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SDC1 acts as a novel molecular marker and prevents rheumatoid arthritis and modulates inflammatory response by targeting the miR-4531/SDC1 axis

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Medical Data Mining 2023年第1期6卷 17-27页

作者： Yi-Wen Tao jin-song su Yi Zhang Yong Zeng Xian-Li Meng Shao-Hui Wang State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China State Key Laboratory of Southwestern Chinese Medicine Resources School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu 611137China

Objective:Rheumatoid arthritis(RA)is a systemic autoimmune disease characterized by chronic erosive *** to the lack of effective biomarkers for diagnosis and treatment,RA patients have many complications in the later stage,seriously affecting their quality of ***,this study was conducted to investigate new therapeutic targets and to discover diagnostic biomarkers in ***:In this study,the expression profiles of GSE55235 and GSE55457 were downloaded from the Gene Expression Omnibus database to obtain DEGs between RA and healthy *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on the common genes existing in the RA-related ***,we used the STRING database to construct the protein‒protein interaction ***,we established the interaction analysis of Hub Genes and microRNA(miRNA)and verified the 10 Hub genes through the GSE77298 dataset and quantitative real-time polymerase chain reaction Results:276 and 69 DEGs were screened from the GSE55235 dataset and GSE55457 dataset,***,we obtained 42 up-regulated genes in two chip datasets *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the 42 up-regulated genes showed that they were mainly concentrated in immune response-activating cell surface receptor signaling pathway,***,the protein-protein interaction network indicated that 10 hub genes are closely related to RA,including MS4A1,CD27,LCK,CD79A,SDC1,CXCL9,CXCL10,CXCL13,IGLL5,and *** addition,we found that miR-4531 is the same target miRNAs between MS4A1 and SDC1 through messenger RNA-miRNA co-expression ***,the GSE77298 gene chip and quantitative real-time polymerase chain reaction verified the expression of 10 Hub *** six Hub genes of CD27,SDC1,CXCL9,CXCL10,CXCL13,and IGJ are significantly ***:We found that SDC1 may be a novel molecular marker for the

关键词： SDC1 rheumatoid arthritis molecular marker microRNA miR-4531/SDC1 axis

Cross-lingual implicit discourse relation recognition with co-training

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维普期刊数据库

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Frontiers of Information Technology & Electronic Engineering 2018年第5期19卷 651-661页

作者： Yao-jie LU Mu XU Chang-xing WU De-yi XIONG Hong-ji WANG jin-song su School of Software Xiamen University State Key Laboratory for Novel Software Technology Nanjing University Institute of Software Chinese Academy of Sciences Provincial Key Laboratory for Computer Information Processing Technology Soochow University

A lack of labeled corpora obstructs the research progress on implicit discourse relation recognition （DRR） for Chinese, while there are some available discourse corpora in other languages, such as English. In this paper, we propose a cross-lingual implicit DRR framework that exploits an available English corpus for the Chinese DRR task. We use machine translation to generate Chinese instances from a labeled English discourse corpus. In this way, each instance has two independent views： Chinese and English views. Then we train two classifiers in Chinese and English in a co-training way, which exploits unlabeled Chinese data to implement better implicit DRR for Chinese. Experimental results demonstrate the effectiveness of our method.

关键词： Cross-lingual Implicit discourse relation recognition Co-training

Treatment of postoperative infectious complications in patients with human immunodef iciency virus infection

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World Journal of Emergency Medicine 2014年第2期5卷 103-106页

作者： Bao-chi Liu Lei Zhang jin-song su Andy Tsun Bin Li Department of surgery Shanghai Public Health Clinical Center Affiliated to Fudan University The Unit of Molecular Immunology Key Laboratory of Molecular Virology & Immunology Institut Pasteur of ShanghaiShanghai Institutes for Biological Sciences Chinese Academy of Sciences

