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孕期双酚A暴露对雄性子代大鼠生殖损伤的研究

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中国兽医杂志 2014年第7期50卷 8-10页

作者：靳冠通李健陈耀星王曈河南科技大学动物科技学院河南洛阳471003 中国农业大学动物医学院北京海淀100193

本研究采用组织化学和酶联免疫吸附剂测定(ELISA)方法探讨孕期双酚A暴露对子代大鼠的生殖毒性作用。将15只妊娠0 d的雌性SD大鼠随机分为3组,分别灌胃50μL含0、1、10 mg/kg体重双酚A的橄榄油。分娩出的雄性子代大鼠生长至8周龄,取睾丸... 详细信息

本研究采用组织化学和酶联免疫吸附剂测定(ELISA)方法探讨孕期双酚A暴露对子代大鼠的生殖毒性作用。将15只妊娠0 d的雌性SD大鼠随机分为3组,分别灌胃50μL含0、1、10 mg/kg体重双酚A的橄榄油。分娩出的雄性子代大鼠生长至8周龄,取睾丸、附睾、精囊腺及前列腺称重,并制作组织切片观察组织结构的变化;取睾丸,测定抗氧化能力;取附睾,检测精子品质。结果显示,双酚A显著降低睾丸、附睾、精囊腺及前列腺的重量,抑制器官发育及睾丸精子发生;降低抗氧化酶活性、升高活性氧含量,破坏抗氧化能力;造成精子品质下降。

关键词：双酚A 精子发生精子品质抗氧化酶

Enhancing insights into Global Cancer Statistics 2022: implications for cancer control

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Science China Life Sciences 2025年第1期 294-296页

作者： jingtong Xu Runtian Wang Xiaoxiang guan Department of Oncology the First Affiliated Hospital of Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical University

Globally, there has been a marked escalation in tumor morbidity and mortality,cementing tumors as the predominant cause of death in numerous *** the current tumor burden across various regions is imperative to discern potential risk factors and formulate efficacious strategies for tumor ***, the International Agency for Research on Cancer(IARC) provided a status report on the global tumor burden,estimating the incidence and mortality of 36 cancers in 185 countries(Bray et al.,2024).

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基于剩余碰撞时间的线控制动分层控制策略

江苏大学学报（自然科学版） 2025年第1期46卷 28-35,63页

作者：童叙王宇宁关艺博田韶鹏吴桐武汉理工大学现代汽车零部件技术湖北省重点实验室湖北武汉430070 武汉理工大学汽车零部件技术湖北省协同创新中心湖北武汉430070 武汉理工大学湖北省新能源与智能网联车工程技术研究中心湖北武汉430070 武汉理工大学佛山仙湖实验室广东佛山528200

针对不同制动工况需求的制动策略存在差异的情况,提出一种线控制动分层控制策略.在该分层策略的上层,利用二阶TTC安全碰撞时间模型计算出车辆与前车的剩余碰撞时间,以此作为依据进行制动策略的选取,并建立了汽车二自由度模型、车身法向... 详细信息

针对不同制动工况需求的制动策略存在差异的情况,提出一种线控制动分层控制策略.在该分层策略的上层,利用二阶TTC安全碰撞时间模型计算出车辆与前车的剩余碰撞时间,以此作为依据进行制动策略的选取,并建立了汽车二自由度模型、车身法向受力模型和Burckhardt轮胎模型;在该分层策略的下层,进行了制动力在轮间的分配,使用序列二次规划(SQP)方法,分别在一般制动、紧急制动、失稳制动3种工况下,以轮胎滑移率为对象建立优化函数,对车辆制动力进行了优化分配.使用MATLAB/Simulink和Carsim进行了联合仿真,对所提出3种工况下的制动分配策略进行了有效性验证.结果表明:在一般制动工况下,采用该策略时相比对照工况制动距离减少18.08%,制动时间减少25.12%;在紧急制动工况下,采用该策略时相比对照工况制动距离减少19.17%,制动时间减少12.79%;在失稳制动工况下,该策略可通过轮胎差扭来提升车辆的横向稳定性.采用文中制动策略显著提升了车辆的制动效能.

