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World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： wei Zhu Shanghai XiRong Information Science and Technology Co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan Li wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Explosive synchronization of multi-layer frequency-weighted coupled complex systems

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Chinese Physics B 2019年第7期28卷 168-173页

作者： Yan-Liang jin Lin Yao wei-Si Guo Rui Wang xue Wang xue-Tao Luo Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication Shanghai Institute for Advanced Communication and Data Science Shanghai University Shanghai 200072 China School of Engineering University of Warwick Coventry UK Alan Turing Institute London UK

Synchronization is a phenomenon that is ubiquitous in engineering and natural *** study of explosive synchronization on a single-layer network gives the critical transition coupling strength that causes explosive ***, no significant findings have been made on multi-layer complex *** paper proposes a frequency-weighted Kuramoto model on a two-layer network and the critical coupling strength of explosive synchronization is obtained by both theoretical analysis and numerical *** is found that the critical value is affected by the interaction strength between layers and the number of network *** explosive synchronization will be hindered by enhancing the interaction and promoted by increasing the number of network *** results have importance across a range of engineering and biological research fields.

关键词： explosive synchronization Kuramoto model complex systems

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv wei Qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Stability of Retained Austenite Through a Combined Intercritical Annealing and Quenching and Partitioning(IAQP) Treatment

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 386-393页

作者： Ri-Ming Wu wei Li Cheng-Lin Wang Yi Xiao Li Wang xue-Jun jin School of Materials Science and Engineering Shanghai Jiao Tong University School of Materials Science and Engineering Shanghai University State Key Lab of Development and Application Technology of Automotive Steels Baosteel Research Institute

Intercritical annealing（IA） at various temperatures followed by quenching and partitioning（IAQP） treatments was conducted on a cold-rolled Fe-0.2C-1.42Si-l.87Mn（wt%） sheet *** microstructure and enhanced mechanical properties were achieved through appropriate adjustment of IA *** steel which was annealed at1,033 K for 600 s,then quenched to 573 K and partitioned at 693 K for 20 min,designated as 1033 QP steel,exhibits maximum 16.3 vol% retained austenite（RA） with good mechanical properties（ultimate tensile strength 886 MPa and total elongation 27%）.It was found that the thermal and mechanical stabilities of RA are mainly influenced by the combined effect of its average carbon content and amount of adjacent ***,the transformation-induced plasticity effect increased the peak n-values observed at the second stage of the work hardening of IAQP steels.

关键词： Intercritical annealing and quenching and partitioning treatment(IAQP) Retained austenite(RA) Average carbon content(ACC) Amount of adjacent martensite(AAM) Transformation-induced plasticity(TRIP)

Reshaping plasmon modes by film interference

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Science China(Physics,Mechanics & Astronomy) 2023年第11期66卷 136-144页

作者： jin Liu wei Li Junyu Li Jie Zhong He Feng Renming Liu xue-Hua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou510275China School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou510006China School of Physics and Electronics Henan UniversityKaifeng475004China

Localized surface plasmon resonances(LSPRs)in metal nanostructures have been a central subject of nano-photonics due to their ability to manipulate light beyond the optical diffraction ***,the large intrinsic dissipations of LSPRs have severely hindered their applications,so the on-demand control of the LSPR modes is highly desired and remains open ***,we experimentally and theoretically demonstrate that the plasmon mode can be effectively engineered by interacting with constructive or destructive modes supported by film *** a metal nanoparticle interacts with a constructive mode,the dissipation linewidth of its LSPR mode shows a significant reduction of 58%.Simultaneously,the scattering intensity is remarkably enhanced,in vast favor of measuring weak signals from small ***,the film-destructiveinterference splitting in the scattering spectrum by weak coupling,rather than strong coupling,is revealed if the plasmon particles interact with the destructive mode,resulting in two new hybrid plasmon modes with narrow *** effective polarizability model of reshaping the LSPR modes by the film interference is present to well understand the experimental *** work may pave the way toward low-loss plasmonic photonics and its practical applications.

关键词： plasmon reshaping dissipation film-destructive-interference splitting film interference

Non-Martensitic α-phase formed in Sol-Gel &reduction method and promoted martensitic transformation of Fe-Ni nanoparticles

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Non-Martensitic α-phase formed in Sol-Gel &reduction method...