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From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders

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World Journal of Gastroenterology 2024年第23期30卷 2934-2946页

作者： Duo-Lun Gao Meng-Ran Lin Nan Ge jin-tao guo Fan Yang Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of *** focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive ***,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be *** recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal *** interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment *** the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been *** article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关键词： Mitophagy Gastrointestinal diseases Parkin Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease

Essential role of postoperative follow-up in the management of clear cell sarcoma

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World Journal of Clinical Cases 2024年第23期12卷 5299-5303页

作者： Zi-Han Zhang jin-tao guo Ying Xie Si-Yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques Shenyang 110004Liaoning ProvinceChina

Clear cell sarcoma(CCS)is a rare melanocytic soft tissue sarcoma known for itspropensity to metastasize to the lymph nodes and typically has an ***,surgical resection is the primary treatment for localizedCCS,while radiotherapy and chemotherapy are preferred for metastatic *** roles of adjuvant chemotherapy,radiotherapy,and lymph node dissection *** immunotherapy has emerged as a promising avenue inCCS treatment research,there are no established clinical standards for *** editorial discusses a recent article by Liu et al,with afocus on current diagnostic modalities,treatment approaches,and the challengingprognosis associated with *** aim is to underscore the importance of longtermpatient follow-up in CCS management.

关键词： Clear cell carcinoma Diagnosis Treatment Prognosis Follow-up

Screening of colorectal cancer: Methods and strategies

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World Journal of Clinical Oncology 2024年第7期15卷 799-805页

作者： Zhen Liao jin-tao guo Fan Yang Shu-Peng Wang Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Colorectal cancer(CRC)has high incidence and mortality rates,and the em-ergence and application of CRC screening have helped us effectively control the occurrence and development of ***,common international screening methods include tests based on feces and blood,and examination methods that allow for visualization,such as sigmoidoscopy and *** methods have been widely used,whereas others such as multi-target stool RNA test are still being explored and developed,and are expected to become front-line screening methods for CRC in the *** choice of screening method is affected by external conditions and the patients'situation,and the clinician must choose an appropriate strategy according to the actual situation and the patient's *** article introduces various CRC screening methods and analyzes the factors relevant to the screening strategy.

关键词： Colorectal cancer Screening Stool-based test Endoscopic examination Computed tomography colonography Blood-based test

Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial

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World Journal of Gastroenterology 2016年第48期22卷 10673-10679页

作者： guo-Xin Wang Xiang Liu Sheng Wang Nan Ge jin-tao guo Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

AIM To analyze the effects of premedication with Pronase for endoscopic ultrasound(EUS) examination of the *** This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution was a mixed solution of 20000 U of Pronase and 60 m L sodium bicarbonate solution in the Pronase group, while an equal amount of sodium bicarbonate solution was administered to the placebo group. All operators, image evaluators and experimental recorders in EUS did not participate in the preparation and allocation of pretreatment solution. Two blinded investigators assessed the obscurity scores for the EUS images according to the size of artifacts(including ultrasound images of the gastric cavity and the gastric wall). Differences in imaging quality, the duration of examination and the usage of physiological saline during the examination process between the Pronase group and the control group were *** No differences existed in patient demographics between the two groups. For the gastric cavity, the Pronase group had significantly lower mean obscurity scores than the placebo group(1.0476 ± 0.77 vs 1.6129 ± 0.96, respectively, P = 0.000). The mean obscurity scores for the gastric mucosal surface were significantly lower in the Pronase group than the placebo group(1.2063 ± 0.90 vs 1.7581 ± 0.84, respectively, P = 0.001). The average EUS procedure duration for the Pronase group was 11.60 ± 3.32 min, which was significantly shorter than that of the placebo group(13.13 ± 3.81 min, P = 0.007). Less saline was used in the Pronase group than the placebo group, and the difference was significant(417.94 ± 121.38 m L vs 467.42 ± 104.52 mL, respectively, P = 0.016).CONCLUSION The group that had Pronase premedication prior to the EUS examination had clearer images than the placebo group. With Pronase premedication, the examination time was shorter, and the amount of saline us

关键词： Artifacts Randomized controlled trial Endosonography Pronase Stomach

Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology:Progress and updates

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 1-18页

作者： Fan Yang Si-Yu Sun Sheng Wang jin-tao guo Xiang Liu Nan Ge guo-Xin Wang Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Gastrointestinal(GI)tumors,including liver,pancreatic,gastric,and colorectal cancers,have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent *** and postoperative chemoradiotherapy have largely reduced the fatality rates for most GI tumors,but these therapeutic approaches result in poor prognoses due to severe adverse reactions and the development of drug *** studies have shown that ferroptosis plays an important role in the onset and progression of GI *** is a new non-apoptotic form of cell death,which is iron-dependent,non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species(ROS).The activation of ferroptosis can lead to tumor cell ***,regulating ferroptosis in tumor cells may become a new therapeutic approach for tumors,making it become a research *** studies suggest that ferroptosis is mainly triggered by the accumulation of lipid ***,several studies have indicated that ferroptosis may be a new approach for the treatment of GI ***,we review current research progress on the mechanism of ferroptosis,current inducers and inhibitors of ferroptosis,and the role of ferroptosis in GI tumors to propose new methods for the treatment of such tumors.

关键词： Ferroptosis Gastrointestinal oncology Hepatocellular carcinoma Pancreatic cancer Gastric cancer Colorectal cancer

Delayed perforation after endoscopic resection of a colonic laterally spreading tumor:A case report and literature review

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World Journal of Clinical Cases 2020年第16期8卷 3608-3615页

作者： Ge-Yu-Jia Zhou jin-Long Hu Sheng Wang Nan Ge Xiang Liu guo-Xin Wang Si-Yu Sun jin-tao guo Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been widely used for the treatment of early gastrointestinal *** piecemeal mucosal resection(EPMR)is derived from the combination of EMR and *** perforation with peritonitis after colonic EPMR is a rare but severe complication,sometimes requiring *** are some associated risk factors,including patient-(location,diameter,and presence of fibrosis)and procedure-related *** recognition and timely treatment are crucial for its *** SUMMARY We report a case in which delayed perforation with peritonitis was treated using endoscopic closure.A 54-year-old man was diagnosed with a 30-mm-diameter laterally spreading tumor in the colonic hepatic *** hours after endoscopic resection,peritonitis caused by delayed perforation occurred and gradually *** treatment was ineffective and no obvious perforation was *** timely endoscopic closure,the patient was discharged on postoperative day *** In occasion of localized peritonitis aggravating without macroscopic perforation,endoscopic closure is an effective treatment for delayed perforation with stable vital signs in the early stage.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Endoscopic piecemeal mucosal resection Delayed perforation Endoscopic closure Case report

Endoscopic resection of the pancreatic tail and subsequent wound healing mechanisms in a porcine model

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World Journal of Gastroenterology 2019年第21期25卷 2623-2635页

作者： Sheng Wang Kai Zhang jin-Long Hu Wei-Chao Wu Xiang Liu Nan Ge jin-tao guo guo-Xin Wang Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

BACKGROUND Laparoscopic resection of the pancreatic body and tail is the predominant methodology to remove lesions in these locations;its safety and surgical planning are relatively mature, but it remains a complex and high-precision surgical operation, requiring abundant experience and skills in laparoscopic surgery, with a 10% rate of complications. AIM To verify the feasibility and safety, as well as to examine the complications of endoscopic pancreatectomy and healing mechanisms of pancreatic wounds after endoscopic resection. METHODS Transgastric endoscopic resections of varying sizes of pancreases were performed in 15 healthy Bama miniature pigs. The technical success rate, the incidence of serious complications, and the survival of the animals were studied. The healing of the wounds was evaluated by sacrificing the animals at various time points. Finally, the expression of transforming growth factor-β1 and Smad3/Smad7 in the surgical site was examined by immunohistochemistry to explore the role of these factors in wound healing of the pancreas. RESULTS Partial and total resections were successfully performed in two groups of animals, respectively. The technical success rate and the survival rate of the pigs were both 100%. We obtained 12 pancreatic tissue samples by endoscopic resection. The pancreatic wounds were closed with metal clips in one group and the wounds healed well by forming scars. There was a small amount of pancreatic leakage in the other group, but it can be fully encapsulated. The level of transforming growth factor-β1 (TGF-β1) in the wounds increased during the inflammatory and fibrous hyperplasia phases, and decreased in the scar phase. The expression of Smad3 paralleled that of TGF-β1, while the expression of Smad7 had an inverse relationship with the expression of TGF-β1. CONCLUSION Purely transgastric endoscopic resection of the pancreas is a safe, effective, and feasible procedure, but the incidence of pancreatic leakage in total pancre

关键词： Pancreatic resection Endoscopy Wound healing Transforming growth factor-β1 Smad

Measurement of pore diffusion factor of porous solid materials

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Petroleum Science 2022年第4期19卷 1897-1904页

作者： jin-tao guo Ya-Qian Wei Sheng-Li Chen Wei Sun Ting-Ting Fan Ming-Ri Xu Chang-Cheng Zhang State Key Laboratory of Heavy Oil Processing and Department of Chemical EngineeringChina University of Petroleum-BeijingBejing102249China Petrochemical Research Institute of PetroChina Company Limited Daqing163000HeilongjiangChina

Internal diffusion of molecules in porous materials plays an important role in many chemical ***, the pore diffusion capacity of porous materials cannot be measured by conventional catalyst characterization methods. In the present paper, a pore diffusion factor, the ratio of the diffusionconstriction factor to the pore tortuosity of the porous materials, was proposed to measure the diffusion ability of pores inside solid materials, and a method was proposed for measuring the diffusion factor using a well-defined and uniform pore size material as a reference. The diffusion factor was calculated based on the effective diffusion coefficients and the diffusion-constriction factor and pore tortuosity of the reference porous materials. The pore diffusion factor measurement can be performed at room temperature and atmospheric pressure. The pore diffusion factor of conventional porous materials was found to be much smaller than 1, indicating that there is a lot of room for improving the diffusion ability of the conventional catalysts and adsorbents, and could be significantly increased through adding small number of fibers into the conventional porous materials as template.

关键词： Porous materials Well-defined and uniform pore structure materials Internal diffusion Diffusion factor Tortuosity

In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： Wei-Jian guo Ao Zhou Wen-Wen Cai jin-tao Zhang Key Laboratory for Colloid and Interface Chemistry (Ministry of Education) School of Chemistry and Chemical EngineeringShandong University

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO2) into high-value chemicals, thereby presenting a promising avenue toward achieve carbon neutrality. However, addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting task. In this study, the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ pyrolysis. The porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer, thus enhancing their electrocatalytic activity and stability. Additionally, nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions, thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical calculation. Consequently, Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential windows. Notably, its faradaic efficiency(FE) of formate reaches 92.7% in H-cell and94.9% in flow cell, respectively, with good electrocatalytic stability. The in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Carbon dioxide reduction Electron delocalization N-doping Porous carbon nanofiber