关键词：线控制动制动力优化分配分层控制序列二次规划方法 ECE法规制动仿真滑模控制碰撞时间

Field experiment of rainfall infiltration on a soil slope and simulations based on a water-air two-phase flow model

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Journal of Mountain Science 2021年第8期18卷 2159-2167页

作者： LIU Gang ZHA Xin-yuan guan jin-kun tong Fu-guo Hubei Key Laboratory of Construction and Management in Hydropower Engineering China Three Gorges UniversityYichang443000China College of Hydraulic&Environment Engineering China Three Gorges UniversityYichang443000China

Rainfall infiltration on a soil slope is usually an unsaturated seepage process that can be described by a water-air two-phase flow *** effect of pore air pressure on rainfall infiltration has been widely recognized and validated by means of numerical simulations and laboratory ***,whether a slope can actually seal pore air continues to be debated by *** this study,a water-air two-phase flow model is used to simulate the rainfall infiltration process on a soil slope,and a field experiment is conducted to realistically test the sealing conditions of a *** to the numerical simulation,the areas of water and air flow in and out on the slope surface are relatively stable and can be classified as the“inhalation zone”and“overflow zone”,*** rainfall on the soil slope has an amplifying effect on pore air pressure because rainfall intensity is usually at the millimeter level,and it causes pore air pressure to reach the cm level.A field experiment was performed to determine whether a slope can realistically seal pore air and subsequently verify the regularity of rainfall *** pressure sensors were buried in the slope to monitor the pore air pressures during the rainfall *** monitoring results show that the pore air pressure in the slope changed,which indicates that the slope can seal ***,the amplification effects of intermittent rainfall on pore air pressure were observed for natural rainfall,which agrees well with the numerical simulation results.

关键词： Rainfall infiltration Runoff regularity Field experiment Water-air two-phase flow

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua guan jing Dong Bixian Chen Lujie Jia jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Constructing nitrided aluminum metal skeleton to improve the reversibility and cyclicity of Si film electrode

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Progress in Natural Science:Materials International 2023年第6期33卷 789-796页

作者： Jiali tong Tingfeng guan Qilin tong Yan Cheng Zhaozhe Yu Guilin University of Electronic Technology guangxi Key Laboratory of Manufacturing Systems and Advanced Manufacturing Technology

Silicon is a promising anode material for lithium-ion batteries(LIBs) due to its high theoretical capacity, low discharge potential, environmental friendliness and cost-effectiveness. However, its low conductivity, high volume variation and poor cycling performance hamper its practical application. Herein, we prepare Si-Al(Al N)composite film anodes containing a nitrided aluminum metal conductive skeleton. The Al(Al N) creates a multiphase interface, buffers the volume expansion of the electrode, and also plays a role in conducting electricity and supporting the electrode structure. As a result, the Si-Al(Al N) electrode exhibits excellent performance with a high initial coulombic efficiency of 86 %, an outstanding cycling stability of roughly 1955 m Ah g-1after 200 cycles at420 m A g-1and retains 916 m Ah g-1after 300 cycles even at 4200 m A g-1(the capacity retention rate of 83 %).This work provides an effective method for adjusting anode performance with greater freedom.

关键词： Silicon film anode Nitrided aluminum metal conducting skeleton Cycling stability Lithium-ion battery

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Boundary Points,Minimal L^(2)Integrals and Concavity PropertyⅢ—Linearity on Riemann Surfaces and Fibrations over Open Riemann Surfaces

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2091-2152页

作者： Qi An guan Zhi tong MI Zheng YUAN School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044P.R.China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190P.R.China

In this article,we consider a modified version of minimal L^(2) integrals on sublevel sets of plurisubharmonic functions related to modules at boundary points,and obtain a concavity property of the modified *** applications,we give characterizations for the concavity degenerating to linearity on open Riemann surfaces and on fibrations over open Riemann surfaces.

关键词： Minimal L^(2)integrals plurisubharmonic functions boundary points weakly pseudoconvex Kähler manifold