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Contralateral C7 transfer combined with acellular nerve allografts seeded with differentiated adipose stem cells for repairing upper brachial plexus injury in rats

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Neural Regeneration Research 2019年第11期14卷 1932-1940页

作者： Jian-tao Yang jin-tao fang Liang Li Gang Chen Ben-Gang Qin Li-Qiang Gu Department of Microsurgery & Orthopedic Trauma the First Affiliated Hospital of Sun Yat-sen University

Nerve grafting has always been necessary when the contralateral C7 nerve root is transferred to treat brachial plexus injury. Acellular nerve allograft is a promising alternative for the treatment of nerve defects, and results were improved by grafts laden with differentiated adipose stem cells. However, use of these tissue-engineered nerve grafts has not been reported for the treatment of brachial plexus injury. The aim of the present study was to evaluate the outcome of acellular nerve allografts seeded with differentiated adipose stem cells to improve nerve regeneration in a rat model in which the contralateral C7 nerve was transferred to repair an upper brachial plexus injury. Differentiated adipose stem cells were obtained from Sprague-Dawley rats and transdifferentiated into a Schwann cell-like phenotype. Acellular nerve allografts were prepared from 15-mm bilateral sections of rat sciatic nerves. Rats were randomly divided into three groups: acellular nerve allograft, acellular nerve allograft + differentiated adipose stem cells, and autograft. The upper brachial plexus injury model was established by traction applied away from the intervertebral foramen with micro-hemostat forceps. Acellular nerve allografts with or without seeded cells were used to bridge the gap between the contralateral C7 nerve root and C5–6 nerve. Histological staining, electrophysiology, and neurological function tests were used to evaluate the effect of nerve repair 16 weeks after surgery. Results showed that the onset of discernible functional recovery occurred earlier in the autograft group first, followed by the acellular nerve allograft + differentiated adipose stem cells group, and then the acellular nerve allograft group;moreover, there was a significant difference between autograft and acellular nerve allograft groups. Compared with the acellular nerve allograft group, compound muscle action potential, motor conduction velocity, positivity for neurofilament and S100, diameter o

关键词： nerve regeneration peripheral nerve injury brachial plexus injury contralateral C7 nerve root acellular nerve adipose stem cells Schwann cells tissue engineering nerve nerve grafting nerve defect neural regeneration

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IWHR HIGH SPEED WATER TUNNEL FOR CAVITATION RESEARCH

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Journal of Hydrodynamics 1989年第4期1卷 59-66页

作者： jin Tai-lai tao fang-xuan Yue Yuan-zhang Pan Shui-bo Institute of Water Conservancy and Hydroelectric Power Research,Beijing,P.R.China

The paper concerns with the design philosophy,feasibility study,as well as some peculiar features of IWHR water tunnel for cavitation *** highlights worth-mentioning are the maximum velocity of 35m/s and Reynolds numb... 详细信息

关键词： IWHR HIGH SPEED WATER TUNNEL FOR CAVITATION RESEARCH

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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-fang Wu Yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei Liu Shilong fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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外科腹腔感染患者PCT与TNF-α及CRP和IL-6水平与感染程度的研究

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中华医院感染学杂志 2017年第20期27卷 4712-4715页

作者：张宗祥金弢方迪龙叶宇尹雪峰杭州市红十字会医院普外科浙江杭州310003

目的观察外科腹腔感染患者血清降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)和白细胞介素6(IL-6)的水平变化与感染程度的相关性,为临床指导抗菌药物应用提供依据。方法选择医院普通外科2012年11月-2016年12月收治的69例外... 详细信息

目的观察外科腹腔感染患者血清降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)和白细胞介素6(IL-6)的水平变化与感染程度的相关性,为临床指导抗菌药物应用提供依据。方法选择医院普通外科2012年11月-2016年12月收治的69例外科腹腔感染和24例非腹腔感染患者,依据腹腔感染范围不同,分为无感染组24例,局部感染组38例和弥漫性感染组31例,检测患者入院时及抗感染治疗第3天的体温(T)、白细胞(WBC)、中性粒细胞百分率(N%)、血清PCT、TNF-α、CRP和IL-6的水平,分析其与WBC的相关性。结果弥漫性感染组、局部感染组入院时T、WBC、N%、CRP、TNF-α和IL-6表达显著高于无感染组(P<0.05);弥漫性腹腔感染组TNF-α和IL-6表达高于局部感染组;弥漫性感染组与局部感染组、无感染组比较,PCT表达明显升高;抗感染治疗3天后,两组感染患者T、WBC、N%、CRP、TNF-α、PCT和IL-6表达较入院时均明显下降(P<0.05),而弥漫性感染组TNF-α、PCT和IL-6水平仍高于局部感染组。PCT、TNF-α、CRP、IL-6与WBC均呈正相关。结论临床检测血清PCT、TNF-α、CRP和IL-6均有助于鉴别是否存在外科腹腔感染,与CRP和WBC相比,PCT、TNF-α和IL-6检测更有助于评估腹腔感染严重程度,对抗菌药物应用有一定的指导作用。