BACKGROUND: Antibiotics are widely given for surgical patients to prevent infection. Because of the lack of study on the rational use of antibiotics in patients with human immunodef iciency virus(HIV)-infected during surgical procedures, we analyzed the risk factors affecting postoperative infectious complications in HIV-infected patients and explore the rational use of perioperative ***: This retrospective study consisted of 308 HIV-infected patients, 272 males and 36 females, who had undergone operation at the Shanghai Public Health Clinical Center from November 2008 to April 2012. The patients were divided into postoperative infection and non-infection groups. Their age and clinical variables were compared. The correlation between surgical incision, surgical site infection(SSI) and postoperative sepsis was analyzed. Prophylactic antibiotics were used for patients with type I and II incisions for less than 2 days. Patients with type III incisions were given antibiotics until the infection was controlled. Antiretroviral therapy(ART) was prescribed preoperatively for patients whose preoperative CD4 count was sulfamethoxazole and fluconazole were given preoperatively as prophylactic agents controlling Pneumocystis carinii pneumonia and fungal ***: A total of 196 patients developed postoperative infectious complications, and 7 patients died. Preoperative CD4 counts, ratio of CD4/CD8 cells, hemoglobin level, and postoperative CD4 counts, hemoglobin and albumin levels were risk factors of perioperative infection in HIV-infected patients. Patients with a preoperative CD4 count surgical incision. The rate of SSI in patients with type I surgical incisi

关键词： Human immunodeficiency virus Acquired immunodeficiency syndrome Perioperative period surgical site infection Antibiotics

Reconstruction of 3-D Temperature Field in Holographic Interferometry

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Semiconductor Photonics and Technology 2001年第1期7卷 45-49,55页

作者： PENG jin-song, HUANG su-yi (Dept. of Power Eng., Huazhong University of Sci. and Tech., Wuhan 430074, CHN) 华中科技大学动力系湖北武汉 430074

The tomography technique is commonly used for the reconstruction of holographic interferometry. However, the current reconstruction method doesn’t consider the measurement errors which are non-avoidable in the measurement and will degrade the reconstruction quality. The factors affecting the reconstruction quality are analyzed and the distribution law of the reconstruction error with experimental errors is discussed. Finally, a method to improve the reconstruction quality—the Kalman filter method is presented.

关键词： Holographic interferometry Temperature measurement Kalman filter

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广西壮族自治区双语教育政策绩效研究

云南民族大学学报（哲学社会科学版） 2017年第5期34卷 146-151页

作者：杨胜才柳劲松苏美玲中南民族大学教育学院湖北武汉430074

在构建起涵盖了"内部条件、外部条件、主观绩效和客观绩效"四个纬度的双语教育政策绩效评价指标体系的基础上,通过对广西壮族自治区南宁市武鸣区4所中小学中的2000多名师生为样本进行问卷调查和访谈并运用因子分析方法进行的分析研究表... 详细信息

在构建起涵盖了"内部条件、外部条件、主观绩效和客观绩效"四个纬度的双语教育政策绩效评价指标体系的基础上,通过对广西壮族自治区南宁市武鸣区4所中小学中的2000多名师生为样本进行问卷调查和访谈并运用因子分析方法进行的分析研究表明:"教师教学能力"和"政策满意度"对双语教育政策实施绩效的影响最大,学生的"学习基础""政策知晓度"和"教材课程等支持条件"位居其次,而学生的"学习动机与方法"对双语教育政策实施绩效也产生一定影响。为切实提高双语教育政策绩效存,应加强规划统筹协调,加大经费投入强度;构建双语教育体系,创新教育教学模式;加强双语课程建设,科学制定教材规划;推进教师队伍建设,确保质量同步提增;把握规律导向舆论,有效提升育人能力;精心打造创新工程,彰显独特文化功能。

关键词：双语教育政策政策绩效边疆民族地区

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试析矿产资源测绘工作过程综合技术的应用

世界有色金属 2018年第16期43卷 37-37,39页

作者：宋金成苏圣来内蒙古自治区第九地质矿产勘查开发院内蒙古锡林浩特026000

本文以全球定位系统为切入点,通过介绍其功能和特点,引出矿产资源测绘工作中各种测绘装备的综合运用情况。并且也详细地分析讨论了各种计算机软件在测绘工作中的应用情况,同时也对这些先进的、具有一定综合性的技术对矿产资源测绘工作... 详细信息

本文以全球定位系统为切入点,通过介绍其功能和特点,引出矿产资源测绘工作中各种测绘装备的综合运用情况。并且也详细地分析讨论了各种计算机软件在测绘工作中的应用情况,同时也对这些先进的、具有一定综合性的技术对矿产资源测绘工作所带来的正面效应进行了分析和阐述。

关键词：矿产资源测绘工作综合技术应用

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang su Zhang Ruixin Zhang song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics