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Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin jin Wenke jin Linlin Tong Jia Zhao Lan zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

Pion-photon and kaon-photon transition distribution amplitudes in the Nambu–Jona-Lasinio model

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Chinese Physics C 2024年第8期48卷 94-103页

作者： jin-Li zhang Jun Wu Department of Mathematics and Physics Nanjing Institute of TechnologyNanjing 211167China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China

The Nambu–Jona-Lasinio model is utilized to investigate the pion-and kaon-photon leading-twist transition distribution amplitudes using proper time ***,the properties of the vector and axial vector pion-photon transition distribution amplitudes are examined,and the results meet the desired *** study involves sum rule and polynomiality *** vector and axial vector pion-photon transition form factors that are present in theπ^(+)→γe^(+)νprocess are the first Mellin moments of the pion-photon transition distribution *** vector transition form factor originates from the internal structure of hadrons,the axial current can be coupled to a pion,this pion is virtual,and its contribution will be present independently of the external *** kaon transition form factors are *** vector form factor's value at zero momentum transfer is determined by the axial anomaly,while this is not the case for the axial *** vector and axial form factors,as well as the neutral pion vector form factor F_(πγγ)(t),are *** to our findings,the pion axial transition form factor is harder than the vector transition form factor and harder than the electromagnetic form *** also discuss the link betweenπ−γandγ−πtransitions distribution amplitudes.

关键词： transition form factors NJL model transition distribution amplitudes

Photostriction effect and electric properties of La-doped PMN-PT transparent ferroelectric ceramics

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International Journal of Smart and Nano Materials 2024年第2期15卷 296-311页

作者： Zhiqiang song Zhuo zhang Yirong Yu Dabin Lin Department of Automation and Robotics Engineering School of AutomationWuxi UniversityWuxiChina School of Optoelectronic Engineering Xian Technological UniversityXi'anChina

Ferroelectric ceramics display a remarkable photostriction effect,which could facilitate the prevention of electromagnetic interference and promote the integration and miniaturization of actuator systems,indicating potential applications in glim-mer *** this work,highly transparent La-doped 0.9Pb(Mg1/3Nb2/3)O3-0.1PbTiO3(0.9PMN-0.1PT)ceramicswere synthesized using a solid-state reaction method in an oxyge-nated *** and SEM were used to analyze the phase structure of the dense samples,which displayed a pure perovskite structure,with no trace of a pyrochlore *** La doping,the phase transitiontemperature shows a decreasing trend,and its dielectric constant could reach up to 20,*** P-E loop of the samples was gradually refined into a straight line with an increase in the doping *** La doping,the transparency of the 0.9PMN-0.1PT cera-mics was significantly enhanced and reached up to 61%at the near-infrared ***,the photogenerated voltage and deformation of the La-doped 0.9PMN-0.1PT ceramics were investigated under ultraviolet light of various *** 20 s of irradiation at an intensity of 800 mW/cm²,the max-imum voltage and deformation,with values of 40 V and 250 nm,respectively,were both found in the 1%La-doped 0.9PMN-0.1PT ceramics.

关键词： Photostriction ferroelectric Raman piezoelectric

Research on Data Tampering Prevention Method for ATC Network Based on Zero Trust

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Computers, Materials & Continua 2024年第3期78卷 4363-4377页

作者： Xiaoyan Zhu Ruchun Jia Tingrui zhang song Yao School of Computer Science Hefei University of TechnologyHefei230000China College of Computer Science Sichuan UniversityChengdu610065China Sichuan University-Pittsburgh Institute Sichuan UniversityChengdu610065China School of Information and Business Management Chengdu Neusoft UniversityChengdu610065China

The traditional air traffic control information sharing data has weak security characteristics of personal privacy data and poor effect,which is easy to leads to the problem that the data is *** from the application of the ATC(automatic train control)network,this paper focuses on the zero trust and zero trust access strategy and the tamper-proof method of information-sharing network *** the improvement of ATC’s zero trust physical layer authentication and network data distributed feature differentiation calculation,this paper reconstructs the personal privacy scope authentication structure and designs a tamper-proof method of ATC’s information sharing on the *** the single management authority to the unified management of data units,the systematic algorithm improvement of shared network data tamper prevention method is realized,and RDTP(Reliable Data Transfer Protocol)is selected in the network data of information sharing resources to realize the effectiveness of tamper prevention of air traffic control data during *** results show that this method can reasonably avoid the tampering of information sharing on the Internet,maintain the security factors of air traffic control information sharing on the Internet,and the Central Processing Unit(CPU)utilization rate is only 4.64%,which effectively increases the performance of air traffic control data comprehensive security protection system.

关键词： Zero trust access policy air traffic information sharing network privacy data tam-per-proof certification features

First Record of Cyclocarya from the Early Oligocene Qaidam Basin,North Tibet:Implications for the Paleogeography and Paleoecology

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Journal of Earth Science 2024年第1期35卷 201-211页

作者： Yafei Hou Bowen song Xiangchuan Li Fang Han Xu zhang Kexin zhang Institute of Geological Survey China University of GeosciencesWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China College of Earth Sciences and Resources&Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of Education Chang'an UniversityXi'an 710054China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China School of Earth Sciences East China University of TechnologyNanchang 330013China

As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the *** this study,based on morphological comparison,fossil fruit of Cyclocarya from the Early Oligocene Shangganchaigou Formation in the Qaidam Basin is assigned as Cyclocarya *** discovery of Cyclocarya *** demonstrates the occurrence of Cyclocarya in the Oligocene sediment in Qaidam *** is the first record of Cyclocarya fossil of Early Oligocene Age in China and indicates that Cyclocarya has existed on the northeastern TP since at least the Early *** living analogues of the current fossil now lives in sub-tropical China,where the East Asian Monsoon is *** the new fossils and previously reported fossil remains of plants and fishes,it can be inferred that the Early Oligocene Qaidam Basin was primarily influenced by westerly circulation and had a relatively warm and humid climate,which was in sharp contrast to the present-day climate in Qaidam Basin.

关键词： biostratigraphy climate change winged-fruit fossil Qaidam Basin Early Oligocene paleoclimate paleogeography

Fine-Grained Ship Recognition Based on Visible and Near-Infrared Multimodal Remote Sensing Images: Dataset,Methodology and Evaluation

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Computers, Materials & Continua 2024年第6期79卷 5243-5271页

作者： Shiwen song Rui zhang Min Hu Feiyao Huang Department of Aerospace Science and Technology Space Engineering UniversityBeijing101416China

Fine-grained recognition of ships based on remote sensing images is crucial to safeguarding maritime rights and interests and maintaining national ***,with the emergence of massive high-resolution multi-modality images,the use of multi-modality images for fine-grained recognition has become a promising ***-grained recognition of multi-modality images imposes higher requirements on the dataset *** key to the problem is how to extract and fuse the complementary features of multi-modality images to obtain more discriminative fusion *** attention mechanism helps the model to pinpoint the key information in the image,resulting in a significant improvement in the model’s *** this paper,a dataset for fine-grained recognition of ships based on visible and near-infrared multi-modality remote sensing images has been proposed first,named Dataset for Multimodal Fine-grained Recognition of Ships(DMFGRS).It includes 1,635 pairs of visible and near-infrared remote sensing images divided into 20 categories,collated from digital orthophotos model provided by commercial remote sensing *** provides two types of annotation format files,as well as segmentation mask images corresponding to the ship ***,a Multimodal Information Cross-Enhancement Network(MICE-Net)fusing features of visible and near-infrared remote sensing images,has been *** the network,a dual-branch feature extraction and fusion module has been designed to obtain more expressive *** Feature Cross Enhancement Module(FCEM)achieves the fusion enhancement of the two modal features by making the channel attention and spatial attention work cross-functionally on the feature map.A benchmark is established by evaluating state-of-the-art object recognition algorithms on ***-Net conducted experiments on DMFGRS,and the precision,recall,mAP0.5 and mAP0.5:0.95 reached 87%,77.1%,83.8%and 63.9%,*** experiments demons

关键词： Multi-modality dataset ship recognition fine-grained recognition attention mechanism

Balanced Fracturing and Cold-welding of Magnesium during Ball Milling Assisted by Carbon Coating:Experimental and Molecular Dynamic Simulation

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 895-903页

作者：韩宗盈 DONG Hui DING Guoyang zhang Jiale song Xiufang College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China

The lignite-derived carbon from self-protection pyrolysis was employed to balance the fracturing and cold-welding of magnesium during ball *** size analysis indicates that the introduction of lignite-derived carbon can effectively reduce the particle size of Mg while the introduction of graphite does no ***,the effect of lignite-derived carbon on crystallite size reduction of Mg is also better than graphite.A moderate cold-welding phenomenon was observed after ball-milling Mg with the lignite-derived carbon,suggesting less Mg is wasted on the milling vials and *** dynamic simulations reveal that the balanced fracturing and cold-welding of magnesium during ball milling is mainly attributed to the special structure of the lignite-derived carbon:graphitized short-range ordered stacking function as dry lubricant and irregular shape/sharp edge function as milling *** preliminary findings in current study are expected to offer implications for designing efficient Mg-based hydrogen storage materials.

关键词： magnesium lignite-derived carbon cold-welding ball milling molecular dynamic

DeepCRBP:improved predicting function of circRNA-RBP binding sites with deep feature learning

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Frontiers of Computer Science 2024年第2期18卷 235-237页

作者： Zishan XU Linlin song Shichao LIU Wen zhang College of Informatics Huazhong Agricultural UniversityWuhan 430070China

1 Introduction Recently,there is growing evidence that it is essential to predict the interactions between circRNAs and RBP binding sites for diagnosing diseases and providing a potential target to treat diseases[1].Many studies have predicted the binding sites of circRNA-RBPs by using deep learning methods based on the sequence information of circRNAs for each ***,many methods focus on diversified view of sequence encoding for improving the performance of the predictive models.

关键词： learning Deep function

Experimental study on the effect of flexible joints of a deep-buried tunnel across an active fault under high in-situ stress conditions

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Underground Space 2024年第6期19卷 189-207页

作者： Jiawei zhang Zhen Cui Qian Sheng Wanhua Zhao Liang song State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China School of Civil Engineering and Architecture Wuhan Polytechnic UniversityWuhan 430023China

During dislocation,a tunnel crossing the active fault will be damaged to varying degrees due to its permanent stratum *** previous studies did not consider the influence of the tunnel’s deep burial and the high in-situ stress,so the results were not entirely *** this paper,the necessity of solving the anti-dislocation problem of deep-buried tunnels is systemically *** the model test of tunnels across active faults,the differences in failures between deep-buried tunnels and shallow-buried tunnels were compared,and the dislocation test of deep-buried segmental tunnels was carried out to analyze the external stress change,lining strain,and failure mode of *** results are as follows.(1)The overall deformation of deep-buried and shallow-buried tunnels is both *** failure mode of deep-buried tunnels is primarily characterized by shear and tensile failure,resulting in significant compressive deformation and a larger damaged *** contrast,shallow-buried tunnels mainly experience shear failure,with the tunnel being sheared apart at the fault crossing,leading to more severe damage.(2)After the segmental structure design of the deep-buried tunnel,the‘‘S”deformation pattern is transformed into a‘‘ladder”pattern,and the strain of the tunnel and the peak stress of the external rock mass are reduced;therefore,damages are significantly mitigated.(3)Through the analysis of the distribution of cracks in the tunnel lining,it is found that the tunnel without a segmental structure design has suffered from penetrating failure and that cracks affect the entire *** cracks in a flexible segmental tunnel affect about 66.6%of the entire length of the tunnel,and cracks in a tunnel with a short segmental tunnel only affect about 33.3%of the entire length of the ***,a deep-buried tunnel with a short segmental tunnel can yield a better anti-dislocation effect.(4)By comparing the shallow-buried segmental tunnel in previous

关键词： Tunnel project Crossing active fault High in-situ stress Segmental structure design Flexible joint