Jun yin Wen-Tao Bo Jian Sun Xiao Xiang jin-yi lang Jian-Hong zhong Le-Qun Li Department of Radiation Oncology Sichuan Cancer Hospital & Institute Sichuan Cancer Center School of Medicine University of Electronic Science and Technology of China Chengdu China Department of Hepatobiliary Surgery Sichuan Cancer Hospital &Institute Sichuan Cancer Center School of Medicine University of Electronic Science and Technology of China Chengdu China Department of Medical Affairs ZiBo Hospital of Integrated Traditional Chinese and Western Medicine Zibo China Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China

Portal vein tumor thrombosis (PVTT) is an intractable condition but common phenomenon in hepatocellular carcinoma (HCC).HCC patients with PVTT may have worse liver function,a higher chance of comorbidity related to portal hypertension,lower tolerance to treatment and poorer *** Western guidelines,patients are offered palliative treatment with sorafenib or other systemic agents because HCC with PVTT is grouped together with metastatic HCC during the planning of its *** recent years,various treatment options have become available for patients with HCC and *** has also shifted toward evidencebased ***,policies for the management of HCC with PVTT have not been *** comprehensive literature review aims to present current and available management options for patients with HCC and *** is mainly based on studies published after 2010.

关键词： Hepatic resection Hepatocellular carcinoma Portal vein tumor thrombosis Transarterial chemoembolization

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Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

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Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： yi-lang Qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical *** investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

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Inhibiting shuttle effect of lithium polysulfides by double metal selenides for high-performance lithium-sulfur batteries

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Rare Metals 2024年第6期43卷 2546-2559页

作者： Lei Li Xue-jing Yang yi-Yang Li Bo jin Hui Liu Meng-Yang Cui Dong-Bo Guan Xing-You lang Qing Jiang Key Laboratory of Automobile Materials Ministry of Educationand College of Materials Science and EngineeringJilin UniversityChangchun 130022China

Lithium-sulfur batteries(LSBs)have attracted the attention of more and more researchers due to the advantages of high energy density,environmental friendliness,and low production ***,the low electronic conductivity of active material and shuttling effect of lithium polysulfides(LiPSs)limit the commercial development of *** solve these problems,we design a core-shell composite with nitrogen-doped carbon(NC)and two types of selenides(FeSe_(2)-NC@ZnSe-NC).The FeSe_(2)-NC@ZnSe-NC has a strong adsorption capacity,and can effectively adsorb *** the same time,it also effectively alleviates the shuttling effect of LiPSs,and improves the utilization of the active substance during the charge/discharge reaction *** mechanism involved in FeSe_(2)-NC@ZnSe-NC is demonstrated by both experiments and density-functional theory(DFT)*** electrochemical test results indicate that LSB with S/FeSe_(2)-NC@ZnSe-NC delivers an initial discharge capacity of 1260 mAh·g^(-1)at *** after 500 cycles at 1C,the capacity decay rate per cycle is 0.031%,and the capacity retention rate is 85%.The FeSe_(2)-NC@ZnSe-NC core-shell structure verifies a rational strategy to construct an electrode material for high-performance LSBs.

关键词： Lithium-sulfur batteries Shuttling effect Metal selenide Nitrogen-doped carbon Lithium polysulfides

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N-Heterocyclic carbene-catalyzed enantioselective(dynamic) kinetic resolutions and desymmetrizations

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Science China Chemistry 2024年第2期67卷 482-511页

作者： yi Zhang Hui Cai Xiuhai Gan Zhichao jin National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang550025China

N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions,dynamic kinetic resolutions,and desymmetrization reactions are systematically *** content is organized according to the activation modes involved i... 详细信息

关键词： N-heterocyclic carbene kinetic resolution dynamic kinetic resolution desymmetrization organocatalysis

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Clinical observation on 90 cases of primary dysmenorrhea treated by buccal acupuncture therapy:a randomized controlled study

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Journal of Traditional Chinese Medicine 2024年第1期44卷 172-181页

作者： YANG yi YE Huijun ZHENG Huiling jin Lihua Department of Obstetrics and Gynecology the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityXinhua Hospital of Zhejiang ProvinceHangzhou 310005China