关键词：外科腹腔感染降钙素原肿瘤坏死因子α C-反应蛋白白细胞介素6

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扬子板块西南缘早前寒武纪地质演化:来自撮科元古宙变沉积岩碎屑锆石U-Pb年龄、Hf-O同位素的制约

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岩石学报 2025年第1期41卷 304-320页

作者：高嘉敏谢士稳刘倩王舫陶鹏龙涛中国地质大学(北京)地球科学与资源学院北京100083 中国地质科学院地质研究所北京离子探针中心北京100037 山东省第四地质矿产勘查院潍坊261021

扬子板块的太古宙-古元古代基底出露十分有限,制约了对扬子早前寒武纪地质演化的认识。本次研究对扬子板块西南缘撮科地区的大红山群和昆阳群变沉积岩开展了碎屑锆石原位U-Pb年龄、Hf-O同位素及微量元素研究。测年结果显示,大红山群谐... 详细信息

扬子板块的太古宙-古元古代基底出露十分有限,制约了对扬子早前寒武纪地质演化的认识。本次研究对扬子板块西南缘撮科地区的大红山群和昆阳群变沉积岩开展了碎屑锆石原位U-Pb年龄、Hf-O同位素及微量元素研究。测年结果显示,大红山群谐和锆石年龄分布于3092~1786Ma之间,最年轻碎屑锆石年龄为1786Ma,限定大红山群最大沉积时代为古元古代晚期。昆阳群谐和锆石年龄分布于2874~1031Ma之间,最年轻碎屑锆石年龄为1031Ma,表明昆阳群最大沉积时代为中元古代晚期。除少量较年轻锆石(<1.75Ga)外,昆阳群和大红山群具有相似的年龄分布特征,两个主要的年龄峰为2.0~1.85Ga和2.4~2.2Ga。尽管古元古代碎屑锆石的年龄峰与撮科地区已报道的古元古代岩浆活动期次一致,但仅有少部分碎屑锆石的Hf-O同位素特征与撮科古元古代岩浆岩相似,大多数碎屑锆石Hf-O同位素组成与加拿大Rae克拉通古元古代变沉积岩中碎屑锆石相似,暗示古元古代碎屑物质可能仅少部分来自撮科地区已识别的古元古代岩浆岩,而大部分可能来自与Rae克拉通发育的古元古岩浆岩相似的源区。大红山群和昆阳群中1.9~1.03Ga的碎屑锆石可能来自扬子西南缘发育的古元古代晚期-中元古代晚期岩浆岩。结合前人的资料,我们认为我国撮科和越南北部的Phan Si Pan带经历了与加拿大Rae克拉通相似的古元古代演化过程,支持2.4~2.3Ga扬子西南缘卷入Arrowsmith造山事件,并与Rae克拉通一起参与哥伦比亚超大陆聚合过程的认识。

关键词：扬子西南缘撮科地区哥伦比亚超大陆大红山群和昆阳群碎屑锆石

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan fang Li-Hui Li Ming-Qian He Yue Ji Dong-Yan Lu Li-Bing Zhang jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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Adsorption of Zinc and Cyanide from Cyanide Effluents on Anionic Ion-exchange Resin

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Chemical Research in Chinese Universities 2013年第1期29卷 144-149页

作者： ZHANG Ya-li fang tao YU Xian-jin School of Chemical Engineering Shandong University of Technology Zibo 255081 P. R. China

The adsorption of zinc and cyanide from cyanide effluents onto strong and weak basic anion exchange re sins was studied in a batch adsorption system. Factors influencing the adsorption rates such as resin selection, resin amounts, contact time and temperature were studied and scanning electron microscopyenergy disperse spectrosco py（SEMEDS） was used in the analysis. The present study shows that the adsorption capacity of resin 201 x7 is better than that of resin 301. The adsorption process was relatively fast and came to equilibrium after 60 min. The kinetic data were analyzed with three models and the pseudosecondorder kinetic model was found to agree with the expe rimental data well. The equilibrium data could also be described well by Langmuir isotherm model. Thermodynamic parameters such as enthalpy change（AH0）, free energy change（AG0） and entropy change（AS0） were calculated and the adsorption process was spontaneous and endothermic.

关键词： Ion-exchange Adsorption Adsorption isotherm Adsorption kinetics Thermodynamic parameter

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Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang Kai Rong Shanlei Chang Youxing fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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