OBJECTIVE:To explore the short-term and long-term efficacy of buccal acupuncture therapy in the treatment of patients with primary dysmenorrhea(PD).METHODS:A total of 90 patients with PD who were admitted to the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from January 2020 to December 2021 were included in this study and randomly divided into three groups,including the observation group,the control group,and the placebo group,with 30 patients in each *** in the observation group were treated according to the syndrome types of Traditional Chinese Medicine,those in the control group were treated with Saridon,and those in the placebo group received a *** visual analog scale(VAS)scores of these patients were evaluated at different time points(before treatment,5 min after needle retention,30 min after needle retention,1 h after treatment,2 h after treatment,1 d after treatment,and 2 d after treatment).The Cox Menstrual Symptom Scale(CMSS)scores were assessed before the treatment and after three courses of ***,these two scales were also evaluated during ***,the pain score and adverse reactions of these patients were assessed during ***:After treatment,the VAS and CMSS scores in the observation group decreased significantly(P<0.05)5 and 30 min after needle retention and after ***:Buccal acupuncture therapy is verified to have short-term efficacy in the treatment of *** addition,this therapy has an immediate analgesic effect and long-term efficacy in reducing the severity and frequency of PD.

关键词： buccal acupuncture therapy primary dysmenorrhea pain score randomized controlled trial

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Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

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Rare Metals 2024年第2期43卷 758-769页

作者： Yu-Long Li Xi-lang jin yi-Ting Ma jing-Rui Liu Fazal Raziq Peng-Yuan Zhu Zhi-Feng Deng Hong-Wei Zhou Wei-Xing Chen Wen-Huan Huang School of Materials and Chemical Engineering Xi’an Technological UniversityXi’an710021China Yulin Boyi-jingking Research Institute of Industrial Technology Development Research Yulin719054China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China National and Local Joint Engineering Laboratory for Slag Comprehensive Utilization and Environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong723001China

Developing fluorescence porous probe for detecting and eliminating Cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable ***,improving the fluorescence detecting efficiency while enhancing the adsorption capacity of the porous probe is of great ***,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-COF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)***-COF displayed rapid detection of Cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were *** importantly,the fluorescence quenching mechanism of TTP-COF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among C=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of Cu^(2+).

关键词： Covalent organic framework(COF) Excited-state intramolecular proton transfer(ESIPT) Copper ion detection Copper ion adsorption Renewability

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1.42-fold enhancement of formate selectivity by linker conversion on the Zn-based metal organic framework catalyst

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Journal of Energy Chemistry 2024年第3期90卷 183-190,I0006页

作者： Yayu Guan Yuyu Liu Fanghua Ning jin yi Jiujun Zhang Institute for Sustainable Energy College of SciencesShanghai UniversityShanghai 200444China

Electro-reduction of carbon dioxide(ERCO_(2)) is considered an effective method to alleviate the greenhouse effect and produce value-added *** the dominant selectivity of Zn-based catalysts for formate remains a *** this article,the ZnIn-E_(12) catalyst is successfully prepared by solvent assisted ligand exchange(SALE) method to convert organic ligands,achieving a Faradaic efficiency of 72.28% for formate at-1.26 V ***(V_(RHE)),which is 1.42 times higher than the original *** shows that the successful conversion of organic ligands can transform the catalyst from the original large size polyhedron to cross-linked network of particles with a diameter of about 30 *** increased specific surface area can expose more active sites and facilitate the electrocatalytic conversion of CO_(2) to *** work is expected to provide inspiration for the regulation of formate selectivity and catalyst size in Zn-based catalysts.

关键词： Electrocatalyst Carbon dioxide Formate Linker conversion

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Measurement,Modelling and Analysis of Residence Time Distribution Characteristics in a Continuous Hydrothermal Reactor

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Journal of Thermal Science 2024年第4期33卷 1301-1311页

作者： LI yi ZHAI Binjiang WANG Junying WANG Weizuo jin Hui State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China

Understanding the residence time distribution(RTD)of a continuous hydrothermal reactor is of great significance to improve product quality and reaction *** this work,an on-line measurement system is attached to a continuous reactor to investigate the characteristics of *** approach that can accurately fit and describe the experimental measured RTD curve by finding characteristic values is proposed for analysis and *** RTD curves of three experiment groups are measured and the characteristic values are *** show that increasing total flow rate and extending effective reactor length have inverse effect on average residence time,but they both cause the reactor to approach a plug flow reactor and improve the materials *** branch flow rate fraction has no significant effect on RTD characteristics in the scope of the present work except the weak negative correlation with the average residence ***,the natural convection stirring effect can also increase the average residence time,especially when the forced flow is *** analysis reveals that it is necessary to consider the matching of natural convection,forced flow and reactor size to control RTD when designing the hydrothermal reactor and working conditions.

关键词： continuous reactor residence time distribution modelling

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